{"title":"肥胖儿童胰岛素样生长因子1与左心室质量指数的相关性","authors":"Wanxia Niu, Chen Li, Zhaorui Wang, Shuang Liang","doi":"10.1186/s12902-025-01921-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Low levels of Insulin-like Growth Factor 1 (IGF-1) are known risk factors for cardiovascular diseases. Left Ventricular Mass Index (LVMI) serves as an early predictor of adverse cardiovascular events. Obese children have relatively low concentrations of IGF-1 in their blood. To date, there is no research on whether there is a correlation between IGF-1 levels and LVMI in obese children. This study aims to investigate the potential correlation between IGF-1 and LVMI in obese children at a single center.</p><p><strong>Methods: </strong>A total of 104 obese children were selected as the case group, while 61 healthy children undergoing physical examinations served as the normal control group. Anthropometric measurements, assessments of IGF-1, and cardiovascular metabolic factors were conducted. Echocardiographic examinations were also performed to calculate the LVMI.</p><p><strong>Results: </strong>Compared to the control group, the obese group had significantly higher LVMI and significantly lower standard deviation scores for Insulin-like Growth Factor 1 (IGF-1 SDS). After controlling for confounding factors including total cholesterol (TC), triglycerides (TG), and uric acid (UA), there was a significant linear negative correlation between IGF-1 SDS and LVMI, and a significant linear positive correlation between homeostasis model of assessment for insulin resistance (HOMA-IR) and LVMI. Each unit increase in IGF-1 SDS resulted in a 16.1% decrease in LVMI (β = -0.161; p = 0.046), and each unit increase in HOMA-IR resulted in a 24.1% increase in LVMI (β = 0.241; p = 0.007).</p><p><strong>Conclusion: </strong>IGF-1 and LVMI exhibit an independent negative correlation. Monitoring IGF-1 levels might provide valuable insights into the cardiovascular health of obese children, facilitating early identification and management of cardiovascular risk factors.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"99"},"PeriodicalIF":2.8000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004568/pdf/","citationCount":"0","resultStr":"{\"title\":\"The correlation between insulin-like growth factor 1 and left ventricular mass index in obese children.\",\"authors\":\"Wanxia Niu, Chen Li, Zhaorui Wang, Shuang Liang\",\"doi\":\"10.1186/s12902-025-01921-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Low levels of Insulin-like Growth Factor 1 (IGF-1) are known risk factors for cardiovascular diseases. Left Ventricular Mass Index (LVMI) serves as an early predictor of adverse cardiovascular events. Obese children have relatively low concentrations of IGF-1 in their blood. To date, there is no research on whether there is a correlation between IGF-1 levels and LVMI in obese children. This study aims to investigate the potential correlation between IGF-1 and LVMI in obese children at a single center.</p><p><strong>Methods: </strong>A total of 104 obese children were selected as the case group, while 61 healthy children undergoing physical examinations served as the normal control group. Anthropometric measurements, assessments of IGF-1, and cardiovascular metabolic factors were conducted. Echocardiographic examinations were also performed to calculate the LVMI.</p><p><strong>Results: </strong>Compared to the control group, the obese group had significantly higher LVMI and significantly lower standard deviation scores for Insulin-like Growth Factor 1 (IGF-1 SDS). After controlling for confounding factors including total cholesterol (TC), triglycerides (TG), and uric acid (UA), there was a significant linear negative correlation between IGF-1 SDS and LVMI, and a significant linear positive correlation between homeostasis model of assessment for insulin resistance (HOMA-IR) and LVMI. Each unit increase in IGF-1 SDS resulted in a 16.1% decrease in LVMI (β = -0.161; p = 0.046), and each unit increase in HOMA-IR resulted in a 24.1% increase in LVMI (β = 0.241; p = 0.007).</p><p><strong>Conclusion: </strong>IGF-1 and LVMI exhibit an independent negative correlation. Monitoring IGF-1 levels might provide valuable insights into the cardiovascular health of obese children, facilitating early identification and management of cardiovascular risk factors.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>\",\"PeriodicalId\":9152,\"journal\":{\"name\":\"BMC Endocrine Disorders\",\"volume\":\"25 1\",\"pages\":\"99\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004568/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Endocrine Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12902-025-01921-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Endocrine Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12902-025-01921-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
The correlation between insulin-like growth factor 1 and left ventricular mass index in obese children.
Objective: Low levels of Insulin-like Growth Factor 1 (IGF-1) are known risk factors for cardiovascular diseases. Left Ventricular Mass Index (LVMI) serves as an early predictor of adverse cardiovascular events. Obese children have relatively low concentrations of IGF-1 in their blood. To date, there is no research on whether there is a correlation between IGF-1 levels and LVMI in obese children. This study aims to investigate the potential correlation between IGF-1 and LVMI in obese children at a single center.
Methods: A total of 104 obese children were selected as the case group, while 61 healthy children undergoing physical examinations served as the normal control group. Anthropometric measurements, assessments of IGF-1, and cardiovascular metabolic factors were conducted. Echocardiographic examinations were also performed to calculate the LVMI.
Results: Compared to the control group, the obese group had significantly higher LVMI and significantly lower standard deviation scores for Insulin-like Growth Factor 1 (IGF-1 SDS). After controlling for confounding factors including total cholesterol (TC), triglycerides (TG), and uric acid (UA), there was a significant linear negative correlation between IGF-1 SDS and LVMI, and a significant linear positive correlation between homeostasis model of assessment for insulin resistance (HOMA-IR) and LVMI. Each unit increase in IGF-1 SDS resulted in a 16.1% decrease in LVMI (β = -0.161; p = 0.046), and each unit increase in HOMA-IR resulted in a 24.1% increase in LVMI (β = 0.241; p = 0.007).
Conclusion: IGF-1 and LVMI exhibit an independent negative correlation. Monitoring IGF-1 levels might provide valuable insights into the cardiovascular health of obese children, facilitating early identification and management of cardiovascular risk factors.
期刊介绍:
BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.