BMC Endocrine Disorders最新文献

{"title":"Prognostic biomarkers of future diabetes in South Asian women diagnosed with gestational diabetes: a prospective cohort study.","authors":"Sandi M Azab, Amel Lamri, Anastasia Gayowsky, Meera Shanmuganathan, Dipika Desai, Natalie C Williams, Zachary Kroezen, Rahul Chanchlani, Elizabeth K Darling, Philip Britz-McKibbin, Joseph Beyene, Wei Deng, Marie Pigeyre, Katherine M Morrison, Gita Wahi, Russell J de Souza, Sonia S Anand","doi":"10.1186/s12902-026-02290-2","DOIUrl":"https://doi.org/10.1186/s12902-026-02290-2","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes (GDM) confers an increased risk of future type-2 diabetes (T2D). We aimed to identify determinants of the progression of GDM to T2D in South Asian women and develop a precision prognostics model for potential future clinical application.</p><p><strong>Methods: </strong>This study included 247 South Asian women with GDM from the prospective South Asian Birth Cohort (START) study in Ontario, Canada. Metabolomics was performed on 2nd trimester fasting serum samples by multisegment injection-capillary electrophoresis-mass spectrometry. We determined incidence of postpartum T2D through validated diagnostic codes using health administrative data. We used multivariable logistic regression to identify predictors of incident T2D through backward elimination. We assessed diagnostic performance of models using area under the receiver operating characteristic curve (AUC ROC) and 5-fold cross-validation to assess model stability.</p><p><strong>Results: </strong>Of 247 South Asian women diagnosed with GDM with a mean age of 30.9 years and median total follow-up of 9.7 years, 45 (18.2%) developed T2D within a median of 4.9 years. Pre-pregnancy body mass index, area-under-the-curve glucose, and level of education, were identified as the strongest determinants of T2D post-GDM (AUC ROC = 0.83 [95% Confidence Intervals (CI), 0.78-0.88]). Addition of metabolite biomarkers-specifically, the hypoxanthine-to-creatinine ratio-only modestly improved predictive performance (AUC ROC = 0.853 [CI, 0.80-0.91]). Folds mean (SD) of the AUC ROC from 5-fold cross-validation models was 0.81 (0.12).</p><p><strong>Conclusions: </strong>We developed a parsimonious five-factor model combining clinical, anthropometric, and metabolic markers that accurately predicts T2D progression after GDM in South Asian women. This model can be potentially deployed at the time of GDM diagnosis to improve risk assessment and target intensive postpartum interventions.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid disorders in idiopathic inflammatory myopathies: prevalence and related clinical scenarios.","authors":"Linda Carli, Michele Diomedi, Chiara Cardelli, Simone Barsotti, Federico Fattorini, Elenia Laurino, Alessandra Tripoli, Marta Mosca","doi":"10.1186/s12902-026-02243-9","DOIUrl":"https://doi.org/10.1186/s12902-026-02243-9","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between sarcopenia and carotid artery plaque: a mediation analysis of inflammatory biomarkers.","authors":"Hongze Lin, Shuling Liu, Jushun Zhang, Wenying Zhong, Mei Tu, Wen Wei","doi":"10.1186/s12902-026-02299-7","DOIUrl":"https://doi.org/10.1186/s12902-026-02299-7","url":null,"abstract":"<p><strong>Background: </strong>Carotid artery plaque (CAP) and sarcopenia are notable complications in patients with type 2 diabetes mellitus (T2DM). This study aims to explore whether the inflammatory biomarkers neutrophil-to-lymphocyte ratio (NLR) and systemic inflammatory response index (SIRI) mediate the association between sarcopenia and CAP in such patients.</p><p><strong>Methods: </strong>Sarcopenia was diagnosed using the criteria of the Asian Working Group for Sarcopenia (AWGS 2019), and CAP was assessed by carotid ultrasonography. Inflammatory biomarkers including NLR and SIRI were calculated, with their natural logarithm-transformed values (Ln-NLR, Ln-SIRI) derived. Restricted cubic spline (RCS) analysis, univariate and multivariate logistic regression analyses were used to investigate the associations among these inflammatory biomarkers, sarcopenia and CAP. Additionally, mediation analysis was performed to explore the mediating role of these inflammatory biomarkers.</p><p><strong>Results: </strong>A total of 749 patients with T2DM were enrolled in this study. The prevalence of CAP and sarcopenia in the study was 58.9% (n=441) and 33.9% (n=254), respectively. Patients with CAP had significantly higher levels of NLR, SIRI, and a higher prevalence of sarcopenia than those without CAP (all p < 0.05). RCS analysis revealed linear correlations of NLR and SIRI with both sarcopenia and CAP (all p for nonlinear > 0.05). Multivariate logistic regression analysis showed that sarcopenia (adjusted odds ratio (aOR) = 1.67, 95% confidence interval (CI): 1.10-2.54, p = 0.016), NLR (aOR = 1.63, 95% CI: 1.01-2.66, p = 0.047), SIRI (aOR = 1.23, 95% CI: 1.01-1.59, p = 0.046), Ln-NLR (aOR = 1.77, 95% CI: 1.10-2.80, p = 0.037), and Ln-SIRI (aOR = 1.38, 95% CI: 1.02-1.74, p = 0.035) were independently and positively associated with CAP. Mediation analysis further indicated that NLR and SIRI partially mediated the association between sarcopenia and CAP, with mediated proportions of 10.39% and 11.40%, respectively. Similarly, Ln-NLR and Ln-SIRI also exerted partial mediating effects, with mediated proportions of 9.73% and 9.29%.</p><p><strong>Conclusions: </strong>Sarcopenia is an independently positively associated factor for CAP in patients with T2DM. NLR and SIRI may partially account for the association between sarcopenia and CAP.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between T4 and TSH with lipid profile is attenuated in patients with established dyslipidemia.","authors":"Mahdis Rahimi Naiini, Alireza Jafari, Beydolah Shahouzehi","doi":"10.1186/s12902-026-02235-9","DOIUrl":"https://doi.org/10.1186/s12902-026-02235-9","url":null,"abstract":"<p><strong>Background: </strong>Dyslipidemia is a major modifiable risk factor for cardiovascular disease (CVD). While thyroid dysfunction is a well-established secondary cause of dyslipidemia, the strength and nature of this association in individuals with pre-existing, significant dyslipidemia remain less clear. This study aimed to investigate the association between thyroid parameters Thyroid Stimulating Hormone and Thyroxine (TSH and T4) and the lipid profile in a dyslipidemia population.</p><p><strong>Methods: </strong>This cross-sectional analysis was conducted using baseline data from the Kerman Coronary Artery Disease Risk Factors Study (KERCADRS), an ongoing population-based prospective cohort study carried out in Kerman, southeastern Iran, from 2009, involving 303 dyslipidemia adults. In this study, we included adults with dyslipidemia, defined as meeting at least three of the four standard lipid criteria (TC ≥ 220 mg/dL, TG ≥ 200 mg/dL, HDL-C < 40 mg/dL in men or < 50 mg/dL in women, LDL-C ≥ 130 mg/dL). Serum T4 and TSH levels were measured by ELISA. Participants were stratified by thyroid status. Multivariable linear regression was used to assess the independent associations between thyroid hormones and a comprehensive panel of lipid parameters, adjusted for age, sex, Body Mass Index (BMI), and fasting blood sugar (FBS).</p><p><strong>Results: </strong>Most participants with dyslipidemia were euthyroid (77.9%). Subclinical hypothyroidism was the most common thyroid disorder (13.53%). A key finding was the lack of significant differences in conventional lipid parameters or advanced atherogenic indices across different thyroid status groups. In regression models, a higher serum T4 level was independently associated with lower levels of TC (βa: -2.44, p = 0.007), LDL-C (βa: -1.97, p = 0.012), and HDL-C (βa: -0.74, p = 0.020). TSH showed a significant inverse association only with TC (βa: -0.80, p = 0.027). No significant differences in conventional lipid parameters (TC, TG, HDL-C, LDL-C) or advanced atherogenic indices (AIP, AI, LCI, TG/HDL ratio, TyG and its variants) across thyroid status groups. In this dyslipidemia population, thyroid status categories did not differentiate lipid levels, and the independent effects of T4 and TSH were small relative to the dominant impact of established dyslipidemia.</p><p><strong>Conclusion: </strong>In the participants characterized by significant dyslipidemia, variations in thyroid status were not a primary determinant of the lipid profile. The findings suggest that the influence of thyroid dysfunction on lipids may be attenuated in patients with severe dyslipidemia, shifting the clinical focus towards managing the dyslipidemia itself as the dominant risk factor. The independent role of T4 warrants further investigation.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of resistance training in improving beta-cell function in type 2 diabetes: a systematic review and meta-analysis.","authors":"Haolan Li, Yu Fang, Weimin Zhang","doi":"10.1186/s12902-026-02286-y","DOIUrl":"10.1186/s12902-026-02286-y","url":null,"abstract":"<p><strong>Background: </strong>Beta-cell function is a critical parameter for diagnosing and managing Type 2 diabetes mellitus (T2DM). Progressive β-cell failure is a key driver of disease progression and long-term complications in T2DM. While aerobic exercise has been shown to improve glycemic control, the specific effect of resistance training (RT) on β-cell function remains less explored. The aim of this review is to investigate whether RT improves β-cell function in people living with prediabetes or T2DM compared to control conditions, and to estimate the magnitude of this effect.</p><p><strong>Methods: </strong>This systematic review and meta-analysis followed PRISMA 2020 guidelines. Six controlled trials involving a total of 581 participants were included. The sample consisted of adults with prediabetes or T2DM participating in structured RT programs. Measures of β-cell function, including HOMA-β, HOMA2-β, and the disposition index (DI), were assessed. Fasting-based indices were pooled using random-effects models where sufficient data were available, and remaining studies were synthesized narratively. The Cochrane RoB 2 tool and ROBINS-I were used to assess the risk of bias, and the GRADE framework was used to assess the certainty of evidence.</p><p><strong>Results: </strong>Meta-analysis of three RCTs showed that resistance training produced significant improvements in fasting β-cell function indices compared with non-exercise or control conditions (Standardized Mean Difference [SMD] = 0.56; 95% CI: 0.19-0.91, p = 0.002). Included interventions ranged from 8 to 52 weeks, with moderate-to-high intensity protocols (60-80% 1-RM). Narrative synthesis of all six trials indicated favorable changes in fasting glucose and HbA1c, though not all comparisons reached statistical significance. Overall heterogeneity was moderate (I² = 34.6%).</p><p><strong>Conclusions: </strong>The findings suggest that resistance training may enhance β-cell performance and cardiometabolic markers in adults with prediabetes or T2DM, with moderate-certainty evidence from RCTs. These results support the inclusion of RT in routine exercise prescriptions for diabetes management. However, the limited number of available trials and reliance on fasting-based indices highlight the need for larger, well-controlled studies using dynamic measures of β-cell function.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD420251137273 .</p><p><strong>Clinical trial registration number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference interval of parathyroid hormone based on the Korea National Health and Nutrition Examination Survey 2024.","authors":"Rihwa Choi, Sung-Eun Cho, Sang Gon Lee","doi":"10.1186/s12902-026-02292-0","DOIUrl":"https://doi.org/10.1186/s12902-026-02292-0","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a biochemical model for identifying prediabetes in Chinese adults: a case-control study.","authors":"Baohu Zhang, Peiyun Li, Caiyan Huang, Yu Qi, Li Chen, Lingling Zhang, Qingshan Lin, Ying Huang, Jie Zhou, Xueqing Zhou, Li Zhang, Yi Qian, Shucai Yang","doi":"10.1186/s12902-026-02288-w","DOIUrl":"https://doi.org/10.1186/s12902-026-02288-w","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of albumin-adjusted calcium and calcium‒phosphorus difference in screening for primary hyperparathyroidism.","authors":"Ataru Okumura, Tatsuya Bando, Ryosei Ashida, Mitsuhiro Kuno, Naoki Tamaki, Toshihiro Mizuguchi, Issei Uchida, Hiroshi Arima","doi":"10.1186/s12902-026-02223-z","DOIUrl":"https://doi.org/10.1186/s12902-026-02223-z","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A High-accuracy and compliance-driven paradigm for pediatric type 2 diabetes screening based on simplified OGTT --- a multicenter study.","authors":"Zhaoyuan Wu, Jianwei Zhang, Minghao Chen, Rahim Ullah, Ruimin Chen, Haiyan Wei, Jianfang Zhu, Dandan Peng, Ke Huang, Wei Wu, Guanping Dong, Jianbing Wang, Junfen Fu","doi":"10.1186/s12902-026-02260-8","DOIUrl":"https://doi.org/10.1186/s12902-026-02260-8","url":null,"abstract":"<p><strong>Background: </strong>The incidence of type 2 diabetes (T2D) in children is rising rapidly, yet many cases remain undetected. Conventional diagnostic tools, including fasting glucose, HbA1c, and the gold-standard oral glucose tolerance test (OGTT), have limitations and often show low compliance in pediatric populations. This study aimed to evaluate a simplified OGTT (s-OGTT) with adjusted capillary glucose cut-off values as a novel approach for screening and diagnosing T2D in children and adolescents.</p><p><strong>Methods: </strong>A total of 468 children from four clinical centers in China underwent s-OGTT with capillary glucose testing. Capillary glucose values were compared with venous glucose levels using Bland-Altman analysis. Sensitivity and specificity for diagnosing diabetes and prediabetes were assessed using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Capillary glucose levels showed a strong correlation with venous measurements. Based on gold-standard criteria, 37 children were diagnosed with diabetes, 41 with impaired fasting glucose (IFG), and 74 with impaired glucose tolerance (IGT). Using optimized capillary cut-offs tailored for point-of-care testing, the s-OGTT demonstrated excellent diagnostic performance and improved specificity compared with applying conventional venous-based thresholds directly: for diabetes based on fasting glucose (sensitivity 97.56%, specificity 98.40%), diabetes based on 2 h postload glucose (sensitivity 100.00%, specificity 99.67%), IFG (sensitivity 97.60%, specificity 98.30%), and IGT (sensitivity 88.89%, specificity 92.04%). Validation analyses confirmed high agreement between s-OGTT and venous results.</p><p><strong>Conclusion: </strong>The s-OGTT provides a reliable, accurate, and child-friendly approach for diagnosing diabetes and abnormal glucose tolerance. These optimized thresholds enhance diagnostic specificity and support its use for large-scale pediatric screening.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Nelson's syndrome with adrenal crisis occurring 21 years post-adrenalectomy for Cushing's disease.","authors":"Mengmeng Wang, Yan Xu, Ziyang Dong, Yanli Song","doi":"10.1186/s12902-026-02282-2","DOIUrl":"https://doi.org/10.1186/s12902-026-02282-2","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}