Risk factors for progression to albuminuria in individuals with newly diagnosed type 2 diabetes: a 5-year cohort study.

IF 3.3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2025-09-02 DOI:10.1186/s12902-025-02014-y

Lingli Zhou, Junxia Yu, Xiaoling Cai, Yu Zhu, Meng Li, Xueyao Han, Linong Ji

{"title":"Risk factors for progression to albuminuria in individuals with newly diagnosed type 2 diabetes: a 5-year cohort study.","authors":"Lingli Zhou, Junxia Yu, Xiaoling Cai, Yu Zhu, Meng Li, Xueyao Han, Linong Ji","doi":"10.1186/s12902-025-02014-y","DOIUrl":null,"url":null,"abstract":"Background: This study aimed to determine the 5-year incidence of albuminuria in Chinese individuals with newly diagnosed type 2 diabetes mellitus (T2DM) and identify baseline risk factors for progression to albuminuria.Methods: An observational cohort study was conducted with 604 individuals aged ≥ 18 years diagnosed with T2DM between January 2014 and December 2017 at a tertiary hospital in China, followed through November 2022. The cumulative incidence of progression from normoalbuminuria to albuminuria was assessed. Risk factors for progression were evaluated using multiple logistic regression.Results: Of the 368 individuals with normoalbuminuria at diagnosis, the mean (SD) age was 54 (11) years. The 5-year cumulative incidence of progression to albuminuria was 7.9%. Higher urine albumin-to-creatinine ratio (UACR) (OR 1.18; 95% CI, 1.10-1.26) and higher homeostasis model assessment of insulin resistance (HOMA-IR) (OR 1.18; 95% CI, 1.15-1.32) at diagnosis were independently associated with progression. After adjusting for baseline UACR, higher HOMA-IR at diagnosis was linked to a more rapid increase in UACR over time.Conclusion: Early screening for UACR and management of insulin resistance in individuals with T2DM may help delay the onset of microalbuminuria.","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"25 1","pages":"203"},"PeriodicalIF":3.3000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403927/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Endocrine Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12902-025-02014-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Background: This study aimed to determine the 5-year incidence of albuminuria in Chinese individuals with newly diagnosed type 2 diabetes mellitus (T2DM) and identify baseline risk factors for progression to albuminuria.

Methods: An observational cohort study was conducted with 604 individuals aged ≥ 18 years diagnosed with T2DM between January 2014 and December 2017 at a tertiary hospital in China, followed through November 2022. The cumulative incidence of progression from normoalbuminuria to albuminuria was assessed. Risk factors for progression were evaluated using multiple logistic regression.

Results: Of the 368 individuals with normoalbuminuria at diagnosis, the mean (SD) age was 54 (11) years. The 5-year cumulative incidence of progression to albuminuria was 7.9%. Higher urine albumin-to-creatinine ratio (UACR) (OR 1.18; 95% CI, 1.10-1.26) and higher homeostasis model assessment of insulin resistance (HOMA-IR) (OR 1.18; 95% CI, 1.15-1.32) at diagnosis were independently associated with progression. After adjusting for baseline UACR, higher HOMA-IR at diagnosis was linked to a more rapid increase in UACR over time.

Conclusion: Early screening for UACR and management of insulin resistance in individuals with T2DM may help delay the onset of microalbuminuria.

Abstract Image

查看原文本刊更多论文

新诊断的2型糖尿病患者进展为蛋白尿的危险因素：一项5年队列研究

背景：本研究旨在确定中国新诊断的2型糖尿病（T2DM）患者5年蛋白尿发生率，并确定进展为蛋白尿的基线危险因素。方法：2014年1月至2017年12月，在中国一家三级医院对604名年龄≥18岁的T2DM患者进行了一项观察性队列研究，随访至2022年11月。评估从正常蛋白尿进展到蛋白尿的累积发生率。使用多元逻辑回归评估进展的危险因素。结果：368例诊断时尿白蛋白正常的患者，平均（SD）年龄为54（11）岁。5年累积进展为蛋白尿的发生率为7.9%。诊断时较高的尿白蛋白-肌酐比（UACR）（OR 1.18; 95% CI, 1.10-1.26）和较高的胰岛素抵抗稳态模型评估（HOMA-IR）（OR 1.18; 95% CI, 1.15-1.32）与病情进展独立相关。在调整基线UACR后，诊断时较高的HOMA-IR与随着时间的推移UACR的快速增加有关。结论：早期筛查UACR和管理T2DM患者的胰岛素抵抗可能有助于延迟微量白蛋白尿的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.