Synthesis of homocarnosine for applications in bioactive peptide and functional food studies.

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-20 DOI:10.1093/bbb/zbaf075

Tomoka Nagao, Kanako Sato, Takeshi Arima, Takumi Komaru, Sudathip Sae-Tan, Masubon Thongngam, Hisato Kuniyoshi, Makoto Hirayama, Yoshiaki Nakamura, Akiko Koi, Jun-Ichi Kakimura, Hitoshi Fujitaka, Ruge Cao, Noriyuki Yanaka, Thanutchaporn Kumrungsee

引用次数: 0

Abstract

Homocarnosine is a brain-specific dipeptide composed of γ-aminobutyric acid and L-histidine. In contrast to its well-known analog carnosine, homocarnosine is under-explored and non-commercially available. Here, we report an in-house and practical procedure for solid-phase synthesis of homocarnosine yielding a purity of > 95%. Applications of the synthesized homocarnosine in in vitro assays exhibited antioxidant and muscle-fiber-cell viability activities.

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正肌肽的合成及其在生物活性肽和功能性食品研究中的应用。

同型肌肽是由γ-氨基丁酸和l -组氨酸组成的脑特异性二肽。与其众所周知的类似物肌肽相比，同肌肽尚未得到充分开发，也未商业化。在这里，我们报告了一种内部和实用的固相合成方法，纯度为bbb95 %。合成的高肌肽在体外实验中显示出抗氧化活性和肌肉纤维细胞活力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).