埃塞俄比亚西北部东Gojjam区公立医院糖尿病患者糖尿病酮症酸中毒的危险因素:一项无与伦比的病例对照研究。

IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Yonas Wondie, Awoke Minwuyelet, Alemwork Dessalegn Bogale, Getachew Hailu, Emiru Ayalew Mengstie
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引用次数: 0

摘要

背景:糖尿病酮症酸中毒(DKA)是一种严重且可能致命的并发症,主要见于诊断为1型糖尿病(T1DM)的个体,尽管在特定情况下也可能发生在2型糖尿病(T2DM)患者中。虽然DKA可以通过有效的糖尿病管理策略来预防,但如果不及时处理,后果可能会很严重。及时认识到DKA,再加上适当的药物治疗,对于提高患者的预后和减轻与该病症相关的持久并发症的风险至关重要。本研究的目的是确定在埃塞俄比亚西北部东Gojjam区公立医院接受治疗的糖尿病患者发生DKA的危险因素。方法:于2023年4月10日至7月30日在东高jam区选定公立医院进行病例对照研究。随机选择5家公立医院,采用系统随机抽样方法,共招募408名研究对象。采用Logistic回归分析确定与结果显著相关的变量,显著性水平为P。结果:研究纳入102例病例和306例对照。确定了DKA的几个关键危险因素,包括缺乏定期随访[AOR = 2.21, 95% CI(1.31-3.71)]、未参加医疗保险[AOR = 3.30, 95% CI(1.75-6.24)]、距离医疗机构大于5公里[AOR = 1.85, 95% CI(1.09-3.14)]、感染[AOR = 2.15, 95% CI(1.12-3.89)]和胰岛素剂量减少[AOR = 2.13, 95% CI(1.19-3.83)]。结论:研究结果表明,缺乏定期随访,居住距离医疗机构超过5公里,在没有充分医疗指导的情况下减少胰岛素剂量,缺乏社区健康保险,以及存在感染显著增加了DKA的可能性。因此,医疗保健提供者应该对确定的DKA危险因素进行干预,以防止DKA的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk factors of diabetic ketoacidosis among patients with diabetes attending at public hospitals of East Gojjam Zone, Northwest Ethiopia: an unmatched case - control study.

Background: Diabetic Ketoacidosis (DKA) is a critical and potentially fatal complication predominantly seen in individuals diagnosed with Type 1 Diabetes Mellitus (T1DM), though it may also arise in those with Type 2 Diabetes Mellitus (T2DM) under specific circumstances. Although DKA is preventable through effective diabetes management strategies, the consequences can be severe if the condition is not addressed promptly. The timely recognition of DKA, coupled with suitable medical treatment, is essential to enhance patient outcomes and mitigate the risk of enduring complications related to this condition. The objective of this research was to identify the risk factors of DKA in diabetic patients receiving care at public hospitals in the East Gojjam Zone of Northwestern Ethiopia.

Methods: An unmatched case-control study was carried out in selected public hospitals located in the East Gojjam Zone between April 10 and July 30, 2023. Five public hospitals were randomly selected, and a systematic random sampling technique was employed to recruit 408 study participants. Logistic regression analysis was performed to identify variables significantly associated with the outcomes, using a significance level of P < 0.05 and a 95% confidence interval.

Results: The study included 102 cases and 306 controls. Several key risk factors for DKA were identified, including the absence of regular follow-up [AOR = 2.21, 95% CI (1.31-3.71)], not being a member of health insurance [AOR = 3.30, 95% CI (1.75-6.24)], distance from a health facility greater than 5 km [AOR = 1.85, 95% CI (1.09-3.14)], infection [AOR = 2.15, 95% CI (1.12-3.89)], and reduction in insulin dosage [AOR = 2.13, 95% CI (1.19-3.83)].

Conclusions: The findings declared that lack of regular follow-up, living more than five kilometers from a healthcare facility, reducing insulin doses without adequate medical guidance, lack of community-based health insurance, and the presence of infections significantly increase the likelihood of DKA. Therefore, healthcare providers should intervene on the identified risk factors for DKA to prevent the occurrence of DKA.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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