BMC Endocrine Disorders最新文献

{"title":"Prevalence and predictors of thyroid nodules among adults: analyzing the association with metabolic syndrome in a cross-sectional study.","authors":"Golbarg Abrishami, Maryam Emadzadeh, Aida Bakhshi, Yasamin Moeinipour, Ghazaleh Taghavi, Solmaz Hasani","doi":"10.1186/s12902-025-01869-5","DOIUrl":"https://doi.org/10.1186/s12902-025-01869-5","url":null,"abstract":"<p><strong>Background: </strong>Thyroid nodules are prevalent clinical findings with potential for malignancy, particularly in aging populations. Metabolic syndrome, characterized by interrelated metabolic abnormalities, has been implicated as a potential risk factor. This study explores the prevalence of thyroid nodules and their association with metabolic syndrome, leveraging data from a large cohort.</p><p><strong>Methods: </strong>A cross-sectional study was conducted within the Persian Organizational Cohort in Mashhad, comprising 4,121 participants aged 35-70 years. Thyroid nodules were identified via ultrasonography, and metabolic syndrome was assessed using the NCEP ATP III criteria. Demographic, clinical, and laboratory data were analyzed using descriptive statistics, chi-square tests, and logistic regression models to identify predictors of thyroid nodules.</p><p><strong>Results: </strong>Thyroid nodules were detected in 27.4% of participants, with a higher prevalence in females (60%) than males (40%, p < 0.001). The average age of individuals with nodules was significantly higher than those without (47.9 vs. 43.5 years, p < 0.001). Metabolic syndrome prevalence was notably higher among those with thyroid nodules (5.3% vs. 3.8%, p = 0.028). Logistic regression analysis identified metabolic syndrome (OR = 1.43, p = 0.03), age (OR = 1.05 per year increase, p < 0.001), and gender as significant predictors of thyroid nodules.</p><p><strong>Conclusion: </strong>Metabolic syndrome significantly predicts the presence of thyroid nodules, suggesting shared pathophysiological mechanisms, including chronic inflammation and hormonal dysregulation. These findings underscore the importance of integrating metabolic health management into thyroid nodule evaluation and highlight the need for multidisciplinary approaches to optimize care and prevention strategies.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"40"},"PeriodicalIF":2.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram for predicting the risk of cervical lymph node metastases and recurrence in papillary thyroid carcinoma based on the thyroid differentiation score system and clinical characteristics.","authors":"Yutong Liu, Xuanjie Wang, Xiaodan Sun, Hongxue Li, Lidong Wang","doi":"10.1186/s12902-025-01867-7","DOIUrl":"10.1186/s12902-025-01867-7","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify independent predictors of cervical central lymph node metastasis (CLNM), cervical lateral lymph node metastasis (LLNM), and recurrence in patients with PTC, which could help guide the surgical management of these patients.</p><p><strong>Methods: </strong>This retrospective study analyzed data from 542 patients with PTC, who underwent thyroid surgery and were enrolled in The Cancer Genome Atlas and Gene Expression Omnibus databases. Patients were categorized into two groups based on the presence or absence of cervical LNM, classified as CLNM or LLNM. Data were randomly partitioned into training and validation sets in a ratio of 7:3. Age, sex, thyroid differentiation score (TDS), and other relevant attributes, were compared between the two groups using univariate and multivariate analyses and reported as odds ratios (OR) or hazard ratios (HR) with 95% confidence intervals (CI). Independent predictors were identified and used to develop nomograms. To assess the accuracy, discrimination, and clinical utility of the prediction model, calibration, receiver operating characteristic (ROC), and decision curve analysis (DCA) were performed for both the training and validation sets.</p><p><strong>Results: </strong>Of the 542 patients, 261 (48.15%) and 130 (23.99%) presented with CLNM and LLNM, respectively. The analyses identified several independent predictors for CLNM, including the presence of extrathyroidal invasion (OR 2.53, 95% CI 1.60-4.00), larger tumor dimension (OR 1.17, 95% CI 1.02-1.34), age over 55 years (OR 0.52, 95% CI 0.33-0.82), non-classic papillary subtype (OR 0.38, 95% CI 0.23-0.61), and lower TDS (OR 0.50, 95% CI 0.33-0.76). A greater number of excised cervical LNs (OR 12.30, 95% CI 4.35-34.77), the presence of CLNM (OR 1.07, 95% CI 1.04-1.10), and lower TDS (OR 0.09, 95% CI 0.04-0.21) were independent predictors for LLNM. Additionally, the independent predictors for relapse included age greater than 55 years (HR 1.87, 95% CI 1.00-3.49) and lower TDS (HR 0.35, 95% CI 0.20-0.62). These predictors were used to develop nomograms for CLNM, LLNM, and recurrence. ROC and DCA confirmed the discrimination and clinical utility of the models.</p><p><strong>Conclusions: </strong>This study identified independent predictors of cervical CLNM, LLNM, and recurrence. Clinically relevant nomograms were developed that can assist in guiding cervical lymph node dissection and prediction of recurrence in patients with PTC.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"39"},"PeriodicalIF":2.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific association between a novel atherogenic index of plasma, metabolic parameters and inflammation among obese adults.","authors":"Keyan Zhao, Shibo Ling","doi":"10.1186/s12902-024-01813-z","DOIUrl":"10.1186/s12902-024-01813-z","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have demonstrated the association between lipoprotein combined index (LCI), as a novel atherogenic index with cardiovascular disease, fatty liver, diabetes and numerous other health problems; however, its association with metabolic syndrome risk and its components has not been investigated before. The current study was aimed to investigate the association between LCI metabolic and inflammatory risk factors among obese men and women.</p><p><strong>Methods: </strong>In the current cross-sectional study, the association between LCI, anthropometric parameters and metabolic risk factors including serum lipids, glycemic markers, insulin resistance and C - reactive protein (CRP) concentrations were measured. LCI was calculated as (total cholesterol [TC] × triglyceride [TG] × low density lipoprotein cholesterol [LDL]) / (high density lipoprotein cholesterol [HDL]).</p><p><strong>Results: </strong>Highest quartiles of LCI was accompanied with higher waist to hip ratio (P = 0.017). Also, higher systolic and diastolic blood pressure, higher serum lipids and lower high density lipoprotein concentrations were observed in higher quartiles of LCI HDL (P < 0.05). Among men and women, higher LCI was also associated with higher CRP and lower HDL in men (P < 0.05); while among women, higher CRP, TG, TC and lower HDL was observed in highest versus lowest quartiles of LCI (P < 0.05). Among anthropometric and biochemical variables, TG has the highest power for identification of metabolic syndrome with area under curve (AUC) of 0.82 and Youden index of 0.58 while LCI was in the second place after TG in prediction of metabolic syndrome (e.g. AUC of 0.80 and Youden index of 0.47).</p><p><strong>Conclusion: </strong>LCI was in direct association with lipid parameters and inflammation among obese men and women. Although predictive power of LCI for metabolic syndrome was acceptable, but it came in the second place after TG for men and women. Further studies are warranted to make a better conclusion.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"38"},"PeriodicalIF":2.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow cytometry immune profiling of recurrent and newly diagnosed growth hormone secreting pituitary neuroendocrine tumors: comparison of two clinical cases.","authors":"Daria Lisina, Valeria Mazeeva, Elena Zakharova, Alyona Sorokina, Lilya Dzhemileva, Andrey Grigoriev, Vilen Azizyan, Alexandra Shutova, Ekaterina Pigarova, Larisa Dzeranova, Galina Melnichenko, Sergei Rumiantsev, Natalia Mokrysheva, Vladimir Chekhonin, Marina Loguinova","doi":"10.1186/s12902-025-01865-9","DOIUrl":"https://doi.org/10.1186/s12902-025-01865-9","url":null,"abstract":"<p><p>Early detection of aggressive pituitary neuroendocrine tumors (PitNETs) remains challenging due to the absence of reliable markers that can predict disease progression. Aggressive tumors are typically identified through long-term observation. Tumor immune microenvironment (TIME) is crucial for understanding PitNETs' heterogeneity and identifying potential predictors of tumor aggressiveness. In this study, we analyzed immune profile of micro- and macroenvironment in two somatotropinomas (aggressive and non-aggressive) using flow cytometry. We observed lymphopenia and elevated neutrophil levels in the periphery in the patient with tumor recurrence. The aggressive TIME showed greater leukocyte infiltration, with lymphoid cells predominating over myeloid cells along with a higher proportion of CD4 + T cells over CD8 + T cells. We detected double-positive CD4 + CD8 + population, high level of regulatory T cells and a sharp increase in PD-1 + expressing T cells over six months during recurrence. In the blood of the patient with tumor recurrence, we observed reduced granule-mediated cytotoxicity of CD8 + T cells and NK-cells. In the aggressive TIME the number of effector cells producing perforin and granzyme B-both independently and simultaneously was significantly lower. The proportion of CD3-CD20- NK cells and CD3-CD56 + NK cells was low after the first recurrence but increased sharply after six months. The ratio of monocyte subpopulations in tumor differed from that in blood, with CD16 + expressing monocytes predominating in the TIME of both patients. M2 macrophages in TIME rose sharply to 60.8% over six months during recurrence. In several immunological parameters, the patient with tumor recurrence exhibited a more pronounced immunosuppressive profile.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"37"},"PeriodicalIF":2.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of liberal glucose control on critically ill patients: a systematic review and meta-analysis.","authors":"Jiahui Ma, Xu Wang, Yan Zhang, Chunyan Ge","doi":"10.1186/s12902-025-01864-w","DOIUrl":"10.1186/s12902-025-01864-w","url":null,"abstract":"<p><strong>Background: </strong>Most current guideline statements support some level of unrestricted glycemic management in critically ill adult patients. Nevertheless, the effectiveness of liberal glucose control is currently not well-supported by evidence. Therefore, our objective is to investigate the influence of liberal glucose control (> 180 mg/dl) on critically ill patients in the intensive care unit (ICU).</p><p><strong>Methods: </strong>Until November 23, 2023, English language literature was thoroughly and systematically searched through multiple databases, including PubMed, Embase, Cochrane Library, and Web of Science. Our primary endpoints of interest were the occurrence of hypoglycemia, mortality in the ICU, and mortality during hospitalization. In addition, our secondary outcomes comprised of 90-day mortality, bloodstream infections, the proportion of patients necessitating renal replacement therapy (RRT), the length of time under mechanical ventilation, duration of stay in the ICU, and length of the overall hospitalization. Weighted mean difference (WMD) and relative risk (RR) were respectively computed as overall effect size for continuous and dichotomous data and reported with their 95% confidence intervals (95% CI).</p><p><strong>Results: </strong>A total of 9 studies were incorporated, which included 14,878 patients in the ICU. Compared with other blood glucose target control groups, liberal glucose control significantly reduced the incidence of hypoglycemia (RR = 0.41; 95% CI:0.25 to 0.69; P = 0.001), but increased ICU mortality (RR = 1.23; 95% CI:1.03 to 1.48; P = 0.023), in-hospital mortality risk (RR = 1.18; 95% CI:1.03 to 1.35; P = 0.020), and the risk of requiring RRT (RR = 1.26; 95% CI:1.11 to1.42; P < 0.001).</p><p><strong>Conclusion: </strong>Liberal glucose control can reduce the risk of hypoglycemia but increases the risks of ICU mortality, in-hospital mortality, and the requirement for RRT. To confirm the outcomes further, large-scale, high-quality clinical trials are necessary.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"36"},"PeriodicalIF":2.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between grip strength and diabetic nephropathy among U.S. adults with type 2 diabetes mellitus: a cross-sectional NHANES analysis.","authors":"Xue Chen, Yi Lin, Weisong Dong, Xiuxiu Wen, Yidan Zuo","doi":"10.1186/s12902-025-01862-y","DOIUrl":"10.1186/s12902-025-01862-y","url":null,"abstract":"<p><strong>Aim: </strong>To examine the relationship between grip strength (GS) and diabetic nephropathy (DN).</p><p><strong>Materials and methods: </strong>Data on patients with type 2 diabetes mellitus collected between 2011 and 2014 were obtained from National Health and Nutrition Examination Survey (NHANES). Demographic characteristics (sex, age, race, marital status, and educational level), clinical measures (smoking status, drinking status, body mass index [BMI], glycated hemoglobin [HbA1c], urinary albumin creatinine ratio [UACR], diabetes duration, and hypertension), and grip strength assessments were collected. The relationship between GS and DN was analyzed using a logistic regression model. Subgroup analyses were showed as forest plots, conducted while accounting for confounding variables. Restricted cubic splines were applied to investigate nonlinear correlations. A sensitivity analysis was conducted to assess the robustness of the findings.</p><p><strong>Results: </strong>This study included 1,539 participants. In the multivariate logistic regression model, the odds ratios (ORs) were 0.96 (95% CI, 0.94-0.98) in male and 0.94 (95% CI, 0.91-0.98) in female. Compared with those in the lowest quartiles, participants in the uppermost GS quartiles were less susceptible to DN in male [OR 0.35 (95% CI, 0.20-0.62)] and female [OR 0.37 (95% CI, 0.20-0.67)] (p for trend < 0.001). After adjusting for all variables, the ORs were 0.96 (95% CI, 0.94-0.98) in male and 0.94 (95% CI, 0.91-0.98) in female. Compared with those in the lowest quartiles, participants in the uppermost GS quartiles were less susceptible to DN in male [OR 0.35 (95% CI, 0.20-0.62)] (p for trend < 0.001) and female [OR 0.37 (95% CI, 0.20-0.67)] (p for trend < 0.001). Subgroup analysis demonstrated a reliable connection between GS and DN (all p for interaction > 0.05). We discovered a nonlinear relationship between GS and DN in both male and female participants (all p for nonlinearity < 0.05). More precisely, the data revealed L-shaped relationship and inverted-S relation in male and female participants, respectively.</p><p><strong>Conclusion: </strong>The results of this cross-sectional study using NHANES data indicated a potential negative association between GS and DN. Additional extensive studies are necessary to elucidate these trends.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"35"},"PeriodicalIF":2.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11818093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect and safety of pemafibrate for patients with type 2 diabetes mellitus and hypertriglyceridemia: a retrospective analysis of clinical data.","authors":"Aki Okamoto, Hirohide Yokokawa, Tomoko Nagamine, Kento Goto, Hiroshi Fukuda, Teruhiko Hisaoka, Toshio Naito","doi":"10.1186/s12902-025-01872-w","DOIUrl":"10.1186/s12902-025-01872-w","url":null,"abstract":"<p><strong>Objectives: </strong>Fibrates are suitable for the treatment of patients with high triglyceride (TG) levels. Although pemafibrate (PEMA) has been reported to have beneficial and pleiotropic actions, clinical examinations of the efficacy of PEMA for Japanese patients with hypertriglyceridemia are still limited in actual clinical settings. The aim was to evaluate the efficacy of PEMA by analyzing data from diabetic patients treated with PEMA in clinical practice.</p><p><strong>Methods: </strong>Patients with type 2 diabetes mellitus and hypertriglyceridemia who were started on PEMA for at least 3 months were included in the analysis. Changes in lipid metabolism, liver function, renal function, and blood tests from before to after 3 months of PEMA treatment were evaluated.</p><p><strong>Results: </strong>A total of 100 eligible patients were included in the analysis (72 males, mean age 52.9 years). TG levels decreased significantly, and high-density lipoprotein cholesterol levels increased significantly after 3 months of therapy. Low-density lipoprotein cholesterol levels were not significantly changed. Liver-related parameters showed a significant decrease. In addition, a significant decrease in creatinine levels was found in patients switching from other fibrates. There were no severe adverse events.</p><p><strong>Conclusion: </strong>PEMA showed beneficial effects on lipid metabolism and liver function. The improvement of lipid metabolism was found in patients switching from other fibrates. It is possible that PEMA may improve lipid metabolism in patients with hypertriglyceridemia.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"34"},"PeriodicalIF":2.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary and plasma atherogenic and thrombogenic indices and cardiometabolic risk factors among overweight and individuals with obesity.","authors":"Reyhaneh Mokhtari, Mahdieh Abbasalizad Farhangi","doi":"10.1186/s12902-025-01844-0","DOIUrl":"10.1186/s12902-025-01844-0","url":null,"abstract":"<p><strong>Background: </strong>Obesity and hyperlipidemia are the two central metabolic disorders linked to non-communicable diseases (NCDs) that increase the risk of cardiovascular disease (CVD). Apart from dyslipidemia, the Atherogenic Index of Plasma (AIP), which is associated with dietary consumption, is another marker for predicting the risk of CVD. Healthy fat quality indicators may impact AIP. The purpose of this study is to ascertain whether there is any connection between Iranian obese people's plasma and dietary indices and cardiometabolic risk factors.</p><p><strong>Methods: </strong>This cross-sectional study, consisted of 645 overweight and obese participants. The study included assessments of body composition and anthropometric measurements. Dietary fatty acid consumption was evaluated using a validated Food Frequency Questionnaire (FFQ) containing 168 items. Additionally, biochemical parameters, including serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), fasting serum glucose (FSG), and insulin levels, were measured using enzymatic methods. The lipid profile was quantified.</p><p><strong>Results: </strong>For participants in higher tertiles of the AIP, the percentage of men was significantly higher than women (men: 48.1%, women: 51.7%, p < 0.001). Additionally, individuals in higher tertiles of AIP had a higher waist-to-hip ratio (WHR) (mean WHR: 0.92 ± 0.05 vs. 0.86 ± 0.04 in lower tertile, p < 0.001). Participants in the highest tertile of AIP had higher systolic blood pressure (SBP: 132 ± 8 mmHg vs. 118 ± 6 mmHg in lower tertile, p < 0.001), total cholesterol (TC: 210 ± 15 mg/dL vs. 185 ± 12 mg/dL, p < 0.001), triglycerides (TG: 180 ± 20 mg/dL vs. 120 ± 15 mg/dL, p < 0.001), and glucose concentrations (fasting glucose: 105 ± 10 mg/dL vs. 90 ± 8 mg/dL, p < 0.001). Participants in the lower tertile of AIP had higher HDL cholesterol levels (HDL: 60 ± 5 mg/dL vs. 45 ± 4 mg/dL in higher tertile, p < 0.001). In the model for Thrombogenicity Index (TI), participants in the higher tertile had higher glucose concentrations (glucose: 110 ± 12 mg/dL vs. 95 ± 9 mg/dL in lower tertile, p = 0.04).</p><p><strong>Conclusion: </strong>This research introduces a novel field of investigation and emphasizes the possible importance of TI, AI, and AIP indices in regulating cardiometabolic risk factors.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"33"},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple low-dose radiation ameliorates type-2 diabetes mellitus via gut microbiota modulation to activate TLR4/MyD88/NF-κB pathway.","authors":"Lijing Qin, Rongrong Liu, Zhen Jia, Weiqiang Xu, Li Wang, Hongyuan Tian, Xinru Lian, Wen Li, Yali Qi, Huan He, Zhicheng Wang","doi":"10.1186/s12902-025-01861-z","DOIUrl":"10.1186/s12902-025-01861-z","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is the fastest-growing metabolic disease in the world. The gut microbiota is linked to T2DM. Recent studies have showed that the metabolism of gut microbiota can trigger T2DM. Low dose radiation (LDR) has been proved to activate various protective bioeffects on diabetes. However, the underlying mechanisms remain unclear.</p><p><strong>Methods: </strong>In this study, T2DM model was established using high fat diet combined with streptozocin (STZ) injection in C57BL/6 mice, and then exposed to multiple 75 mGy LDR every other day for one month. The changes of blood glucose levels, body weight, and the damage of pancreas were measured. In addition, 16 S rDNA amplicon sequencing was used to detect gut microbiota alteration. Metabolic profiling was carried out using the liquid mass spectrometry system, followed by the combinative analysis of gut microbiota alteration. Furthermore, the inflammatory factors and related pathways were detected.</p><p><strong>Results: </strong>We found that LDR attenuate blood glucose levels and the weights of body in T2DM mice, and reduce pancreas impairment. In addition, in the gut, LDR regulated the relative abundance of Bacilli, Desulfobacterota, Verrucomicrobiota, and Proteobacteria. The non-target metabolomics analysis found that LDR significantly improve the metabolic abnormalities in T2DM, which is closely related to the gut microbiota abundance. Furthermore, the inflammatory effects activated by TLR4/MyD88/NF-κB pathways in T2DM were ameliorated by LDR.</p><p><strong>Conclusion: </strong>These results suggest that LDR may exert a beneficial role in T2DM by modulating gut microbiota and metabolites, especially in TLR4/MyD88/NF-κB pathway.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"32"},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum uric acid to creatinine ratio as a predictor of insulin resistance, β cell function, and metabolic syndrome in normal Korean adults: a cross-sectional study.","authors":"Misuk Oh, Soo Hyun Cho","doi":"10.1186/s12902-025-01860-0","DOIUrl":"10.1186/s12902-025-01860-0","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine the relations between serum uric acid to creatinine ratio(SUA/Cr) and insulin resistance, pancreatic β cell function, and outbreak of metabolic syndrome (MetS) in normal Korean participants.</p><p><strong>Materials and methods: </strong>This study included 14,984 participants without diabetes mellitus or gout who participated in the 2019-2021 Korea National Health and Nutrition Examination Survey. To evaluate insulin resistance and β cell function, the homeostasis model assessment (HOMA) was used. Insulin resistance was suggested by HOMA-IR, and β cell function was presented as HOMA-β. Multivariate logistic linear regression analysis was used to identify the factors affecting HOMA-IR, HOMA-β, and MetS. Cut-off values of SUA/Cr to predict insulin resistance, β cell dysfunction, and MetS risk were also been suggested.</p><p><strong>Results: </strong>Consequent to dividing SUA/Cr into tertiles, the higher the SUA/Cr, the higher the HOMA-IR and dysfunction of β cell, and the rate of MetS increased (p < 0.05). SUA/Cr was associated with insulin resistance, β cell function, and existence of MetS (adjusted odds ratio [OR]; 1.231 [95% confidence interval [CI]; 1.204-1.259], 1.033 [1.011-1.057], and 1.065 [1.026-1.106], respectively). In addition, the group with the clinical significance was the 3rd tertile. In this group, insulin resistance, β cell dysfunction, and MetS risk could be predicted when SUA/Cr value was 8.2716, 8.8710, and 7.9762, respectively. Based on the total number of people, meaningful SUA/Cr values were 7.0175, 6.7925, and 6.9369.</p><p><strong>Conclusions: </strong>The SUA/Cr may be a useful marker for predicting the insulin resistance, β cell function and incidence of MetS in normal Korean participants.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"31"},"PeriodicalIF":2.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}