自闭症谱系障碍儿童的睡眠障碍:发育影响和干预策略。

IF 2.8 3区 医学 Q3 NEUROSCIENCES
Maria Ludovica Albertini, Giulia Spoto, Graziana Ceraolo, Maria Flavia Fichera, Carla Consoli, Antonio Gennaro Nicotera, Gabriella Di Rosa
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引用次数: 0

摘要

睡眠障碍在自闭症谱系障碍(ASD)儿童中非常普遍,严重影响他们的神经发育和日常功能。睡眠结构和调节机制的改变有助于睡眠开始、维持和整体睡眠质量的困难。通常在ASD中观察到的感觉加工差异可能会通过影响睡眠中的唤醒调节和环境反应而进一步加剧这些障碍。鉴于睡眠在大脑成熟中的基本作用,睡眠的中断会对突触可塑性和神经发育产生负面影响,特别是在关键时期。这些与睡眠相关的改变可以影响认知和行为结果,并可能作为ASD的早期指标,突出了它们在早期诊断和干预中的潜在价值。了解睡眠和ASD之间的神经生物学机制对于制定有针对性的治疗策略至关重要。正在进行的研究越来越多地集中在旨在减轻睡眠障碍及其对神经发育的级联效应的药理、营养和行为干预上。通过多学科视角优化这些治疗方法对于提高ASD儿童的临床结果和整体生活质量至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sleep Disorders in Children with Autism Spectrum Disorder: Developmental Impact and Intervention Strategies.

Sleep disorders are highly prevalent in children with Autism Spectrum Disorder (ASD), profoundly impacting their neurodevelopment and daily functioning. Alterations in sleep architecture and regulatory mechanisms contribute to difficulties with sleep onset, maintenance, and overall sleep quality. Sensory processing differences, commonly observed in ASD, may further exacerbate these disturbances by affecting arousal regulation and environmental responsiveness during sleep. Given the fundamental role of sleep in brain maturation, its disruption negatively impacts synaptic plasticity and neurological development, particularly during critical periods. These sleep-related alterations can influence cognitive and behavioral outcomes and may serve as early indicators of ASD, highlighting their potential value in early diagnosis and intervention. Understanding the neurobiological mechanisms linking sleep and ASD is essential for developing targeted therapeutic strategies. Ongoing research increasingly focuses on pharmacological, nutraceutical, and behavioral interventions aimed at mitigating sleep disorders and their cascading effects on neurodevelopment. Optimizing these therapeutic approaches through a multidisciplinary lens is crucial for enhancing clinical outcomes and improving overall quality of life in children with ASD.

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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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