Comparison of triglyceride glucose index and other insulin resistance indexes in children with overweight and obesity.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2025-04-09 DOI:10.1186/s12902-025-01922-3

Derya Kalyoncu, Melis Kavrak Kursun

{"title":"Comparison of triglyceride glucose index and other insulin resistance indexes in children with overweight and obesity.","authors":"Derya Kalyoncu, Melis Kavrak Kursun","doi":"10.1186/s12902-025-01922-3","DOIUrl":null,"url":null,"abstract":"Objectives: The aim of the study was to determine the correlation between insulin resistance (IR) indexes in children with overweight or obesity.Methods: A total of 276 children with overweight or obesity and 100 normal-weight children were enrolled in the study. IR indexes such as homeostasis model assessment insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), fasting glucose/insulin ratio (FGIR), Triglyceride glucose index (TyG), and lipid-derived ratios were determined.Results: The mean ages were 13.0 ± 2.6, 13.1 ± 2.7 and 12.72 ± 2.23 (range:6 - 18 years) for children with overweight, obesity and normal-weight, respectively. A statistically significant positive correlation was found between HOMA-IR and TyG index, and a negative correlation between QUICKI, FGIR and TyG index (r = 0.193, P < 0.001; r = - 0.456, P < 0.001 and r = - 0.392, P < 0.001, respevtively). TyG index, triglyceride (TG)/high-density lipoprotein (HDL), total cholesterol (TC)/HDL, and low-density lipoprotein (LDL)/HDL were higher in children with IR than those without IR (P < 0.05). In receiver operating characteristic curves analysis, cut-off points were found to be ≤ 0.31 for QUICKI (94.31% sensitivity and 97.58% specificity), ≤ 6.3 for FGIR (89.1% sensitivity and 93.94% specificity), and > 4.62 for TyG (49.29% sensitivity and 84.85% specificity).Conclusion: HOMA-IR, FGIR, and QUICKI constitute stronger predictors of IR than TyG index in children with overweight and obesity.","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"96"},"PeriodicalIF":2.8000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980104/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Endocrine Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12902-025-01922-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: The aim of the study was to determine the correlation between insulin resistance (IR) indexes in children with overweight or obesity.

Methods: A total of 276 children with overweight or obesity and 100 normal-weight children were enrolled in the study. IR indexes such as homeostasis model assessment insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), fasting glucose/insulin ratio (FGIR), Triglyceride glucose index (TyG), and lipid-derived ratios were determined.

Results: The mean ages were 13.0 ± 2.6, 13.1 ± 2.7 and 12.72 ± 2.23 (range:6 - 18 years) for children with overweight, obesity and normal-weight, respectively. A statistically significant positive correlation was found between HOMA-IR and TyG index, and a negative correlation between QUICKI, FGIR and TyG index (r = 0.193, P < 0.001; r = - 0.456, P < 0.001 and r = - 0.392, P < 0.001, respevtively). TyG index, triglyceride (TG)/high-density lipoprotein (HDL), total cholesterol (TC)/HDL, and low-density lipoprotein (LDL)/HDL were higher in children with IR than those without IR (P < 0.05). In receiver operating characteristic curves analysis, cut-off points were found to be ≤ 0.31 for QUICKI (94.31% sensitivity and 97.58% specificity), ≤ 6.3 for FGIR (89.1% sensitivity and 93.94% specificity), and > 4.62 for TyG (49.29% sensitivity and 84.85% specificity).

Conclusion: HOMA-IR, FGIR, and QUICKI constitute stronger predictors of IR than TyG index in children with overweight and obesity.

查看原文本刊更多论文

超重和肥胖儿童甘油三酯葡萄糖指数与其他胰岛素抵抗指标的比较

目的：本研究的目的是确定超重或肥胖儿童胰岛素抵抗（IR）指标之间的相关性。方法：选取276名超重或肥胖儿童和100名正常体重儿童作为研究对象。测定胰岛素抵抗稳态模型评估（HOMA-IR）、胰岛素敏感性定量检查指数（QUICKI）、空腹葡萄糖/胰岛素比值（fir）、甘油三酯葡萄糖指数（TyG）、脂质衍生比值等IR指标。结果：超重、肥胖和正常体重患儿的平均年龄分别为13.0±2.6岁、13.1±2.7岁和12.72±2.23岁（6 ~ 18岁）。HOMA-IR与TyG指数呈正相关，QUICKI、FGIR与TyG指数呈负相关(r = 0.193, P < 0.001；r = - 0.456, P < 0.001, r = - 0.392, P < 0.001, respevtively)。IR患儿TyG指数、甘油三酯(TG)/高密度脂蛋白（HDL）、总胆固醇(TC)/HDL、低密度脂蛋白(LDL)/HDL均高于未IR患儿（TyG敏感性为49.29%，特异性为84.85%,P = 4.62）。结论：与TyG指数相比，HOMA-IR、FGIR和QUICKI是超重和肥胖儿童IR的更强预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.