BMC Endocrine Disorders最新文献

{"title":"Erectile dysfunction among diabetic patients in Western Uganda: prevalence and associated factors in a multicentre study across three selected clinics.","authors":"Venance Emmanuel Mswelo, Afizi Kibuuka, Tijjani Salihu Shinkafi, Wardat Rashid Ali, Elias Joseph Xwatsal, Abdisamad Guled Hersi, Zakarie Abdullahi Hussein, David Elia Saria, Wisdom Njumwa, Hanan Asad Hassan, Abukar Ali Ahmed, Adan Abdi Hassan, Abdisalam Ahmed Sandeyl, Theoneste Hakizimana, David Mumbere Mayani, Josiah J Mkojera, Feisal Dahir Kahie, Dalton Kambale Munyambalu, Jacinto Amandua","doi":"10.1186/s12902-025-02048-2","DOIUrl":"https://doi.org/10.1186/s12902-025-02048-2","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"238"},"PeriodicalIF":3.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of weight reduction effectiveness with liraglutide in diabetes mellitus type 2 patients: a retrospective cohort study.","authors":"Pitsinee Wangpattanamongkol, Worapaka Manosroi","doi":"10.1186/s12902-025-02066-0","DOIUrl":"https://doi.org/10.1186/s12902-025-02066-0","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"240"},"PeriodicalIF":3.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145353767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring genotype-phenotype correlation of FSHR polymorphisms in polycystic ovary syndrome.","authors":"Mandeep Kaur, Sukhjashanpreet Singh, Archana Beri, Anupam Kaur","doi":"10.1186/s12902-025-01979-0","DOIUrl":"https://doi.org/10.1186/s12902-025-01979-0","url":null,"abstract":"<p><strong>Purpose: </strong>Single nucleotide polymorphisms (SNPs) in FSHR were reported to increase PCOS susceptibility. The present study was conducted to analyse the association of FSHR polymorphisms (rs1394205, rs11692782, and rs2349415) with PCOS in Punjab, India.</p><p><strong>Methods: </strong>A case-control study comprised of 823 women (443 PCOS cases and 380 healthy controls). Along with anthropometric measurements, lipid and hormonal profiles (LH, FSH, and testosterone levels) were also recorded. The genotyping of FSHR polymorphisms was performed with PCR-RFLP method. Continuous variables were compared using the student's t-test while the genetic association analysis was performed utilizing chi-square, binary logistic regression, and odds ratio with a 95% confidence interval. All the statistical analyses were performed on SPSS v.21 and GraphPad 9.</p><p><strong>Results: </strong>A significant association of rs2349415 polymorphism was observed with PCOS. The recessive model conferred higher PCOS risk (Adjusted OR-1.64, p = 0.012). The genetic association of rs1394205 and rs11692782 remained non-significant (p > 0.05). rs2349415 and rs1394205 were significantly related to dyslipidemia, while rs11692782 had shown a role in the modulation of gonadotropic hormones. Haploview analysis showed a modest linkage disequilibrium in the block of 133 kb, and no association of FSHR haplotypes was identified with PCOS.</p><p><strong>Conclusion: </strong>The present findings concluded that a polymorphism, rs2349415, has a significant role in PCOS in the Punjabi population. Also, variations in the FSHR significantly modulate lipid metabolism and hormonal levels.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"239"},"PeriodicalIF":3.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145353757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index association with kidney function in adults; a population-based study.","authors":"Yahya Pasdar, Sepideh Kazemi Neya, Hamid Reza Nikbakht, Ebrahim Shakiba, Farid Najafi, Mehran Pournazari, Mehdi Moradi Nazar, Bita Anvari, Mitra Darbandi","doi":"10.1186/s12902-025-02063-3","DOIUrl":"https://doi.org/10.1186/s12902-025-02063-3","url":null,"abstract":"<p><strong>Background: </strong>Hyperglycemia and hypertriglyceridemia, two key elements of insulin resistance, are linked with developing kidney dysfunction. The Triglyceride-glucose (TyG) index, composed of blood lipids and glucose, may help assess the risk of kidney dysfunction. This study aimed to clarify the effect of TyG on estimated glomerular filtration rate (eGFR) reduction in adults in western Iran.</p><p><strong>Methods: </strong>This cross-sectional study involved a total of 9,661 participants, aged 35 to 65 years, drawn from the Ravansar Non-Communicable Diseases (RaNCD) cohort. Among these, 1,044 individuals were identified with chronic kidney disease (CKD), while 8,617 were classified as healthy. The triglyceride-glucose index (TyG) was calculated using the formula ln [triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2]. Additionally, an eGFR less than of 60 ml/min per 1.73 m² was employed to indicate kidney dysfunction.</p><p><strong>Results: </strong>48% of participants were male, and 40.14% were from rural areas. The prevalence of reduced eGFR was 10.81%. Compared to the first quartile, the fourth had significantly higher rates of hypertension, type 2 diabetes, cardiovascular disease, and dyslipidemia (P < 0.001). The odds of kidney dysfunction (eGFR reduction) were 47% in the third quartile (OR: 1.47; 95% CI: 1.20, 1.81) and 75% in the fourth quartile (OR: 1.75; 95% CI: 1.42, 2.17), significantly higher than those in the first quartile of the TyG index (P trend < 0.001), after adjustment for confounding factors.</p><p><strong>Conclusion: </strong>Lipid and glucose imbalances may be markers for decreased kidney function, and it is recommended that patients with such imbalances be screened for kidney disease.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"236"},"PeriodicalIF":3.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial thickness measurements on high-resolution ultrasonography in diabetics with and without macrovascular complications and their relationship with homocysteine level.","authors":"Suqin Jin, Siyu Zhao, Xiaoyu Yue, Mei Zhang, Xianghua Zhuang, Zhaohong Xie, Mingjun Xu","doi":"10.1186/s12902-025-02064-2","DOIUrl":"https://doi.org/10.1186/s12902-025-02064-2","url":null,"abstract":"<p><strong>Background: </strong>Pathological changes in the arterial vasculature play a pivotal role in the development of macrovascular and microvascular complications of diabetes mellitus (DM). Compared with traditional measurements of carotid artery intima-media thickness, separate measurements of the thickness of the intima and the media using high-resolution ultrasonography could reveal vascular anatomical changes more precisely. Homocysteine (HCY) is closely related to vascular complications in DM patients. This study aimed to explore the thickness of the intima and media separately in the carotid, radial, and dorsalis pedis arteries in DM patients, to examine their diagnostic value for DM with complications and their relationship with HCY.</p><p><strong>Methods: </strong>This was a cross-sectional study. A total of 123 DM patients and 102 healthy controls were enrolled. Arterial ultrasonography was performed using a 24-MHz probe to measure the thickness of the intima and media in the carotid, radial, and pedal arteries. Serum levels of fasting glucose, low-density lipoprotein cholesterol, HCY, and clinical information were also collected. Multivariate linear regression was performed to investigate the association between ultrasonographic parameters and risk factors, and binary logistic regression was used to explore the diagnostic value of combination model for DM with complications.</p><p><strong>Results: </strong>Carotid, radial, and pedal artery intima thickness were substantially thicker in DM patients than controls. Compared with DM patients without macrovascular complications, those with macrovascular complications exhibited a thicker media in all three arteries, a thicker carotid intima, and a thicker carotid artery intima-media thickness. The relative difference was greatest for carotid artery media thickness (28.4%). HCY positively correlated with all MTs and CIT in DM patients. CIT was associated with traditional risk factors including age, systolic blood pressure and HCY. Combination model of age, SBP and CIT provides a satisfactory diagnostic value for DM patients with macrovascular complications (area under the curve, 0.827).</p><p><strong>Conclusions: </strong>Measurement of arterial intima and media thickness using high-resolution ultrasonography might be a promising tool to reveal arterial pathological changes in DM patients.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"237"},"PeriodicalIF":3.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum adiponectin level with glycemic control and atherogenic lipid profile in Sudanese patients with type 2 diabetes mellitus.","authors":"Halima Babikir Eltahir, Elmahdi Mohamed Ali, Abdelrahim Osman Mohamed","doi":"10.1186/s12902-025-02053-5","DOIUrl":"10.1186/s12902-025-02053-5","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"235"},"PeriodicalIF":3.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12542329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of miR-302a-3p in diabetic nephropathy and its role in inflammatory response.","authors":"Lingbo Lv, Xin Zhang, Guoxia Luo","doi":"10.1186/s12902-025-02051-7","DOIUrl":"10.1186/s12902-025-02051-7","url":null,"abstract":"<p><strong>Background: </strong>This research aims to reveal the regulatory mechanism of miR-302a-3p in diabetic nephropathy (DN) and its role in inflammatory responses.</p><p><strong>Methods: </strong>Serum samples were collected from DN patients and healthy controls, and RT-qPCR was employed to determine miR-302a-3p expression levels. The diagnostic value of this molecule in DN was evaluated through the receiver operating characteristic curve. A high-glucose condition was induced in HK-2 cells to establish an in vitro cell model. CCK-8 and flow cytometry were used to assess cell viability and apoptosis changes. ELISA was used to detect the levels of inflammatory factors, and the ROS assay kit was used to assess the level of ROS. The dual-luciferase reporter assay confirmed the targeted binding relationship between miR-302a-3p and FGF-16. Functional rescue experiments were conducted by knocking down FGF-16.</p><p><strong>Results: </strong>The level of miR-302a-3p in the serum of patients with DN was significantly increased, and its area under the curve (AUC) for diagnosing DN was 0.9168. High glucose induced an upregulation of miR-302a-3p in HK-2 cells. Inhibiting miR-302a-3p significantly reversed high glucose-induced cell apoptosis and release of ROS and pro-inflammatory factors. miR-302a-3p directly targets and inhibits FGF-16. In HK-2 cells induced by high glucose, knocking down FGF-16 would eliminate the protective effect of miR-302a-3p inhibitor on the cells.</p><p><strong>Conclusions: </strong>miR-302a-3p enhances inflammatory response, oxidative stress and cell apoptosis by targeting and inhibiting FGF-16, thereby promoting renal tubular damage in DN.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"233"},"PeriodicalIF":3.3,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12532427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interpretable multimodal machine learning model for predicting malignancy of thyroid nodules in low-resource scenarios.","authors":"Fuqiang Ma, Fengchang Yu, Xinyu Gu, Lihua Zhang, Zhilin Lu, Lele Zhang, Herong Mao, Nan Xiang","doi":"10.1186/s12902-025-02031-x","DOIUrl":"10.1186/s12902-025-02031-x","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"232"},"PeriodicalIF":3.3,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12532389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenge faced in diagnosis and treatment of congenital hypothyroidism presenting with isosexual puberty and bilateral ovarian mass in low and middle income country: a case report.","authors":"Ashagre Gebremichael Ganta, Wintana Tesfaye Desta","doi":"10.1186/s12902-025-02058-0","DOIUrl":"10.1186/s12902-025-02058-0","url":null,"abstract":"<p><p>Congenital hypothyroidism (CH) is a prevalent condition that can lead to significant neurodevelopmental issues in infants if not diagnosed and treated promptly. Van Wyk and Grumbach Syndrome (VWGS), characterized by hypothyroidism, precocious puberty, and ovarian masses, is often misdiagnosed in low- and middle-income countries (LMICs) due to limited diagnostic resources. This case highlights systemic challenges, including delayed diagnosis and unnecessary surgical referrals.We present an 8-year-old girl diagnosed with Van Wyk-Grumbach syndrome, characterized by severe hypothyroidism, isosexual precocious puberty, and ovarian hyperstimulation. She exhibited symptoms including vaginal bleeding, abdominal distention, and marked obesity with stunted growth. Investigations revealed severe hypothyroidism (TSH: 96 mU/L) and enlarged bilateral ovarian cysts. After initiating levothyroxine therapy, the patient demonstrated remarkable clinical improvement, including reduced abdominal swelling and normalizing thyroid function. This case underscores the importance of considering hypothyroidism in differential diagnoses of ovarian masses in children, especially in regions lacking newborn screening protocols, to prevent unnecessary surgical interventions and ensure appropriate management of the condition.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"234"},"PeriodicalIF":3.3,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12532396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive compilation of data on the association between XRCC3 polymorphisms and thyroid cancer susceptibility.","authors":"Mahdi Khosravi-Mashzi, Seyed Masoud HaghighiKian, Amirhosein Naseri, Alireza Negahi, Mohammad Vakili-Ojarood, Bahareh Mehdikhani, Rezvan Nezameslami, Alireza Nezameslami, Amirhossein Rahmani, Amihossein Shahbazi, Amirmasoud Shiri, Hossein Neamatzadeh","doi":"10.1186/s12902-025-02044-6","DOIUrl":"10.1186/s12902-025-02044-6","url":null,"abstract":"<p><strong>Background: </strong>Polymorphisms in the XRCC3 gene, a key component of homologous recombination repair, have been studied for their potential role in thyroid cancer susceptibility. However, published findings remain inconsistent across populations and genetic variants. This meta-analysis aimed to clarify the associations between XRCC3 polymorphisms and thyroid cancer risk, with emphasis on variant- and ethnicity-specific effects.</p><p><strong>Methods: </strong>A systematic search of PubMed, EMBASE, Scopus, CNKI, and other databases up to July 10, 2025 identified case-control studies reporting genotype distributions of XRCC3 polymorphisms in thyroid cancer. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under fixed- or random-effects models. Subgroup analyses by ethnicity, sensitivity tests, and publication bias assessments (Egger's and Begg's tests) were performed.</p><p><strong>Results: </strong>Twenty-four eligible studies were included: 14 for rs861539, six for rs1799796, and four for rs1799794, comprising 4,502 cases and 6,048 controls. For rs861539, no significant association with thyroid cancer risk was observed in the overall population (T vs. C: OR = 1.089, 95% CI = 0.908-1.306, p = 0.358), with consistent null results across Asian and Caucasian subgroups. For rs1799796, no overall association was detected (G vs. A: OR = 0.970, 95% CI = 0.875-1.075, p = 0.558), but a protective effect emerged in Asian populations (GA vs. AA: OR = 0.835, 95% CI = 0.701-0.995, p = 0.043). For rs1799794, significant associations were found under recessive models (GG vs. AA: OR = 1.371, 95% CI = 1.066-1.762, p = 0.014; GG vs. GA + AA: OR = 1.316, 95% CI = 1.037-1.669, p = 0.024). Considerable heterogeneity was observed (I² = 42.2-93.3%), and eight studies deviated from Hardy-Weinberg equilibrium.</p><p><strong>Conclusions: </strong>XRCC3 rs1799794 polymorphism is associated with increased thyroid cancer risk, particularly under recessive genetic models. The rs1799796 variant may confer a protective effect in Asian populations, whereas rs861539 shows no significant association. These results highlight population-specific genetic effects and underscore the importance of considering ethnicity in genetic association studies. Further large, well-designed investigations are warranted to confirm these findings and to explore potential gene-environment interactions.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"231"},"PeriodicalIF":3.3,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12529809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}