BMC Endocrine Disorders最新文献

{"title":"Triglyceride-glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals.","authors":"Amr Ali Mohamed Abdelgawwad El-Sehrawy, Lusine G Khachatryan, Aziz Kubaev, M M Rekha, Safia Obaidur Rab, Mandeep Kaur, Manmeet Singh, Manish Srivastava, Abed J Kadhim, Ahmed Hussein Zwamel","doi":"10.1186/s12902-025-01887-3","DOIUrl":"https://doi.org/10.1186/s12902-025-01887-3","url":null,"abstract":"<p><strong>Background: </strong>The strong potential of triglyceride to glucose index (TyG) in prediction of metabolic abnormalities is well identified in numerous disease including diabetes, metabolic syndrome and kidney disorders. However, no study is available to assess its validity and association with metabolic phenotype among obese individuals. In the current study, we aimed to evaluate the TyG index, its validity and association with metabolic parameters among obese individuals.</p><p><strong>Methods and materials: </strong>In the current cross-sectional study, 300 obese individuals were enrolled. Their demographic, anthropometric measurements were done and laboratory parameters including serum lipids, glycemic markers and insulin resistance were evaluated. Blood pressure was also measured with standard methods. The TyG index was calculated as the ln (fasting triglyceride level [mg/dL] × fasting glucose level [mg/dL]/2). Eating pattern was measured with three factor eating behavior questionnaire (TFEQ). Receiver operator characteristic curve was used to assess the TyG validity.</p><p><strong>Results: </strong>Subjects at the higher TyG tertile had higher waist o hip ratio (WHR) and eating disorder compared with lowest tertiles. Also, those at the highest tertiles had significantly higher total cholesterol (TC), triglyceride (TG), and fasting blood sugar (FBS), and lower high density lipoprotein cholesterol (HDL). According to the ROC curve analysis for various metabolic parameters, TyG demonstrated the highest area under curve (AUC) value of 0.838 compared with other metabolic parameters in identification of metabolic syndrome.</p><p><strong>Conclusion: </strong>The current study provides valuable insights into the relationship between TyG index, metabolic parameters, and eating behaviors among obese individuals.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"71"},"PeriodicalIF":2.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking is associated with adverse clinical outcomes after thyroidectomy: a 5-year retrospective analysis.","authors":"Yue Chen, Junxin Chen, Yanrui Huang, Weijian Ke, Shuang Yu, Weiwei Liang, Haipeng Xiao, Yanbing Li, Hongyu Guan","doi":"10.1186/s12902-025-01901-8","DOIUrl":"https://doi.org/10.1186/s12902-025-01901-8","url":null,"abstract":"<p><strong>Objective: </strong>Tobacco use has been confirmed to be a risk factor for postoperative complications, but the impact of smoking on adverse outcomes following thyroidectomy remains largely unknown.</p><p><strong>Methods: </strong>Using data spanning 2016-2020 from the National Inpatient Sample, patients aged ≥ 18 years who underwent thyroidectomy for thyroid malignancy or other thyroid disorders were identified and classified into two groups: current smokers and non-smokers. We compared outcome variables between the two groups via univariate analysis and adjusted multivariate logistic regression.</p><p><strong>Results: </strong>The present study included 13,737 records of patients who underwent thyroidectomy, among whom 1,360 (9.90%) were identified as current smokers. After propensity score matching, logistic regression analysis suggested that smoking was associated with a heightened risk of unfavorable discharge (aOR = 1.27, 95% CI [1.05-1.54], P = 0.012), vocal dysfunction (aOR = 1.25, 95% CI [1.00-1.55], P = 0.049), hypocalcemia (aOR = 1.23, 95% CI [1.05-1.44], P = 0.010), hypomagnesemia (aOR = 1.58, 95% CI [1.19-2.09], P = 0.001), and respiratory complications (aOR = 1.39, 95% CI [1.16-1.68], P < 0.001). Similar results were observed in both patients who underwent thyroidectomy for thyroid malignancy and those who underwent thyroidectomy for other thyroid disorders when a stratified analysis by surgical indications was performed.</p><p><strong>Conclusion: </strong>Smoking is an independent risk factor for adverse clinical outcomes after thyroidectomy.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"70"},"PeriodicalIF":2.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of chronic diabetic complications and associated risk factors among follow-up diabetic patients: estimates from a referral national diabetes center in Yemen.","authors":"Gamil Ghaleb Alrubaiee","doi":"10.1186/s12902-025-01893-5","DOIUrl":"10.1186/s12902-025-01893-5","url":null,"abstract":"<p><strong>Background: </strong>Emergence and progression of diabetic complications are associated with several risk factors. Identifying these risk factors related to diabetes helps avoid such complications and develop preventive measures to protect patients and improve their quality of life. This study aimed to estimate the prevalence of chronic complications among Yemeni diabetic patients and investigate the associations between these complications, sociodemographic characteristics, and diabetic risk factors.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at the National Diabetic Referral Center in Sana'a, Yemen, from September 1 to October 30, 2023. Of the 228 respondents, 222 were considered valid for analysis. Data for this study were collected using the World Health Organization (WHO) STEPS Surveillance questionnaire and a simple physical assessment. IBM SPSS version 24.0 was utilized to manage and analyze the data. Descriptive statistics were used to determine the prevalence of diabetes complications. The chi-square test and binary logistic regression were used to determine the associations and risk factors. A p-value of less than 0.05 was used to determine statistical significance.</p><p><strong>Results: </strong>Diabetes-related complications were reported by 62.6% of respondents, with females having a greater risk of diabetic foot, nephropathy, and retinopathy, while males had an increased risk of neuropathy complications. Unemployment, obesity, non-adherence to diabetes regimens, uncontrolled hypertension, longer duration of type 1 diabetes (T1DM), and irregular physician check-ups were identified as key predictors of diabetes-related complications. Administration of statins as lipid-lowering medications was associated with a reduced risk of coronary artery disease (CAD) or ischemic stroke complications.</p><p><strong>Conclusion: </strong>Chronic complications related to diabetes were common among patients in Yemen. Factors such as unemployment, obesity, non-adherence to diabetes regimens, uncontrolled hypertension, longer duration of T1DM, and irregular physician check-ups were identified as key predictors of these complications. Implementation of the WHO non-communicable disease package is strongly recommended. This package comprises comprehensive measures aimed at detecting, treating, preventing, and controlling diabetic complications and ultimately improving the overall management of diabetes in Yemen.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"68"},"PeriodicalIF":2.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphic variants and risk of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: systematic review and meta-analysis.","authors":"Daniella Vinelli-Arzubiaga, Carmen Elizabeth Suasnabar Campos, María Cristina Laso-Salazar, Hugo Abarca-Barriga","doi":"10.1186/s12902-025-01897-1","DOIUrl":"10.1186/s12902-025-01897-1","url":null,"abstract":"<p><strong>Background: </strong>Neuropathy is a frequent complication of diabetes mellitus, a disease that is growing exponentially worldwide. Genetic research has emerged as an important tool for better understanding its predisposition, although a systematic synthesis of existing evidence is needed to better comprehend its association. The objective of this review was to determine the association between polymorphic variants identified through massive genomic testing and the risk of peripheral diabetic neuropathy in patients with type 2 diabetes mellitus.</p><p><strong>Methods: </strong>Inclusion criteria were case-control, cohort, and cross-sectional studies examining polymorphic variants and diabetic neuropathy (DNP) risk in type 2 diabetes, studies using GWAS, EWAS, or microarray for identifying genetic polymorphisms, studies involving adults, and articles in English or Spanish. Exclusion criteria included case reports, case series, ecological studies, editor letters, reviews, or secondary studies and conference abstracts. Exhaustive search in PubMed, Scopus, and Web of Science databases, using keywords. Risk of bias was determined through Newcastle-Ottawa scale. A qualitative synthesis of the results was performed (frequency), including meta-analysis where applicable (forest plot and funnel plot).</p><p><strong>Results: </strong>The searching strategy identified 370 studies, from which 7 were chosen for the systematic review, included 9478 participants. The quality of the studies was mostly good, but a significant heterogeneity in methods was found. We identify a significant association between peripheral neuropathy and plenty of single nucleotide variants (SNVs). Just the SNV rs10555080 in the gene THEG5 showed a higher likelihood of neuropathy (OR:1,34; IC 95%: 1,19 - 1,49).</p><p><strong>Discussion: </strong>This study faced limitations due to heterogeneity in DNP definitions, genotyping methods, and a focus on white and Arab populations, limiting generalization. Only English and Spanish articles were included, potentially excluding relevant research in other languages. Multiple SNVs were identified through genomic testing that were associated with peripheral diabetic neuropathy in patients with type 2 diabetes mellitus; however, the SNVs were not similar between studies.</p><p><strong>Trial registration: </strong>This research received no funding and was registered in PROSPERO (ID CRD42024505256).</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"69"},"PeriodicalIF":2.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of estimated small dense low-density lipoprotein cholesterol with diabetes mellitus: a large-scale multicenter retrospective cohort study.","authors":"Yingkai Gao","doi":"10.1186/s12902-025-01880-w","DOIUrl":"10.1186/s12902-025-01880-w","url":null,"abstract":"<p><strong>Background: </strong>Estimated small dense low-density lipoprotein cholesterol (sdLDL-C) was related to atherosclerosis, coronary heart disease and metabolic syndrome. Despite these findings, limited evidence is available on the relationship between sdLDL-C levels and the onset of diabetes mellitus (DM).</p><p><strong>Methods: </strong>The study analyzed data from 118,080 adults enrolled at the Rich Healthcare Group between 2010 and 2016. The relationship between sdLDL-C levels and the risk of DM was examined using Cox proportional hazards regression. In order to evaluate potential nonlinear associations, cubic spline functions and smooth curve fitting were incorporated into the Cox regression framework. Furthermore, a two-piecewise Cox proportional hazards regression was employed to pinpoint the inflection point of sdLDL-C regarding DM risk.</p><p><strong>Results: </strong>SdLDL-C was found to have a significant correlation with DM risk after controlling for confounders (HR: 1.04, 95% CI: 1.03-1.04, P < 0.0001). The inflection point for sdLDL-C was calculated to be 29.49 mg/dL. The HR was measured at 1.08 (95% CI: 1.06-1.10) when sdLDL-C was below 29.49 mg/dL, and it decreased to 1.03 (95% CI: 1.03-1.04) when above 29.49 mg/dL.</p><p><strong>Conclusion: </strong>This investigation reveals a nonlinear positive connection between sdLDL-C levels and the risk of developing DM in Chinese adults. Notably, sdLDL-C levels lower than 29.49 mg/dL were strongly associated with a greater risk of DM.</p><p><strong>Clinical trial number: </strong>not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"66"},"PeriodicalIF":2.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease and liver fibrosis in US adults.","authors":"Wanqian Liu, Xiaozhong Li, Ling Chen, Xiao Luo","doi":"10.1186/s12902-025-01891-7","DOIUrl":"10.1186/s12902-025-01891-7","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, also considered a metabolic syndrome, and is associated with poor prognosis. eGDR (estimated glucose disposal rate) is a new biomarker to assessment insulin resistance (IR). The association between eGDR and MASLD and liver fibrosis is currently unclear.</p><p><strong>Objective: </strong>The aim of this cross-sectional study is to appraise the association between eGDR and MASLD and liver fibrosis.</p><p><strong>Methods: </strong>This study have enrolled 3,100 participants from the 2017-2018 National Health and Nutrition Examination Surveys (NHANES). Binary logistic regression analysis was used to assess the association between eGDR and MASLD and liver fibrosis. Receiver operating characteristic (ROC) was applied to estimate the ability of eGDR to identify MASLD.</p><p><strong>Results: </strong>The mean age of the subjects was 54.59 (17.29) years, and 49.26% were female. The prevalence of MASLD and liver fibrosis was 62.19% and 11.15%, respectively. In the fully adjusted models, there were negative associations of eGDR with the controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), with βs of -15.18 and - 0.74 (all p < 0.01), respectively. There were negative associations of eGDR with MASLD and liver fibrosis, with odds ratios (ORs) and 95% confidence intervals of 0.53 (95% CI: 0.48-0.74) and 0.40 (95% CI: 0.28-0.57) (all p < 0.01). The area under the curve (AUC) of the eGDR for identifying MASLD and liver fibrosis is 0.74 and 0.75, respectively.</p><p><strong>Conclusion: </strong>The study findings suggest a significant association between eGDR and MASLD as well as liver fibrosis. eGDR may serve as a biomarker for identifying MASLD.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"67"},"PeriodicalIF":2.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to low carbohydrate diet is inversely associated with metabolic syndrome: evidence from MASHAD study.","authors":"Sanaz Soltani, Glareh Koochakpoor, Melika Gharizadeh, Simin Rashidian Yazd, Maryam Mohammadi-Bajgiran, Alireza Ghajary, Ali Zeyqami, Gordon A Ferns, Majid Ghayour-Mobarhan","doi":"10.1186/s12902-025-01878-4","DOIUrl":"10.1186/s12902-025-01878-4","url":null,"abstract":"<p><strong>Background: </strong>We studied the link between adherence to a low carbohydrate diet (LCD) and metabolic syndrome (MetS) and its components in Iranian population.</p><p><strong>Methods: </strong>In this cross-sectional study, a validated 65-item food frequency questionnaire was used to collect dietary intakes from 3847 Iranian adults aged 35 to 65 years. These intakes were then used to calculate the LCD scores. The definition of metabolic syndrome followed the guidelines provided by the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI). To explore the association between LCD and MetS, multivariate logistic regression was employed in three models.</p><p><strong>Results: </strong>After accounting for potential confounding factors, individuals in the highest quartile of LCD score demonstrated a lower probability of having MetS compared to those in the lowest quartile (OR: 0.70; 95% CI: 0.56-0.88). When the analyses were performed for components of MetS, we found that compared to individuals in the bottom quartile, those in the top quartile of LCD score had a lower odds of enlarged waist circumference (OR: 0.62; 95% CI: 0.49-0.79), low serum HDL cholesterol (OR: 0.75; 95% CI: 0.62-0.92) and elevated blood pressure (OR: 0.71; 95% CI: 0.57-0.88). Regarding other components of MetS, no significant association was seen between LCD score and high serum triacylglycerol concentrations and abnormal glucose homeostasis.</p><p><strong>Conclusions: </strong>We found that adherence to a LCD was inversely related to MetS and its components including low serum HDL-C, elevated blood pressure, and enlarged waist circumference.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"62"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of SGLT2 inhibitors on metabolic phenotype and FGF-21 expression from the adipose tissue and the liver are less pronounced in ob/ob mice.","authors":"Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Paola Fioretto, Roberto Vettor, Marco Rossato","doi":"10.1186/s12902-025-01879-3","DOIUrl":"10.1186/s12902-025-01879-3","url":null,"abstract":"<p><strong>Background: </strong>the metabolic effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i), such as lipolysis and ectopic fat reduction, seem related to the synthesis of fibroblast growth factor-21 (FGF-21), and FGF-21 analogs are now under investigation for the treatment of obesity complications such as metabolic dysfunction-associated steatotic liver disease. However, FGF-21 levels are paradoxically higher in obesity, indicating a hormone-resistant state that may hinder the benefits of SGLT2i.</p><p><strong>Methods: </strong>To define if a different energy status influences the response to SGLT2i, we evaluated the effects of dapagliflozin administration on nine-week-old C57BL/6J wild-type and B6.V-LEP ob/ob mice as a model of genetic obesity. Blood glucose, body weight and food intake were evaluated, and the FGF-21 expression was determined in subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and brown adipose tissue (BAT). In the liver, FGF-21 gene expression, protein concentration and triglyceride content were evaluated.</p><p><strong>Results: </strong>glucose plasma levels and body weight were higher in ob/ob than in lean mice. After four weeks of treatment, dapagliflozin reduced blood glucose levels and body weight in both animal models, but weight loss was more significant in lean mice. The baseline expression of FGF-21 was higher in both SAT, VAT and the liver of ob/ob mice, whereas it was almost undetectable in BAT in both animal groups. After the treatment period, dapagliflozin was shown to increase FGF-21 expression in VAT only in lean animals, while the expression was unaffected in ob/ob mice. Similar effects were observed in the liver analyses, along with no variation in triglyceride content.</p><p><strong>Conclusions: </strong>SGLT2i administration results in less pronounced metabolic effects in ob/ob mice than in lean mice. This data suggests a less sensitive response in obesity, probably due to a chronic stimulation leading to abnormalities of the SGLT2i-FGF-21 axis which should be considered in managing patients affected by genetic obesity.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"63"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroidectomy, especially total thyroidectomy, adversely affects erectile function in men.","authors":"Yushu Huang, Dan Guo, Daixing Hu, Yaru Yang, Qin Deng","doi":"10.1186/s12902-025-01886-4","DOIUrl":"10.1186/s12902-025-01886-4","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the frequency of erectile dysfunction in male patients who undergo thyroidectomy using the International Index of Erectile Function (IIEF-5), and explore possible risk factors.</p><p><strong>Methods: </strong>163 male patients who undergo partial, unilateral or bilateral thyroidectomy between December 2021 and September 2022 were retrospectively studied. The IIEF-5 questionnaires were completed 6 and 12 months after surgery, and patients who reported erectile dysfunction (ED) before surgery were not included. Sociodemographic factors (age, education status, and employment status) and health behavior (smoking and alcohol consumption) were also recorded. The above factors and clinical data were included for statistical analysis.</p><p><strong>Results: </strong>Fifty-five patients underwent total thyroidectomy (TT), 67 underwent hemithyroidectomy (HT), and 41 underwent partial thyroidectomy (PT). Six months after surgery, 33 patients (60%) in the TT group, 38 (56.7%) patients in the HT group, and 11(26.8%) patients in the PT group reported ED. The lowest scores were observed in the TT group (TT: 19.22 ± 3.895, HT: 20.67 ± 2.836, PT: 21.98 ± 1.651, P < 0.05). At the 12-month postoperative visit, the mean IIEF-5 scores were better in the HT and PT groups and worse in the TT group (TT: 18.36 ± 4.335, HT: 21.40 ± 2.692, PT: 22.54 ± 1.206, P < 0.05). Binary logistic regression analysis revealed that age and extent of resection significantly affected the onset of postoperative ED.</p><p><strong>Conclusions: </strong>Thyroidectomy, especially the total thyroidectomy, adversely affects erectile function. In addition to the operative procedure, age was also found to be significantly associated with postoperative ED.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"61"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum chloride and prevalence of metabolic syndrome in the general U.S. adult population: evidence from NHANES 2011-2018.","authors":"Lun Zhang, Hongpeng Liu, Xiaoling Lv, Jianmei Zhou, Rongfang Zhou, Wenming Xing, Qing Wu","doi":"10.1186/s12902-025-01847-x","DOIUrl":"10.1186/s12902-025-01847-x","url":null,"abstract":"<p><strong>Aim: </strong>Numerous studies have revealed the decisive role of serum chloride in the outcome of specific patients. However, the potential role of serum chloride in general populations has been rarely investigated. This study aims to assess the association of serum chloride with MetS risk in the general population.</p><p><strong>Methods: </strong>A total of 13,290 adult participants were obtained from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The association between serum chloride and MetS was investigated using weighted logistic regression analyses. The weighted restricted cubic spline (RCS) was constructed based on the fully adjusted model to explore its dose-response relationship. Further stratified analyses were also conducted. All data and analyses were conducted using the \"Survey\" package in R software (Version 4.4.1).</p><p><strong>Results: </strong>The average age of this population was 48.20 ± 0.35, the average BMI was 29.42 ± 0.12 kg/m², included 48.54% males, and the weighted prevalence of MetS was 37.83%. After adjusting full covariates, serum chloride was negatively associated with MetS risk in overweight or obese participants who did not smoke or heavy drink. Meanwhile, serum chloride was significantly inversely correlated with the raised fast glucose (FG), total cholesterol (TG) and blood pressure (BP), and positively related with the reduced high density lipoprotein cholesterol (HDL-C). Consistent results were observed in the RCS analysis.</p><p><strong>Conclusion: </strong>This study suggested a potential inverse relationship between serum chloride levels and MetS risk. Understanding this link may offer fresh perspectives on preventing and treating MetS, presenting new therapeutic targets and strategies for public health improvement.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"64"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}