pdrn样标记DNA通过其单链形式显示出对皮肤有益的特性。

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-05 DOI:10.1093/bbb/zbaf067

Hye-Won Lim, Yu-Hua Huang, Hye-Seung Baek, Hong-Gyum Kim, Kyu Earn Kim, Chang-Jin Lim

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引用次数: 0

摘要

利用标记DNA，这项工作旨在澄清PDRNs（多脱氧核糖核苷酸）的两种构象状态，ssDNA随机线圈或dsDNA螺旋形式，作为一种基于DNA的补救措施，作为一个活跃的参与者。对标记DNA溶液（BN）进行高温处理，得到具有增强的ssDNA的热变性BN溶液（BN- h）。BN-H表现出显著更高的有益特性。ssDNA状态负责其药理特性。

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PDRN-like marker DNA shows skin beneficial properties through its single-stranded form.

Using marker DNA, this work aimed to clarify which of the two conformational states of PDRNs (Polydeoxyribonucleotides) as a DNA-based remedy, ssDNA random coil or dsDNA helical form, acts as an active player. The marker DNA solution (BN) was subjected to high temperature, which yielded the thermal-denatured BN solution (BN-H) with the enhanced ssDNA. BN-H exhibited significantly higher beneficial properties. The ssDNA state is responsible for its pharmacological properties.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).