BMC Endocrine Disorders最新文献

{"title":"A multimodal study on predicting extrathyroidal extension of papillary thyroid carcinoma based on radiopathomics.","authors":"Jiao Yao, Di Wang, Kun-Ming Pu, Wei-Han Xiao, Xiao-Min Hu, Jin-Feng Qin, Wei Yuan, Hong-Mei Yuan, Xiao-Ling Liu, Fan-Ding He, Chao-Xue Zhang, Xia-Chuan Qin","doi":"10.1186/s12902-026-02308-9","DOIUrl":"https://doi.org/10.1186/s12902-026-02308-9","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to develop and validate a radiopathomics model for predicting extrathyroidal extension (ETE) in papillary thyroid carcinoma (PTC).</p><p><strong>Methods: </strong>This retrospective study included 388 PTC patients with preoperative ultrasound and 400× cytology images from five medical centers between June 2017 and April 2024. We analyzed ultrasound and cytology images using Python and CellProfiler to extract features. Feature selection was performed using univariate analysis, Spearman correlation, and LASSO regression. The XGBoost algorithm was then used to build radiomics, pathomics, and combined radiopathomics models. The diagnostic performance of the radiopathomics model was compared with that of radiologists in an external validation cohort. Model and radiologist performance was evaluated using the area under the receiver operating characteristic curve (AUC). The radiopathomics model was visualized and interpreted through SHAP analysis.</p><p><strong>Results: </strong>The radiopathomics model selected 21 features for construction. The AUC of the radiopathomics model was 0.887, 0.857, and 0.873 in the training, internal validation, and external validation cohorts, respectively, exceeding those of the single radiomics model (0.824, 0.787, and 0.804) and the pathomics model (0.809, 0.811, and 0.794). Compared with radiologists, the radiopathomics model improved the mean accuracy from 0.661 to 0.821. SHAP analysis showed that radiomics features played a major role in diagnosing ETE, while pathomics features provided additional support.</p><p><strong>Conclusion: </strong>The radiopathomics model serves as a promising auxiliary tool for preoperative ETE risk stratification and can help improve radiologists' diagnostic performance.</p><p><strong>Clinical trial number: </strong>Not Applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of unilateral adrenal vein sampling with simple and biochemical/imaging correction: a study on early screening and typing for primary aldosteronism.","authors":"Yi Yan, Caie Li, Jianshu Chen, Wei Liang, Qiongying Wang, Jiazheng Li, Fang Du, Yuzhe Song, Lijuan Huang, Zhaofen Wang, Jing Yu, Peng Chang","doi":"10.1186/s12902-026-02303-0","DOIUrl":"https://doi.org/10.1186/s12902-026-02303-0","url":null,"abstract":"<p><strong>Objective: </strong>Adrenal vein sampling (AVS) is the gold standard for distinguishing subtypes for primary aldosteronism. However, its technical challenges and frequent intubation failures pose difficulties. Our study aimed to establish diagnostic models for unilateral primary aldosteronism (UPA) to guide appropriate treatment in early patients.</p><p><strong>Methods: </strong>We retrospectively analyzed 274 consecutive patients undergoing AVS without adrenocorticotropic hormone (ACTH) stimulated. We established a diagnostic model corrected by biochemical/imaging, and evaluated the diagnostic value of adrenal vein aldosterone/cortisol concentration (A/C) and its ratio to inferior vena cava (AV/IVC) before and after adjusted.</p><p><strong>Results: </strong>In a population with a median hypertension history of 3.5 years, the area under the curve (AUC) of adrenal vein A/C index for diagnosing ipsilateral and contralateral disease was 0.829 and 0.609, respectively. AUC of AV/IVC was 0.809 and 0.754, respectively. Factors like aldosterone concentration after saline infusion test (SIT), lowest blood potassium, and the presence of consistent adrenal gland nodules on CT were associated with UPA diagnosis, which were therefore included in the diagnostic models. The biochemical/imaging-corrected model correctly classified majority of patients (AUC: 0.828 - 0.893). For diagnosing ipsilateral aldosteronism, when 95% specificity achieved, sensitivities were 60% and 64% in A/C-adjusted and AV/IVC-adjusted models, respectively. As for diagnosing contralateral disease, when 95% specificity achieved, sensitivities were 50% and 53% in A/C-adjusted and AV/IVC-adjusted models, respectively.</p><p><strong>Conclusions: </strong>For early primary aldosteronism patients, the integration of unilaterally adjusted AVS guided by biochemical and imaging indicators into clinical practice is feasible. While it does not play a definitive role, it provides valuable insights to support treatment decisions.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic disparities and methodological quality of type 2 diabetes prediction models: a systematic review and meta-analysis of 97 models.","authors":"Suelen Queiroz, Júlia Gonçalves Gadelha, Noor Husain","doi":"10.1186/s12902-026-02301-2","DOIUrl":"https://doi.org/10.1186/s12902-026-02301-2","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Accurate risk prediction is essential for targeted prevention of type 2 diabetes mellitus (T2DM). However, the global applicability and methodological rigor of existing prediction models remain uncertain.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To systematically review and meta-analyze the geographic distribution, methodological quality, and predictive performance of all published T2DM risk prediction models.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data sources: &lt;/strong&gt;PubMed, Embase, Web of Science, Cochrane Library, CNKI, WanFang, and VIP were searched from inception to December 2025 (eAppendix S1 in the Supplement).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study selection: &lt;/strong&gt;Studies that developed or validated a multivariable prediction model for incident T2DM in general adult populations and reported at least one performance measure.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data extraction and synthesis: &lt;/strong&gt;Two reviewers independently extracted data and assessed risk of bias using the PROBAST tool. A random-effects meta-analysis was used to pool C-statistics. Heterogeneity was explored via subgroup analyses and meta-regression. The study followed TRIPOD-SRMA and PRISMA reporting guidelines.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The primary outcome was the geographic origin of models. Secondary outcomes included pooled measures of discrimination (C-statistic/AUC) stratified by region and an overall assessment of methodological quality (PROBAST).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 65 studies comprising 97 distinct prediction models were included (eTable 1). Geographic distribution was highly skewed, with 70.1% of models developed in Asian populations (China: 47.4%; Japan: 13.4%; South Korea: 9.3%), while only 7.2% originated from the US and 4.1% from Europe. Logistic regression was used in 97.9% of models. External validation was performed for only 21 models (21.6%). According to PROBAST, 91.8% of models were at high risk of bias (eTable 2), primarily due to inadequate handling of missing data, lack of external validation, and poor calibration reporting. Meta-analysis revealed wide variation in discrimination by geographic region (eTable 7). US-based models achieved the highest pooled AUC (0.97; 95% CI, 0.94-0.99), but this finding is likely influenced by overfitting, small sample bias, and publication bias (see Discussion). European models showed a pooled AUC of 0.84 (0.81-0.87), while Chinese models showed the lowest performance (AUC, 0.79; 0.76-0.82). Due to very high heterogeneity (I² &gt; 80% in most regions), these pooled estimates should be interpreted as descriptive summaries rather than precise estimates of true regional performance. Performance was lowest in prediabetic cohorts (AUC, 0.72; 0.68-0.76); however, this finding is preliminary due to the limited number of models and high heterogeneity. Funnel plot asymmetry suggested potential publication bias (Egger's test p=0.03); The most frequently included predictors were age (69.1%), body mass index (64.9","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between endothelial activation and stress index and mortality in critically ill patients with diabetes mellitus: a retrospective cohort study.","authors":"Rong Ding, Rui Su, Yanhua Deng, Xin Niu, Jia Liu, Jiayu Wu, Liqiong Wang, Hui Zhao","doi":"10.1186/s12902-026-02298-8","DOIUrl":"https://doi.org/10.1186/s12902-026-02298-8","url":null,"abstract":"<p><strong>Background: </strong>The Endothelial Activation and Stress Index (EASIX) serves as a biomarker of endothelial dysfunction. Although EASIX is prognostic in critical illnesses such as sepsis, its specific association with mortality in critically ill patients with diabetes mellitus (DM) is undetermined. This study was designed to evaluate this relationship.</p><p><strong>Methods: </strong>This retrospective study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. EASIX was calculated as lactate dehydrogenase (U/L) × creatinine (mg/dL) / platelet count (10⁹/L) and analyzed as log2-transformed values and by tertiles. The primary outcome was 30-day mortality, with 365-day mortality as a secondary outcome. Cox proportional hazards regression, Kaplan-Meier analysis, restricted cubic splines, subgroup analyses, and mediation analysis with lactate as a mediator were employed to evaluate the prognostic association. Sensitivity analyses, including propensity score matching, were performed to assess the robustness of the findings.</p><p><strong>Results: </strong>This study included 4,175 critically ill patients with DM. After full adjustment, each log2‑unit increase in the EASIX score was associated with a significantly increased risk of both 30‑day mortality (HR 1.20, 95% CI 1.16-1.24) and 365‑day mortality (HR 1.14, 95% CI 1.11-1.17). Mortality risk demonstrated a graded increase across ascending EASIX tertiles. A linear dose‑response relationship was confirmed, and this association remained consistent across most predefined subgroups. Propensity score matching analysis further supported this association. Mediation analysis indicated that lactate levels partially mediated the observed relationship between EASIX and mortality.</p><p><strong>Conclusions: </strong>EASIX is independently associated with increased 30‑day and 365‑day mortality in critically ill patients with DM, an effect partially mediated by lactate.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic profile in Prader-Willi syndrome patients followed at a single expert center of rare endocrine diseases.","authors":"Nikolinka Yordanova, Mila Vasileva, Sonya Galcheva, Violeta Iotova","doi":"10.1186/s12902-026-02302-1","DOIUrl":"https://doi.org/10.1186/s12902-026-02302-1","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Prader-Willi syndrome (PWS) is a rare imprinting disorder characterized by typical dysmorphic features, lack of satiety, infantile hypotonia, and later morbid obesity with complications, short stature, hypogonadotropic hypogonadism, skeletal and psychiatric problems. From the literature, it is well known that patients with PWS have a more favorable metabolic pattern than healthy controls.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The aim of the study is to assess the metabolic profile of PWS patients followed at an Expert Center for Rare Endocrine Diseases compared with healthy controls and to look for relations between components of the metabolic syndrome (MetS), adipokines, and the compartments of body composition (BC-lean and fat mass).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients and methods: &lt;/strong&gt;The current study is a cross-sectional evaluation of 25 patients with Prader-Willi syndrome (mean age 11.3 ± 8.2 years), with a total of 183.6 patient-years of regular follow-up (from the first visit to the center to the data collection cutoff date), compared with 24 age-, sex-, and BMI-matched healthy controls (mean age 11.3 ± 3.9 years). Each participant underwent anthropometric measurements, physical examination, biochemical and hormonal blood sampling, and whole-body DXA scan. Statistical analysis (SPSS 15.0 statistical package, Chicago, IL, USA) was performed to assess the relations between the metrics in the PWS group compared with controls.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Patients with PWS showed a better profile of glucose homeostasis with significantly lower serum insulin concentration and calculated HOMA-IR index compared with the controls (p &lt; 0.05). Taking into consideration age, sex, and body mass index (BMI) in the PWS group, the analysis showed strong positive correlations between waist circumference (WC) and systolic blood pressure (SBP) (r = 0.864, p &lt; 0.001), and WC and diastolic blood pressure (DBP) (r = 0.534, p = 0.033). Partial correlation analysis with respect to age, sex, and pubertal development found significant positive WC correlations with insulin (r = 0.796, p = 0.006), HOMA-IR (r = 0.697, p = 0.025), LDL-cholesterol (r = 0.735, p = 0.002), uric acid (r = 0.735, p = 0.002), CRP (r = 0.600, p = 0.023), and leptin (r = 0.730, p = 0.005). Strong negative correlations existed between WC and SHBG (r = -0.772, p = 0.002) and HMW adiponectin (r = -0.998, p = 0.044). Additionally, a negative correlation of HMW adiponectin and SBP was demonstrated. 88% of the patients were treated with recombinant human growth hormone (rhGH). Bone mineral density adjusted for height (BMD/height) was significantly lower in patients with PWS (p &lt; 0.05) compared with healthy controls. The analysis did not reveal significant relationships between BC compartments and metabolic and auxological parameters in the PWS group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our study confirms that patients with PWS have a favorable metabolic profile compared with heal","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance-related indices, sarcopenia, and cardiovascular risk in CKM stages 1-3: a prospective cohort study from CHARLS.","authors":"Huanjie Zhou, Congshui Wang, Chao Ou, Yuehong Lao, Yongbiao Luo, Ming Lao, Jinfeng Liu, Juan Xie, Hao Huang","doi":"10.1186/s12902-026-02305-y","DOIUrl":"https://doi.org/10.1186/s12902-026-02305-y","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia often coexists with metabolic and renal dysfunction and may increase cardiovascular disease (CVD) risk. Insulin resistance (IR) is a key mechanism linking sarcopenia and cardiometabolic disorders. However, evidence on IR-related indices and CVD risk among individuals with sarcopenia across cardiovascular-kidney-metabolic (CKM) stages remains limited. This study aimed to examine associations between multiple IR-related indices and incident CVD, and to evaluate their predictive and mediating roles across CKM stages 1-3 and sarcopenia status.</p><p><strong>Methods: </strong>We analysed 5,965 adults with CKM stages 1-3 from the China Health and Retirement Longitudinal Study (CHARLS), categorised as no sarcopenia, possible sarcopenia, or sarcopenia. We assessed associations between sarcopenia, eight IR-related indices-including triglyceride-glucose index-body mass index (TyG-BMI) and estimated glucose disposal rate (eGDR)-and incident CVD using Cox and the Fine-Gray competing risks model. Missing data were handled by multiple imputation. Dose-response relationships were evaluated with restricted cubic splines, and predictive performance was assessed with the area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Mediation and sensitivity analyses explored potential pathways and the robustness of the results.</p><p><strong>Results: </strong>63.8% of participants had possible sarcopenia or sarcopenia and were at higher risk of incident CVD and all-cause mortality. Mean follow-up was approximately 9 years. TyG-BMI was positively associated with CVD risk (HR = 3.58, 95% CI 2.50-5.14), whereas eGDR was inversely associated (HR = 0.36, 95% CI 0.28-0.47). The combined TyG-BMI and eGDR model improved CVD risk discrimination (AUC = 0.614, 95% CI 0.595-0.634), with gains in NRI (0.117, 95% CI 0.058-0.161) and IDI (0.013, 95% CI 0.007-0.023). IR-related indices accounted for 20%-46% of the association between CKM stage 3 (vs. stage 1) and CVD.</p><p><strong>Conclusion: </strong>Possible sarcopenia and sarcopenia were associated with increased CVD risk, particularly in CKM stage 3. IR-related indices, especially TyG-BMI and eGDR, were strongly associated with CVD risk and improved prediction, suggesting that IR may partially mediate the impact of CKM progression and sarcopenia on CVD outcomes.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study on the lifestyle of patients with Hashimoto's thyroiditis.","authors":"Shuai Ma, Peng Yu, Qiyu Chen, Miriayi Alimujiang, Dilidaer Muhanhali, Lei Zhang, Jiejie Zhao, Xiaoyang Sun, Yan Ling","doi":"10.1186/s12902-026-02296-w","DOIUrl":"https://doi.org/10.1186/s12902-026-02296-w","url":null,"abstract":"<p><strong>Background: </strong>Hashimoto's thyroiditis (HT) is the most common autoimmune cause of hypothyroidism, often accompanied by persistent non-specific symptoms despite normalized thyroid hormone levels. Lifestyle factors, including mood, sleep, diet, and exercise, are increasingly considered in the supportive management of HT, but comprehensive characterization of lifestyle patterns in HT patients remains limited.</p><p><strong>Objective: </strong>To systematically assess the lifestyle patterns of HT patients, including psychological well-being, sleep quality, quality of life, dietary habits, and physical activity.</p><p><strong>Methods: </strong>A single-center, cross-sectional study was conducted with 226 participants (105 HT patients and 121 healthy controls). Emotional status was assessed using the GAD-7 and PHQ-9; sleep quality with the Pittsburgh Sleep Quality Index (PSQI); and health-related quality of life with the SF-36. Dietary habits and physical activity were evaluated using validated questionnaires. Serum TPOAb and TgAb levels were measured, and correlations with exercise parameters were analyzed using Spearman correlation and multivariable linear regression. All HT participants were biochemically euthyroid at enrollment; prior clinical history of hypothyroidism and LT4 treatment were extracted from medical records.</p><p><strong>Results: </strong>HT patients exhibited higher anxiety and depression scores, poorer sleep quality, and lower quality of life compared with controls. They also reported distinct dietary patterns, including higher daily intake of meat, dairy, vegetables, and fruits and less frequent use of iodized salt. In terms of physical activity, HT patients showed more conservative exercise patterns, with greater time spent in low-intensity activity and less in moderate-intensity activity. Among HT patients, high-intensity exercise time was inversely associated with TPOAb levels after multivariable adjustment.</p><p><strong>Conclusion: </strong>HT patients displayed poorer psychological status, impaired sleep, and reduced quality of life, together with distinct dietary adjustments and conservative exercise patterns. In this biochemically euthyroid HT cohort, high-intensity exercise time was inversely associated with TPOAb levels.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between TyHGB and hyperuricemia and gout in patients with type-2 diabetes mellitus.","authors":"Qian Zhang, Jing Xu, Yanying Qian","doi":"10.1186/s12902-026-02294-y","DOIUrl":"https://doi.org/10.1186/s12902-026-02294-y","url":null,"abstract":"<p><strong>Background: </strong>Triglyceride high-density cholesterol-glucose body index (TyHGB) has been identified as a reliable predictor for the risk of metabolic diseases. However, its significance concerning hyperuricemia and gout has not been investigated. Thus, this research aims to examine the link between TyHGB and the risk of hyperuricemia and gout in individuals with T2DM.</p><p><strong>Methods: </strong>In this cross-sectional study, 2527 patients with T2DM admitted to the hospital between 2018 and 2023 were evaluated. Restricted cubic spline (RCS) and logistic regression techniques were utilized, along with further stratified and interaction analyses.</p><p><strong>Results: </strong>A positive linear association was identified between TyHGB and the prevalence of both hyperuricemia and gout. As TyHGB levels increased, there was a significant rise in the proportion of patients diagnosed with hyperuricemia or gout. Specifically, the prevalence of gout was 2.8%, 3.2%, 4.1%, and 10.4%, while the prevalence of hyperuricemia was 17.4%, 20.8%, 26.4%, and 42.7%, respectively. Multivariable logistic regression analysis revealed that each 1-unit increase in TyHGB was associated with a 15% increasing risk of hyperuricemia (OR = 1.15, 95% CI = 1.10, 1.19) and a 10% increasing risk of gout (OR = 1.10, 95% CI = 1.05, 1.15). Subgroup analyses indicated that this association was more pronounced in females. Furthermore, ROC analysis demonstrated that TyHGB exhibited a superior discriminatory performance compared to either TyG, TG/HDL, BMI, and FPG alone in predicting hyperuricemia (AUC = 0.666) and gout (AUC = 0.693).</p><p><strong>Conclusion: </strong>TyHGB demonstrates a positive association with the risk of hyperuricemia and gout, highlighting its potential utility as a cost-effective biomarker for stratifying individuals at risk for these conditions.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Helicobacter pylori infection and thyroid dysfunction in adults visiting a tertiary care hospital in Karachi, Pakistan: a cross-sectional study.","authors":"Ashraf Jahangeer, Rakhshinda Jabeen, Sameen Fatima, Iqra Ahmed Ali, Ashhad Rabeegh, Dua Ahmed Ali, Sohaib Raza, Abdulraziq Ziar","doi":"10.1186/s12902-026-02293-z","DOIUrl":"https://doi.org/10.1186/s12902-026-02293-z","url":null,"abstract":"<p><strong>Background: </strong>Thyroid dysfunction and Helicobacter pylori (H. pylori) infection are both highly prevalent in Pakistan. Several studies have proposed a potential immunological link between H. pylori infection and autoimmune thyroid disease, though evidence remains controversial. Given the cross-sectional design of this study, causal relationships cannot be inferred; the objective was to determine whether a statistically significant association exists between H. pylori infection and thyroid dysfunction in adults attending a tertiary care hospital in Karachi, Pakistan.</p><p><strong>Methods: </strong>A cross-sectional study was conducted over four months at Civil Hospital Karachi. Adult patients presenting with gastrointestinal symptoms were enrolled using consecutive sampling. H. pylori infection was confirmed using an immunochromatographic stool antigen test. Thyroid dysfunction was assessed by measuring thyroid-stimulating hormone (TSH) levels using the Electrochemiluminescence Immunoassay (ECLIA) technique, with normal TSH defined as 0.4-4.0 mIU/L; values outside this range indicated thyroid dysfunction. Statistical analysis was performed using SPSS version 23.0, applying chi-square tests and binary logistic regression. Odds ratios (ORs) with 95% confidence intervals (CIs) were reported; significance was set at p < 0.05. Sample size was calculated based on an estimated H. pylori prevalence of 50% with a 95% confidence level and ± 6% margin of error, yielding 267 participants.</p><p><strong>Results: </strong>A total of 267 participants were included. Thyroid dysfunction was identified in 19.3% of participants based on abnormal TSH levels. Although thyroid dysfunction was observed at a numerically higher frequency among H. pylori-negative participants, this difference was not statistically significant (OR = 1.376, 95% CI: 0.747-2.537, p = 0.305). H. pylori infection was more prevalent in male participants. Constipation was prevelant in hpylori positive patients but neither constipation nor diarrhea showed a statistically significant association with H. pylori infection.</p><p><strong>Conclusions: </strong>In this cross-sectional study, no statistically significant association was observed between H. pylori infection and thyroid dysfunction. These preliminary findings do not support a significant association between the two conditions in this population; however, given the study's methodological limitations, they are insufficient to make a definitive recommendation regarding routine thyroid screening in H. pylori-infected patients. Larger prospective studies incorporating thyroid autoantibodies, fT3/fT4 levels, and H. pylori strain typing are needed before any firm clinical conclusions can be drawn.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TSH reference intervals among Sub-Saharan African adults: a pilot study in Cameroon.","authors":"Stéphane Fargeon Mbouna Massin, Marcelle-Nourya Yemelong Meli, Bertille Elodie Edinga, Ngolé Néri Atabe, Stéphanie Zibi, Manuela Betala, Jean Maximilien Tang, Danielle Cécile Tang-Likeng, Vicky Jocelyne Ama-Moor","doi":"10.1186/s12902-026-02295-x","DOIUrl":"https://doi.org/10.1186/s12902-026-02295-x","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}