BMC Endocrine Disorders最新文献

{"title":"Effects of Genistein on polycystic ovary syndrome of rats: a systematic review and meta-analysis.","authors":"Pingping Su, Zhouhengte Xu, Liang Pang, Yirui Chen, Jiajia Dong, Yun Sun","doi":"10.1186/s12902-025-02035-7","DOIUrl":"10.1186/s12902-025-02035-7","url":null,"abstract":"<p><strong>Background: </strong>PCOS is a complex endocrine-metabolic disorder that is closely associated with oxidative stress. GEN, a naturally occurring isoflavone, has demonstrated beneficial effects in addressing hormonal imbalances and metabolic disturbances, primarily due to its potent antioxidant properties. While accumulating evidence supports its potential in managing PCOS, the full extent of GEN's therapeutic efficacy in alleviating PCOS-related symptoms remains inadequately defined, warranting further detailed investigation.</p><p><strong>Purpose: </strong>This study aims to systematically evaluate the pharmacological efficacy of GEN in the management of PCOS through a meta-analytic synthesis of preclinical data.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across six major databases-CNKI, Wanfang Data, VIP, PubMed, and Web of Science-covering publications from database inception until May 2025. The methodological quality of eligible studies was assessed using SYRCLE's risk of bias tool. Data synthesis and meta-analysis were performed using Rev Man 5.3 and Stata 17 software to ensure statistical analysis of the pooled outcomes.</p><p><strong>Results: </strong>A total of ten studies were included in the meta-analysis. Compared to the control group, GEN exhibited significant therapeutic effects in the treatment of PCOS, including a reduction in body weight (P < 0.00001) and ovarian weight (P < 0.00001) in PCOS rats, as well as a reversal of elevated serum levels of T (P = 0.003) and LH (P < 0.00001). GEN also significantly reduced FBG (P = 0.007), INS (P = 0.0006), and HOMA-IR indices (P = 0.01), decreased MDA content (P = 0.0002) in ovarian tissue, and enhanced antioxidant activity, as indicated by increases in TAC (P < 0.00001), SOD (P < 0.00001), and GPx (P = 0.02). Furthermore, GEN lowered serum levels of LDL-C (P < 0.00001).</p><p><strong>Conclusion: </strong>GEN demonstrates considerable therapeutic potential in managing PCOS through multiple mechanisms. These include modulation of body and ovarian weight, restoration of endocrine balance by reducing hyperandrogenism and normalizing reproductive hormone profiles, improvement of metabolic parameters through enhanced insulin sensitivity and glycemic control, and attenuation of oxidative stress via increased antioxidant enzyme activity and reduction of lipid peroxidation markers. These findings emphasize GEN's promise as a multifaceted intervention for PCOS, underscoring the need for further translational research to confirm its clinical efficacy.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"213"},"PeriodicalIF":3.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive effect of the triglyceride glucose index on abnormal blood glucose metabolism events in populations with sarcopenia: a cross-sectional study.","authors":"Yingying Zhu, Jiabei He, Xin Li, Yunping Xu, Jingshuang He, Liang Li","doi":"10.1186/s12902-025-02026-8","DOIUrl":"10.1186/s12902-025-02026-8","url":null,"abstract":"<p><strong>Background: </strong>Recent studies reveal that obesity and reduced muscle mass are key factors implicated in insulin resistance (IR) and abnormal glycemic metabolism. Nonetheless, it remains ambiguous which demographic, particularly those with obesity or diminished muscle mass, exhibits a greater vulnerability to insulin resistance.</p><p><strong>Objective: </strong>The aim of this study is to investigate the relationship between insulin resistance assessed by the triglyceride and glucose index (TyG index) and abnormal blood glucose metabolism in individuals with both reduced muscle mass and obesity. Furthermore, we assess the efficacy of the TyG index in forecasting occurrences of atypical blood glucose metabolism within this particular demographic.</p><p><strong>Methods: </strong>This cross-sectional study utilized data collected from adults who underwent a health assessment at our institution between December 2022 and September 2024. The evaluation of insulin sensitivity was conducted utilizing the TyG index, whereas muscle mass was quantified through bioelectrical impedance analysis (BIA). Logistic regression, Receiver Operating Characteristic (ROC) curve analysis, subgroup analysis, and interaction effect analysis were employed to evaluate the association between triglyceride-glucose index levels with subgroups based on different body masses.</p><p><strong>Results: </strong>This study comprised 1278 people with diminished muscle mass. We found a positive association between TyG index (OR = 7.73; 95% CI: 4.62-13.51; P < 0.001) and the risk of abnormal glucose metabolism among those who were overweight/obese. The analysis of the ROC curve revealed that the TyG index possesses a significant predictive capability for identifying abnormal glucose metabolism in individuals exhibiting diminished muscle mass (AUC = 0.906). This predictive value is particularly pronounced in those who do not present with overweight or obesity (AUC = 0.915), in contrast to its effectiveness in individuals who have both reduced muscle mass and overweight or obesity. Subgroup analyses confirmed the positive association of TyG index with abnormal blood glucose incidence.</p><p><strong>Conclusion: </strong>This study assessed the link between TyG and abnormal blood glucose metabolism events risk in people with sarcopenia and compared its predictive power for abnormal blood glucose metabolism events onset in those with low muscle mass but not overweight or obese. We recommend using the TyG index as the best predictive marker for assessing abnormal blood glucose metabolism events risk in individuals without concurrent overweight or obesity, regardless of their body mass index.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"212"},"PeriodicalIF":3.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative symptoms in patients with thyroid cancer: a cross-sectional and longitudinal network analysis.","authors":"Yuyan Yin, Zilin Fang, Xin Sheng, Jiaqi Li, Juan Xu, Ting Wang","doi":"10.1186/s12902-025-02032-w","DOIUrl":"10.1186/s12902-025-02032-w","url":null,"abstract":"<p><strong>Background: </strong>Patients with thyroid cancer experience a range of symptoms during surgical treatment. Identifying their core symptoms and understanding their dynamic changes can help improve the efficiency of clinical symptom management.</p><p><strong>Methods: </strong>A longitudinal observational study design was used, and convenience sampling method was applied to select thyroid cancer patients who attended the Department of Thyroid and Breast Surgery in a tertiary hospital in Suzhou City from October 2024 to April 2025. A general information questionnaire and the Chinese version of the Memory Symptom Assessment Scale were used to assess the patients 1 day before surgery (T1), 1-2 days after surgery (T2) and 2 weeks after surgery (T3). The symptom severity bias correlation network was constructed through R language, and the core symptoms of T1, T2 and T3 were identified.</p><p><strong>Results: </strong>This study finally included 248 patients with thyroid cancer. The results showed that the three symptoms with the highest strength centrality in the T1 network were lack of appetite (r_s=1.536), worrying (r_s=1.442), and feeling nervous (r_s=1.439). The three symptoms with the highest strength centrality in the T2 network were numbness/tingling in hands/feet (r_s=1.613), lack of appetite (r_s=1.433), and nausea (r_s=1.294). The three symptoms with the highest strength centrality in the T3 network were difficulty swallowing (r_s=1.778), feeling nervous (r_s=1.681), and neck discomfort (r_s=1.520). Neck discomfort (r_s2=1.281, r_s3=1.520) was the core symptom that was more stable postoperatively. In the test of network structural invariance, there were significant differences between T1 and T2 (M=0.78, P<0.001), T1 and T3 (M=0.45, P=0.009), and T2 and T3 (M=0.66, P<0.001). In terms of overall network connectivity strength, there were significant differences between T1 (GS=6.86) and T3 (GS=4.12), T2 (GS=7.66) and T3 (P<0.05), while there was no significant difference between T1 and T2 (P=0.65).</p><p><strong>Conclusion: </strong>The study identified the core symptoms present at each stage of the perioperative period in patients with thyroid cancer, suggesting that clinical practitioners can develop efficient, targeted and precise management strategies based on the core symptoms at different times, with a view to improving the perioperative symptom experience of patients and increasing the efficiency of symptom management.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"211"},"PeriodicalIF":3.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of carnosine or beta-alanine supplementation therapy for prediabetes or type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.","authors":"Na Li, Xueqin Yan, Jiayi Lin, Meng Wu, Xingyu He, Jingxian Yang, Hongling Li, Wenjun Wei, Yinlei Zhang, Yuting Zhong, Guangya Xu, Zhonglin Fan, Xingrong Hu, Yao Wang, Zheng Shi","doi":"10.1186/s12902-025-02016-w","DOIUrl":"10.1186/s12902-025-02016-w","url":null,"abstract":"<p><strong>Background: </strong>Carnosine and beta-alanine (β-alanine) have shown potential in the management of chronic conditions, including metabolic disorders. However, their therapeutic efficacy in individuals with type 2 diabetes mellitus (T2DM) and prediabetes remains inconclusive due to heterogeneity in clinical trial results and limited synthesis of human evidence.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aim to evaluate the effects of carnosine and β-alanine supplementation on patients with prediabetes and T2DM.</p><p><strong>Methods: </strong>We searched PubMed, Cochrane Library, Web of Science, and Embase from inception to 9 October 2024 for randomized controlled trials that compared carnosine or β-alanine supplementation to placebo in prediabetic and diabetic populations. The quality of evidence was appraised using the Jadad scale, and the risk of bias was assessed using the Cochrane Risk of Bias tool. Data were analyzed using RevMan and Stata, employing fixed-effects models and I-V methods.</p><p><strong>Results: </strong>Eight trials met the inclusion criteria, totaling 377 participants. Our analysis indicated that supplementation significantly reduced fasting blood glucose (FBG) (SMD: -0.53; 95% CI: -0.75 to -0.31; p < 0.00001) and hemoglobin A1c (HbA1c) levels (SMD:-0.36; 95% CI:-0.59 to -0.12; p = 0.003) compared to placebo. No significant effects were observed on body mass index (BMI), fasting insulin. low-density lipoprotein cholesterol (LDL-c) or high-density lipoprotein cholesterol (HDL-c), but a lowering effect was observed in total cholesterol (TC). Notably, Homeostasis Model Assessment of Beta-cell Function (HOMA-β) values were improved, suggesting enhanced β-cell function, while changes in homeostasis model assessment of insulin resistance (HOMA-IR) did not reach statistical significance.</p><p><strong>Conclusions: </strong>Carnosine and β-alanine supplementation show potential as adjunct therapies for improving FBG, HbA1c and HOMA-β in prediabetes and T2DM. Further rigorous studies are warranted to establish optimal dosage, treatment duration, and long-term efficacy in clinical practice.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"210"},"PeriodicalIF":3.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble receptor for advanced glycation end product (sRAGE) levels in adolescents with obesity, insulin resistance and metabolic syndrome: A case-control study and the review of the literature.","authors":"Pembe Soylu Ustkoyuncu, Derya Kocer","doi":"10.1186/s12902-025-02025-9","DOIUrl":"10.1186/s12902-025-02025-9","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to evaluate sRAGE levels in adolescents with obesity, and to determine the relationship between sRAGE, insulin resistance, and metabolic syndrome in a case-control study.</p><p><strong>Methods: </strong>Thirty adolescents with insulin resistance, 28 adolescents without insulin resistance between 10 and 18 years old and 30 Healthy gender and age matched control group were included in the study. Patients with a body mass index z-score above 2, comprised the obesity group. HOMA-IR value above 3.16 was accepted as insulin resistance. Metabolic syndrome was defined based on the International Diabetes Federation definition.</p><p><strong>Results: </strong>sRAGE levels of the both groups with obesity were lower than control and they were negative correlated with weight, body mass index, C-reactive protein, uric acid, diastolic blood pressure, waist circumference, waist circumference/height ratio and white blood cell count. There were no significant differences in sRAGE levels between adolescents with or without metabolic syndrome, nor between boys and girls. Also, there were no significant differences in sRAGE levels between with or without insulin resistance.</p><p><strong>Conclusions: </strong>sRAGE levels of the adolescents with obesity decreased. There was no difference in sRAGE levels between those with insulin resistance and metabolic syndrome compared to those without. Metabolic complications associated with obesity are important in terms of causing mortality and morbidity. Understanding the mechanisms could help to identify therapeutic strategies.</p><p><strong>Trial registration: </strong>NCT06771986| | https://www.</p><p><strong>Clinicaltrials: </strong>gov/ . Clinical Trial Registration Date: 2025/01/13.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"209"},"PeriodicalIF":3.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between TYG mediated pregnancy diabetes history and SII in American women: a retrospective cohort study of NHANES 2011-2018.","authors":"Yanan Duan, Ru Zhang, Yan Zhang, Yuanxuan Ma, Miaomiao Li, Wenke Zhang, Shiguo Liu","doi":"10.1186/s12902-025-02042-8","DOIUrl":"10.1186/s12902-025-02042-8","url":null,"abstract":"<p><strong>Background: </strong>Gestational Diabetes Mellitus (GDM) is known to pose long-term health risks, but the biological mechanisms are not fully understood. The role of the Triglyceride-Glucose Index (TyG) in mediating these effects requires further exploration.</p><p><strong>Method: </strong>This study investigated the mediation effect of the TyG index on the relationship between GDM history and the Systemic Inflammatory Index (SII) using retrospective data analysis. Mediation analysis quantified the contribution of the TyG index.</p><p><strong>Result: </strong>Multivariate regression analysis confirmed that the TyG index mediated approximately 40% of the relationship between a history of GDM and elevated SII, highlighting a significant linkage (β = 0.23, 95% CI: 0.18 to 0.28, P < 0.0001 for TyG; β = 28.95, 95% CI: 22.88 to 35.02, P < 0.0001 for SII). The TyG index was found to mediate approximately 40% of the effect of GDM history on SII, illustrating a significant biological link. These findings highlight the role of metabolic health in influencing systemic inflammation levels associated with GDM.</p><p><strong>Conclusion: </strong>The study emphasizes the importance of monitoring and managing metabolic and cardiovascular health in women with a history of GDM to mitigate long-term health risks. Future research should focus on prospective studies and the utilization of biomarkers to fully understand the impact of GDM and optimize intervention strategies.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"208"},"PeriodicalIF":3.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of risk factors and ultrasonographic characteristics for the differentiation between malignant and benign thyroid nodules in Beni-Suef governorate, Egypt.","authors":"Ahmed Moheyeldien Hamed, Khaled Elsayed Elhadidy, Mahmoud Farid Kamel, Ahmed Sayed Abd El Basset, Ahmed Saad Ahmed, Saeed M Shaaban, Nadia Ahmed Abd El-Moeze, Hazem Samy Matar","doi":"10.1186/s12902-025-02038-4","DOIUrl":"10.1186/s12902-025-02038-4","url":null,"abstract":"<p><strong>Background: </strong>Thyroid nodules (TNs) are frequent and often benign. Accurately differentiating between benign and malignant nodules is crucial for proper management. This research aims to use ultrasonography to examine TNs and identify possible risk factors in order to improve patient outcomes and diagnostic accuracy.</p><p><strong>Methods: </strong>The study included 128 euthyroid participants who underwent thyroidectomy, splitted into two groups (benign and malignant) regarding the histopathological outcomes. Data on age, sex, family history of thyroid cancer and radiation exposure were collected. Ultrasound (US) was used to assess nodule number, size, vascularity and TIRAD scores. US Lymph node status was also evaluated. Statistical analysis compared benign and malignant nodules.</p><p><strong>Results: </strong>No significant differences were found between benign and malignant groups regarding age, sex, family history, and radiation exposure. Significant differences were observed in nodule size (p < 0.05), echogenicity (p < 0.001), and margins (p < 0.05), with larger, hyper/isoechoic, and smooth-margined nodules more common in the benign group. TIRAD scores (p < 0.001) and lymph node status (p < 0.001) also differed significantly, with benign cases showing TR3 scores and non-suspicious lymph nodes, while malignant cases had more TR4 scores and suspicious lymph nodes. Additionally, malignant nodules were significantly more hypoechoic (p < 0.001). Most benign cases were nodular colloid hyperplasia, followed by follicular adenoma and thyroiditis. Most malignant cases were Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC). PTC was associated with younger age (p = 0.006), smaller nodule size (p = 0.04), and hypoechoic nodules (p = 0.04).</p><p><strong>Conclusion: </strong>Sex, age, family history of thyroid cancer, and radiation exposure history did not significantly vary between groups with benign and malignant thyroid tumors, according to the research. Higher TIRAD scores and hypoechoic nodules were more common in malignant nodules. Benign nodules had smoother margins, were bigger, and were more likely to be hyper/isoechoic.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"207"},"PeriodicalIF":3.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between thyroid sensitivity indices and bone metabolism in newly diagnosed middle aged and elderly patients with type 2 diabetes mellitus with normal thyroid function.","authors":"Lixuan Fang, Cuiping Lin, Lijuan Gu, Haixia Zeng, Yuying Zhang, Jianping Liu","doi":"10.1186/s12902-025-02030-y","DOIUrl":"10.1186/s12902-025-02030-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the association between thyroid hormone sensitivity indices and bone metabolism markers in newly diagnosed middle-aged and elderly type 2 diabetes mellitus (T2DM) patients with normal thyroid function.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;We retrospectively analyzed 350 newly diagnosed T2DM patients (≥ 45 years), stratified by bone mineral density into Group A (normal bone density group) and Group B (low bone mass and osteoporosis group). General data and clinical biochemical parameters were collected: free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), osteocalcin (OC), bone-specific alkaline phosphatase (BALP), serum calcium (Ca), serum phosphorus (P), fasting plasma glucose (FPG), glycosylated hemoglobinA1c (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), serum creatinine (SCr), serum uric acid (SUA), and estimated Glomerular Filtration Rate (eGFR). Thyroid sensitivity indices calculated were: thyrotropin resistance index (TT4RI), TSH index (TSHI), the ratio of FT3/FT4, and the secretory capacity of the thyroid (SPINA-GT). Associations were assessed using multiple linear regression, binary logistic regression, and stratified analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Group B patients had lower BMI, DBP, FT3, FT3/FT4 ratio, FPG, HbA1c, TG, SCr and SUA and higher age, female proportion, OC and HDL-C (P &lt; 0.05). Spearman Correlation analysis showed that 25(OH)D was positively associated with FT3/FT4 ratio; Ca was positively associated with FT3; and P was associated with TSH, TT4RI and TSHI and negatively associated with SPINA-GT (P &lt; 0.05). Multiple linear regression analysis showed that FT3, FT3/FT4 ratios were positive factors for serum OC, BALP and Ca, and FT4 was an inverse correlation with serum BALP (P &lt; 0.05). Binary Logistic regression analysis showed that the elevated FT3/FT4 ratio was a protective factor for the occurrence of low bone mass and osteoporosis (P &lt; 0.05). Stratified by HbA1c, the effect of FT3/FT4 ratio on low bone mass and osteoporosis showed that the FT3/FT4 ratio was inversely associated with the occurrence of low bone mass and osteoporosis in the HbA1c &lt; 7% group (P &lt; 0.05). Simple effect analysis of the interaction between FT3/FT4 ratio, HbA1c and bone density showed that T2DM patients with HbA1c ≥ 7% had a lower FT3/FT4 ratio and a higher risk of developing low bone mass and osteoporosis compared to those with HbA1c &lt; 7%.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In newly diagnosed middle-aged and elderly T2DM patients with normal thyroid function, the peripheral sensitivity to thyroid hormone indix FT3/FT4 ratio was significantly associated with serum OC, BALP, and Ca levels. The lower FT3/FT4 ratio may increase the risk of low bone mass and osteoporosis in newly diagnosed T2DM patients with normal thyr","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"206"},"PeriodicalIF":3.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of triglyceride-glucose index and atherogenic index of plasma in euthyroid Hashimoto's thyroiditis patients and healthy controls.","authors":"Semra Özkan, Mustafa Harı","doi":"10.1186/s12902-025-02019-7","DOIUrl":"10.1186/s12902-025-02019-7","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"201"},"PeriodicalIF":3.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oxidative balance score and gestational diabetes mellitus risk: a case-control study.","authors":"Fatemeh Maleki Sedgi, Amir Hossein Hassani, Amir Hossein Faghfouri, Shahsanam Gheibi, Yousef Mohammadpour, Amin Mokari-Yamchi","doi":"10.1186/s12902-025-02028-6","DOIUrl":"10.1186/s12902-025-02028-6","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) is a common pregnancy complication closely associated with increased oxidative stress. The Oxidative Balance Score (OBS) integrates dietary and lifestyle factors influencing oxidative stress, yet its relationship with GDM remains unclear.</p><p><strong>Methods: </strong>In this case-control study, 150 pregnant women with GDM and 170 healthy controls were recruited from primary healthcare centers in Urmia, Iran. Dietary intake was assessed using a validated 168-item Food Frequency Questionnaire (FFQ), and OBS was calculated based on dietary and lifestyle pro-oxidant and antioxidant components. Logistic regression models were used to examine the association between OBS tertiles and GDM risk, adjusting for potential confounders.</p><p><strong>Results: </strong>Women with GDM had significantly lower total OBS (18.37 ± 8.77 vs. 20.64 ± 10.98, p = 0.041) and dietary OBS (16.1 ± 6.46 vs. 17.89 ± 8.66, p = 0.036) compared to controls. key antioxidant nutrient intake, including riboflavin, folate, magnesium, and zinc, were significantly lower in the GDM group (p < 0.05). In contrast, lifestyle OBS was significantly higher in the GDM group (4.05 ± 1.4 vs. 3.65 ± 1.62, p = 0.018). Women in the highest OBS tertile had a 23% lower risk of GDM (aOR = 0.77; 95% CI: 0.48-0.92). Higher dietary and lifestyle OBS were also inversely associated with GDM risk.</p><p><strong>Conclusion: </strong>A higher OBS, particularly in its dietary and lifestyle components, is associated with a reduced risk of GDM. These findings highlight the importance of antioxidant-rich diets and lifestyle modifications in GDM prevention.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"205"},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}