BMC Endocrine Disorders最新文献

{"title":"Risk factors of diabetic ketoacidosis among patients with diabetes attending at public hospitals of East Gojjam Zone, Northwest Ethiopia: an unmatched case - control study.","authors":"Yonas Wondie, Awoke Minwuyelet, Alemwork Dessalegn Bogale, Getachew Hailu, Emiru Ayalew Mengstie","doi":"10.1186/s12902-025-02023-x","DOIUrl":"https://doi.org/10.1186/s12902-025-02023-x","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Ketoacidosis (DKA) is a critical and potentially fatal complication predominantly seen in individuals diagnosed with Type 1 Diabetes Mellitus (T1DM), though it may also arise in those with Type 2 Diabetes Mellitus (T2DM) under specific circumstances. Although DKA is preventable through effective diabetes management strategies, the consequences can be severe if the condition is not addressed promptly. The timely recognition of DKA, coupled with suitable medical treatment, is essential to enhance patient outcomes and mitigate the risk of enduring complications related to this condition. The objective of this research was to identify the risk factors of DKA in diabetic patients receiving care at public hospitals in the East Gojjam Zone of Northwestern Ethiopia.</p><p><strong>Methods: </strong>An unmatched case-control study was carried out in selected public hospitals located in the East Gojjam Zone between April 10 and July 30, 2023. Five public hospitals were randomly selected, and a systematic random sampling technique was employed to recruit 408 study participants. Logistic regression analysis was performed to identify variables significantly associated with the outcomes, using a significance level of P < 0.05 and a 95% confidence interval.</p><p><strong>Results: </strong>The study included 102 cases and 306 controls. Several key risk factors for DKA were identified, including the absence of regular follow-up [AOR = 2.21, 95% CI (1.31-3.71)], not being a member of health insurance [AOR = 3.30, 95% CI (1.75-6.24)], distance from a health facility greater than 5 km [AOR = 1.85, 95% CI (1.09-3.14)], infection [AOR = 2.15, 95% CI (1.12-3.89)], and reduction in insulin dosage [AOR = 2.13, 95% CI (1.19-3.83)].</p><p><strong>Conclusions: </strong>The findings declared that lack of regular follow-up, living more than five kilometers from a healthcare facility, reducing insulin doses without adequate medical guidance, lack of community-based health insurance, and the presence of infections significantly increase the likelihood of DKA. Therefore, healthcare providers should intervene on the identified risk factors for DKA to prevent the occurrence of DKA.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"222"},"PeriodicalIF":3.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication adherence and illness perception among diabetic patients in Upper Egypt.","authors":"Zeinab G Abdelhamid, Doaa Mazen Abdel-Salam, Ghada A Mohamed, Hosnia S Abd El-Megeed","doi":"10.1186/s12902-025-01966-5","DOIUrl":"https://doi.org/10.1186/s12902-025-01966-5","url":null,"abstract":"<p><strong>Background: </strong>Effective diabetes management depends on medication adherence and the illness perception of patients. The primary aim of this study is to investigate medication adherence and illness perception and their correlates among diabetic patients in Upper Egypt.</p><p><strong>Methods: </strong>A cross sectional study was carried out from August 2022 to January 2023 among diabetic patients attending Diabetes Clinic in Upper Egypt. Data was collected through patient interviews. Morisky Medication Adherence Scale has been used to assess medication adherence. Illness perception was measured by using Brief Illness Perception Questionnaire. To identify the predictors of medication adherence and illness perception, logistic regression was performed using SPSS version 26. P value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Out of 417 participants, 30.2% were low adherent to their diabetic medications. Predictors associated with low adherence to diabetic medications were; gender (AOR = 1.93, CI: 1.12-3.34), age (AOR = 0.40, CI: 0.19-0.87), education (AOR = 1.96, CI: 1.08-3.56), diabetes duration (AOR = 2.06, CI: 1.08-3.91), the presence of diabetes complications (AOR = 3.69, CI: 1.73-7.89), body mass index (AOR = 2.08, CI: 1.01-4.29), receiving health education in the last 6 months (AOR = 2.02, CI: 1.21-3.36), and illness perception (AOR = 6.70, CI: 3.62-12.40). A high level of illness perception was detected among 79.4% of the participants. High level of illness perception was significantly associated with residence (AOR = 2.48, CI: 1.37-4.51), presence of other comorbid conditions (AOR = 2.10, CI: 1.18-3.75), and price of medication (AOR = 2.53, CI: 1.07-5.99).</p><p><strong>Conclusions: </strong>Low adherence to diabetic medications was detected among 30.2% of the studied participants. Strategies aimed at enhancing adherence to diabetic medications should be compulsory. Furthermore, the findings of the current study recommend that illness perceptions of diabetic patients need to be improved.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"223"},"PeriodicalIF":3.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aeromedical evaluation and successful return to flight in a military pilot with lingual thyroid: a case report and follow-up.","authors":"Pangmin Li, Liangchen Wang, Li Xiao, Lin Ding, Dandan Wang, Caizhe Yang, Di Zhu","doi":"10.1186/s12902-025-02041-9","DOIUrl":"https://doi.org/10.1186/s12902-025-02041-9","url":null,"abstract":"<p><strong>Background: </strong>Lingual thyroid is a rare congenital anomaly resulting from the aberrant migration of thyroid tissue during embryonic development. Although frequently asymptomatic, its identification in military aircrew poses particular challenges given the rigorous standards of aeromedical certification.</p><p><strong>Case presentation: </strong>A 37-year-old male military helicopter pilot was incidentally diagnosed with lingual thyroid during routine health screening. The patient remained asymptomatic throughout the clinical course. Comprehensive evaluations-including thyroid function tests, biochemical profiling, cervical magnetic resonance imaging, electronic laryngoscopy, radionuclide scanning, and portable sleep monitoring-confirmed the presence of a lingual thyroid with subclinical hypothyroidism. Imaging demonstrated the ectopic tissue at the tongue base to be the sole functioning thyroid gland. Levothyroxine therapy was initiated, resulting in normalization of thyroid hormone levels. Polysomnography was performed due to the anatomical location of the lesion and excluded obstructive sleep apnea or ventilatory compromise. Given the patient's strong motivation to resume flight duties, a multidisciplinary aeromedical evaluation was conducted. Based on clinical stability, absence of symptoms, and treatment response, the pilot was deemed aeromedically fit. Since June 2021, he has accumulated over 900 flight hours, with preserved thyroid function and no evidence of disease progression on longitudinal follow-up.</p><p><strong>Conclusions: </strong>To the best of our knowledge, this represents the first documented case in China of a military pilot with lingual thyroid successfully certified for continued flying duties. This case suggests that congenital endocrine anomalies may be compatible with high-demand occupational roles in select cases, pending comprehensive individual evaluation and risk-based aeromedical assessment. It further supports the adoption of a risk-stratified, non-invasive management paradigm in aviation medicine, with implications for enhancing both flight safety and personnel retention.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"219"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of soluble apoptotic biomarkers (FAS,TNFR1 and TRAIL-R2) with β-cell dysfunction in early glucose dysregulation.","authors":"Rama Ayash, Younes Kabalan, Sahar Chamaa","doi":"10.1186/s12902-025-02001-3","DOIUrl":"https://doi.org/10.1186/s12902-025-02001-3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to investigate the association of soluble death receptors (FAS, TNFR1, and TRAIL-R2) with β-cell function in individuals with naïve prediabetes and newly diagnosed, treatment - naïve type 2 diabetes, and to assess the strength of this association to determine the independent variable that contributes to the variance of HOMA-B.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods and materials: &lt;/strong&gt;This was a cross-sectional study done at the Endocrine Clinics of National Hospital. There were two groups: group 1 included 49 newly diagnosed, drug-naive prediabetic patients, and group 2 consisted of 29 newly diagnosed, drug-naive,T2DM patients. Written informed consent was obtained from all participants. This study was approved by the Medical Ethics Committee of Damascus University (No. m/471 -12/5/2021) and registered with the Australian New Zealand Clinical Trials Registry (Trial ID: ACTRN12624001135505). Inclusion criteria included newly diagnosed prediabetic or T2DM subjects who had received no treatment, based on the 2015 American Diabetes Association criteria. Exclusion criteria entailed past histories of severe cardiovascular, renal, tumor, or autoimmune diseases and use of drug therapies including oral hypoglycemic agents. General and demographic information (Sex, age, BMI) was obtained, and blood samples were taken after fasting for 12 h. Fasting plasma glucose (FPG) levels were measured using an automatic analyzer (AMS, Italy). HbA1c levels were measured photometrically using the HemoCue (HbA1c 501 analyzer,America).Insulin levels were determined via an ELISA kit (Diametra, Italy), and soluble death receptors (TNFR1, Fas, TRAIL-R2) were measured using ELISA kits (Raybiotech, USA). The following formula calculates Homeostatic Model Assessment of Beta Cell Function( HOMA-B), HOMA-B (%) = [360 × basal insulin (µIU/mL)] / [basal glucose (mg/dL) - 63]. Statistical analyses were carried out in SPSS version 25. Distribution of the data was carried out using the Kolmogorov-Smirnov test for normality. Student t test for independent samples were done for normally distributed data, while Mann-Whitney U test was used for nonnormal variables. The relationships between HOMA-B and FBG in addition to other variables with significance level were performed using linear regressions with p values &lt; 0.05 were deemed to be statistically significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The levels of TNFR1, Fas, and TRAIL-R2 were significantly higher in T2DM compared with prediabetes (p &lt; 0.0001). TNFR1 and Fas exhibited a strong negative correlation with HOMA-B in both groups. Regression analysis indicated that Fas, followed by TRAIL-R2, was the main predictor of β-cell function. They combined accounted for 60% and 42% of the HOMA-B variance in prediabetes and T2DM, respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Elevated soluble death receptor levels, particularly Fas, are a marker of impaired β-cell function in prediabetes and T2DM. These ob","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"218"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum CA 19 - 9 and CA 72 - 4 levels in hashimoto's thyroiditis: a prospective case-control study.","authors":"Huseyin Demirci, Enes Ucgul, Ebru Aydogan, Huriye Unal","doi":"10.1186/s12902-025-02037-5","DOIUrl":"https://doi.org/10.1186/s12902-025-02037-5","url":null,"abstract":"<p><strong>Background: </strong>Hashimoto's thyroiditis is a common autoimmune thyroid disorder and a leading cause of subclinical hypothyroidism. Tumor markers such as CA 19 - 9 and CA 72 - 4 may also be elevated in certain benign inflammatory conditions. This study aimed to investigate the levels of CA 19 - 9 and CA 72 - 4 in patients with subclinical hypothyroidism due to Hashimoto's thyroiditis and to evaluate the effects of levothyroxine treatment.</p><p><strong>Methods: </strong>This prospective case-control study included 30 patients with subclinical hypothyroidism due to Hashimoto's thyroiditis and 30 healthy controls matched by age and sex. Serum levels of CA 19 - 9, CA 72 - 4, TSH, free T4, TPOAb, and TgAb were measured at baseline and after 6 weeks of levothyroxine therapy. Additionally, correlations between tumor markers and thyroid function parameters were analyzed.</p><p><strong>Results: </strong>Initially, there were no significant differences in CA 19 - 9 and CA 72 - 4 levels between the patient and control groups. Following treatment, a significant decrease in CA 19 - 9 levels was observed in patients who achieved euthyroidism (p = 0.020), whereas no significant change was detected in CA 72 - 4 levels.</p><p><strong>Conclusions: </strong>CA 19 - 9 and CA 72 - 4 levels do not appear to differ significantly between patients with subclinical hypothyroidism due to Hashimoto's thyroiditis and healthy individuals. However, CA 19 - 9 levels may decrease upon restoration of euthyroidism, potentially reflecting a reduction in thyroid-related inflammation. Further studies with larger cohorts and longer follow-up periods are warranted to confirm and clarify these observations.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"217"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between TyG index and MASLD in lean young adults: a retrospective study.","authors":"Wenjing Xiao, Xinghe Sun, Hui Lv, Xiaohui Liu, Jihong Zhu","doi":"10.1186/s12902-025-02029-5","DOIUrl":"https://doi.org/10.1186/s12902-025-02029-5","url":null,"abstract":"<p><strong>Background: </strong>The relationship between the TyG index and MASLD in lean young populations remains unclear.</p><p><strong>Methods: </strong>In this retrospective study, we analyzed data from individuals aged 18 to 35 Years old who underwent abdominal ultrasound examinations at a healthcare management center from January 2019 to December 2023. First, we categorized the TyG index into quartiles and used logistic regression models to examine the relationship between MASLD and TyG. Next, we applied restricted cubic splines (RCS) to assess whether the relationship between TyG and MASLD followed a nonlinear pattern. Additionally, we stratified the analysis by sex to explore whether the association between MASLD and TyG differed between males and females.</p><p><strong>Results: </strong>A total of 20,242 participants (14763 women [72.9%]; [mean ± SD] age, 29.07 [3.60]) were included in the study. The overall incidence of MASLD was 5.1%. The median (IQR) TyG index was 8.0 (7.6, 8.2). The association between TyG index and the incidence of MASLD followed a reverse L-shaped, with a cut-off value of 8.3. For each 1-unit increase in the TyG index, the association was significant both below 8.3 (HR = 2.1; 95%CI: 1.4-3.4 ) and above this threshold (HR = 12.1; 95%CI: 8.2-17.8). A significant interaction between sex and the TyG index was observed (P < 0.001). Both males and females showing an increase in MASLD risk after the TyG index exceeded 8.3.</p><p><strong>Conclusion: </strong>In young populations, higher TyG index is associated with an increased risk of MASLD, with distinct patterns observed between sexes. The risk of MASLD rises sharply once the TyG index exceeds 8.3.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"220"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between AIP and incident T2DM in patients with NAFLD: a retrospective study.","authors":"Yan Chen, Qiufang Bai, Hao Hua","doi":"10.1186/s12902-025-02046-4","DOIUrl":"https://doi.org/10.1186/s12902-025-02046-4","url":null,"abstract":"<p><strong>Background and aim: </strong>This study aimed to investigate the relationship between atherogenic index of plasma (AIP) and incident type 2 diabetes mellitus (T2DM) in non-alcoholic fatty liver disease (NAFLD) patients.</p><p><strong>Methods and results: </strong>In this retrospective study, 2,370 NAFLD patients were stratified into tertiles based on AIP levels. Baseline demographic, anthropometric, and biochemical characteristics were compared across tertiles. Multivariable logistic regression models were employed to assess the association between AIP and incident T2DM, adjusting for potential confounders, including age, sex, body mass index (BMI), hemoglobin A1c (HbA1c), smoking status, high blood pressure (HBP), and liver enzymes. Restricted cubic splines (RCS) evaluated dose-response relationships, and receiver operating characteristic (ROC) curves compared the predictive performance of AIP against individual parameters. In the fully adjusted model (Model 3), the highest tertile (Q3) demonstrated a 1.99-fold increased T2DM risk (OR = 1.99, 95% CI: 1.29-3.08, P = 0.002) versus Q1. A linear dose-response relationship was observed (P for non-linearity = 0.663), with each 1-unit AiP increase corresponding to a 2.76-fold higher T2DM risk (OR = 2.76, 95% CI: 1.54-4.93, P < 0.001). AIP demonstrated superior predictive performance for incident T2DM compared to traditional markers, as evidenced by higher area under the receiver operating characteristic curve (AUC) values. The relationship between AIP and incident T2DM remained consistent across various population subgroups (all interaction P-values>0.05).</p><p><strong>Conclusions: </strong>Elevated AIP is independently associated with an increased risk of incident T2DM in NAFLD patients, highlighting its potential as a predictive biomarker for diabetes in this high-risk population.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"221"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Sectional analysis of the association between type 2 diabetes and earlier onset of natural menopause in Syrian women.","authors":"Bayan Bobes, Yousef Saffaf, Suaad Hamsho, Mohammed Alaswad, Zaynab Alourfi, Younes Kabalan","doi":"10.1186/s12902-025-02033-9","DOIUrl":"https://doi.org/10.1186/s12902-025-02033-9","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, represents a growing global health burden. Natural menopause in women is defined as continuous cessation of menstruation for more than twelve consecutive months, and it is an important determinant of their future health. The average age at natural menopause is around 51 years. Early menopause is defined as the onset of menopause between the ages of 40 and 45 years, while genetic and environmental factors influence menopause timing, evidence suggests T2DM may accelerate ovarian aging. The aim of this study is to explore the existence of a relationship between T2DM and the natural age of menopause in Syrian women-a population with unique genetic and lifestyle factors underrepresented in existing literature.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at Al-Mouwasat and National University Hospitals in Damascus, from 2022 to 2024. 175 naturally postmenopausal women aged over 45 years were included in the study, with participants stratified by T2DM status, which was confirmed either by an HbA1c level of ≥ 6.5% or a physician's diagnosis. The age at menopause was ascertained based on self-reported cessation of menses for at least 12 months, exclusion of surgical or iatrogenic menopause cases, and validation against medical records. Data were analyzed using SPSS 25.0 with multivariable linear regression (α = 0.05).</p><p><strong>Results: </strong>The mean age at natural menopause did not differ significantly between women with and without T2DM (p = 0.099); key differences emerged in subgroup analyses. Women with T2DM demonstrated a 2.3-fold higher prevalence of early menopause (< 45 years) compared to non-diabetic counterparts (20.2% vs. 10.5%; p = 0.023). Notably, those with long-standing diabetes (> 10 years duration) experienced menopause ~ 2 years earlier than controls (p = 0.040). Furthermore, women with T2DM microvascular complications- specifically retinopathy (p = 0.044) and nephropathy (p = 0.000) - showed significantly earlier menopause compared to diabetes-free women.</p><p><strong>Conclusions: </strong>T2DM itself was not associated with a significantly earlier average age at natural menopause in Syrian women, but specific aspects of T2DM were significantly linked to earlier menopause, which are longer disease duration (> 10 years), and presence of microvascular complications (retinopathy or nephropathy). Critically, women with T2DM had a significantly higher prevalence of early menopause, indicating a doubled risk compared to non-diabetic women.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"216"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variations in amino acid metabolism-related genes are associated with risk of papillary thyroid carcinoma: a case-control study.","authors":"Hongjing Meng, Zhifu Xiao, Qiang Wang, Dewei Li, Zhuyan Li","doi":"10.1186/s12902-025-02034-8","DOIUrl":"10.1186/s12902-025-02034-8","url":null,"abstract":"<p><strong>Background: </strong>Abnormal amino acid metabolic pathways, especially those of glutamine, serine and proline, are crucial to tumourigenesis and the development of papillary thyroid carcinoma (PTC). However, genetic variants in key genes regulating these metabolic pathways remain poorly characterized in PTC.</p><p><strong>Methods: </strong>Seven SNPs in the SLC1A5, SLC1A3, SHMT1, and PRODH genes were genotyped in 620 patients with PTC and 620 controls using a flight mass spectrometry platform.</p><p><strong>Results: </strong>The frequency of the minor allele A of SLC1A5-rs2070246 was significantly greater in the PTC group than in the control group, thereby increasing the risk of PTC by 1.587 times (p < 0.0001). Similarly, the minor alleles C, T and A of SLC1A3-rs16903247, SHMT1-rs4925166 and PRODH-rs372055 increased susceptibility to PTC by 2.584, 1.346 and 1.349 times, respectively (p_rs16903247 < 0.0001, p_rs4925166 = 0.00024, and p_rs372055= 0.001, respectively). Moreover, carriers of the rs2070246-GA/AA genotype had a 1.77- and 2.35-fold increased risk of PTC, and the rs16903247-PTC/CC genotype was associated with a 2.42- and 9.46-fold increased risk of PTC (p < 0.0001). In addition, carriers of the TG or TT genotypes of rs4925166 and the AA genotype of rs372055 all presented a greater risk of PTC (p_rs4925166 = 0.0005, p_rs372055= 0.0021). Genetic model data further confirmed that the above four SNPs indeed increased the individual's sensitivity to PTC, as these SNPs were all associated with an elevated disease risk under different models (Bonferroni p < 0.0014).</p><p><strong>Conclusion: </strong>Our results revealed significant associations between amino acid metabolism gene polymorphisms and PTC risk, suggesting potential biomarkers for PTC susceptibility.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"214"},"PeriodicalIF":3.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between the first-trimester non-traditional lipid parameters with the risk of gestational diabetes mellitus in pregnancy.","authors":"Junmiao Xiang, Ruru Bao, Yundong Pan, Zhuhua Cai","doi":"10.1186/s12902-025-02024-w","DOIUrl":"10.1186/s12902-025-02024-w","url":null,"abstract":"<p><strong>Introduction: </strong>Gestational diabetes mellitus (GDM) is a common complication in pregnancy, linked to adverse outcomes for mothers and infants. Elevated levels of non-traditional lipid parameters have been associated with metabolic disorders. This study explores the predictive value of first-trimester non-traditional lipid parameters for GDM diagnosis at 24-28 weeks.</p><p><strong>Methods: </strong>A retrospective study involving 1197 patients from The Third Affiliated Hospital of Wenzhou Medical University (January 2019 - August 2023) examined the correlation between non-traditional lipid parameters and GDM using logistic regression and stratified analyses. The diagnostic performance of the lipid parameters was evaluated using the area under the curve (AUC) method. Pearson correlation analysis clarified the relationship between non-traditional lipid parameters and neonatal birth weight, as well as their association with oral glucose tolerance test (OGTT) glycemic measures.</p><p><strong>Results: </strong>Among 1197 participants, 201 were diagnosed with GDM. The GDM group exhibited significantly higher levels of non-traditional lipid parameters. Multivariate analysis identified these lipid measures, particularly Non-HDL-C with an AUC of 64.0% (95% CI: 59.6%-68.4%), as independent predictors of GDM across all models (P < 0.05), except for RC/HDL-C in model3. Most non-traditional lipid parameters demonstrated a linear relationship with GDM, with the exception of Non-HDL-C. Strong positive correlations were observed between fasting blood glucose levels and lipid ratios such as Non-HDL-C/HDL-C, LDL/HDL-C, TG/HDL-C, TC/HDL-C, and RC/HDL-C in patients with GDM. No significant differences were found in non-traditional lipid parameters among the single, double, and triple positive groups.</p><p><strong>Conclusion: </strong>First-trimester non-traditional lipid parameters are significant predictors of GDM, particularly when considering fasting blood glucose levels. These parameters offer potential value for early diagnosis.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"215"},"PeriodicalIF":3.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}