BMC Endocrine Disorders最新文献

{"title":"Altered cortical thickness in type 2 diabetes mellitus patients revealed by coordinate-based meta-analysis.","authors":"Shengbo Han, Jie Li, Hongli Zhang, Liangliang Ping, Cong Zhou","doi":"10.1186/s12902-026-02276-0","DOIUrl":"https://doi.org/10.1186/s12902-026-02276-0","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid improvement in glycaemic control is associated with increased circulating osteocalcin in type 2 diabetes: a concise observational comparative study.","authors":"Dured Dardari, Francois-Xavier Laborne, Claire Thomas, Caroline Tourte, Elodie Henry, Philippe Lopes","doi":"10.1186/s12902-026-02277-z","DOIUrl":"https://doi.org/10.1186/s12902-026-02277-z","url":null,"abstract":"<p><strong>Background: </strong>Poor glycaemic control in type 2 diabetes is associated with low bone turnover and skeletal fragility. Osteocalcin has been linked to glucose homeostasis, but its short-term response to rapid improvement in chronic hyperglycaemia in adults remains insufficiently described.</p><p><strong>Methods: </strong>We conducted a single-centre observational comparative study in adults with type 2 diabetes. Group 1 had chronic poor control (HbA1c > 8.5% for at least 6 months) and underwent individualised treatment optimisation over 3 months as part of routine care. Group 2 had stable good control (HbA1c < 7% for at least 6 months) and served as a reference group for temporal stability. Total serum osteocalcin was measured at baseline (T0) and at 3 months (T3) and is reported in ng/mL. Body weight was retrieved retrospectively from the medical records. Analyses were exploratory.</p><p><strong>Results: </strong>Sixty participants were included (mean age 52 +/- 9 years; 50% women). Baseline osteocalcin concentrations were similar in Group 1 and Group 2 (12.4 +/- 4.3 vs. 12.5 +/- 3.9 ng/mL; between-group mean difference - 0.1 ng/mL, 95% CI -2.2 to 2.0). In Group 1, osteocalcin increased from 12.4 +/- 4.3 to 20.4 +/- 4.8 ng/mL (absolute mean change + 8.0 ng/mL; p < 0.0001), whereas Group 2 remained stable (12.5 +/- 3.9 to 12.8 +/- 3.7 ng/mL; absolute mean change + 0.3 ng/mL; p = 0.94). At 3 months, Group 1 osteocalcin exceeded Group 2 by 7.6 ng/mL (95% CI 5.4 to 9.8). Overall body weight increased descriptively from 79 +/- 3 kg at baseline to 81 +/- 2.4 kg at 3 months.</p><p><strong>Conclusions: </strong>Rapid improvement in glycaemic control was associated with increased circulating total osteocalcin over 3 months in chronically poorly controlled type 2 diabetes, while osteocalcin remained stable in a well-controlled reference group. Because the study was observational and important treatment, weight and lifestyle confounders were incompletely captured, the findings should be interpreted as hypothesis-generating rather than causal.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT04893135; first posted 19 May 2021.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of serum Farnesoid X Receptor (FXR) levels and their associations with obesity-related metabolic parameters: a clinical study.","authors":"Zeyneb Irem Yuksel Salduz, Rana Turgut, Zeynep Seval Coskun, Ozge Pasin, Murat Kartal, Aclan Ozder","doi":"10.1186/s12902-026-02231-z","DOIUrl":"10.1186/s12902-026-02231-z","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of herpes zoster and post-zoster SGLT2 inhibitors initiation on cardiorenal outcomes in type 2 diabetes mellitus.","authors":"Mei-Zhen Wu, Christopher Tze-Wei Tsang, Cheng Peng, Jia-Yi Huang, Ran Guo, Yi-Kei Tse, Yap-Hang Chan, Chi-Ho Lee, Jing-Nan Zhang, Wen-Li Gu, Xin-Li Li, Qing-Wen Ren, Kai-Hang Yiu","doi":"10.1186/s12902-026-02263-5","DOIUrl":"https://doi.org/10.1186/s12902-026-02263-5","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid dysfunction and its association with micronutrients, lipids, and inflammation: an analytical case-control study.","authors":"Dilshad Hamad Mustafa, Kochr Ali Mahmood, Faisal Faruq Sadiq, Saman Taher Barzinjy, Dawan Jamal Hawezy, Sirwan Khalid Ahmed","doi":"10.1186/s12902-026-02275-1","DOIUrl":"https://doi.org/10.1186/s12902-026-02275-1","url":null,"abstract":"<p><strong>Background: </strong>Biochemical, inflammatory, and immunological markers may provide insight into systemic alterations in individuals with or without thyroid dysfunction.</p><p><strong>Aim: </strong>This study compared a comprehensive biomarker profile between adults without thyroid disease and those with thyroid dysfunction, and examined gender differences, correlations, and predictive markers.</p><p><strong>Methods: </strong>In this case-control study, 120 adults without thyroid disease (cases) and 120 adults with thyroid dysfunction (controls) were enrolled. Demographics, anthropometry, and biochemical parameters-including thyroid hormones, micronutrients, lipid profiles, inflammatory markers, and Epstein-Barr virus PCR-were assessed. Between-group differences were analyzed using the Mann-Whitney U test and the χ² test. Spearman's rho was used to determine correlations, and multivariable linear regression was used to identify predictors of group status.</p><p><strong>Results: </strong>Cases and controls were similar in age (60 ± 12 vs. 60 ± 10.5 years) and body mass index (BMI) (24.85 ± 3.69 vs. 25.58 ± 3.39 kg/m²). Compared with controls, cases had significantly lower zinc (97.98 vs. 143.03 µg/dL), vitamin D₃ (88.24 vs. 152.76 nmol/L), and HDL (88.75 vs. 152.25 mg/dL), but higher serum cholesterol (159.56 vs. 81.44 mg/dL), triglycerides (TG) (171.08 vs. 69.92 mg/dL), LDL (136.06 vs. 104.94 mg/dL), and CRP (140.05 vs. 100.95 mg/L) (all p < 0.001). In controls, TSH correlated positively with the Urea Breath Test (UBT) (rho = 0.334) and negatively with LDL (rho=-0.255). In cases, T3 showed a strong correlation with UBT (rho = 0.625) and a moderate correlation with PCR-EBV (rho = 0.417), while TSH correlated with UBT (rho = 0.434) and CRP (rho = 0.264). Regression analysis identified serum TG (β = 76.806, R²=0.462) and cholesterol (β = 64.834, R²=0.337) as the strongest predictors of case-control status.</p><p><strong>Conclusion: </strong>Adults without thyroid disease exhibit distinct biochemical and inflammatory profiles compared with those with thyroid dysfunction, highlighting lipid, micronutrient, and inflammatory markers as potential targets for risk stratification and clinical monitoring.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction model for metformin intolerance in Chinese elderly patients with type 2 diabetes: derivation and external validation in a cross‑sectional study.","authors":"Wen Tan, Yizhe Li, Bin Lu, Jing Zhang, Yuxin Huang","doi":"10.1186/s12902-026-02278-y","DOIUrl":"https://doi.org/10.1186/s12902-026-02278-y","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors and predictive model construction of perioperative blood glucose fluctuations in patients with coronary heart disease complicated with type 2 diabetes mellitus undergoing percutaneous coronary intervention.","authors":"Xuemei Zhao, Yi Wen, Mingxia Zheng","doi":"10.1186/s12902-026-02265-3","DOIUrl":"https://doi.org/10.1186/s12902-026-02265-3","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin prescription patterns among patients with type 2 diabetes mellitus for primary and secondary prevention of cardiovascular disease.","authors":"Asmaa Mohamed Abdelaal, Mohamed Ghonem, Yasmin Atwa Mohamed, Ahmad S Hasan, Fady Kyrillos","doi":"10.1186/s12902-026-02242-w","DOIUrl":"10.1186/s12902-026-02242-w","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A community‑based study of platelet‑to‑white blood cell ratio and new‑onset type 2 diabetes in older adults.","authors":"Huan Sheng, Junyang Xu, Zhaoxiang Wang, Ying Pan","doi":"10.1186/s12902-026-02258-2","DOIUrl":"https://doi.org/10.1186/s12902-026-02258-2","url":null,"abstract":"<p><strong>Purpose: </strong>The platelet-to-white blood cell ratio (PWR) is a potential hematological indicator of dynamic changes in chronic inflammation. We aimed to investigate the association between the PWR and the risk of new-onset type 2 diabetes (T2D) in older adults.</p><p><strong>Methods: </strong>This retrospective community-based cohort study included 7571 community-dwelling older adults without diabetes from Kunshan, Jiangsu, China, who underwent health check-ups between January 2018 and December 2023. The PWR was calculated as the platelet count divided by the white blood cell count. The primary outcome was new-onset T2D. Associations were assessed using Cox proportional hazards models to compute hazard ratios (HRs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>During follow-up, 773 incident T2D cases occurred, and higher baseline PWR was significantly associated with a lower risk of T2D. Participants in the highest PWR quartile had a 24.0% lower risk (HR 0.760, 95% CI 0.615-0.940, P = 0.011) compared to the lowest quartile. Restricted cubic spline analysis revealed an approximately linear, inverse dose-response relationship (P overall < 0.001, P non-linear = 0.282). Subgroup and sensitivity analyses confirmed the robustness of this association.</p><p><strong>Conclusions: </strong>A higher baseline PWR is associated with a reduced risk of new-onset T2D in older adults, suggesting its potential as a simple, cost-effective inflammatory biomarker for T2D risk assessment in this population.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world prescribing patterns and early weight and blood pressure outcomes of GLP-1-based therapies: a retrospective observational study in the United Arab Emirates.","authors":"Salma Almemari, Nour Almulla, Yasmin Alsarraf, Ghada Badri, Nelofar Sami Khan","doi":"10.1186/s12902-026-02273-3","DOIUrl":"https://doi.org/10.1186/s12902-026-02273-3","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}