BMC Endocrine Disorders最新文献

{"title":"A combined model integrating adiponectin and anthropometric indices for the identification of insulin resistance in patients with type 2 diabetes mellitus.","authors":"Xiuping Yin, Yunna Zhang, Cuiliu Li, Xinxin Yang, Jinxiu Xu, Fang Gao, Jie Ma, Renyong Huang, Guangya Wang","doi":"10.1186/s12902-026-02382-z","DOIUrl":"10.1186/s12902-026-02382-z","url":null,"abstract":"<p><strong>Background: </strong>To investigate the associations of adiponectin (APN), body mass index (BMI), and waist-to-hip ratio (WHR) with insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM), and to evaluate a combined model for discriminatory performance and potential clinical value for the identification of IR.</p><p><strong>Methods: </strong>A total of 394 hospitalized patients with T2DM were retrospectively analyzed. Participants were divided into low-IR and high-IR groups based on the median HOMA-IR. Clinical data were then analyzed by Spearman's correlation, trend analysis, multiple linear regression, logistic regression, and receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Compared with the low-IR group, patients in the high-IR group exhibited a higher BMI and WHR but lower APN levels (P < 0.05 for all). Furthermore, APN was negatively correlated with HOMA-IR, whereas BMI and WHR were positively correlated (all P < 0.01). Multivariable analysis further revealed that APN (β = -0.335), BMI (β = 0.243), and WHR (β = 0.138) were independently associated with IR (P < 0.01 for all). The combined model showed better discrimination (AUC = 0.82) than APN (0.78), WHR (0.72), and BMI (0.69) alone.</p><p><strong>Conclusions: </strong>APN, BMI, and WHR were independently associated with IR in patients with T2DM. Our combined model demonstrates superior discriminative performance to individual indicators and may be useful for identifying individuals at high risk of IR.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual care for young adults with type 1 diabetes: a 12-month follow-up of a wait-list randomized controlled trial.","authors":"Rebecka Husdal, Eva Toft, Jan W Eriksson, Johan Fischier, Andreas Rosenblad, Elisabet Nerpin, Janeth Leksell","doi":"10.1186/s12902-026-02371-2","DOIUrl":"10.1186/s12902-026-02371-2","url":null,"abstract":"<p><strong>Background: </strong>Digital tools are increasingly used in diabetes care, but their long-term effectiveness remains uncertain. A previous randomized controlled trial (RCT) demonstrated promising effects on perceived burden and quality of life after 6 months. The present study extends these findings through a 12-month follow-up, aiming to evaluate the long-term effects of virtual care on glycaemic control, treatment satisfaction, and quality of life among young adults with type 1 diabetes.</p><p><strong>Methods: </strong>This single-centre wait-list RCT included 70 young adults aged 18-25 years with type 1 diabetes in Stockholm, Sweden. Participants randomized to the intervention group had access to the virtual platform for 12 months whereas participants in the wait-list control group received access after 6 months. The platform facilitated real-time communication with healthcare providers. Glycated haemoglobin (HbA1c) levels, time in range, time below range, diabetes treatment satisfaction, and quality of life were assessed at baseline and at the 6- and 12-month follow-ups. Comparisons within and between groups were performed using Welch's paired and independent samples t-test, the Wilcoxon signed rank test, and the Mann-Whitney test.</p><p><strong>Results: </strong>At the 12-month follow-up, the intervention group showed a decreased HbA1c level from baseline (62.8 to 58.6 mmol/mol; P = 0.051) and improved time in range (46.6% to 56.9%; P = 0.002). In the wait-list control group, social burden decreased significantly from baseline to 12 months (4.3 to 0.03; P = 0.030). Other measures of quality of life, including social and emotional health, showed no significant differences.</p><p><strong>Conclusions: </strong>Virtual diabetes care may enhance engagement and modestly improve glycaemic control in young adults, serving as a practical complement to standard outpatient follow-up.</p><p><strong>Trial registration: </strong>ISRCTN (ref: 73435627, registration date: 23/10/2019): https://doi.org/10.1186/ISRCTN73435627.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical profiles and precipitating factors of diabetic ketoacidosis among type 1 and type 2 diabetes patients: a retrospective analysis from Syria.","authors":"Mohammad Basheer Alameer, Anas Bitar, Ghaith Alhajjar, Mhd Wajih Kharbutly, Mhd Haitham Bastati, Zuhair Hamoush, Zaynab Alourfi","doi":"10.1186/s12902-026-02372-1","DOIUrl":"10.1186/s12902-026-02372-1","url":null,"abstract":"<p><strong>Background: </strong>Diabetic ketoacidosis (DKA) is a life-threatening metabolic emergency characterized by hyperglycemia, ketosis, and acidosis due to insulin deficiency and counterregulatory hormone imbalances. Its prevalence is notably higher in the Arab world than in Western regions. Understanding biochemical differences between type 1 and type 2 diabetes patients with DKA is essential for individualized treatment strategies. This study examines the biochemical profiles and precipitating factors of DKA in Syrian patients, assessing differences between initial and recurrent episodes amid local healthcare challenges.</p><p><strong>Methods: </strong>This retrospective study has ethical approval from Damascus University and Damascus Hospital, allowing access to patient charts. The study included individuals diagnosed with diabetic ketoacidosis (DKA) and admitted to Damascus Hospital. Of 997 patients, 464 charts were excluded due to missing data or uncertain diagnoses. Patients were classified into first-time and recurrent DKA, with only initial episodes considered for analysis. Diagnosis criteria varied by age group, ensuring standardized classification. Laboratory tests were performed exclusively in the hospital's central lab. Extracted variables included demographic details, hospitalization duration, diabetes type, precipitating factors, and biochemical markers.</p><p><strong>Results: </strong>The study analyzed 533 hospital admissions for diabetic ketoacidosis (DKA), with 263 (49.3%) being first episodes. Among these, 126 patients (47.9%) had type 1 diabetes, and 71 (26.9%) were diagnosed with diabetes after their first DKA episode. Type 2 diabetes patients exhibited higher in-hospital mortality (16.0% vs. 4.3%, p < 0.001) and longer hospital stays. Significant biochemical differences were observed between types, particularly in pH, bicarbonate, and creatinine levels. Insulin omission and unknown precipitating factors were common, especially in recurrent DKA cases.</p><p><strong>Conclusions: </strong>In conclusion, DKA as the first presentation of diabetes is prevalent among Syrian patients. Type 1 patients were more acidotic, but their admission was shorter, probably due to comorbidities among type 2 patients. Unknown factors and insulin omission are the most prevalent triggers of DKA, especially among patients with recurrent episodes.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of endogenous hypercortisolism with hepatic hemangiomas in cushing's disease: a retrospective cohort study.","authors":"Lanlan Zhao, Jiao Liu, Na Li, Ying Wei, Pin Wang, Jie Li, Songyun Zhang","doi":"10.1186/s12902-026-02333-8","DOIUrl":"10.1186/s12902-026-02333-8","url":null,"abstract":"<p><strong>Purpose: </strong>The association between persistent endogenous hypercortisolism and hepatic hemangioma (HH) remains unclear. This study compared the prevalence of HH between patients with Cushing's disease (CD) and silent corticotroph adenomas (SCA) and explored factors associated with HH in CD patients.</p><p><strong>Methods: </strong>This retrospective observational study included 96 CD patients and 219 SCA patients treated between May 2015 and December 2025. Demographic, laboratory, and imaging data were collected. Propensity score matching (PSM) balanced baseline characteristics. HH was diagnosed by contrast-enhanced abdominal CT. Multivariate analyses, including logistic regression, LASSO regression, and Firth-corrected likelihood regression, were performed. Model performance was assessed using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>After PSM, HH prevalence was higher in CD patients than in SCA patients (20.0% vs. 9.5%, P = 0.024). Among CD patients, elevated midnight cortisol (OR = 1.402, 95% CI: 1.078-2.031, P = 0.010) and increased 24-hour urinary free cortisol (OR = 1.013, 95% CI: 1.006-1.023, P < 0.001) were independently associated with HH. The predictive model demonstrated good discrimination (AUC = 0.982, 95% CI: 0.961-1.000) and acceptable calibration, with potential clinical utility supported by DCA.</p><p><strong>Conclusion: </strong>HH was more prevalent in patients with Cushing's disease than in those with silent corticotroph adenomas. Elevated cortisol levels may be an important factor associated with HH. This study offers a predictive tool to support early risk assessment and clinical management.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13285318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint association of TyG-ABSI composite index and inflammatory score with diabetes in middle-aged and older Chinese adults: a prospective cohort study from CHARLS (2011-2020).","authors":"Qingqing Liu, Kunjie Zheng, Liping Hou","doi":"10.1186/s12902-026-02370-3","DOIUrl":"10.1186/s12902-026-02370-3","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus represents a major global public health challenge, especially in middle-aged and older populations. The triglyceride-glucose A Body Shape Index (TyG-ABSI) composite index and inflammatory score are potential predictors of type 2 diabetes mellitus (T2DM). However, their independent and joint associations with incident T2DM in middle-aged and older Chinese adults remain unclear.</p><p><strong>Methods: </strong>Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2020), including 6,216 participants without diabetes at baseline. The TyG-ABSI index and inflammatory score (constructed from high-sensitivity C-reactive protein and white blood cell counts) were calculated. Multivariate Cox regression models, restricted cubic splines were used to evaluate their associations with incident T2DM.</p><p><strong>Results: </strong>Higher TyG-ABSI and higher inflammatory score were independently associated with an increased T2DM risk (fully adjusted hazard ratio [HR]: 1.42, 95% confidence interval [CI]: 1.17-1.72 and 1.21, 95% CI: 1.02-1.44, respectively). Participants with concurrent high TyG-ABSI and high inflammatory score had a 69% higher T2DM risk (HR: 1.69, 95% CI: 1.30-2.21) than the reference group. Restricted cubic spline analyses showed approximately linear dose-response relationships. The combined index demonstrated superior discriminative ability (Harrell's C-index) and significantly improved risk reclassification (NRI) and overall discrimination (IDI) compared with traditional risk factors alone.</p><p><strong>Conclusion: </strong>TyG-ABSI composite index and inflammatory score were independently and jointly associated with incident T2DM in middle-aged and older Chinese adults. This combined application can improve T2DM risk stratification and facilitate early prevention.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic risk profiling in childhood obesity through hormonal dysfunction and genetic variants: findings from a retrospective study.","authors":"Xueqin Shi, Qianqian Wang, Wenli Yin, Chong Zhou","doi":"10.1186/s12902-026-02336-5","DOIUrl":"10.1186/s12902-026-02336-5","url":null,"abstract":"<p><strong>Background: </strong>Childhood obesity is frequently accompanied by endocrine dysfunction and genetic susceptibility, but their combined contribution to metabolic risk remains insufficiently defined. This retrospective study evaluated hormonal, metabolic, and genetic determinants of metabolic syndrome (MetS) in children and adolescents with obesity.</p><p><strong>Methods: </strong>Electronic medical records from January 2021 to May 2025 were reviewed. A total of 429 children and adolescents with obesity were included. Clinical, biochemical, endocrine, and targeted SNP genotyping data for FTO rs9939609, MC4R rs17782313, and LEPR rs1137101 were analyzed. MetS was defined according to pediatric criteria. Multivariable logistic regression and receiver operating characteristic analysis were performed.</p><p><strong>Results: </strong>MetS was present in 187 participants (43.6%). Fasting glucose averaged 5.3 ± 0.5 mmol/L, HbA1c averaged 5.24 ± 0.22%, and median HOMA-IR was 4.4 (2.7-5.7). Insulin resistance was observed in 68.0% of Tanner stage I participants and 73.3% of Tanner stage II-V participants. Elevated HOMA-IR was strongly associated with MetS (OR = 2.89, 95% CI: 1.71-4.99, P < 0.001). Leptin was positively associated with MetS risk (OR = 1.32, 95% CI: 1.02-1.70, P = 0.033), whereas adiponectin was inversely associated (OR = 0.63, 95% CI: 0.49-0.80, P < 0.001). FTO and MC4R risk allele carriage independently predicted MetS, with ORs of 1.88 and 1.71, respectively. The combined endocrine-genetic model showed acceptable discrimination (AUC = 0.751).</p><p><strong>Conclusion: </strong>Insulin resistance, adipokine imbalance, and FTO/MC4R variants were independently associated with MetS in pediatric obesity. Integrated endocrine-genetic profiling may improve early metabolic risk stratification.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vitamin D deficiency on hyperlipidemia and hyperuricemia in pregnant women with gestational diabetes mellitus in Bangladesh.","authors":"Mohammad Abul Hasnat, Mosammat Halima Khanam, Syeda Ummul Khair Fatima, Zafrul Hasan, Md Waseque Mia, Jubayer Khan, Md Mostafij Talukder","doi":"10.1186/s12902-026-02343-6","DOIUrl":"10.1186/s12902-026-02343-6","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D (Vit-D) deficiency is considered a path to metabolic disturbance during pregnancy, especially among women with gestational diabetes mellitus (GDM). This study aimed to investigate the impact of Vit-D status on hyperlipidemia, hyperuricemia, and hypocalcemia in pregnant women with GDM in Bangladesh.</p><p><strong>Materials and methods: </strong>Serum biochemical parameters were measured in 335 pregnant women using an automated chemistry and immunoassay analyzer. The associations among these parameters were investigated using the IBM SPSS statistical package. A P value of less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Among the population, 80.30% and 19.70% were without GDM and GDM, respectively. 30.45%, 48.36%, and 21.19% of the participants were identified as Vit-D sufficient (> 30 ng/mL), insufficient (20-30 ng/mL), and, deficient (< 20 ng/mL) respectively, with a higher prevalence of Vit-D deficiency and insufficiency in the second trimester during pregnancy. Serum Vit-D levels were significantly positively associated with calcium and HDL levels, whereas negative associations were observed with uric acid, fasting blood sugar (FBS), cholesterol (Cho), triglycerides (TG), and LDL (p < 0.05). Remarkably, significantly (P < 0.01) increased levels of uric acid, Cho, TG, LDL, and FBS along with decreased Ca and HDL were observed in the Vit-D-deficient plus GDM group, compared to Vit-D-sufficient plus without GDM group.</p><p><strong>Conclusion: </strong>Pregnant women with GDM, particularly those with Vit-D deficiency, are significantly associated with a high risk of hyperlipidemia, hyperuricemia, and hypocalcemia. The outcomes of this study emphasize the importance of routine Vit-D screening during pregnancy to minimize the threat of hostile metabolic outcomes during pregnancy and the postpartum period.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging evidence for skeletal muscle as a target of BPA exposure.","authors":"Muneebah Vaid, Hilda Dahbur, Hadi Dahbour, Isabel Martinez-Pena Y Valenzuela","doi":"10.1186/s12902-026-02355-2","DOIUrl":"10.1186/s12902-026-02355-2","url":null,"abstract":"<p><p>Endocrine disruptors are exogenous chemicals that interfere with hormonal signaling, and among them, bisphenol-A (BPA) is one of the most widely used and globally prevalent. Human exposure to BPA occurs through multiple routes, and measurable levels are detected in the majority of biological samples worldwide. At the molecular level, BPA interacts with several nuclear and membrane receptors, conferring estrogenic and anti-androgenic properties that disrupt endocrine, metabolic, and cardiovascular systems. Although the biological effects of BPA have been extensively studied in reproductive, neural, hepatic, and adipose tissues, its impact on skeletal muscle has been comparatively understudied, despite the central role of this tissue in glucose homeostasis and energy metabolism. In addition, direct human evidence specifically linking BPA exposure to skeletal muscle structure or function remains limited. This review summarizes current evidence regarding the effects of BPA on skeletal muscle structure and function. Experimental studies indicate that BPA disrupts insulin signaling in skeletal muscle by impairing insulin receptor-dependent pathways, reducing Akt phosphorylation and GLUT4 translocation, and promoting inflammatory responses, ultimately leading to insulin resistance and glucose intolerance. Developmental exposure to BPA further alters muscle fiber composition, gene expression, calcium signaling, and excitation-contraction coupling, with persistent effects on muscle phenotype and function. Collectively, the findings reviewed here identify skeletal muscle as a critical, yet underrecognized, target of BPA toxicity and underscore the need for future studies addressing chronic low-dose exposure and long-term outcomes, particularly in human populations.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13479709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index and systemic immune-inflammation index are associated with left ventricular hypertrophy in type 2 diabetes mellitus patients.","authors":"Peipei Xu, Kangwen Lu, Jingjing Liu, Xiaoqin Zhao, Renyue Hu, Yi Sun, Jie Yuan, Yunjuan Gu, Chen Qian, Xinlei Wang","doi":"10.1186/s12902-026-02359-y","DOIUrl":"10.1186/s12902-026-02359-y","url":null,"abstract":"<p><strong>Objective: </strong>To examine the relationship between triglyceride-glucose (TyG) index, systemic immune-inflammation index (SII) and left ventricular hypertrophy (LVH) in type 2 diabetes mellitus (T2DM) patients. Additionally, to assess the ability of the combination of TyG index and SII to predict LVH.</p><p><strong>Methods: </strong>We enrolled 600 patients with T2DM and divided them into two groups according to the diagnostic criteria for LVH. Differences in demographic characteristics and clinical indicators between the two groups were compared. Spearman's or Pearson's correlation analysis was employed to find the correlation between TyG index, SII and left ventricular mass index (LVMI). Logistic regression was utilized to examine the associations of the TyG index, SII and LVH. The ability of the combination of TyG index and SII to predict LVH in T2DM patients was assessed by plotting a receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>In the LVH group, both the TyG index and SII demonstrated markedly elevated levels compared to the non-LVH group, and these parameters exhibited a positive association with LVMI. Logistic regression revealed that, after adjusting for confounders, both the TyG index (OR = 5.62, 95% CI: 2.882 ~ 10.959, P < 0.001) and SII (OR = 1.014, 95% CI: 1.01 ~ 1.017, P < 0.001) were independent predictors for LVH in T2DM. ROC analysis demonstrated that the combined index provided the strongest predictive capability for the occurrence of LVH (area under the curve: AUC = 0.857, 95% CI: 0.826 ~ 0.888, sensitivity 84.4%, specificity 72.9%).</p><p><strong>Conclusion: </strong>Both TyG index and SII are independent predictors for LVH. The combined index of TyG index and SII shows stronger discriminative ability for identifying LVH in T2DM patients.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of poor glycemic control in diabetic hypertensive patients: a systematic review and meta-analysis.","authors":"Dula Dessalegn Bosho, Yonas Deressa Guracho, Selamawit Worku Asmare, Behailu Terefe Tesfaye, Diriba Dereje Olana, Tesema Etefa Birhanu","doi":"10.1186/s12902-026-02357-0","DOIUrl":"10.1186/s12902-026-02357-0","url":null,"abstract":"<p><strong>Introduction: </strong>Poor glycemic control is a significant public health issue, contributing to the development of complications, increasing healthcare costs, and quality of life. The objective of the meta-analysis is to estimate the prevalence of poor glycemic control and its prevalence according to diagnostic criteria in diabetic hypertensive patients. Findings will be critical in reducing the burden of poor glycemic control and complications.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted in accordance with the PRISMA 2020 guidelines. Three electronic databases (PubMed, Web of Science, and SCOPUS) were searched for studies published in English between January 2015 and January 2025. Primary studies assessed glycemic control among diabetic-hypertensive patients using one or more of the following: a fasting blood glucose (FBG) level (> 126 mg/dL, > 130 mg/dL, or > 130 mg/dL) and/or glycated hemoglobin A1C level (≥ 7%). Random-effects models (metaprop, REML) were used to estimate pooled prevalence. Heterogeneity, sensitivity test, subgroup analysis, and publication bias assessments were performed.</p><p><strong>Results: </strong>In this study, ten papers involving a total of 2552 individuals were utilized to derive the pooled estimate. The pooled prevalence of poor glycemic control was 59% (95%CI; 0.49-0.69). Based on diagnostic criteria the pooled prevalence of poor glycemic control in diabetic hypertensive patients was 46% (95%CI: 0.31-0.61), and 65% (95%CI; 0.54-0.76) for fasting blood glucose and glycosylated hemoglobin respectively. There is substantial heterogeneity but no significant publication bias on visual inspection of the forest plot.</p><p><strong>Conclusion: </strong>Around two-third of study participants have poor glycemic control in diabetic hypertensive patients. This finding is important as a baseline for refining clinical guidelines and improving long-term outcomes for this high-risk group. Future researchers will evaluate effective interventions to improve glycemic control in diabetic hypertensive patients across diverse study settings.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}