BMC Endocrine Disorders最新文献

{"title":"Hyperprolactinemia, hyperandrogenemia, pituitary adenoma, and metabolic disorders in Wiedemann-Steiner syndrome: a case report.","authors":"Hanting Liang, Jing Kong, Xiang Li, Xiaohong Xu, Chao Zheng","doi":"10.1186/s12902-026-02256-4","DOIUrl":"https://doi.org/10.1186/s12902-026-02256-4","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Spexin and Phoenixin-20 in girls during puberty.","authors":"Serkan Bilge Koca, Tarık Kırkgöz, Leyla Kara, Ebru Gök, Derya Koçer, Hüseyin Demirbilek","doi":"10.1186/s12902-026-02268-0","DOIUrl":"https://doi.org/10.1186/s12902-026-02268-0","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between triglyceride-glucose index and diabetic kidney disease in adults with type 1 diabetes.","authors":"Jie Xiang, Wei Gao, Yao Yao, Chan Lu","doi":"10.1186/s12902-026-02259-1","DOIUrl":"https://doi.org/10.1186/s12902-026-02259-1","url":null,"abstract":"<p><strong>Background: </strong>Diabetic kidney disease (DKD) is a major microvascular complication of type 1 diabetes mellitus (T1DM) and is associated with insulin resistance (IR). The triglyceride glucose (TyG) index has been identified as an alternative marker of IR. This study aimed to investigate the association between the TyG index and DKD in in adult patients with T1DM.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 210 adult patients with T1DM who were admitted to a single center between January 2021 and August 2025. The patients were divided into a non-DKD group (n = 150) and a DKD group (n = 60). They were further categorized into three groups according to tertiles of the TyG index. Demographic characteristics and biochemical parameters were collected and analyzed. Correlation analysis, logistic regression analysis, and receiver operating characteristic (ROC) curve analysis were performed. The calibration curve and decision curve analysis (DCA) were used to evaluate the accuracy and clinical utility.</p><p><strong>Results: </strong>Patients with DKD had significantly higher TyG values than those without DKD and were more likely to present with chronic diabetic complications and comorbidities (P < 0.05). After adjusting for confounding factors, the TyG index was positively correlated with the urinary albumin-to-creatinine ratio (UACR, r = 0.202, P < 0.05) and negatively correlated with the estimated glomerular filtration rate (eGFR, r = - 0.190, P < 0.05). Logistic regression analysis showed that in Model 3, compared with the T1 group, the odds ratio (OR) for DKD in the T3 group was 2.248 (95% CI: 1.390-3.635, P = 0.001). ROC curve analysis demonstrated that the area under the curve (AUC) for the TyG index was 0.682 (95% CI: 0.605-0.758, P < 0.001), with a sensitivity of 0.750 and a specificity of 0.681. In comparison, the AUCs for the estimated glucose disposal rate (eGDR) and HbA1c was 0.554 (95% CI: 0.467-0.641, P = 0.235) and 0.586 (95% CI: 0.500-0.672, P = 0.059), respectively. DCA confirmed the clinical practicality of TyG model.</p><p><strong>Conclusion: </strong>The TyG index demonstrated a positive association with DKD in patients with T1DM and may serve as an adjunctive marker for early risk stratification or as a component of a multi-marker panel, rather than as a standalone diagnostic tool for DKD.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced glycation end-products and sclerostin are elevated across diabetes phenotypes and associated with vertebral fractures in type 2 diabetes.","authors":"Sevdenur Taskin Kursun, Eren Imre, Dilek Gogas Yavuz","doi":"10.1186/s12902-026-02254-6","DOIUrl":"https://doi.org/10.1186/s12902-026-02254-6","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated gamma glutamyl transferase levels as screening marker of stage 3-4 hepatic fibrosis in youth-onset type 2 diabetes mellitus: a retrospective chart review.","authors":"Aditi Dasgupta, Panteha Hayati Rezvan, Tania Mitsinikos, Nancy Chang, Juan C Espinoza, Lily C Chao","doi":"10.1186/s12902-026-02255-5","DOIUrl":"https://doi.org/10.1186/s12902-026-02255-5","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between DXA-derived parameters of body composition and bone mass density in patients with T2DM and metabolic dysfunction-associated steatotic liver disease: a cross-sectional study.","authors":"Emil Fraenkel, Martin Kaško, Tomáš Koky, Ivica Lazúrová","doi":"10.1186/s12902-026-02262-6","DOIUrl":"https://doi.org/10.1186/s12902-026-02262-6","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease(MASLD) is associated with the deterioration of bone mass density(BMD), but the independent contributions of soft tissue parameters of body composition are not fully understood. We aimed to evaluate the relationship between the degree of liver steatosis, as assessed by vibration-controlled transient elastography(FibroScan^®), and DXA-derived BMD indices in the European population.</p><p><strong>Methods: </strong>156 patients, 95 females and 61 males, aged 33-78 years, treated for T2DM and MASLD with oral antidiabetic medication, were included in this cross-sectional study. Subgroup analyses were conducted by sex, age, BMI, lean mass index, and the extent of fibrosis. Multiple linear regression models were fitted with BMD indices as the dependent variable and the Controlled Attenuation Parameter(CAP) as a measure of liver steatosis, serving as the independent variable. The models were adjusted for age, sex, HOMA-IR, BMI, lean mass index, and android fat mass%. Accordingly, ROC curves with T-score(Z-score)=-1.0 were plotted as a classifier of bone mass deterioration.</p><p><strong>Results: </strong>The total BMD and CAP were positively correlated in the entire group(r = 0.21,p = 0.001) and in the female group(r = 0.29,p = 0.004), but not in the male group(r = 0.08,p = 0.51). The association maintained significance after adjustment for total body fat%(r = 0.23,p = 0.003), AGR(r = 0.22,p = 0.005), lean mass index(r = 0.19,p = 0.02) and osteocalcin(r = 0.16,p = 0.04) but not for BMI(r = 0.13,p = 0.09). The AUC in the female group for total BMD in the model calculated from CAP and android fat mass% and adjusted for age, was: ROC = 0.746(95%CI 0.62-0.88).</p><p><strong>Conclusions: </strong>Our results demonstrate existing discrepancies in the association between BMD and MASLD across sex-, age-, BMI-, lean mass index-, and fibrosis-stratified analyses. CAP and android fat% may have clinical value in predicting osteopenia in patients with MASLD and T2DM.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of continuous glucose monitoring in comparison to self-blood glucose monitoring in patients with type 2 diabetes mellitus under insulin treatment: a systematic review and meta-analysis.","authors":"Jingjing Zhu, Lu Zhang","doi":"10.1186/s12902-026-02167-4","DOIUrl":"10.1186/s12902-026-02167-4","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous glucose monitoring reveals distinct clinical implications of glucose levels at the start and end of hemodialysis in people with type 2 diabetes.","authors":"Akinori Hayashi, Rihito Takaesu, Haruna Sogabe, Yuiko Tani, Nagisa Aoki, Yoshiki Ko, Satoshi Tsuji, Ibuki Moriguchi, Naoyuki Kobayashi, Takeshi Miyatsuka","doi":"10.1186/s12902-026-02261-7","DOIUrl":"https://doi.org/10.1186/s12902-026-02261-7","url":null,"abstract":"<p><strong>Background: </strong>The clinical significance of glucose levels at the start and end of hemodialysis (HD) sessions in people with type 2 diabetes remains insufficiently explored.</p><p><strong>Methods: </strong>We retrospectively analyzed 116 individuals with type 2 diabetes undergoing HD (age 61 ± 12 years; 69% male; HbA1c 6.5 ± 1.3%; glycated albumin 21.1 ± 6.9%). Continuous glucose monitoring (CGM) data were collected from two dialysis institutions to evaluate sensor glucose levels at the start and end of HD sessions and their associations with CGM metrics and hypoglycemia.</p><p><strong>Results: </strong>Glucose levels were significantly higher at the start than at the end-of-HD (175.6 ± 55.4 mg/dL vs. 118.7 ± 43.3 mg/dL, P < 0.0001), with no correlation (r = 0.095, P = 0.31). Start-of-HD glucose was independently associated with dialysis duration (β = -0.184, P = 0.015) and time above range > 180 mg/dL (TAR¹⁸⁰; β = 0.576, P < 0.0001), whereas end-of-HD glucose was associated with glycemic variability (%CV; β = -0.412, P < 0.0001) and TAR¹⁸⁰ (β = 0.360, P < 0.0001). HD-induced hypoglycemia occurred in 25 participants (21.6%), including 14 (12.1%) during HD and 22 (19.0%) after HD. Lower end-of-HD glucose was significantly associated with all-cause hypoglycemia (OR 0.97; 0.95-0.98), HD-induced hypoglycemia (OR 0.96; 0.94-0.98), hypoglycemia during HD (OR 0.93; 0.90-0.97), and post-dialysis hypoglycemia (OR 0.95; 0.93-0.98; all P < 0.0001). An end-of-HD glucose level < 90 mg/dL was linked to increased all-cause (76.9% vs. 17.8%) and HD-induced (61.5% vs. 10.0%) hypoglycemia, demonstrating clinically meaningful discrimination for hypoglycemia risk stratification.</p><p><strong>Conclusion: </strong>Glucose levels at the start and end of HD sessions demonstrate distinct clinical relevance. End-of-HD glucose level serves as a useful marker for hypoglycemia risk, highlighting the potential importance of tailored monitoring strategies to support glycemic risk assessment in this high-risk population.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-specific TSH reference limits and early levothyroxine effects in postmenopausal women with subclinical hypothyroidism: a prospective cohort study in Vietnam.","authors":"Han Thi Ngoc Nguyen, Huong Thi Thanh Nguyen, Phan Ngoc Vu Dang, Hoa Thai Nguyen, Chau Thi Kim Doan, An Viet Tran, Nga Bich Vu","doi":"10.1186/s12902-026-02245-7","DOIUrl":"https://doi.org/10.1186/s12902-026-02245-7","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum prolactin and anterior pituitary dysfunction in pituitary stalk interruption syndrome: a retrospective study of 155 patients from a large tertiary medical center in China.","authors":"Lei Fu, Yan Xiao, Deyue Jiang, Lingtong Ye, Yiming Mu, Zhaohui Lyu, Qinghua Guo","doi":"10.1186/s12902-026-02252-8","DOIUrl":"https://doi.org/10.1186/s12902-026-02252-8","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}