Brain Sciences最新文献

{"title":"Dynamic Neural Network States During Social and Non-Social Cueing in Virtual Reality Working Memory Tasks: A Leading Eigenvector Dynamics Analysis Approach.","authors":"Pinar Ozel","doi":"10.3390/brainsci15010004","DOIUrl":"10.3390/brainsci15010004","url":null,"abstract":"<p><strong>Background/objectives: </strong>This research investigates brain connectivity patterns in reaction to social and non-social stimuli within a virtual reality environment, emphasizing their impact on cognitive functions, specifically working memory.</p><p><strong>Methods: </strong>Employing the LEiDA framework with EEG data from 47 participants, I examined dynamic brain network states elicited by social avatars compared to non-social stick cues during a VR memory task. Through the integration of LEiDA with deep learning and graph theory analyses, unique connectivity patterns associated with cue type were discerned, underscoring the substantial influence of social cues on cognitive processes. LEiDA, conventionally utilized with fMRI, was creatively employed in EEG to detect swift alterations in brain network states, offering insights into cognitive processing dynamics.</p><p><strong>Results: </strong>The findings indicate distinct neural states for social and non-social cues; notably, social cues correlated with a unique brain state characterized by increased connectivity within self-referential and memory-processing networks, implying greater cognitive engagement. Moreover, deep learning attained approximately 99% accuracy in differentiating cue contexts, highlighting the efficacy of prominent eigenvectors from LEiDA in EEG analysis. Analysis of graph theory also uncovered structural network disparities, signifying enhanced integration in contexts involving social cues.</p><p><strong>Conclusions: </strong>This multi-method approach elucidates the dynamic influence of social cues on brain connectivity and cognition, establishing a basis for VR-based cognitive rehabilitation and immersive learning, wherein social signals may significantly enhance cognitive function.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Planning Improved After Cycling Exercise in Older Adults with Down Syndrome.","authors":"Shannon D R Ringenbach, Nathaniel E Arnold, Forouzan Rafiei Rezvani, Chih-Chia Chen","doi":"10.3390/brainsci15010002","DOIUrl":"10.3390/brainsci15010002","url":null,"abstract":"<p><strong>Background/objectives: </strong>Cognitive functions are a crucial part of daily living, especially for adults with Down syndrome (DS) who have a high likelihood of developing Alzheimer's disease in adulthood. In addition, adults with DS move slower and are not meeting the standard aerobic activity guidelines each week. The aim of this study was to examine if Assisted Cycle Therapy (ACT) would improve cognitive planning as measured by the Tower of London (TOL), set switching as measured by the modified Wisconsin Card Sorting Test, and spatial memory as measured by the Corsi Block Test in adults with DS as compared to self-paced cycling.</p><p><strong>Methods: </strong>Twenty-four participants were randomly assigned to one of two interventions over eight weeks. (1) Thirteen older adults with DS completed the ACT intervention, which is stationary cycling with the assistance of a motor to maintain a cadence at least 35% greater than voluntary cycling. (2) Eleven older adults with DS completed voluntary cycling (VC).</p><p><strong>Results: </strong>Our results showed that cognitive planning as measured by total correct score in the TOL showed improvement for both ACT and VC after 8 weeks of exercise, F(1, 22) = 6.22, <i>p</i> = 0.021. There were no significant differences for spatial memory or set switching.</p><p><strong>Conclusions: </strong>We concluded that cycling exercise has a positive impact on cognitive function, especially problem solving in older adults with DS. Our results are discussed with respect to upregulation of neurotrophic factors that increase functioning in the prefrontal cortex that accompanies exercise and leads to improvements in cognitive planning which is essential to many activities of daily living and quality of life for older adults with DS.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Anterior Choroidal Artery Aneurysms: A Retrospective Cohort Study.","authors":"Andrew Falzon, Shigeta Miyake, Tze Phei Kee, Hugo Andrade-Barazarte, Timo Krings","doi":"10.3390/brainsci15010005","DOIUrl":"10.3390/brainsci15010005","url":null,"abstract":"<p><p><b>Background:</b> Anterior choroidal artery (AChoA) aneurysms pose a challenge for both endovascular and clipping procedures. The eloquent territory supplied by the parent vessel has limited collateralization and its compromise can lead to significant morbidity. This study aims to analyze the clinical outcomes and procedure-related complications of clipping and endovascular treatment of AChoA aneurysms to aid physician decision making. <b>Methods:</b> Thirty-two ruptured and unruptured AChoA aneurysms that underwent catheter angiography at a single neurovascular center between January 2000 and December 2023 were included. Either conservative management, clipping, and/or endovascular treatment were performed. Clinical outcomes and complications were analyzed retrospectively. <b>Results:</b> Twenty-four endovascular treatments and seven clipping procedures were included. Of the total 24 endovascular procedures, 46% were primary coiling, 25% were balloon-assisted coiling, 13% were flow diverting stent, 8% were combined balloon-assisted coiling and flow diverting stent, and 8% were combined balloon-assisted and stent-assisted coiling. There was no procedure-related mortality in both groups. No intra- or post-procedural ruptures/re-ruptures occurred during follow-up in both endovascular and clipping cohorts. AChoA territory infarcts occurred in 4% of the endovascular and 29% of the clipping cohorts. Other thromboembolic complications occurred in 4% of the endovascular cohort. The recurrence rate requiring retreatment was 12.5% for the endovascular and 43% for the clipping cohort. A favorable clinical outcome (mRS ≤ 2) was 78% for the endovascular cohort and 67% for the clipping cohort. <b>Conclusions:</b> Endovascular and clipping outcomes align with prior studies, with endovascular showing a favorable safety profile. Both approaches are viable, though they present distinct risks and advantages.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological Entrainment: A Key Mind-Body Mechanism for Cognitive, Motor and Affective Functioning, and Well-Being.","authors":"Marco Barbaresi, Davide Nardo, Sabrina Fagioli","doi":"10.3390/brainsci15010003","DOIUrl":"10.3390/brainsci15010003","url":null,"abstract":"<p><strong>Background: </strong>The human sensorimotor system can naturally synchronize with environmental rhythms, such as light pulses or sound beats. Several studies showed that different styles and tempos of music, or other rhythmic stimuli, have an impact on physiological rhythms, including electrocortical brain activity, heart rate, and motor coordination. Such synchronization, also known as the \"entrainment effect\", has been identified as a crucial mechanism impacting cognitive, motor, and affective functioning.</p><p><strong>Objectives: </strong>This review examines theoretical and empirical contributions to the literature on entrainment, with a particular focus on the physiological mechanisms underlying this phenomenon and its role in cognitive, motor, and affective functions. We also address the inconsistent terminology used in the literature and evaluate the range of measurement approaches used to assess entrainment phenomena. Finally, we propose a definition of \"physiological entrainment\" that emphasizes its role as a fundamental mechanism that encompasses rhythmic interactions between the body and its environment, to support information processing across bodily systems and to sustain adaptive motor responses.</p><p><strong>Methods: </strong>We reviewed the recent literature through the lens of the \"embodied cognition\" framework, offering a unified perspective on the phenomenon of physiological entrainment.</p><p><strong>Results: </strong>Evidence from the current literature suggests that physiological entrainment produces measurable effects, especially on neural oscillations, heart rate variability, and motor synchronization. Eventually, such physiological changes can impact cognitive processing, affective functioning, and motor coordination.</p><p><strong>Conclusions: </strong>Physiological entrainment emerges as a fundamental mechanism underlying the mind-body connection. Entrainment-based interventions may be used to promote well-being by enhancing cognitive, motor, and affective functions, suggesting potential rehabilitative approaches to enhancing mental health.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regression-Based Classification of the Middle-Latency Auditory-Evoked Potentials in Vestibular Migraine and Concussion Patients with Dizziness.","authors":"Carolina Beppi, Daniel Agostino, Antonella Palla, Nina Feddermann-Demont, Julia Dlugaiczyk, Dominik Straumann","doi":"10.3390/brainsci15010001","DOIUrl":"10.3390/brainsci15010001","url":null,"abstract":"<p><strong>Background/objectives: </strong>The auditory middle-latency responses (AMLRs) assess central sensory processing beyond the brainstem and serve as a measure of sensory gating. They have clinical relevance in the diagnosis of neurological conditions. In this study, magnitude and habituation of the AMLRs were tested for sensitivity and specificity in classifying dizzy patients with vestibular migraine (VM) and post-concussive syndrome.</p><p><strong>Methods: </strong>Twenty-three healthy individuals, 12 concussion and 26 VM patients were recruited. AMLR were recorded performing five blocks of 200 binaural click-stimulations at 60 dB sensation level with a repetition rate of 6.1 Hz. Reduction in P0, Na and Pa magnitudes between blocks was measured. Group classifications were performed through logistic and multiple regression.</p><p><strong>Results: </strong>Among healthy subjects, a consistent P0 and Na habituation can be observed. Concussed subjects show control-like Na habituation, despite a lower magnitude, while P0 habituation was negligible. VM patients showed poor habituation for all waves. Regression analyses suggest that P0 and Na better distinguish healthy subjects from neurological patients, whereas Pa best distinguishes concussion from VM patients.</p><p><strong>Conclusions: </strong>The results support that AMLR habituation can contribute to unraveling different mechanisms of dizziness due to concussion compared to VM, providing insights that can complement routine diagnostic assessments.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Related Decline in Disengaging Spatial Attention in Physiological Aging.","authors":"Tiziana Pedale, Serena Mastroberardino, Nicola Tambasco, Valerio Santangelo","doi":"10.3390/brainsci15010006","DOIUrl":"10.3390/brainsci15010006","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Attention is a complex process involving various components such as alerting, orienting, and resolving conflicts. These components have been widely examined using the Attention Network Test (ANT), which has also been used to explore attentional decline associated with aging. However, discrepancies exist in the literature regarding which specific aspects of attention are most impacted by aging. These inconsistencies could be due to methodological issues such as group comparisons that may exaggerate differences between groups while flattening subtle variations within groups. <b>Methods:</b> To address this issue, we administered the ANT to 60 healthy participants aged between 62 and 90 years. Using a multivariate regression analysis, we examined whether increasing age was associated with changes in alerting, orienting, and conflict resolution, while controlling for overall performance in terms of both reaction times and accuracy. <b>Results:</b> The results showed a general and age-insensitive decline in two of the three attentional components: the alerting effect, which was abolished, and a large conflict effect, which was present regardless of age. In contrast, the orienting of spatial attention was found to linearly increase with increasing age. More focused analyses revealed that the ability to shift attention from the central (initial) to the peripheral (target) location slowed down as a function of age. <b>Conclusions:</b> These results suggest that aging is associated with a greater difficulty in disengaging endogenous attention from the central, uninformative cue to direct attention on task-relevant peripheral targets.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"15 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew.","authors":"Shawn G Rhind, Maria Y Shiu, Oshin Vartanian, Shamus Allen, Miriam Palmer, Joel Ramirez, Fuqiang Gao, Christopher J M Scott, Meissa F Homes, Gary Gray, Sandra E Black, Joan Saary","doi":"10.3390/brainsci14121296","DOIUrl":"https://doi.org/10.3390/brainsci14121296","url":null,"abstract":"<p><strong>Background/objectives: </strong>Military aviators can be exposed to extreme physiological stressors, including decompression stress, G-forces, as well as intermittent hypoxia and/or hyperoxia, which may contribute to neurobiological dysfunction/damage. This study aimed to investigate the levels of neurological biomarkers in military aviators to assess the potential risk of long-term brain injury and neurodegeneration.</p><p><strong>Methods: </strong>This cross-sectional study involved 48 Canadian Armed Forces (CAF) aviators and 48 non-aviator CAF controls. Plasma samples were analyzed for biomarkers of glial activation (GFAP), axonal damage (NF-L, pNF-H), oxidative stress (PRDX-6), and neurodegeneration (T-tau), along with S100b, NSE, and UCHL-1. The biomarker concentrations were quantified using multiplexed immunoassays.</p><p><strong>Results: </strong>The aviators exhibited significantly elevated levels of GFAP, NF-L, PRDX-6, and T-tau compared to the CAF controls (<i>p</i> < 0.001), indicating increased glial activation, axonal injury, and oxidative stress. Trends toward higher levels of S100b, NSE, and UCHL-1 were observed but were not statistically significant. The elevated biomarker levels suggest cumulative brain damage, raising concerns about potential long-term neurological impairments.</p><p><strong>Conclusions: </strong>Military aviators are at increased risk for neurobiological injury, including glial and axonal damage, oxidative stress, and early neurodegeneration. These findings emphasize the importance of proactive monitoring and further research to understand the long-term impacts of high-altitude flight on brain health and to develop strategies for mitigating cognitive decline and neurodegenerative risks in this population.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"14 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-Induced Brain Injury: Mechanistic Insights and the Promise of Gut-Brain Axis Therapies.","authors":"Mengting Li, Fan Tong, Bian Wu, Xiaorong Dong","doi":"10.3390/brainsci14121295","DOIUrl":"https://doi.org/10.3390/brainsci14121295","url":null,"abstract":"<p><p>Radiation therapy is widely recognized as an efficacious modality for treating neoplasms located within the craniofacial region. Nevertheless, this approach is not devoid of risks, predominantly concerning potential harm to the neural structures. Adverse effects may encompass focal cerebral necrosis, cognitive function compromise, cerebrovascular pathology, spinal cord injury, and detriment to the neural fibers constituting the brachial plexus. With increasing survival rates among oncology patients, evaluating post-treatment quality of life has become crucial in assessing the benefits of radiation therapy. Consequently, it is imperative to investigate therapeutic strategies to mitigate cerebral complications from radiation exposure. Current management of radiation-induced cerebral damage involves corticosteroids and bevacizumab, with preclinical research on antioxidants and thalidomide. Despite these efforts, an optimal treatment remains elusive. Recent studies suggest the gut microbiota's involvement in neurologic pathologies. This review aims to discuss the causes and existing treatments for radiation-induced cerebral injury and explore gut microbiota modulation as a potential therapeutic strategy.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"14 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Description of the Role of the Relationship Between Serum Amyloid P Components and Nuclear Factors/Pro-Cytokines During Critical Periods of Toxoplasmic Encephalitis.","authors":"Gungor Cagdas Dincel, Hasan Tarik Atmaca, Saeed El-Ashram","doi":"10.3390/brainsci14121298","DOIUrl":"https://doi.org/10.3390/brainsci14121298","url":null,"abstract":"<p><p><b>Background/Objectives:</b><i>Toxoplasma gondii</i> (<i>T. gondii</i>), an obligate food-borne intracellular parasite, causes severe neuropathology by establishing a persistent infection in the host brain. We have previously shown that <i>T. gondii</i> infection induces severe neuropathology in the brain manifested by increased nitric oxide production, oxidative stress, glial activation/BBB damage, increased pro-inflammatory cytokine glia maturation factor-beta and induced apoptosis. <b>Methods:</b> The aim of this experimental study was to investigate the serum amyloid P (SAP) components, nuclear factor kappa B (NF-κB), interleukin-1 beta (IL-1β), caspase 1 (Casp 1), tumor necrosis factor-alpha (TNF-α) and complement 3 (C3) gene expressions on the 10th, 20th and 30th days after infection with <i>T. gondii</i> in the neuroimmunopathogenesis of toxoplasmic encephalitis (TE) in mouse brains by real-time quantitative polymerase chain reaction. The study also aimed to determine whether there was a correlation between the markers included in the study on these critical days, which had not previously been investigated. The mRNA expression levels of SAP components, NF-κB, IL-1β, Casp 1, TNF-α and C3 were examined. <b>Results:</b> The most notable outcome of this investigation was the observation that SAP components exhibited a 13.9-fold increase on day 10 post-infection, followed by a rapid decline in the subsequent periods. In addition, IL-1β expression increased 20-fold, while SAP components decreased 13-fold on day 20 after infection. Additionally, the TNF-α, Casp 1 and NF-κB expression levels were consistently elevated to above normal levels at each time point. <b>Conclusions:</b> This study identified SAP components, NF-κB, IL-1β, Casp 1 and TNF-α expressions as playing critical roles in TE neuroimmunopathogenesis. Furthermore, to the best of our knowledge, this is the first study to investigate SAP components during the transition from acute systemic infection to early/medium chronic and chronic infection and to explore the relationship between SAP components and other nuclear factors/pro-cytokines.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"14 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Rhythmicity, Depressive Ruminative Thinking and Suicidal Ideation as Possible Correlates of an Unrecognized Autism Spectrum in Patients with Borderline Personality Disorder.","authors":"Ivan Mirko Cremone, Liliana Dell'Osso, Benedetta Nardi, Federico Giovannoni, Francesca Parri, Cristiana Pronestì, Chiara Bonelli, Gabriele Massimetti, Stefano Pini, Barbara Carpita","doi":"10.3390/brainsci14121297","DOIUrl":"https://doi.org/10.3390/brainsci14121297","url":null,"abstract":"<p><strong>Background/objectives: </strong>Recent research has explored the presence of subthreshold autistic traits (ATs) in individuals with borderline personality disorder (BPD), suggesting that these traits may contribute to the severity of BPD symptoms and increase the risk of other mental health issues, including suicidal behaviors. This study aims to investigate the relationship between ATs and affective symptoms, such as mood instability and suicidality, in people diagnosed with BPD.</p><p><strong>Methods: </strong>A total of 48 subjects with BPD were assessed with self-report questionnaires including the Adult Autism Subthreshold Spectrum (AdAS Spectrum), the mood spectrum self-report version (MOODS-SR) and the ruminative response scale (RRS).</p><p><strong>Results: </strong>Subjects with significant ATs scored higher than BPD subjects in all domains and in the total score of AdAS Spectrum, RRS, and MOODS-SR, as well as in the items investigating suicidality. RRS total score, its depression domain, and the MOODS-SR rhythmicity domain, as well as suicidality, were predictors of the presence of ATs.</p><p><strong>Conclusions: </strong>Our data confirm the relationship between the presence of clinically significant ATs and affective symptoms, ruminative thinking, and suicidality in patients with BPD.</p>","PeriodicalId":9095,"journal":{"name":"Brain Sciences","volume":"14 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}