BMC Endocrine Disorders最新文献

{"title":"Systemic immune-inflammation index to albumin (SII/ALB) ratio as a novel dual-dimensional powerful predictor for hip fractures in elderly females with diabetes: a postmenopausal longitudinal cohort study.","authors":"Jie Lu, Fenglian Wei, Jingxia Sun, Zhenwei Zhai, Jiangmei Pan, Shishan Huang, Haolun Wang, Qiu Wang, Wenxin Chu, Jinming Yu, Jianhao Huang, Xubin Wu, Wensheng Lu","doi":"10.1186/s12902-025-01889-1","DOIUrl":"10.1186/s12902-025-01889-1","url":null,"abstract":"<p><strong>Purpose: </strong>Hip fracture is the most dangerous and potentially lethal fracture, described as \"the last fracture of life\" in older adults. Previous studies have shown that excessive immunoinflammatory response and nutrient deficiency may be involved. Nevertheless, a predictor for hip fracture risk that combines a thorough evaluation of immunoinflammatory with malnutritional conditions in postmenopausal women with type 2 diabetes mellitus (T2DM) remains scarce. This study explored the relationship between the SII/ALB ratio (SAR) and fragility fracture risk in postmenopausal older adults with T2DM.</p><p><strong>Methods: </strong>Between January 2014 and January 2021, a total of 509 postmenopausal female participants with T2DM were recruited from the Medical Record Database of the People's Hospital of Guangxi Zhuang Autonomous Region. Finally, 363 participants with an age median of 69.00 (64.00-75.00), were eligible for inclusion in this analysis. According to the statistical tertiles of the SAR, all participants were split into three groups: low-level (≤ 98.24, n = 121), moderate-level (98.24-157.25, n = 121), and high-level (≥ 157.25, n = 121). The participants were followed up for seven years, with a median follow-up time of 45.9 months (1389 person-years). The relationships between the SAR and a real-world fragility fracture event and an individualized future 10-year probability of major osteoporotic fracture (MOF) and hip fracture (HF) calculated by the fracture risk assessment tool (FRAX) were evaluated through Spearman's partial correlation analysis, restricted cubic spline (RCS) model, Cox proportional hazards regression model, and Kaplan-Meier survival analysis. Furthermore, some indicators such as geriatric nutritional risk index (GNRI), prognostic nutritional index (PNI), and SII were also calculated and compared to their diagnostic efficacy and the clinical application value through the receiver operating characteristic (ROC) curve analysis and the decision curve analysis (DCA), respectively.</p><p><strong>Results: </strong>Of the 363 participants, 69 suffered a real-world fragility fracture event (19%). Spearman's partial correlation analysis indicated that SAR was negatively related to femoral neck (FN) bone mineral density (BMD) (r = -0.108, P = 0.041) and total hip (TH) BMD (r = -0.118, P = 0.025), but not lumbar spine (LS) BMD (all Models P > 0.05); positively correlated with an individualized future 10-year probability of MOF (r = 0.136, P = 0.010) and HF (r = 0.139, P = 0.008) calculated by FRAX, especially in hip fracture risk. The RCS model demonstrated the relationship between the SAR and a fragility fracture endpoint event in a J-shaped dose-dependent manner (P for overall < 0.001, P for nonlinear = 0.866). Multivariate Cox regression analysis indicated that the SAR was positively associated with fragility fracture risk (P < 0.001). Kaplan-Meier survival analysis showed that patients with higher levels of SAR ","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"57"},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal volume index is associated with higher oxidized LDL, high blood pressure and lower HDL among obese adults.","authors":"Mansuor Ahmed Alanazi, Khaled Alshehri, Faisal H Alerwy, Tariq Alrasheed, Hassan Fareed M Lahza, Nisreen Khalid Aref Albezrah, Yazeed Ibrahim Alghabban, Mahfoudh Almusali Mohammed Abdulghani","doi":"10.1186/s12902-025-01884-6","DOIUrl":"10.1186/s12902-025-01884-6","url":null,"abstract":"<p><strong>Objectives: </strong>Central obesity is a well-known risk factor of numerous disease. Numerous indicators are developed for central obesity measurement, among them, abdominal volume index (AVI), reflecting total volume of the abdomen, precisely estimates the visceral fat volume. As a relatively new health measure and potent prognostic marker of metabolic disturbances, no study is available to investigate its role in cardio-metabolic health and oxidized LDL among obese young adults. In the current study we aimed to evaluate the association between abdominal volume index (AVI) with cardio-metabolic profile including serum lipids, glycemic markers of serum glucose, hemoglobin (Hb) A₁C, insulin, oxidized LDL and blood pressure among young obese adults.</p><p><strong>Methods: </strong>Two hundred twenty young adults aged 18 to 25 years old with overweight or obesity were enrolled in the current study. Anthropometric measurements were done and AVI were calculated. Biochemical variables including serum total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), triglyceride (TG), glycemic markers, including fasting serum glucose (FBS), insulin, hemoglobin (Hb) A₁C and blood pressure were also measured with an automatic analyzer.</p><p><strong>Results: </strong>Participants in the third tertiles of AVI had higher body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) (p < 0.001 for all). Among biochemical variables, oxidized LDL, TG and HDL demonstrated significant associations across AVI tertiles in the first and second models, with higher oxidized LDL and TG and lower HDL levels observed in higher AVI tertiles (p < 0.05). Moreover, those at the highest AVI tertiles showed significantly higher odds ratios for elevated cardio-metabolic index and systolic and diastolic blood pressures compared to the first tertiles (p < 0.05).</p><p><strong>Conclusions: </strong>In the current study, we comprehensively investigated the association between AVI with cardio-metabolic health in young obese adults and accordingly, AVI was unfavorably associated with metabolic health among obese adults. Further studies are needed to elaborate the underlying mechanisms.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"56"},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive function of miR-122-5p and its action mechanism by regulating PKM2 in metabolic syndrome.","authors":"Xinglu Zhou, Rui Wu, Guangfeng Tang, Tongtong Shen, Wei Li","doi":"10.1186/s12902-025-01888-2","DOIUrl":"10.1186/s12902-025-01888-2","url":null,"abstract":"<p><strong>Background: </strong>Obesity will cause metabolic syndrome (Mets) easily, and its pathogenesis is not completely clear.</p><p><strong>Aim: </strong>To probe into the predictive value of miR-122-5p and its regulatory mechanism in Mets.</p><p><strong>Method: </strong>The predictive effect of miR-122-5p on Mets was evaluated by constructing a Receiver Operating Characteristic (ROC) curve. The target genes of miR-122-5p were predicted using the ENCORI/starBase and TargetScanHuman databases, and pyruvate kinase M2 (PKM2), closely related to Mets, was screened by GO and KEGG analysis. The roles of miR-122-5p/PKM2 in insulin resistance (IR) were explored by treating the human normal liver cells (HLCs) with palmitic acid (PA) to induce the IR model. The effects of miR-122-5p/PKM2 on glucose metabolism (GM) of HLCs were evaluated by detecting the production of pyruvic acid, lactic acid, and ATP.</p><p><strong>Results: </strong>MiR-122-5p was highly expressed in obese people and Mets patients, and its predicted AUC for Mets was 0.876. In HLCs transfected with wild-type PKM2 luciferase vector (PKM2-wt), luciferase activity was attenuated by the miR-122-5p mimic and enhanced by its inhibitor. The expression of PKM2 was inhibited by the miR-122-5p mimic and up-regulated by its inhibitor. The miR-122-5p mimic enhanced PA-induced IR and inhibited the GM of HLCs, which were reversed by overexpression of PKM2. The miR-122-5p inhibitor exerted the opposite effects of its mimic, which were also reversed by silencing of PKM2.</p><p><strong>Conclusion: </strong>MiR-122-5p, a risk factor for Mets, mediated the IR and abnormal glucose metabolism of HLCs by negatively regulating PKM2.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"54"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between circulating microRNAs and vascular biomarkers in type 2 diabetes based upon physical activity: a biochemical analytic study.","authors":"Hadeel A Al-Rawaf, Sami A Gabr, Talal Alghadir, Faisal Alghadir, Amir Iqbal, Ahmad H Alghadir","doi":"10.1186/s12902-025-01855-x","DOIUrl":"10.1186/s12902-025-01855-x","url":null,"abstract":"<p><strong>Background: </strong>This research investigated how physical activity (PA) might impact the expression of several microRNAs, specifically miR-126, miR-146a, miR-34a, miR-124a, miR-155, and miR-221, in the blood of elderly individuals with type 2 diabetes (T2D). Additionally, the study examined the relationship between these microRNAs and markers of vascular endothelial dysfunction, including vascular endothelial growth factor (VEGF), apolipoprotein A-I (apoA-I), and apolipoprotein B (apoB), to assess their potential in the prevention, early detection, and treatment of diabetes.</p><p><strong>Methods: </strong>This correlational observational study involved 100 male participants, aged between 18 and 65 years, all of whom had been living with type 2 diabetes (T2D) for over six years. The participants were divided into three groups: inactive, moderate, and active, depending on their level of physical activity (PA). Real-time PCR and immunoassays were employed to measure the expression of selected miRNAs, as well as VEGF, apoA-I, apoB, and diabetic management indicators. PA levels were determined using ACTi graph GT1M accelerometer (model WAM 7164; Fort Walton Beach, FL) and energy expenditure was measured in the form of metabolic equivalent (MET) by indirect calorimetry method.</p><p><strong>Results: </strong>The expression levels of miR-146a, miR-34a, and miR-124a were significantly higher in patients with higher physical activity, while no such increase was observed for the other miRNAs in less active participants. Additionally, PA-active individuals showed a more pronounced decrease in fasting blood sugar (FBS), insulin resistance (IR), fasting insulin (FINS), HOMA-IR, HbA1c (%), and levels of VEGF, apoAI, apoB, and the apoB/apoA-I ratio. The alteration in miRNA expression was positively associated with physical activity, VEGF, apoAI, apoB, the apoB/apoA-I ratio, and diabetes-related metrics, while being inversely related to BMI.</p><p><strong>Conclusions: </strong>In diabetic patients with higher physical activity levels, circulating miR-146a, miR-34a, and miR-124a showed elevated expression, accompanied by a notable decrease in vascular biomarkers, including apoAI, apoB, and the apoB/apoA-I ratio. The findings revealed a strong correlation between these vascular biomarkers and the physiological responses of miR-146a, miR-34a, and miR-124a, though larger studies are required to validate these results further.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"55"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of noninvasive fibrosis calculators in an urban diabetes center suggests a large burden of undetected advanced liver disease.","authors":"Ahmed Ebeid, Fatma Mokhtar, Valeria Martinez-Lebron, Susie Park, Seta Degann, Jeremy Payano, Zahid Vahora, Stephen Gray, Lynt Johnson, Diala El-Maouche, Ameer Abutaleb","doi":"10.1186/s12902-025-01881-9","DOIUrl":"10.1186/s12902-025-01881-9","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction associated steatotic liver disease (MASLD) is prevalent in up to 60% of patients with type 2 diabetes mellitus (T2DM). T2DM accelerates the risk of hepatic fibrosis and hepatocellular carcinoma in patients with MASLD. Our goal in this study was to identify patients with suspected MASLD and hepatic fibrosis in a large T2DM clinic by using noninvasive fibrosis scoring systems.</p><p><strong>Methods: </strong>We conducted a retrospective study of patients with T2DM seen by our endocrinologists at the Medical Faculty Associates (MFA) Diabetes Center in Washington, DC, from November 1, 2021, until November 1, 2022. We included all subjects who were over 18 years old with a hemoglobin A1c (HbA1c) of 6.5 or higher. Patients with a history of significant alcohol consumption, decompensated cirrhosis, previous bariatric surgery, or prior chronic liver disease were excluded from the study. We identified patients at risk for hepatic fibrosis by using the Fibrosis-4 (FIB-4) Index, NAFLD Fibrosis Score (NFS) and AST to Platelet Ratio Index (APRI) when lab values were available.</p><p><strong>Results: </strong>A total of 1,411 patients were evaluated for T2DM by an endocrinology provider during the one-year period. Out of these, 336 patients met one or more of the exclusion criteria, leaving a total of 1075 patients included in the analysis. The majority were African American (n = 582, 54%), 261 were Caucasian (24.3%), and 85 were Hispanic (7.9%). Most patients were females (n = 675, 62.7%). The mean HbA1c was 8.1 ± 2.3. 643 patients (59.8%) were insulin dependent. Based on FIB-4 scores, we found that 35 (3.9%) patients had a score of > 2.67 associated with advanced fibrosis and 257 (29%) patients with scores of 1.3-2.67 had moderate fibrosis. Using the NFS calculator, there were 281 (28%) patients with values of > 0.675 consistent with F3-F4 disease. 715 (71.8%) patients with values of < 0.675 consistent with F0-F2 fibrosis. A total of 6(< 1%) patients met criteria for advanced fibrosis by APRI scoring.</p><p><strong>Conclusion: </strong>In our urban Diabetes Center, utilizing the NFS calculator may detect many patients with advanced liver disease. Further research is needed to ensure the internal validity of the non-invasive tests in predicting liver fibrosis and to correlate these findings with transient elastography and other imaging evidence of fatty liver disease.</p><p><strong>Clinical trial number: </strong>Non-applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"53"},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of empagliflozin on non-alcoholic fatty liver disease-related parameters in patients with type 2 diabetes mellitus: a randomized controlled trial.","authors":"Fatemeh Shojaei, Azam Erfanifar, Saeid Kalbasi, Shahriar Nikpour, Latif Gachkar","doi":"10.1186/s12902-025-01882-8","DOIUrl":"10.1186/s12902-025-01882-8","url":null,"abstract":"<p><strong>Background and objective: </strong>The effects of Empagliflozin on liver health in patients with Type 2 Diabetes Mellitus (T2DM) have not been fully elucidated. This study aimed to assess the impact of Empagliflozin on liver steatosis and related biomarkers in T2DM patients.</p><p><strong>Methods: </strong>A before-after clinical trial was conducted with 119 T2DM patients aged 20 to 70 with fatty liver, recruited from Laghman Hakim Hospital, Tehran, Iran. Participants were administered Empagliflozin for 6 months, with clinical and laboratory assessments conducted at baseline, 3 months, and 6 months. Liver function was evaluated through blood tests and imaging, including ultrasound and Magnetic resonance imaging (MRI), to assess hepatic steatosis. Biomarkers such as HbA1c, fasting blood glucose, insulin, lipid profile, and liver enzymes were measured. Insulin resistance was estimated using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) formula. Data were analyzed using SPSS 26 and STATA 14.</p><p><strong>Results: </strong>A total of 119 patients (Intervention (N = 69), Control (N = 50)) were participated. The intervention group demonstrated a significant reduction in liver fat grade compared to the control group, with 17.5% of patients showing a reduction from grade 3 to grade 1 on MRI and 6% in the control group. The odds of worsening fatty liver in the control group were 48 times higher (95% CI: 15.5, 148.5) on MRI and 52 times higher (95% CI: 15.2, 178.1) on ultrasound, compared to the intervention group (NNT = 2). After 6 months, the intervention group showed significantly lower risks for ALT (RR: 0.72, 95% CI: 0.62-0.84), AST, and alkaline phosphatase (Alkp) abnormalities. Liver enzyme levels (ALT, AST, GGT) and systolic blood pressure (SBP) decreased significantly in the Empagliflozin group, with mean differences of -15.33 (95% CI: -18.8, -11.88) for ALT, -12.82 (95% CI: -15.5, -10.13) for AST, and - 6.31 (95% CI: -8.65, -3.97) for systolic blood pressure (SBP).</p><p><strong>Conclusion: </strong>These findings suggest that Empagliflozin could be an effective adjunctive therapy for managing liver dysfunction in T2DM patients with NAFLD.</p><p><strong>Trial registration: </strong>Registered retrospectively in the Iranian Registry of Clinical Trials (IRCT20210811052150N1) on April 16,2023 Access at https://irct.behdasht.gov.ir/search/result?query=IRCT20210811052150N1 .</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"52"},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of comprehensive dietary antioxidant index and hypothyroidism risk: evidence from the National Health and Nutrition Examination Surveys 2007-2012.","authors":"Jie Chang, Ningning Wang, Yanxia Cheng, Xiaoyan Chen","doi":"10.1186/s12902-024-01806-y","DOIUrl":"10.1186/s12902-024-01806-y","url":null,"abstract":"<p><strong>Background: </strong>Hypothyroidism is a common thyroid disease affecting the health of the global population and oxidative stress and inflammation are involved in the pathophysiological process of hypothyroidism. Comprehensive dietary antioxidant index (CDAI), representing the overall dietary antioxidant capacity, has been proved to be associated with a variety of diseases. However, association between CDAI and hypothyroidism risk remains unclear. This study aims to evaluate the association of CDAI and hypothyroidism risk.</p><p><strong>Methods: </strong>Data of this study were extracted from the National Health and Nutrition Examination Surveys (NHANES) database 2007-2012. CDAI, represents the overall dietary nutrients capacity, was calculated by selenium, zinc, magnesium, vitamin A, C and E. Thyroid stimulating hormone (TSH) > 5.6 mIU/L was defined as hypothyroidism. The weighted multivariate logistic regression models and propensity score matching (PSM) analysis were utilized to evaluate the relationship between CDAI and hypothyroidism, with odds ratio (ORs) and 95% confidence intervals (CIs). Subgroup and sensitivity analysis were further evaluated the relationship between CDAI and hypothyroidism. Moreover, the association between the components of CDAI and hypothyroidism was also explored.</p><p><strong>Results: </strong>Totally, 7,959 subjects with information of complete dietary intake and thyroid function measurement were included. Of whom, 213 (2.68%) subjects had hypothyroidism. After adjusted all covariates, we observed high CDAI was related to low hypothyroidism risk (OR = 0.44, 95%CI: 0.27-0.71). This relationship was prominent in subjects with aged < 65 years old (OR = 0.32, 95%CI: 0.16-0.62), male (OR = 0.39, 95%CI: 0.15-0.99) and BMI ≥ 25 kg/m² (OR = 0.38, 95%CI: 0.19-0.76). The association between high CDAI and low hypothyroidism risk remained significant when subjects using thyroid hormones were excluded (OR = 0.47, 95%CI: 0.27-0.81).</p><p><strong>Conclusion: </strong>High CDAI was related to low hypothyroidism risk among U.S. adults. Our finding showed that the intake of an antioxidant-rich dietary is a potential method to reduce the risk of hypothyroidism.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"50"},"PeriodicalIF":2.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of selenium exposure with the odds of metabolic syndrome: a dose-response meta-analysis.","authors":"Rongrong Yuan, Yu Zhang, Jiakai Han","doi":"10.1186/s12902-025-01858-8","DOIUrl":"10.1186/s12902-025-01858-8","url":null,"abstract":"<p><strong>Background: </strong>Selenium is a key regulator of metabolic homeostasis. It has been proposed that exposure to selenium might be associated with metabolic syndrome (MetS). However, the results are contradictory. This meta-analysis was carried out to analyze the relationships between selenium levels in biological samples and odds of Mets.</p><p><strong>Methods: </strong>We searched Scopus and PubMed databases up until September 2024 to identify relevant studies. Odds ratio (OR) and 95% confidence interval was used to pool the data using a random effects model.</p><p><strong>Results: </strong>The meta-analysis encompassed 18 observational studies involving 21,481 participants. It found that higher selenium exposure was related to an elevated likelihood of MetS (OR = 1.30, 95% CI = 1.12-1.51), even after controlling for covariates, such as smoking, age, alcohol consumption, and physical activity. Heterogeneity was significant among the studies (I² = 88.9%, P = 0.001). While elevated serum selenium levels linked to a higher odds of MetS, no such relationship was observed for selenium in urine or toenails. Subgroup analyses indicated that this association was evident only in females (OR = 2.0, 95% CI = 1.17-1.43) and particularly pronounced in individuals aged ≥ 50 years. A dose-response relationship was identified, showing a 6% increase in MetS odds for each additional 10 µg/L of serum selenium, with the odds rising non-linearly when serum levels surpassed 80 µg/L.</p><p><strong>Conclusions: </strong>This study suggests that selenium may associated with the odds of MetS, following a dose-response relationship.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"49"},"PeriodicalIF":2.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Cardiac metabolic index as a predictor of new-onset diabetes in non-alcoholic fatty liver disease patients: a longitudinal cohort analysis.","authors":"Shanbing Hou, Yuqing Wang, Zixuan Wei, Haijun Li, Haonan Fang, Tingting Zhang, Yihang Zhu, Lixia Cui, Lixiang Zhang, Xia Chen, Min Dou","doi":"10.1186/s12902-025-01883-7","DOIUrl":"10.1186/s12902-025-01883-7","url":null,"abstract":"","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"51"},"PeriodicalIF":2.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study on the short-term and long-term efficacy of endoscopic lipolysis, liposuction, and traditional open excision in gynecomastia treatment.","authors":"Xiao Diao, Meng Wang, Di Chen, Haojie Jiang, Wanwan Wang, Linxin Zhang, Hanchao Zhang","doi":"10.1186/s12902-025-01876-6","DOIUrl":"10.1186/s12902-025-01876-6","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the comparative short-term and long-term efficacy of endoscopic lipolysis and liposuction versus traditional open excision in the treatment of gynecomastia.</p><p><strong>Methods: </strong>A total of 140 male patients diagnosed with gynecomastia and admitted to our hospital from April 2021 to May 2022 were enrolled in this study. Patients were randomly assigned to two groups based on the surgical treatment method: the control group (traditional open excision, n = 70) and the observation group (liposuction under endoscope, n = 70). Comprehensive demographic and clinical data were collected for both groups. Surgical indicators, postoperative complication rates, and pain levels measured using the Visual Analog Scale (VAS) one month post-surgery were observed and compared. Additionally, recurrence rates and patient satisfaction scores were evaluated one year after the procedure.</p><p><strong>Results: </strong>There were no significant differences in demographic and clinical characteristics between the two groups (P > 0.05). The observation group exhibited shorter incision lengths, reduced operation times, and decreased hospital stays compared to the control group (P < 0.05), alongside less intraoperative bleeding (P < 0.05). The incidence of postoperative complications was significantly lower in the observation group (P < 0.05). At one and three weeks post-surgery, the observation group reported lower VAS scores for pain compared to the control group (P < 0.05). There were no significant differences in recurrence rates between the groups one year post-surgery (P > 0.05). However, the observation group achieved higher scores in terms of chest appearance, wound scarring, nipple and areola aesthetics, and overall satisfaction (P < 0.05).</p><p><strong>Conclusion: </strong>Endoscopic lipolysis and liposuction not only demonstrate advantages such as lower complication rates and expedited recovery in the treatment of gynecomastia but also provide long-term efficacy comparable to traditional surgical methods. This approach significantly enhances patient satisfaction, establishing it as a preferred treatment option due to its safety profile and ability to deliver superior cosmetic outcomes.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"48"},"PeriodicalIF":2.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}