在资源匮乏环境中接受一线抗逆转录病毒治疗的艾滋病毒感染者的代谢综合征:来自坦桑尼亚基于设施的调查的证据

IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Deogratius Bintabara, Sola T Hyera, Festo K Shayo
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引用次数: 0

摘要

背景:由于抗逆转录病毒治疗、HIV感染和其他伴随因素,代谢综合征(MetS)在HIV感染者(PLWHIV)中变得越来越普遍。撒哈拉以南非洲的艾滋病毒/艾滋病和非传染性疾病负担沉重,因此需要特别关注艾滋病毒感染者的传染性疾病。该研究旨在评估一线抗逆转录病毒治疗的plwhv患者中与MetS相关的因素。方法:这是一个横断面设计,利用方便抽样技术招募了255名参与者。采用访谈式问卷获取研究参与者的相关信息,并记录身体测量(血压、体重、身高和体重指数)和生化特征(空腹血糖、血脂、CD4计数和血红蛋白水平)。MetS是通过使用成人治疗组III标准建立的。采用描述性统计和二元逻辑回归对数据进行分析,所有统计分析均采用Stata 17.0版本进行。P值小于0.05为有统计学意义。结果:平均年龄为46±2岁,BMI为25.0±5.3 kg/m2。其中161人(63.1%)为女性,29人(11.4%)为当前吸烟者或曾经吸烟者。代谢综合征的患病率为21.2%,与代谢综合征相关的因素为年龄0 ~ 45岁(AOR = 10.483, 95% CI = 1.336 ~ 82.231)、肥胖(AOR = 11.39, 95% CI = 2.23 ~ 58.32)、吸烟(AOR = 3.97, 95% CI = 1.10 ~ 14.34)和单身(AOR = 2.84, 95% CI = 1.11 ~ 7.26)。结论:本研究中接受一线ART治疗的plwhv患者met发生率较高。年龄大于45岁、单身、目前吸烟和肥胖是met的独立预测因素。需要定期监测临床和实验室参数,监测药物作用和行为干预,以优化管理和预防PLWHIV代谢紊乱。临床试验号:不适用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic syndrome among people living with HIV on first-line antiretroviral therapy in scarce-resource settings: an evidence from Tanzanian facility-based survey.

Background: Metabolic syndrome (MetS) is becoming prevalent among People living with HIV (PLWHIV), attributed to antiretroviral therapy, HIV infection and other concomitant factors. A high burden of HIV/AIDs and Non-communicable diseases in Sub-Saharan Africa calls for an extra focus on the MetS among people living with HIV. The study aimed at assessing the factors associated with MetS among PLWHIV on the first-line antiretroviral therapy.

Methods: This was a cross-sectional design whereby a convenience sampling technique was used to recruit a sample of 255 participants. The interview-guided questionnaire was used to obtain relevant information from the study participants as well as to record physical measurements (Blood pressure, weight, height and body mass index) and biochemical profiles (fasting blood glucose, lipid profile, CD4 count, and Hemoglobin level). MetS was established by using the Adult Treatment Panel III criteria. Descriptive statistics and binary logistic regression were used to analyze the data, and all statistical analyses were performed using Stata version 17.0. A P value less than 0.05 was considered for statistical significance.

Results: The mean age and BMI were 46 ± 2 years and 25.0 ± 5.3 kg/m2, respectively. The majority 161 (63.1%) of participants were females and 29 (11.4%) were either current smokers or former smokers. The prevalence of MetS was 21.2% and the factors associated with metabolic syndrome were age > 45 years (AOR = 10.483, 95% CI = 1.336-82.231), being obese (AOR = 11.39, 95% CI = 2.23-58.32), currently smoking (AOR = 3.97, 95% CI = 1.10-14.34) and being single (AOR = 2.84, 95% CI = 1.11-7.26).

Conclusion: The prevalence of MetS in this study was relatively high among PLWHIV on first-line ART. Age above 45 years, being single, current smoking, and obesity were independent predictors of MetS. Regular monitoring for clinical and laboratory parameters, surveillance of drug effects and behavioral interventions are needed to optimize the management and prevention of metabolic disorders in PLWHIV.

Clinical trial number: Not applicable.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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