BMC Endocrine Disorders最新文献

{"title":"Association between circulatory immune cell to high-density lipoprotein cholesterol ratios and testosterone level in adult men: findings from NHANES 2011-2016.","authors":"Yangyang Mei, Bo Zhang, Yiming Chen, Renfang Xu, Dong Xue, Qianfeng Zhuang, Xingliang Feng","doi":"10.1186/s12902-025-02015-x","DOIUrl":"10.1186/s12902-025-02015-x","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"194"},"PeriodicalIF":3.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Incidence and predictors of diabetic kidney disease among type 2 diabetes mellitus adult patients in Ethiopia: a systematic review and meta-analysis.","authors":"Muluken Amare Wudu, Tarikua Afework Birhanu, Kirubel Dagnaw Tegegne, Endalk Birrie Wondifraw","doi":"10.1186/s12902-025-02021-z","DOIUrl":"10.1186/s12902-025-02021-z","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"193"},"PeriodicalIF":3.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between stress hyperglycemic ratio and all-cause mortality in diabetic patients with heart failure.","authors":"Zhenrun Zhan, Chao Lan, Yongze Zhang, Jiebin Lin, Ke Zheng, Ximei Shen, Sunjie Yan","doi":"10.1186/s12902-025-02010-2","DOIUrl":"10.1186/s12902-025-02010-2","url":null,"abstract":"<p><strong>Objective: </strong>The stress hyperglycemia ratio (SHR) quantifies the intensity of stress hyperglycemia by highlighting the rate of change in fasting blood glucose during stress. Several studies have validated the association of SHR with poor prognosis in cardiovascular disease. However, the value of SHR in diabetic patients with severe heart failure requiring ICU admission remains unclear. The aim of this study was to investigate the predictive value of SHR for poor prognosis in diabetic patients with heart failure.</p><p><strong>Methods: </strong>This study was based on the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and included diabetic patients with a diagnosis of heart failure. The primary outcome event was all-cause mortality. Patients were grouped according to quartiles of SHR, and the association between SHR and all-cause mortality was assessed using restricted cubic spline analysis, survival analysis, and Cox proportional hazards regression analysis.</p><p><strong>Results: </strong>A total of 1470 patients (55.7% male) were enrolled in this study. In-hospital mortality and intensive care unit (ICU) mortality reached 12.2% and 7.8%, respectively. In-hospital mortality was significantly higher in the highest quartile group of SHR. After correction for confounders, the risk of death was significantly higher in the highest quartile group compared with the lowest quartile group. Restricted cubic spline plot analysis showed a positive linear relationship between SHR and in-hospital and ICU mortality.</p><p><strong>Conclusion: </strong>SHR was significantly associated with in-hospital and ICU all-cause mortality in severe patients. This finding suggests that SHR may be useful in identifying diabetic patients with severe heart failure at high risk for all-cause mortality.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"192"},"PeriodicalIF":3.3,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could carotid artery calcifications and pulp stones be an alarm sign for diabetes mellitus? A retrospective observational study.","authors":"Motahare Baghestani, Mohadese Faregh, Seyed Hossein Razavi, Fatemeh Owlia","doi":"10.1186/s12902-025-02005-z","DOIUrl":"10.1186/s12902-025-02005-z","url":null,"abstract":"<p><strong>Background: </strong>Carotid artery calcifications and pulpal stones are radiopaque findings that may be found accidentally in panoramic views. The risk of affliction with atherosclerotic events in diabetic patients with dystrophic calcification is questionable. This study aimed to investigate the relative frequency of carotid calcifications and pulp stones in panoramic radiographs of diabetic patients.</p><p><strong>Methods: </strong>This retrospective observational study employed a convenience sampling method involving 107 diabetic patients. For comparison, 300 panoramic views from individuals estimated to be healthy in the community were included. The samples were randomly selected from the statistical population using a random numbers table. Data analysis was conducted using descriptive statistics, including mean and standard deviation, as well as analytical tests such as the chi-square test, all performed with SPSS 17 software (Chicago, USA).</p><p><strong>Results: </strong>In this study, panoramic radiographs of 107 diabetic patients (67 women and 40 men) and 300 healthy individuals (196 women and 104 men) were evaluated. The age range was 25 to 64 years, with a mean age of 49.7. The frequency of carotid artery calcification was 42 (14%) in healthy individuals and 44 (41.1%) in diabetic patients. Furthermore, the relative frequency of unilateral and bilateral carotid artery calcification in diabetic patients was significantly higher than in healthy subjects (P < 0.05). The Relative Risk (RR) of pulp stones in the diabetic patient group compared to healthy individuals was 1.8. With a 95% confidence interval, the relative risk ranged from 1.3 to 2.48, which was statistically significant (P < 0.05).</p><p><strong>Conclusions: </strong>Based on the findings, the frequency of carotid artery calcification and pulp stones was higher in diabetic patients. Panoramic radiographic screening in diabetic patients is useful for early detection of carotid artery calcification and timely referral of patients to endocrinologists to prevent adverse sequelae.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"191"},"PeriodicalIF":3.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and predictors of diabetic kidney disease among type 2 diabetes mellitus adult patients in Ethiopia: a systematic review and meta-analysis.","authors":"Muluken Amare Wudu, Tarikua Afework Birhanu, Kirubel Dagnaw Tegegne, Endalk Birrie Wondifraw","doi":"10.1186/s12902-025-02006-y","DOIUrl":"10.1186/s12902-025-02006-y","url":null,"abstract":"<p><strong>Background: </strong>Diabetic kidney disease is a leading cause of end-stage renal disease and mortality among patients with type 2 diabetes mellitus worldwide. Currently, there are no pooled estimates of the incidence of diabetic kidney disease or its modifiable predictors among patients with type 2 diabetes mellitus in Ethiopia. Therefore, this review aimed to determine the pooled incidence and associated factors of diabetic kidney disease in Ethiopia, addressing the existing information gap.</p><p><strong>Methods: </strong>Relevant studies were retrieved from PubMed, Scopus, EMBASE, and Google Scholar. Four reviewers independently screened studies, and data were extracted using a structured form. Quality assessment was conducted using the Joanna Briggs Institute critical appraisal checklist. Data analysis was performed in STATA version 17 using the Šidák-Jonkman random-effects model. Heterogeneity was evaluated using Cochrane's Q-test and the I² statistic, while publication bias was assessed using funnel plots, Egger's test, and a Doi plot.</p><p><strong>Results: </strong>Of the 165,230 studies identified, eight studies involving 3,703 participants were included in the meta-analysis. The pooled incidence of diabetic kidney disease among patients with type 2 diabetes mellitus was 2.37 per 100 person-years (95% CI: 1.76-2.97; I² = 99.85%), based on 29,916.35 person-years of observation. Moreover, study setting and follow-up period (R²=83.21%) were considered as the source of heterogeneity. Furthermore, the pooled median time to develop diabetic kidney disease was 101.38 months (95% CI: 72.79-129.97). Factors associated with diabetic kidney disease included older age (> 60 years) (HR: 1.02, 95% CI: 1.01-1.03), hypertension (HR: 2.07, 95% CI: 1.83-2.34), cardiovascular disease (HR: 1.53, 95% CI: 1.29-1.81), and low high-density lipoprotein cholesterol (HDL-C) levels (< 40 mg/dL) (HR: 1.70, 95% CI: 1.42-2.05).</p><p><strong>Conclusion: </strong>The incidence of diabetic kidney disease in this review was high, highlighting the need for intensified efforts to achieve the 2030 kidney health target and improve patients' quality of life. Moreover, older age, hypertension, cardiovascular disease, and low HDL-C levels were identified as risk indicators of diabetic kidney disease. This suggests strengthening early routine risk-based screening, especially in older adults, and implementing intensive management of hypertension, cardiovascular disease, and dyslipidemia to address the identified factors.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"190"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum thyroid function following LT4 treatment from infertility treatment to delivery in women with subclinical hypothyroidism or high-normal TSH: a retrospective study.","authors":"Yuka Tsukamoto, Yoh Hidaka, Yoshiko Fukuda, Yuko Wada, Kazuyo Okamoto, Yasuyuki Okamoto","doi":"10.1186/s12902-025-02002-2","DOIUrl":"10.1186/s12902-025-02002-2","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"189"},"PeriodicalIF":3.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypharmacy and associated factors among patients with type two diabetes mellitus with comorbidity: a multicenter cross-sectional study in Northwest Ethiopia.","authors":"Fasil Bayafers Tamene, Tirsit Ketsela Zeleke, Akalu Fetene Desalew, Getachew Yitayew Tarekegn, Ashenafi Kibret Sendekie, Selamawit Mengstu Tafere, Mekdes Kiflu, Tilaye Arega Moges, Fisseha Nigussie Dagnew, Samuel Agegnew Wondm","doi":"10.1186/s12902-025-02011-1","DOIUrl":"10.1186/s12902-025-02011-1","url":null,"abstract":"<p><strong>Background: </strong>Patients with Diabetes Mellitus (DM) may have various comorbid illnesses, which necessitates the prescription of multiple drugs. Polypharmacy can raise the risk of adverse drug events, drug interactions, and medication non-adherence, even though using numerous medications is not always inappropriate. The aim of this study was to assess the rate of polypharmacy and associated factors among patients with Type 2 Diabetes Mellitus (T2DM) with comorbidity in Northwest Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 409 T2DM patients with comorbidity in Northwest Ethiopia from April 1 to June 30, 2023. A consecutive sampling technique was used to enroll study participants. Data were entered using EpiData version 4.6.0 and analyzed with SPSS version 26. Polypharmacy was determined by reviewing the number and type of medications based on relevant evidence. A multivariable logistic regression model was fitted to identify factors associated with polypharmacy. Variables with a p-value less than 0.05 at a 95% confidence interval were considered statistically significant.</p><p><strong>Results: </strong>The prevalence of polypharmacy was 59.1%. Duration of illness (AOR = 2.06, 95% CI: 1.14, 3.07) hypoglycemia (AOR = 2.75, 95% CI: 1.45, 5.21) and comorbidity of four, five or more (AOR = 2.19, 95% CI: 1.16, 4.15), (AOR = 3.23, 95% CI: 1.47, 7.09) were significantly associated with polypharmacy.</p><p><strong>Conclusion and recommendation: </strong>In this study, more than half of the participants were found to be on polypharmacy. Patients with longer duration of illness, hypoglycemia and multiple comorbidities need routine follow-up to reduce the rate of polypharmacy.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"188"},"PeriodicalIF":3.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of hypoparathyroidism with cardiovascular complications: interventricular septal dissecting aneurysm in a middle-aged woman.","authors":"Ronghua Huang, Yi Zhou, Xingshou Pan, Liufang Zhou, Zhengjiang Liu","doi":"10.1186/s12902-025-02009-9","DOIUrl":"10.1186/s12902-025-02009-9","url":null,"abstract":"<p><strong>Background: </strong>Hypoparathyroidism (HypoPT) is a rare endocrine disease characterized by hypocalcemia, hyperphosphatemia, and insufficient or no parathyroid hormone (PTH) secretion. Hypoparathyroidism-induced chronic hypocalcemia may lead to cardiovascular complications, including myocardial dysfunction and arrhythmias. Interventricular septal dissecting aneurysm, a rare cardiac anomaly, typically arises following structural or ischemic heart disease. This disease can lead to ventricular septal rupture and aneurysmal cystic chamber formation, causing changes in cardiac structure and hemodynamics as well as giving rise to various heart complications.</p><p><strong>Case presentation: </strong>No study has reported an association between hypocalcemia and cardiac masses. We encountered a case of hypoparathyroidism in a middle-aged woman who developed an interventricular septal dissecting aneurysm. Upon examination, we found that HypoPT has a profound impact on the heart.</p><p><strong>Conclusions: </strong>Hypocalcemia caused by HypoPT can result in structural changes in the heart and myocardial injury. Furthermore, there is a potential link between HypoPT and cardiac aneurysm. The development of an interventricular septal dissecting aneurysm can lead to various cardiac complications; therefore, its early diagnosis and treatment are necessary.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"186"},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of triglyceride glucose index and weight-adjusted waist circumference index in the risk of diabetes: from a national cohort study.","authors":"Yingqi Shan, Qingyang Liu, Tianshu Gao","doi":"10.1186/s12902-025-02003-1","DOIUrl":"10.1186/s12902-025-02003-1","url":null,"abstract":"<p><strong>Objective: </strong>Both triglyceride glucose index(TyG) and weight-adjusted waist circumference index (WWI) are independent predictors of diabetes onset, but the relationship between TyG index and WWI index and diabetes risk is not well understood. The aim of this study was to investigate the interaction between TyG and WWI indices on diabetes risk and to assess whether the combination of TyG and WWI indices is a better predictor of diabetes incidence.</p><p><strong>Methods: </strong>A total of 5555 participants aged 45 years and older without diabetes were enrolled and followed up for a duration of up to 9 years according to the China Health and Retirement Longitudinal Study (CHARLS). After identifying key predictors using the least absolute shrinkage with selection operator (LASSO) technique, COX proportional risk model assessments were performed to evaluate the association between TyG index and WWI index and diabetes risk, Kaplan-Meier analyses were used for cumulative risk and mediation analyses were used to assess the mediated relationship between TyG index, WWI index and diabetes risk. In addition, subgroup analyses and sensitivity analyses were performed to investigate the predictive performance and robustness of the results in different populations.</p><p><strong>Results: </strong>A total of 880 participants developed diabetes over the course of 9 years of follow-up.COX proportional risk regression modelling revealed that participants with high TyG and high WWI had the highest risk (HR = 1.59, 95% CI: 1.28-1.97), followed by participants with high TyG and low WWI (HR = 1.26, 95% CI: 1.01-1.57), and participants with low TyG and low WWI participants (HR = 1.22, 95% CI: 0.97-1.52). Subgroup analyses and sensitivity analyses further confirmed these findings.</p><p><strong>Conclusion: </strong>There is a complex interaction between TyG index, WWI and diabetes risk, and the combined prediction of TyG index and WWI has higher clinical value. These findings highlight the importance of considering both insulin resistance(IR) and visceral adiposity in diabetes risk assessment to improve the identification of at-risk individuals, who can be monitored and intervened on to reduce the overall burden of diabetes.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"187"},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis.","authors":"Huseyin Demirci, Burak Menekse, Enes Ucgul, Yuksel Onaran, Seyit Murat Bayram, Erman Cakal","doi":"10.1186/s12902-025-02008-w","DOIUrl":"10.1186/s12902-025-02008-w","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is the most common metabolic disorder in women and is characterized by chronic oligomenorrhea and hyperandrogenism, often accompanied by insulin resistance. In women with PCOS, insulin resistance, hyperandrogenism, and impaired lipid metabolism contribute to an increased risk of atherogenesis.</p><p><strong>Methods: </strong>Our study was conducted retrospectively on 347 women with PCOS and 132 healthy women who presented at our clinic. The impact of PCOS on the atherogenic plasma index (AIP) was assessed using multivariable linear regression analysis.</p><p><strong>Results: </strong>The AIP was significantly greater in women with PCOS than in controls (p-value < 0.001). A marked increase in AIP was observed when the body mass index (BMI) was ≥ 35 kg/m² (p-value < 0.001). AIP was positively correlated with BMI (r = 0.174, p-value = 0.001) and the homeostatic model assessment for insulin resistance (HOMA-IR) score (r = 0.294, p-value < 0.001). In the multivariable linear regression model including all participants, PCOS diagnosis (B = 0.146, 95% CI = 0.082-0.210; p-value < 0.001) and HOMA-IR (B = 0.017, 95% CI = 0.011-0.022; p-value < 0.001) independently predicted higher AIP. These findings identify PCOS and insulin resistance as independent risk factors for increased atherogenicity.</p><p><strong>Conclusions: </strong>PCOS diagnosis and HOMA-IR are independent risk factors for increased atherogenicity. The increased atherogenic burden in women with PCOS can be assessed by the AIP. A significant increase in atherogenicity was observed in patients with a BMI of 35 kg/m² or higher.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"185"},"PeriodicalIF":3.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}