Brain Sciences最新文献

{"title":"Exploring the Correlation Between Sleep Chronotype and the Volumes of Subcortical Structures and Hippocampal Subfields in Young Healthy Population.","authors":"Fahad H Alhazmi","doi":"10.3390/brainsci15030295","DOIUrl":"10.3390/brainsci15030295","url":null,"abstract":"<p><strong>Background/objectives: </strong>Chronotypes significantly influence sleep quality, daily performance, and overall activity levels. Although there is growing evidence indicating that individuals with a late chronotype are more likely to experience cognitive decline, the specific neural mechanisms that contribute to this risk remain unclear. This study aims to explore the relationship between morning and evening preferences and the volumes of subcortical structures in a young, healthy population.</p><p><strong>Methods: </strong>A total of 123 participants (80 females), aged between 18 and 35 years, were recruited. They underwent MRI scans and completed several self-reported assessments, including the morningness-eveningness scale of the Chronotype Questionnaire (ChQ-ME), the amplitude scale of the Chronotype Questionnaire (ChQ-AM), the Epworth Sleepiness Scale (ESS), and the Pittsburgh Sleep Quality Index (PSQI). Participants were classified into early chronotype (EC) and late chronotype (LC) groups based on their ChQ-ME scores. High-resolution T1-weighted imaging was utilized to analyze the volumes of subcortical structures and hippocampal subfields.</p><p><strong>Results: </strong>The volumetric analysis indicated that the LC group showed significant reductions in the right Caudate (<i>p</i> = 0.03) and the left SR-SL-SM (<i>p</i> = 0.03) compared to the EC group. Additionally, a notable leftward hemispheric laterality of the Subiculum (<i>p</i> = 0.048) was observed in the EC group relative to the LC group. Furthermore, the ChQ-AM revealed significant positive (r = 0.23) and negative (r = -0.19) correlations with the volumes of the left thalamus and right amygdala, respectively. The PSQI demonstrated a significant negative correlation (r = -0.21) with the right SR-SL-SM, while the ESS indicated a significant positive correlation (r = 0.24) with the left SR-SL-SM. Multiple regression analysis indicated that variations in daytime sleepiness are linked to the change of the left SR-SL-SM volume.</p><p><strong>Conclusions: </strong>Overall, the findings suggest that chronotype preferences are associated with the changes in the volumes of subcortical structures and hippocampal subfields and highlight the role of chronotypes in the neural mechanisms of these brain structures.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATP Alters the Oxylipin Profiles in Astrocytes: Modulation by High Glucose and Metformin.","authors":"Alexey I Drozhdev, Vladislav O Gorbatenko, Sergey V Goriainov, Dmitry V Chistyakov, Marina G Sergeeva","doi":"10.3390/brainsci15030293","DOIUrl":"10.3390/brainsci15030293","url":null,"abstract":"<p><p><b>Background:</b> Astrocytes play a key role in the inflammatory process accompanying various neurological diseases. Extracellular ATP accompanies inflammatory processes in the brain, but its effect on lipid mediators (oxylipins) in astrocytes remains elusive. Metformin is a hypoglycemic drug with an anti-inflammatory effect that has been actively investigated in the context of therapy for neuroinflammation, but its mechanisms of action are not fully elucidated. Therefore, we aimed to characterize the effects of ATP on inflammatory markers and oxylipin profiles; determine the dependence of these effects on the adaptation of astrocytes to high glucose levels; and evaluate the possibility of modulating ATP effects using metformin. <b>Methods:</b> We estimated the ATP-mediated response of primary rat astrocytes cultured at normal (NG, 5 mM) and high (HG, 22.5 mM) glucose concentrations for 48 h before stimulation. Cell responses were assessed by monitoring changes in the expression of inflammatory markers (TNFα, IL-6, IL-10, IL-1β, iNOS, and COX-2) and the synthesis of oxylipins (41 compounds), assayed with ultra-high-performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). Intracellular pathways were assessed by analyzing the phosphorylation of p38; ERK MAPK; transcription factors STAT3 and NF-κB; and the enzymes mediating oxylipin synthesis, COX-1 and cPLA2. <b>Results:</b> The stimulation of cells with ATP does not affect the expression of pro-inflammatory markers, increases the activities of p38 and ERK MAPKs, and activates oxylipin synthesis, shifting the profiles toward an increase in anti-inflammatory compounds (PGD2, PGA2, 12-HHT, and 18-HEPE). The ATP effects are reduced in HG astrocytes. Metformin potentiated ATP-induced oxylipin synthesis (11-HETE, PGD2, 12-HHT, 15-HETE, 13-HDoHE, and 15-HETrE), which was predominantly evident in NG cells. <b>Conclusions:</b> Our data provide new evidence showing that ATP induces the release of anti-inflammatory oxylipins, and metformin enhances these effects. These results should be considered in the development of anti-inflammatory therapeutic approaches aimed at modulating astrocyte function in various pathologies.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactylation and Central Nervous System Diseases.","authors":"Ye Chen, Dongqiong Xiao, Xihong Li","doi":"10.3390/brainsci15030294","DOIUrl":"10.3390/brainsci15030294","url":null,"abstract":"<p><p>As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases and mediates lactylation, an epigenetic modification that occurs under both physiological and pathological conditions. Lactylation is a crucial mechanism by which lactate exerts its functions, participating in vital biological activities such as glycolysis-related cellular functions, macrophage polarization, and nervous system regulation. Lactylation links metabolic regulation to central nervous system (CNS) diseases, such as traumatic brain injury, Alzheimer's disease, acute ischemic stroke, and schizophrenia, revealing the diverse functions of lactylation in the CNS. In the future, further exploration of lactylation-associated enzymes and proteins is needed to develop specific lactylation inhibitors or activators, which could provide new tools and strategies for the treatment of CNS diseases.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Novel Stimulants in ADHD Self-Medication: A Mixed Methods Analysis.","authors":"Tayler Holborn, Fabrizio Schifano, Emma Smith, Paolo Deluca","doi":"10.3390/brainsci15030292","DOIUrl":"10.3390/brainsci15030292","url":null,"abstract":"<p><strong>Background: </strong>Numerous individuals suffer from attentional issues, such as ADHD. While medication is considered the first-line treatment, it is unavailable to some. As a result, certain individuals are choosing to self-medicate with novel stimulants, a phenomenon that remains poorly understood. We aimed to investigate which NPSs are being used to self-medicate ADHD, evaluate their perceived effectiveness, and explore the experiences and motivations of those self-medicating.</p><p><strong>Methods: </strong>Data from respondents (<i>n</i> = 225) (mean age [SD] = 29.5 ± 9.6; male = 83%; female = 12%; non-binary = 5%) were collected via an online survey, with nine participants (mean age = 31.4; male = 5; female = 1; non-binary = 3) undertaking further semi-structured interviews and the data being investigated using a framework analysis.</p><p><strong>Results: </strong>The most-used NPSs were 4F-MPH and 2-FMA. Some individuals perceived self-medication to be more effective than conventional treatment (<i>p</i> < 0.001). A framework analysis identified the following themes surrounding novel stimulant self-medication: (1) the use of NPS stimulants as a stopgap between treatments; (2) poor access to ADHD treatment; (3) a lack of openness and confidence in psychiatrists and healthcare providers.</p><p><strong>Conclusion: </strong>Novel stimulants are being used when access to ADHD treatment is poor. Interventions should aim to reduce long treatment wait times and issues surrounding geographical access. Careful consideration should be given before denying stimulant medication to individuals with co-occurring substance use and psychiatric comorbidity. Individuals desire a more patient-centred ADHD treatment with broader pharmacotherapies.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabinoids Activate Endoplasmic Reticulum Stress Response and Promote the Death of Avian Retinal Müller Cells in Culture.","authors":"Ana Lúcia Marques Ventura, Thayane Martins Silva, Guilherme Rapozeiro França","doi":"10.3390/brainsci15030291","DOIUrl":"10.3390/brainsci15030291","url":null,"abstract":"<p><strong>Background/objectives: </strong>Activation of cannabinoid CB1 or CB2 receptors induces the death of glial progenitors from the chick retina in culture. Here, by using an enriched retinal glial cell culture, we characterized some mechanisms underlying glial death promoted by cannabinoids.</p><p><strong>Methods and results: </strong>Retinal cultures obtained from 8-day-old (E8) chick embryos and maintained for 12-15 days (C12-15) were used. MTT assays revealed that the CB1/CB2 agonist WIN 55,212-2 (WIN) decreased cell viability in the cultures in a time-dependent manner, with a concomitant increase in extracellular LDH activity, suggesting membrane integrity loss. Cell death was also dose-dependently induced by cannabidiol (CBD), Δ⁹-tetrahydrocannabinol (THC), and CP55940, another CB1/CB2 agonist. In contrast to WIN-induced cell death that was not blocked by either antagonist, the deleterious effect of CBD was blocked by the CB2 receptor antagonist SR144528, but not by PF514273, a CB1 receptor antagonist. WIN-treated cultures showed glial cells with large vacuoles in cytoplasm that were absent in cultures incubated with WIN plus 4-phenyl-butyrate (PBA), a chemical chaperone. Since cannabinoids induced the phosphorylation of eukaryotic initiation factor 2-alfa (eIF2α), these results suggest a process of endoplasmic reticulum (ER) swelling and stress. Incubation of the cultures with WIN for 4 h induced a ~five-fold increase in the number of cells labeled with the ROS indicator CM-H2DCFDA. WIN induced the phosphorylation of JNK but not of p38 in the cultures, and also induced an increase in the number of glial cells expressing cleaved-caspase 3 (c-CASP3). The decrease in cell viability and the expression of c-CASP3 was blocked by salubrinal, an inhibitor of eIF2α dephosphorylation.</p><p><strong>Conclusions: </strong>These data suggest that cannabinoids induce the apoptosis of glial cells in culture by promoting ROS production, ER stress, JNK phosphorylation, and caspase-3 processing. The graphical abstract was created at Biorender.com.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycorine Pre-Treatment Alleviates Microglia Inflammation After Cerebral Ischemia by Inhibiting NF-κB Phosphorylation.","authors":"Wuyan Zheng, Wanyu Wu, Yuhan Li, Bo Qin, Yuping Wang, Yunhan Zeng, Betty Yuen Kwan Law, Vincent Kam Wai Wong","doi":"10.3390/brainsci15030290","DOIUrl":"10.3390/brainsci15030290","url":null,"abstract":"<p><strong>Background: </strong>Middle-aged and elderly individuals may experience detrimental health effects due to ischemic stroke (IS). The inflammatory response triggered during IS exacerbates neuronal damage, becoming a barrier to effective IS treatment and leading to poor patient prognosis. Nevertheless, the specific role of microglia in the inflammatory response triggered by IS remains mostly unclear. The primary target of this investigation is to study the neuroinflammatory impact of lycorine (LYC) during the IS process. Our objective is to evaluate whether LYC deploys its anti-inflammatory effect with modulation of the NF-κB signaling pathway, thereby reducing IS symptoms.</p><p><strong>Methods: </strong>In this research, BV-2 cells were pre-treated with LYC for 24 h before LPS was added to induce inflammation.</p><p><strong>Results: </strong>It has been discovered that LYC suppresses BV-2 cell polarization and reduces the levels of inflammatory cytokines (IL-1β, IL-6, TNF-α), showing its potential anti-inflammatory effects in vitro. Furthermore, IκBα and p65 play crucial roles in regulating the inflammatory response within the NF-κB signaling pathway. Mechanistic exploration indicates that LYC can activate the expression of IκBα in LPS-induced BV-2 cells. IκBα inhibits NF-κB by binding to its p65 subunit, sequestering it in the cytoplasm and preventing its translocation to the nucleus, thereby inhibiting inflammation. Additionally, p65 is a key transcription factor for pro-inflammatory genes, and its downregulation leads to decreased transcriptional activity of these genes. The combined effect of increased IκBα and decreased p65 results in significantly reduced NF-κB activity, thereby alleviating the inflammatory response. Meanwhile, in vivo studies indicate that LYC pre-treatment significantly reduces the infarct size caused by middle cerebral artery occlusion (MCAO) in rats. The assessment of cerebral infarction volume, neurological scores, brain edema rate and inflammation levels in MCAO rats pre-treated with LYC indicates positive therapeutic effects.</p><p><strong>Conclusions: </strong>In summary, our research indicates that LYC pre-treatment has significant anti-inflammatory effects by attenuating inflammation levels through NF-κB inhibition, which contributes to potential therapeutic benefits in ischemic stroke (IS) and may improve disease prognosis. LYC may serve as an adjunctive clinical pre-treatment for IS, which has to be confirmed by clinical trials in the future.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kawaii-Ness Mediates Between Demographic Variables, Happiness, and Brain Conditions.","authors":"Keisuke Kokubun, Kiyotaka Nemoto, Taiko Otsuka, Maya Okamoto, Yuko Shiga, Yuya Makizato, Aya Komaki, Yoshinori Yamakawa","doi":"10.3390/brainsci15030289","DOIUrl":"10.3390/brainsci15030289","url":null,"abstract":"<p><p><b>Background/Objectives</b>: In many societies, especially in highly masculine societies like Japan, being a man, getting older, engaging in knowledge work, and earning a high annual salary are seen as conditions for success. On the other hand, an increasing number of studies have shown that incorporating kawaii-ness into our lives can help maintain and improve happiness and well-being. <b>Methods</b>: Therefore, in this study, we employed a variable expressing the response to kawaii-ness together with four demographic variables (sex, age, income, and knowledge work), happiness, and fractional anisotropy brain healthcare quotient (FA-BHQ) which is derived from magnetic resonance imaging (MRI) images calculations to analyze the relationship between them. <b>Results</b>: The results of a path analysis using data obtained from 182 healthy men and women showed that kawaii-ness mediates the association between demographic variables and happiness, which is in turn associated with FA-BHQ. Furthermore, with the correlation analysis between happiness and individual FA regions, we were able to confirm that FA regions, including the limbic-thalamo-cortical pathway, which is responsible for emotional regulation, are related to happiness. <b>Conclusions</b>: These results indicate the following: Men, older people, people engaged in knowledge work, and people with high annual incomes avoid kawaii-ness; As a result, they are unable to obtain the sense of happiness that they should have; as a result, they are unable to keep their brains healthy, and their brain functions, including emotional regulation, are not functioning properly; This may prevent them from maintaining or improving their performance. This study is the first attempt to clarify the relationship between demographic scales, kawaii-ness, happiness, and brain conditions.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Cortisol Levels Play a Role in Suicidal Behaviors and Non-Suicidal Self-Injuries in Children and Adolescents?-A Narrative Review.","authors":"Bartłomiej Sporniak, Monika Szewczuk-Bogusławska","doi":"10.3390/brainsci15030287","DOIUrl":"10.3390/brainsci15030287","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Suicidal behaviors (SBs) and non-suicidal self-injury (NSSI) are significant mental health concerns in children and adolescents. The hypothalamic-pituitary-adrenal (HPA) axis, of which cortisol is a key hormone, has been implicated in these behaviors. This narrative review aims to explore whether cortisol levels play a role in SBs and NSSI in youth and to synthesize current evidence on this topic. <b>Methods:</b> A comprehensive literature search was conducted on studies published through November 2024, using PubMed, Web of Science, and Google Scholar databases. Studies were screened for eligibility, including only human studies published in English, with no animal models or studies excluding cortisol levels. A narrative synthesis approach was used due to the methodological diversity across studies. Due to limited adolescent-focused research, studies involving adults were also considered. <b>Results:</b> Findings indicate inconsistent cortisol patterns in relation to SBs and NSSI. Elevated cortisol levels are linked to SBs, with some studies suggesting they may predict future suicide attempts, though no definitive cause-and-effect relationship is established. Conversely, cortisol levels in relation to NSSI show mixed results, with some studies reporting no differences. Cortisol responses to stress, measured by saliva, blood, and hair, reveal complex interactions with psychological factors such as depression and impulsivity, influencing cortisol secretion. <b>Discussion:</b> Despite some evidence pointing to a role of cortisol dysregulation in SBs and NSSI, the relationship remains unclear due to study heterogeneity, including small sample sizes and methodological variations. Gender and the type of stressor used in studies also complicate the findings. Future research should prioritize longitudinal studies, better control for confounding factors, and utilize more diverse cortisol assessment methods to clarify these links. <b>Conclusions:</b> While cortisol may play a role in the pathophysiology of SBs and NSSI, further research is needed to establish clearer, more reliable patterns. Identifying alterations in cortisol levels may aid in early detection and targeted interventions for at-risk adolescents.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Modal Interactions and Movement-Related Tactile Gating: The Role of Vision.","authors":"Maria Casado-Palacios, Alessia Tonelli, Claudio Campus, Monica Gori","doi":"10.3390/brainsci15030288","DOIUrl":"10.3390/brainsci15030288","url":null,"abstract":"<p><strong>Background: </strong>When engaging with the environment, multisensory cues interact and are integrated to create a coherent representation of the world around us, a process that has been suggested to be affected by the lack of visual feedback in blind individuals. In addition, the presence of voluntary movement can be responsible for suppressing somatosensory information processed by the cortex, which might lead to a worse encoding of tactile information.</p><p><strong>Objectives: </strong>In this work, we aim to explore how cross-modal interaction can be affected by active movements and the role of vision in this process.</p><p><strong>Methods: </strong>To this end, we measured the precision of 18 blind individuals and 18 age-matched sighted controls in a velocity discrimination task. The participants were instructed to detect the faster stimulus between a sequence of two in both passive and active touch conditions. The sensory stimulation could be either just tactile or audio-tactile, where a non-informative sound co-occurred with the tactile stimulation. The measure of precision was obtained by computing the just noticeable difference (JND) of each participant.</p><p><strong>Results: </strong>The results show worse precision with the audio-tactile sensory stimulation in the active condition for the sighted group (<i>p</i> = 0.046) but not for the blind one (<i>p</i> = 0.513). For blind participants, only the movement itself had an effect.</p><p><strong>Conclusions: </strong>For sighted individuals, the presence of noise from active touch made them vulnerable to auditory interference. However, the blind group exhibited less sensory interaction, experiencing only the detrimental effect of movement. Our work should be considered when developing next-generation haptic devices.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Direct Current Stimulation Enhances Motor Performance by Modulating Beta-Phase Synchronization in the Sensorimotor Network: A Preliminary Study.","authors":"Eri Miyauchi, Yoshiki Henmi, Masahiro Kawasaki","doi":"10.3390/brainsci15030286","DOIUrl":"10.3390/brainsci15030286","url":null,"abstract":"<p><strong>Background/objectives: </strong>Synchronized beta-band oscillations (14-30 Hz) are critical for sensorimotor processing and motor performance. Modulating beta activity either locally in targeted brain regions or globally across sensorimotor networks may enhance motor function. This study aimed to explore whether transcranial direct current stimulation (tDCS) and alternating current stimulation (tACS) could enhance sensorimotor responses by modulating beta-band synchronization.</p><p><strong>Methods: </strong>Eight participants performed a stimulus-response task requiring a quick keypress to a visual cue. Response times (RTs) and electroencephalography (EEG) data were recorded during pre-, in-, and post-stimulation sessions for five conditions: motor-anodal tDCS, visual-anodal tDCS, alpha (10 Hz) tACS, beta (20 Hz) tACS, and sham, with a one-week interval between conditions.</p><p><strong>Results: </strong>Significant RT reductions were observed only after motor-anodal tDCS. EEG analysis revealed a positive correlation between these RT reductions and increased beta-phase synchronization between visual and motor areas. In contrast, tACS conditions did not yield significant RT improvements or beta-phase synchronization changes.</p><p><strong>Conclusions: </strong>These findings indicate that motor-anodal tDCS has the potential to enhance sensorimotor performance by facilitating beta-phase synchronization across the visual-motor network. The observed effects likely extend beyond localized neuronal modulation, emphasizing the importance of network-level connectivity in sensorimotor integration. Beta-phase synchronization appears to play a critical role in integrating visual and motor information, contributing to task-related performance improvements. Further research is warranted to build upon these findings and fully elucidate the underlying mechanisms.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}