{"title":"揭示美国成人UHR阈值:来自NHANES研究的早期糖尿病检测的新生物标志物。","authors":"Chao Yu, Zuting Liu, Jian Zhong, Xingyu Liu, Jiali Mo, Jie Kuang","doi":"10.1186/s12902-025-02012-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aims: </strong>This study examines the association between the serum uric acid high-density lipoprotein cholesterol ratio (UHR) biomarker and the risk of prediabetes and diabetes, a relationship that remains under-researched, to provide insights for diabetes prevention.</p><p><strong>Methods and results: </strong>This study utilized data from 13,975 American participants in the National Health and Nutrition Examination Survey (2011-2018). Logistic regression models, restricted cubic splines (RCS) analysis and subgroup analyses were employed to examine the association between UHR and prediabetes/diabetes. The median UHR was 10.4%, with 6,382 (45.7%) cases of prediabetes and diabetes detected. A higher UHR was associated with an increased risk of prediabetes and diabetes, showing a 39% increased risk per standard deviation increment (OR: 1.39; 95% CI: 1.33,1.46). Consistent results were observed when UHR was categorized. Participants in the highest UHR quartile exhibited a significantly higher risk of prediabetes/diabetes than those in the lowest quartile (OR: 2.63, 95% CI: 2.30,3.01). The RCS analysis revealed a nonlinear association, with a threshold value of 12.50%. Below this threshold, higher UHR was significantly associated with prediabetes/diabetes (OR: 1.17, 95% CI: 1.15,1.19), while above this threshold, the association was not significant. Subgroup analyses highlighted a marked gender disparity, with women exhibiting a stronger association.</p><p><strong>Conclusion: </strong>This research found a positive link between UHR and prediabetes and diabetes prevalence, with a nonlinear relationship noted. A significant association was observed below a UHR threshold of 12.50%, especially in females.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"195"},"PeriodicalIF":3.3000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355743/pdf/","citationCount":"0","resultStr":"{\"title\":\"Unveiling the UHR threshold in American adult: a new biomarker for early diabetes detection from NHANES study.\",\"authors\":\"Chao Yu, Zuting Liu, Jian Zhong, Xingyu Liu, Jiali Mo, Jie Kuang\",\"doi\":\"10.1186/s12902-025-02012-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and aims: </strong>This study examines the association between the serum uric acid high-density lipoprotein cholesterol ratio (UHR) biomarker and the risk of prediabetes and diabetes, a relationship that remains under-researched, to provide insights for diabetes prevention.</p><p><strong>Methods and results: </strong>This study utilized data from 13,975 American participants in the National Health and Nutrition Examination Survey (2011-2018). Logistic regression models, restricted cubic splines (RCS) analysis and subgroup analyses were employed to examine the association between UHR and prediabetes/diabetes. The median UHR was 10.4%, with 6,382 (45.7%) cases of prediabetes and diabetes detected. A higher UHR was associated with an increased risk of prediabetes and diabetes, showing a 39% increased risk per standard deviation increment (OR: 1.39; 95% CI: 1.33,1.46). Consistent results were observed when UHR was categorized. Participants in the highest UHR quartile exhibited a significantly higher risk of prediabetes/diabetes than those in the lowest quartile (OR: 2.63, 95% CI: 2.30,3.01). The RCS analysis revealed a nonlinear association, with a threshold value of 12.50%. Below this threshold, higher UHR was significantly associated with prediabetes/diabetes (OR: 1.17, 95% CI: 1.15,1.19), while above this threshold, the association was not significant. Subgroup analyses highlighted a marked gender disparity, with women exhibiting a stronger association.</p><p><strong>Conclusion: </strong>This research found a positive link between UHR and prediabetes and diabetes prevalence, with a nonlinear relationship noted. 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引用次数: 0
摘要
背景与目的:本研究探讨血清尿酸高密度脂蛋白胆固醇比(UHR)生物标志物与前驱糖尿病和糖尿病风险之间的关系,这一关系仍有待研究,为糖尿病预防提供见解。方法和结果:本研究利用了2011-2018年全国健康与营养检查调查(National Health and Nutrition Examination Survey)中13975名美国参与者的数据。采用Logistic回归模型、限制性三次样条(RCS)分析和亚组分析来检验UHR与前驱糖尿病/糖尿病之间的关系。中位UHR为10.4%,检出6382例(45.7%)糖尿病前期和糖尿病。较高的UHR与糖尿病前期和糖尿病的风险增加相关,显示每个标准差增量的风险增加39% (OR: 1.39;95% ci: 1.33,1.46)。当UHR被分类时,观察到一致的结果。UHR最高四分位数的参与者患前驱糖尿病/糖尿病的风险明显高于最低四分位数的参与者(OR: 2.63, 95% CI: 2.30,3.01)。RCS分析显示非线性关联,阈值为12.50%。低于这个阈值,较高的UHR与前驱糖尿病/糖尿病显著相关(OR: 1.17, 95% CI: 1.15,1.19),而高于这个阈值,相关性不显著。亚组分析强调了明显的性别差异,女性表现出更强的相关性。结论:本研究发现UHR与糖尿病前期和糖尿病患病率呈正相关,且呈非线性关系。在UHR阈值12.50%以下观察到显著关联,特别是在女性中。
Unveiling the UHR threshold in American adult: a new biomarker for early diabetes detection from NHANES study.
Background and aims: This study examines the association between the serum uric acid high-density lipoprotein cholesterol ratio (UHR) biomarker and the risk of prediabetes and diabetes, a relationship that remains under-researched, to provide insights for diabetes prevention.
Methods and results: This study utilized data from 13,975 American participants in the National Health and Nutrition Examination Survey (2011-2018). Logistic regression models, restricted cubic splines (RCS) analysis and subgroup analyses were employed to examine the association between UHR and prediabetes/diabetes. The median UHR was 10.4%, with 6,382 (45.7%) cases of prediabetes and diabetes detected. A higher UHR was associated with an increased risk of prediabetes and diabetes, showing a 39% increased risk per standard deviation increment (OR: 1.39; 95% CI: 1.33,1.46). Consistent results were observed when UHR was categorized. Participants in the highest UHR quartile exhibited a significantly higher risk of prediabetes/diabetes than those in the lowest quartile (OR: 2.63, 95% CI: 2.30,3.01). The RCS analysis revealed a nonlinear association, with a threshold value of 12.50%. Below this threshold, higher UHR was significantly associated with prediabetes/diabetes (OR: 1.17, 95% CI: 1.15,1.19), while above this threshold, the association was not significant. Subgroup analyses highlighted a marked gender disparity, with women exhibiting a stronger association.
Conclusion: This research found a positive link between UHR and prediabetes and diabetes prevalence, with a nonlinear relationship noted. A significant association was observed below a UHR threshold of 12.50%, especially in females.
期刊介绍:
BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.