BMC Endocrine Disorders最新文献

{"title":"Age at type 1 diabetes onset does not influence attained brain volume.","authors":"Tor-Björn Claesson, Stefan Mutter, Jukka Putaala, Eero Salli, Daniel Gordin, Per-Henrik Groop, Juha Martola, Lena M Thorn","doi":"10.1186/s12902-025-01868-6","DOIUrl":"10.1186/s12902-025-01868-6","url":null,"abstract":"<p><strong>Introduction: </strong>Type 1 diabetes is suspected to hamper brain growth, implying that people with earlier diabetes onset would, on average, achieve lower maximal brain volume. We set out to test this hypothesis.</p><p><strong>Methods: </strong>Examining brain MRI scans of middle-aged people with type 1 diabetes, we related age at diabetes onset to intracranial volume in 180 participants, as well as to cerebral gray and white matter volumes in a subset of 113 (63%) participants, using fractional polynomial regression models. Of the participants, 118 (67%) had been diagnosed with diabetes before 18 years of age.</p><p><strong>Results: </strong>Of our participants, 54% were women, the median age 40.0 (IQR 33.2-45.0) years and the range of age at diabetes onset was 1.2-39.0 years. We found no association between age at diabetes onset and intracranial volume (p = 0.85), cerebral white (p = 0.10), or gray matter volumes (p = 0.12). Further, correlations between age at diabetes onset and the measured brain volumes were poor in analyses stratified for sex (all correlation coefficients ρ ≤ 0.16).</p><p><strong>Conclusions: </strong>We found no association between age at diabetes onset and attained intracranial volume or gray or white matter volumes, indicating that type 1 diabetes may not have a clinically significant influence on brain growth.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"43"},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex difference in the relationship between childhood obesity and abnormal lipid profiles in young adults.","authors":"Keyang Zheng, Yinkun Yan, Linlin Ma, Rufei Liu, Tianzhu Zhao, Yuxuan Wei, Zixu Zhao, Hong Cheng, Dongqing Hou, Junting Liu, Xiaoyuan Zhao, Wenli Cheng, Jie Mi","doi":"10.1186/s12902-025-01859-7","DOIUrl":"10.1186/s12902-025-01859-7","url":null,"abstract":"<p><strong>Background: </strong>Abnormal lipid profiles are a major risk factor for cardiovascular diseases, and childhood obesity has been linked to changes in lipid metabolism in adults. However, the relationship between childhood obesity and adult lipid profiles, as well as the potential sex differences, remain unclear. This study aimed to examine the association between childhood obesity and abnormal lipid metabolism in young adults, specifically focusing on sex differences.</p><p><strong>Methods: </strong>Data were obtained from the Beijing Blood Pressure Cohort Study, which included 1220 participants aged 28-45 years. Childhood obesity was defined based on body mass index (BMI) and subscapular skinfold thickness (SSFT) measurements. Adult lipid profiles, including triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and total cholesterol (TC), were measured. Logistic regression models were used to assess the association between childhood obesity and adult lipid profiles, adjusting for potential confounders.</p><p><strong>Results: </strong>During the follow-up period, 18 (2.9%) of 617 male subjects with normal weight as children were obese as adults. Of 516 female subjects with normal weight as children, 9 (1.7%) were obese as adults. In males, childhood overweight/obesity was positively associated with high TG in adulthood (OR = 1.72, 95%CI 1.03-2.85). In females, childhood overweight/obesity was significantly associated with high TC (OR = 5.96, 95%CI 1.42-25.00) and high LDL-c (OR = 6.91, 95%CI 1.17-40.75) in adulthood. The analysis of change in adiposity status from childhood to adulthood revealed that males with normal childhood weight and adult obesity could have the highest risk of all lipid disorders. In females, those with childhood obesity and normal adult weight seemed to have the highest risk of hypercholesterolemia and high TC.</p><p><strong>Conclusion: </strong>This study demonstrates a sex difference in the relationship between childhood obesity and abnormal lipid profiles in young adults. Childhood overweight/obesity is associated with adverse lipid profiles in adulthood, with different patterns observed in males and females. These findings highlight the importance of early intervention and prevention strategies for childhood obesity to mitigate the risk of future cardiovascular diseases.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"44"},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ramadan fasting among adolescents with type 1 diabetes: a systematic review and meta-analysis.","authors":"Omid Safari, Arman Shafiee, Afshin Heidari, Fatemeh Nafarzadeh, Dlnya Aminzadeh, Fatemeh Esmaeilpur Abianeh, Mohammad Javad Amini, Mahmood Bakhtiyari, Ayad Bahadori Monfared","doi":"10.1186/s12902-025-01835-1","DOIUrl":"10.1186/s12902-025-01835-1","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis assess the effects of Ramadan fasting in adolescents with type 1 diabetes mellitus (T1DM), on blood sugar factors such as hemoglobin A1C and problems caused by its lack of control such as hypoglycemia and DKA, and metabolic outcomes.</p><p><strong>Methods: </strong>Electronic databases including MEDLINE, Embase, and SINOMED were searched up to February 13, 2024, without language, region, or publication time restrictions. The outcomes were Acute complications, changes in Hemoglobin A1c (HbA1c) and weight changes. Meta-analyses used random-effects models to compute weighted Relative risk (RR) and standard mean differences (SMD). And to check the risk of bias of included studies, the Newcastle-Ottawa scale was used.</p><p><strong>Results: </strong>Nine studies were included, comprising 458 participants, with studies varying in quality from high to low. Meta-analysis showed no significant reduction in HbA1c levels post-Ramadan (SMD: -0.12; 95% CI: -0.38 to 0.14), indicating minimal impact on long-term glycemic control. The incidence of hypoglycemia was notably high (50.79 events per 100 observations), with hyperglycemia and diabetic ketoacidosis (DKA) also reported but less frequently. The variability in complication rates among studies was significant, reflecting the high heterogeneity across the data. Weight changes during Ramadan were minimal and not statistically significant, suggesting fasting's negligible effect on body weight among participants.</p><p><strong>Conclusions: </strong>Ramadan fasting among adolescents with T1DM does not significantly alter HbA1c levels, suggesting potential feasibility under careful monitoring and management. However, the high incidence of hypoglycemia underscores the need for vigilant glucose monitoring and tailored adjustments to diabetes management plans during fasting periods.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"45"},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of peripheral artery disease and risk factors among patients with diabetes mellitus in sub-Saharan Africa: a systematic review and meta-analysis.","authors":"Kirubel Eshetu Haile, Yordanos Sisay Asgedom, Gedion Asnake Azeze, Atitegeb Alebachew Amsalu, Gizachew Ambaw Kassie, Amanuel Yosef Gebrekidan","doi":"10.1186/s12902-025-01866-8","DOIUrl":"10.1186/s12902-025-01866-8","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is a non-communicable disease that presents a substantial public health challenge on a global scale. Peripheral artery disease is a significant macrovascular problem in diabetes mellitus characterized by atherosclerotic narrowing of the artery in the lower extremities, leading to compromised distal perfusion, primarily caused by atherosclerosis, and resulting in impaired functional capacity. Although existing studies on, peripheral artery disease among patients with diabetes mellitus are available, the results have been inconsistent.</p><p><strong>Objective: </strong>To determine the pooled burden and associated factors of peripheral artery disease among patients with diabetes mellitus in sub-Saharan Africa.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were performed following the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. To identify papers published in English up to August 10, 2024, the electronic databases of Medline, Science Direct, Excerpta Medica Database, Cochrane Library, African Journals Online, and Google Scholar were searched. A random-effects model was employed to estimate the pooled prevalence and associated factors of peripheral artery disease. To test for heterogeneity between studies and publication bias, forest plots and funnel plots were used.</p><p><strong>Results: </strong>This study revealed that the pooled prevalence of peripheral artery disease among patients with diabetes mellitus was 32.97% (95% CI 29.7, 36.24), reflecting the significant impact of diabetes mellitus on vascular health. Age (OR = 2.51, 95% CI = 3.41-12.09), increased level of low density lipoprotein (OR = 1.64, 95% CI = 1.05-13.09), BMI (OR = 3.03, 95% CI = 1.74-7.56), and illness duration exceeding 10 years (OR = 2.44, 95% CI = 1.12-5.13), were the significant predictors.</p><p><strong>Conclusion: </strong>Despite the alarming prevalence of peripheral artery disease among patients with diabetes in sub-Saharan Africa, it remains underdiagnosed; therefore, increased awareness, proactive screening initiatives, and management strategies within the clinical setting are necessary.</p><p><strong>Clinical trial number: </strong>Not applicable.</p><p><strong>Prospero: </strong>CRD42024594577.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"42"},"PeriodicalIF":2.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between hepatic enzymes, prediabetes, and diabetes in the Azar cohort population.","authors":"Elnaz Faramarzi, Saba Mehrtabar, Roghayeh Molani-Gol, Saeed Dastgiri","doi":"10.1186/s12902-025-01871-x","DOIUrl":"10.1186/s12902-025-01871-x","url":null,"abstract":"<p><strong>Background: </strong>Early prediabetes screening holds immense significance in decreasing the incidence of diabetes. Therefore, we aimed to evaluate the association of hepatic enzymes with prediabetes and diabetes in the Azar cohort population in Iran.</p><p><strong>Methods: </strong>This cross-sectional study utilized data from the Azar cohort study, initiated in 2014, with 14,865 participants aged 35-70 years. This study defines prediabetes, according to the American Diabetes Association (ADA), as fasting blood sugar (FBS) of 100-125 mg/dl. An FBS ≥ 126 mg/dL or a history of diabetes indicates diabetes. Serum liver enzymes including alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP) were measured, and associations with prediabetes and diabetes were analyzed using binary logistic regression.</p><p><strong>Results: </strong>In a study of 14,865 participants, 16% had prediabetes and 14.1% had diabetes. The serum levels of ALT, AST, GGT, and ALP were significantly higher (P < 0.05) in the prediabetic and diabetic patients. The adjusted logistic regression model showed a dose-response increase for all hepatic enzymes, with the highest ORs in the fourth quartile for both prediabetes and diabetes. The highest OR for prediabetes and diabetes was in the fourth GGT quartile.</p><p><strong>Conclusion: </strong>Our findings suggest that serum ALT, GGT, and ALP levels are strongly associated with prediabetes and diabetes. These hepatic enzymes may be considered easy and valuable early indicators of diabetes risk, prompting timely interventions to slow disease progression.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"41"},"PeriodicalIF":2.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of thyroid nodules among adults: analyzing the association with metabolic syndrome in a cross-sectional study.","authors":"Golbarg Abrishami, Maryam Emadzadeh, Aida Bakhshi, Yasamin Moeinipour, Ghazaleh Taghavi, Solmaz Hasani","doi":"10.1186/s12902-025-01869-5","DOIUrl":"10.1186/s12902-025-01869-5","url":null,"abstract":"<p><strong>Background: </strong>Thyroid nodules are prevalent clinical findings with potential for malignancy, particularly in aging populations. Metabolic syndrome, characterized by interrelated metabolic abnormalities, has been implicated as a potential risk factor. This study explores the prevalence of thyroid nodules and their association with metabolic syndrome, leveraging data from a large cohort.</p><p><strong>Methods: </strong>A cross-sectional study was conducted within the Persian Organizational Cohort in Mashhad, comprising 4,121 participants aged 35-70 years. Thyroid nodules were identified via ultrasonography, and metabolic syndrome was assessed using the NCEP ATP III criteria. Demographic, clinical, and laboratory data were analyzed using descriptive statistics, chi-square tests, and logistic regression models to identify predictors of thyroid nodules.</p><p><strong>Results: </strong>Thyroid nodules were detected in 27.4% of participants, with a higher prevalence in females (60%) than males (40%, p < 0.001). The average age of individuals with nodules was significantly higher than those without (47.9 vs. 43.5 years, p < 0.001). Metabolic syndrome prevalence was notably higher among those with thyroid nodules (5.3% vs. 3.8%, p = 0.028). Logistic regression analysis identified metabolic syndrome (OR = 1.43, p = 0.03), age (OR = 1.05 per year increase, p < 0.001), and gender as significant predictors of thyroid nodules.</p><p><strong>Conclusion: </strong>Metabolic syndrome significantly predicts the presence of thyroid nodules, suggesting shared pathophysiological mechanisms, including chronic inflammation and hormonal dysregulation. These findings underscore the importance of integrating metabolic health management into thyroid nodule evaluation and highlight the need for multidisciplinary approaches to optimize care and prevention strategies.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"40"},"PeriodicalIF":2.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram for predicting the risk of cervical lymph node metastases and recurrence in papillary thyroid carcinoma based on the thyroid differentiation score system and clinical characteristics.","authors":"Yutong Liu, Xuanjie Wang, Xiaodan Sun, Hongxue Li, Lidong Wang","doi":"10.1186/s12902-025-01867-7","DOIUrl":"10.1186/s12902-025-01867-7","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify independent predictors of cervical central lymph node metastasis (CLNM), cervical lateral lymph node metastasis (LLNM), and recurrence in patients with PTC, which could help guide the surgical management of these patients.</p><p><strong>Methods: </strong>This retrospective study analyzed data from 542 patients with PTC, who underwent thyroid surgery and were enrolled in The Cancer Genome Atlas and Gene Expression Omnibus databases. Patients were categorized into two groups based on the presence or absence of cervical LNM, classified as CLNM or LLNM. Data were randomly partitioned into training and validation sets in a ratio of 7:3. Age, sex, thyroid differentiation score (TDS), and other relevant attributes, were compared between the two groups using univariate and multivariate analyses and reported as odds ratios (OR) or hazard ratios (HR) with 95% confidence intervals (CI). Independent predictors were identified and used to develop nomograms. To assess the accuracy, discrimination, and clinical utility of the prediction model, calibration, receiver operating characteristic (ROC), and decision curve analysis (DCA) were performed for both the training and validation sets.</p><p><strong>Results: </strong>Of the 542 patients, 261 (48.15%) and 130 (23.99%) presented with CLNM and LLNM, respectively. The analyses identified several independent predictors for CLNM, including the presence of extrathyroidal invasion (OR 2.53, 95% CI 1.60-4.00), larger tumor dimension (OR 1.17, 95% CI 1.02-1.34), age over 55 years (OR 0.52, 95% CI 0.33-0.82), non-classic papillary subtype (OR 0.38, 95% CI 0.23-0.61), and lower TDS (OR 0.50, 95% CI 0.33-0.76). A greater number of excised cervical LNs (OR 12.30, 95% CI 4.35-34.77), the presence of CLNM (OR 1.07, 95% CI 1.04-1.10), and lower TDS (OR 0.09, 95% CI 0.04-0.21) were independent predictors for LLNM. Additionally, the independent predictors for relapse included age greater than 55 years (HR 1.87, 95% CI 1.00-3.49) and lower TDS (HR 0.35, 95% CI 0.20-0.62). These predictors were used to develop nomograms for CLNM, LLNM, and recurrence. ROC and DCA confirmed the discrimination and clinical utility of the models.</p><p><strong>Conclusions: </strong>This study identified independent predictors of cervical CLNM, LLNM, and recurrence. Clinically relevant nomograms were developed that can assist in guiding cervical lymph node dissection and prediction of recurrence in patients with PTC.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"39"},"PeriodicalIF":2.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific association between a novel atherogenic index of plasma, metabolic parameters and inflammation among obese adults.","authors":"Keyan Zhao, Shibo Ling","doi":"10.1186/s12902-024-01813-z","DOIUrl":"10.1186/s12902-024-01813-z","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have demonstrated the association between lipoprotein combined index (LCI), as a novel atherogenic index with cardiovascular disease, fatty liver, diabetes and numerous other health problems; however, its association with metabolic syndrome risk and its components has not been investigated before. The current study was aimed to investigate the association between LCI metabolic and inflammatory risk factors among obese men and women.</p><p><strong>Methods: </strong>In the current cross-sectional study, the association between LCI, anthropometric parameters and metabolic risk factors including serum lipids, glycemic markers, insulin resistance and C - reactive protein (CRP) concentrations were measured. LCI was calculated as (total cholesterol [TC] × triglyceride [TG] × low density lipoprotein cholesterol [LDL]) / (high density lipoprotein cholesterol [HDL]).</p><p><strong>Results: </strong>Highest quartiles of LCI was accompanied with higher waist to hip ratio (P = 0.017). Also, higher systolic and diastolic blood pressure, higher serum lipids and lower high density lipoprotein concentrations were observed in higher quartiles of LCI HDL (P < 0.05). Among men and women, higher LCI was also associated with higher CRP and lower HDL in men (P < 0.05); while among women, higher CRP, TG, TC and lower HDL was observed in highest versus lowest quartiles of LCI (P < 0.05). Among anthropometric and biochemical variables, TG has the highest power for identification of metabolic syndrome with area under curve (AUC) of 0.82 and Youden index of 0.58 while LCI was in the second place after TG in prediction of metabolic syndrome (e.g. AUC of 0.80 and Youden index of 0.47).</p><p><strong>Conclusion: </strong>LCI was in direct association with lipid parameters and inflammation among obese men and women. Although predictive power of LCI for metabolic syndrome was acceptable, but it came in the second place after TG for men and women. Further studies are warranted to make a better conclusion.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"38"},"PeriodicalIF":2.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow cytometry immune profiling of recurrent and newly diagnosed growth hormone secreting pituitary neuroendocrine tumors: comparison of two clinical cases.","authors":"Daria Lisina, Valeria Mazeeva, Elena Zakharova, Alyona Sorokina, Lilya Dzhemileva, Andrey Grigoriev, Vilen Azizyan, Alexandra Shutova, Ekaterina Pigarova, Larisa Dzeranova, Galina Melnichenko, Sergei Rumiantsev, Natalia Mokrysheva, Vladimir Chekhonin, Marina Loguinova","doi":"10.1186/s12902-025-01865-9","DOIUrl":"10.1186/s12902-025-01865-9","url":null,"abstract":"<p><p>Early detection of aggressive pituitary neuroendocrine tumors (PitNETs) remains challenging due to the absence of reliable markers that can predict disease progression. Aggressive tumors are typically identified through long-term observation. Tumor immune microenvironment (TIME) is crucial for understanding PitNETs' heterogeneity and identifying potential predictors of tumor aggressiveness. In this study, we analyzed immune profile of micro- and macroenvironment in two somatotropinomas (aggressive and non-aggressive) using flow cytometry. We observed lymphopenia and elevated neutrophil levels in the periphery in the patient with tumor recurrence. The aggressive TIME showed greater leukocyte infiltration, with lymphoid cells predominating over myeloid cells along with a higher proportion of CD4 + T cells over CD8 + T cells. We detected double-positive CD4 + CD8 + population, high level of regulatory T cells and a sharp increase in PD-1 + expressing T cells over six months during recurrence. In the blood of the patient with tumor recurrence, we observed reduced granule-mediated cytotoxicity of CD8 + T cells and NK-cells. In the aggressive TIME the number of effector cells producing perforin and granzyme B-both independently and simultaneously was significantly lower. The proportion of CD3-CD20- NK cells and CD3-CD56 + NK cells was low after the first recurrence but increased sharply after six months. The ratio of monocyte subpopulations in tumor differed from that in blood, with CD16 + expressing monocytes predominating in the TIME of both patients. M2 macrophages in TIME rose sharply to 60.8% over six months during recurrence. In several immunological parameters, the patient with tumor recurrence exhibited a more pronounced immunosuppressive profile.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"37"},"PeriodicalIF":2.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of liberal glucose control on critically ill patients: a systematic review and meta-analysis.","authors":"Jiahui Ma, Xu Wang, Yan Zhang, Chunyan Ge","doi":"10.1186/s12902-025-01864-w","DOIUrl":"10.1186/s12902-025-01864-w","url":null,"abstract":"<p><strong>Background: </strong>Most current guideline statements support some level of unrestricted glycemic management in critically ill adult patients. Nevertheless, the effectiveness of liberal glucose control is currently not well-supported by evidence. Therefore, our objective is to investigate the influence of liberal glucose control (> 180 mg/dl) on critically ill patients in the intensive care unit (ICU).</p><p><strong>Methods: </strong>Until November 23, 2023, English language literature was thoroughly and systematically searched through multiple databases, including PubMed, Embase, Cochrane Library, and Web of Science. Our primary endpoints of interest were the occurrence of hypoglycemia, mortality in the ICU, and mortality during hospitalization. In addition, our secondary outcomes comprised of 90-day mortality, bloodstream infections, the proportion of patients necessitating renal replacement therapy (RRT), the length of time under mechanical ventilation, duration of stay in the ICU, and length of the overall hospitalization. Weighted mean difference (WMD) and relative risk (RR) were respectively computed as overall effect size for continuous and dichotomous data and reported with their 95% confidence intervals (95% CI).</p><p><strong>Results: </strong>A total of 9 studies were incorporated, which included 14,878 patients in the ICU. Compared with other blood glucose target control groups, liberal glucose control significantly reduced the incidence of hypoglycemia (RR = 0.41; 95% CI:0.25 to 0.69; P = 0.001), but increased ICU mortality (RR = 1.23; 95% CI:1.03 to 1.48; P = 0.023), in-hospital mortality risk (RR = 1.18; 95% CI:1.03 to 1.35; P = 0.020), and the risk of requiring RRT (RR = 1.26; 95% CI:1.11 to1.42; P < 0.001).</p><p><strong>Conclusion: </strong>Liberal glucose control can reduce the risk of hypoglycemia but increases the risks of ICU mortality, in-hospital mortality, and the requirement for RRT. To confirm the outcomes further, large-scale, high-quality clinical trials are necessary.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"36"},"PeriodicalIF":2.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}