Brazilian Journal of Medical and Biological Research最新文献_第2页

Mesenchymal stem cells from different sources for sepsis treatment: prospects and limitations. 不同来源的间充质干细胞用于败血症治疗：前景与局限。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13457

Heng Chen, Xiaosui Ling, Bo Zhao, Jing Chen, XianYi Sun, Jing Yang, Pibao Li

引用次数: 0

Multipotent mesenchymal stromal/stem cell-based therapies for acute respiratory distress syndrome: current progress, challenges, and future frontiers. 基于多能间充质基质/干细胞的急性呼吸窘迫综合征疗法：当前进展、挑战和未来前沿。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13219

M Sababathy, G Ramanathan, S Ganesan, S Sababathy, A R Yasmin, R Ramasamy, J B Foo, Q H Looi, S H Nur-Fazila

{"title":"Multipotent mesenchymal stromal/stem cell-based therapies for acute respiratory distress syndrome: current progress, challenges, and future frontiers.","authors":"M Sababathy, G Ramanathan, S Ganesan, S Sababathy, A R Yasmin, R Ramasamy, J B Foo, Q H Looi, S H Nur-Fazila","doi":"10.1590/1414-431X2024e13219","DOIUrl":"https://doi.org/10.1590/1414-431X2024e13219","url":null,"abstract":"Acute respiratory distress syndrome (ARDS) is a critical, life-threatening condition marked by severe inflammation and impaired lung function. Mesenchymal stromal/stem cells (MSCs) present a promising therapeutic avenue due to their immunomodulatory, anti-inflammatory, and regenerative capabilities. This review comprehensively evaluates MSC-based strategies for ARDS treatment, including direct administration, tissue engineering, extracellular vesicles (EVs), nanoparticles, natural products, artificial intelligence (AI), gene modification, and MSC preconditioning. Direct MSC administration has demonstrated therapeutic potential but necessitates optimization to overcome challenges related to effective cell delivery, homing, and integration into damaged lung tissue. Tissue engineering methods, such as 3D-printed scaffolds and MSC sheets, enhance MSC survival and functionality within lung tissue. EVs and MSC-derived nanoparticles offer scalable and safer alternatives to cell-based therapies. Likewise, natural products and bioactive compounds derived from plants can augment MSC function and resilience, offering complementary strategies to enhance therapeutic outcomes. In addition, AI technologies could aid in optimizing MSC delivery and dosing, and gene editing tools like CRISPR/Cas9 allow precise modification of MSCs to enhance their therapeutic properties and target specific ARDS mechanisms. Preconditioning MSCs with hypoxia, growth factors, or pharmacological agents further enhances their therapeutic potential. While MSC therapies hold significant promise for ARDS, extensive research and clinical trials are essential to determine optimal protocols and ensure long-term safety and effectiveness.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of convalescent plasma in hospitalized COVID-19 patients: findings from a controlled trial. 疗养血浆对 COVID-19 住院患者的疗效：一项对照试验的结果。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13627

T P Costa, M Aoki, C M Ribeiro, E Socca, L Itinose, R Basso, L Blanes

{"title":"Efficacy of convalescent plasma in hospitalized COVID-19 patients: findings from a controlled trial.","authors":"T P Costa, M Aoki, C M Ribeiro, E Socca, L Itinose, R Basso, L Blanes","doi":"10.1590/1414-431X2024e13627","DOIUrl":"10.1590/1414-431X2024e13627","url":null,"abstract":"The COVID-19 pandemic has driven the search for alternative therapies, including convalescent plasma, historically used in infectious diseases. Despite results in other diseases, its effectiveness against COVID-19 remains uncertain with conflicting results in clinical trials. A pragmatic, single-center, prospective, and open randomized controlled trial was carried out in a hospital in Brazil, with the aim of evaluating the impact of convalescent plasma on the clinical improvement of patients hospitalized with COVID-19. The World Health Organization (WHO) ordinal scale was used to measure clinical improvement, focusing on the reduction in disease severity by up to 2 points, while antibody and C-reactive protein levels were monitored over time. After hospital admission, participants were randomized 1:1 to receive convalescent plasma and standard treatment or to be part of the control group with standard treatment. Follow-up was carried out on days 1, 3, 7, 14 and/or at discharge. From January 14 to April 4, 2022, 38 patients were included, but 3 were excluded due to protocol deviations, resulting in a total of 35 patients: 19 in the control group and 16 in the plasma group. There was no significant difference in clinical improvement between the convalescent plasma group and the control group, nor in secondary outcomes. The study had limitations due to the small number of patients and limited representation of COVID-19 cases. Broader investigations are needed to integrate therapies into medical protocols, both for COVID-19 and other diseases. Conducting randomized studies is challenging due to the complexity of medical conditions and the variety of treatments available.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating JKAP levels may correlate with postpartum anxiety and depression through its interaction with T helper 17 cells. 通过与 T 辅助细胞 17 的相互作用，循环中的 JKAP 水平可能与产后焦虑和抑郁有关。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13253

Jing Zhang, Cui Li, Zhuo Chen, Xiaoling Zhao, Yuanyuan He, Lei Wei, Nana Kong

{"title":"Circulating JKAP levels may correlate with postpartum anxiety and depression through its interaction with T helper 17 cells.","authors":"Jing Zhang, Cui Li, Zhuo Chen, Xiaoling Zhao, Yuanyuan He, Lei Wei, Nana Kong","doi":"10.1590/1414-431X2024e13253","DOIUrl":"10.1590/1414-431X2024e13253","url":null,"abstract":"Jun N-terminal kinase pathway-associated phosphatase (JKAP) regulates CD4+ T-cell differentiation and immunity, which are linked to mental disorders. This study aimed to explore the relationships between JKAP and T helper 17 (Th17)/regulatory T (Treg) ratio, as well as their associations with anxiety and depression in postpartum women. Serum JKAP were measured by enzyme-linked immunosorbent assay and blood Th17 and Treg cells were measured by flow cytometry in 250 postpartum women. Anxiety and depression were evaluated by the 6-item State-Trait Anxiety Inventory (STAI6) and Edinburgh Postnatal Depression Scale (EPDS). Anxiety and depression rates were 22.0 and 28.4%, respectively, among postpartum women. Notably, JKAP was negatively associated with the STAI6 (P=0.002) and EPDS scores (P<0.001) in postpartum women and was lower in postpartum women with anxiety (P=0.023) or depression (P=0.002) than in those without. Moreover, JKAP was inversely related to Th17 cells and Th17/Treg ratio but positively correlated with Treg cells in postpartum women (all P<0.001). Interestingly, Th17 cells and Th17/Treg ratio were both positively associated with STAI6 and EPDS scores in postpartum women (all P<0.001). Furthermore, Th17 cells and Th17/Treg ratio were lower in postpartum women with anxiety or depression than in those without (all P<0.01). Nevertheless, Treg cells were not linked to anxiety or depression in postpartum women. JKAP was negatively associated with Th17 cells and Th17/Treg ratio; moreover, they all related to anxiety and depression in postpartum women, indicating that JKAP may be involved in postpartum anxiety and depression via interactions with Th17 cells.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amelioration of nephrotoxicity by targeting ferroptosis: role of NCOA4, IREB2, and SLC7a11 signaling. 通过靶向铁变态反应改善肾毒性：NCOA4、IREB2 和 SLC7a11 信号的作用。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13116

N Sharawy, B E Aboulhoda, M M Khalifa, G N Morcos, S A A G Morsy, M A Alghamdi, I M Khalifa, W A Abd Algaleel

{"title":"Amelioration of nephrotoxicity by targeting ferroptosis: role of NCOA4, IREB2, and SLC7a11 signaling.","authors":"N Sharawy, B E Aboulhoda, M M Khalifa, G N Morcos, S A A G Morsy, M A Alghamdi, I M Khalifa, W A Abd Algaleel","doi":"10.1590/1414-431X2024e13116","DOIUrl":"10.1590/1414-431X2024e13116","url":null,"abstract":"Nephrotoxicity is a common complication that limits the clinical utility of cisplatin. Ferroptosis is an iron-dependent necrotic cell death program that is mediated by phospholipid peroxidation. The molecular mechanisms that disrupt iron homeostasis and lead to ferroptosis are yet to be elucidated. In this study, we aimed to investigate the involvement of nuclear receptor coactivator 4 (NCOA4), a selective cargo receptor that mediates ferroptosis and autophagic degradation of ferritin in nephrotoxicity. Adult male Sprague-Dawley rats were randomly-assigned to four groups: control group, cisplatin (Cis)-treated group, deferiprone (DEF)-treated group, and Cis+DEF co-treated group. Serum, urine, and kidneys were isolated to perform biochemical, morphometric, and immunohistochemical analysis. Iron accumulation was found to predispose to ferroptotic damage of the renal tubular cells. Treatment with deferiprone highlights the role of ferroptosis in nephrotoxicity. Upregulation of NCOA4 in parallel with low ferritin level in renal tissue seems to participate in iron-induced ferroptosis. This study indicated that ferroptosis may participate in cisplatin-induced tubular cell death and nephrotoxicity through iron-mediated lipid peroxidation. Iron dyshomeostasis could be attributed to NCOA4-mediated ferritin degradation.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteogenic mechanism of deciduous teeth periodontal ligament stem cells in inflammatory environment. 炎症环境下乳牙牙周韧带干细胞的成骨机制。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13606

Jin-Yi Li, Shan-Shan Dai, Zheng-Yang Li, Qing-Yu Guo, Fei Liu

{"title":"Osteogenic mechanism of deciduous teeth periodontal ligament stem cells in inflammatory environment.","authors":"Jin-Yi Li, Shan-Shan Dai, Zheng-Yang Li, Qing-Yu Guo, Fei Liu","doi":"10.1590/1414-431X2024e13606","DOIUrl":"10.1590/1414-431X2024e13606","url":null,"abstract":"This study aimed to illustrate the biological behavior and changes in cell function during the progression of apical periodontitis in deciduous teeth and to explore the underlying molecular mechanism. Deciduous teeth periodontal ligament stem cells (DePDLSCs) were derived and their identity was confirmed. The viability, inflammation, and osteogenic ability of cells were tested by exposing them to various concentrations of lipopolysaccharide (LPS) (0-100 μg/mL) using the cell counting kit-8 (CCK-8) assay, reverse transcription polymerase chain reaction (real-time PCR), alkaline phosphatase (ALP) staining, and ALP activity assay. In addition, osteogenic-induced cells with and without 10 μg/mL LPS were harvested for high-throughput sequencing. Based on sequencing data, proinflammatory factors and ALP expression were measured after interference with the PI3K-AKT signaling pathway activator, 740Y-P. LPS biphasically affected the proliferation and osteogenesis of DePDLSCs. Low concentrations of LPS showed stimulatory effects, whereas inhibitory effects were observed at high concentrations. Sequencing analysis showed that the PI3K-AKT signaling pathway was significantly downregulated when DePDLSCs were treated with 10 μg/mL LPS. The LPS-induced inflammation and osteogenesis inhibition of DePDLSCs were partially rescued by 740Y-P treatment. In conclusion, LPS affected DePDLSCs proliferation and osteogenesis in a biphasic manner. Moderate activation of PI3K-AKT signaling pathway was beneficial for osteogenic differentiation and anti-inflammatory effect in DePDLSCs. This research may provide etiological probes for apical periodontitis and its treatment.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effect of venetoclax and ibrutinib on ibrutinib-resistant ABC-type DLBCL cells. venetoclax和伊布替尼对伊布替尼耐药的ABC型DLBCL细胞具有协同作用。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13278

Fengbo Jin, Limei He, Yingying Chen, Wanlu Tian, Lixia Liu, Ling Ge, Wei Qian, Leiming Xia, Mingzhen Yang

{"title":"Synergistic effect of venetoclax and ibrutinib on ibrutinib-resistant ABC-type DLBCL cells.","authors":"Fengbo Jin, Limei He, Yingying Chen, Wanlu Tian, Lixia Liu, Ling Ge, Wei Qian, Leiming Xia, Mingzhen Yang","doi":"10.1590/1414-431X2024e13278","DOIUrl":"10.1590/1414-431X2024e13278","url":null,"abstract":"Despite the widespread use of R-CHOP therapy in diffuse large B-cell lymphoma (DLBCL), the therapeutic efficacy for this disease remains suboptimal, primarily due to the heterogeneity of refractory and/or relapsed diseases. To address this challenge, optimization of DLBCL treatment regimens has focused on the strategy of combining an additional drug \"X\" with R-CHOP to enhance efficacy. However, the failure of R-CHOP combined with the BTK inhibitor ibrutinib in treating ABC-type DLBCL patients has raised significant concerns regarding ibrutinib resistance. While some studies suggest that venetoclax may synergize with ibrutinib to kill ibrutinib-resistant cells, the underlying mechanisms remain unclear. Our study aimed to validate the enhanced tumor-suppressive effect of combining ibrutinib with venetoclax against ibrutinib-resistant cells and elucidate its potential mechanisms. Our experimental results demonstrated that ibrutinib-resistant cells exhibited significant cytotoxicity to the combination therapy of ibrutinib and venetoclax, inducing cell apoptosis through activation of the mitochondrial pathway and inhibition of aerobic respiration. Furthermore, we validated the inhibitory effect of this combination therapy on tumor growth in in vivo models. Therefore, our study proposes that the combination therapy of ibrutinib and venetoclax is a promising treatment strategy that can be applied in clinical practice for ABC-type DLBCL, offering a new solution to overcome the urgent challenge of ibrutinib resistance.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential biomarkers as a predictive factor of response to primary chemotherapy in breast cancer patients. 作为乳腺癌患者初级化疗反应预测因素的潜在生物标志物。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13599

F O Buono, R D S Pugliese, W A da Silveira, D P C Tirapelli, F J C Dos Reis, J M de Andrade, H H A Carrara, D G Tiezzi

{"title":"Potential biomarkers as a predictive factor of response to primary chemotherapy in breast cancer patients.","authors":"F O Buono, R D S Pugliese, W A da Silveira, D P C Tirapelli, F J C Dos Reis, J M de Andrade, H H A Carrara, D G Tiezzi","doi":"10.1590/1414-431X2024e13599","DOIUrl":"10.1590/1414-431X2024e13599","url":null,"abstract":"In this study, we identified miRNAs and their potential mRNA targets that are intricately linked to primary chemotherapy response in patients with invasive ductal carcinomas. A cohort of individuals diagnosed with advanced invasive breast ductal carcinoma who underwent primary chemotherapy served as the cornerstone of our study. We conducted a comparative analysis of microRNA expression among patients who either responded or did not respond to primary systemic therapy. To analyze the correlation between the expression of the whole transcriptome and the 24 differentially expressed (DE) miRNAs, we harnessed the extensive repository of The Cancer Genome Atlas (TCGA) database. We mapped molecular mechanisms associated with these miRNAs and their targets from TCGA breast carcinomas. The resultant expression profile of the 24 DE miRNAs emerged as a potent and promising predictive model, offering insights into the intricate dynamics of chemotherapy responsiveness of advanced breast tumors. The discriminative analysis based on the principal component analysis identified the most representative miRNAs across breast cancer samples (miR-210, miR-197, miR-328, miR-519a, and miR-628). Moreover, the consensus clustering generated four possible clusters of TCGA patients. Further studies should be conducted to advance these findings.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner. NLRP1 通过介导线粒体失调，以炎性体外依赖的方式抑制肺腺癌的生长。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-09-06 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13885

Chen-Jing Lin, Guang-Ang Tian, Wen-Ya Zhao, Yi Tian, Yi-Ru Liu, Dian-Na Gu, Ling Tian

{"title":"NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner.","authors":"Chen-Jing Lin, Guang-Ang Tian, Wen-Ya Zhao, Yi Tian, Yi-Ru Liu, Dian-Na Gu, Ling Tian","doi":"10.1590/1414-431X2024e13885","DOIUrl":"10.1590/1414-431X2024e13885","url":null,"abstract":"NLRP1, the first identified inflammasome-forming sensor, is thought to be involved in cancer, yet its definite function in lung adenocarcinoma (LUAD) remains unclear. Herein, we explored the expression and function of NLRP1 in LUAD. Decreased NLRP1 expression was identified in LUAD, which was associated with a poor prognosis. Overexpression of NLRP1 inhibited tumor growth in vitro and in vivo. Mechanically, this effect was observed regardless of inflammasome activation. Further studies revealed that overexpression of NLRP1 downregulated the phosphorylation of DRP1 and promoted mitochondrial fusion, which was mediated by inhibition of NF-κB activity. NF-κB agonist could neutralize the effect of NLRP1 on mitochondrial dynamics. In addition, LUAD sensitivity to cisplatin was enhanced by decreased mitochondrial fission resulting from up-regulated NLRP1. In conclusion, our findings demonstrated an unexpected role of NLRP1 in LUAD by modulating mitochondrial activities, which provides strong evidence for its potential in LUAD treatment.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive behavioral stress management effectively facilitates neurologic recovery, alleviates mental distress, and elevates health status in acute ischemic stroke patients. 认知行为压力管理能有效促进急性缺血性脑卒中患者的神经功能恢复、减轻精神压力并改善健康状况。

IF 1.9 4区医学

Brazilian Journal of Medical and Biological Research Pub Date : 2024-09-06 eCollection Date: 2024-01-01 DOI: 10.1590/1414-431X2024e13689

Shihong Yue, Yue Yin, Jie Liu, Zhaojun Liu

{"title":"Cognitive behavioral stress management effectively facilitates neurologic recovery, alleviates mental distress, and elevates health status in acute ischemic stroke patients.","authors":"Shihong Yue, Yue Yin, Jie Liu, Zhaojun Liu","doi":"10.1590/1414-431X2024e13689","DOIUrl":"10.1590/1414-431X2024e13689","url":null,"abstract":"Cognitive behavioral stress management (CBSM) relieves physical and psychological burdens in patients with some central nervous system diseases, while its utility in acute ischemic stroke (AIS) patients is unclear. This study aimed to explore the effect of CBSM on neurologic recovery and psychosomatic health in AIS patients. Totally, 176 naive AIS patients were randomized into routine care (RC) group (n=88) and CBSM group (n=88) to receive a 3-month corresponding intervention. Modified Rankin scale (mRS) scores at the first month after discharge (M1) (P=0.008) and the third month after discharge (M3) (P=0.016) were lower in the CBSM group than in the RC group. The proportion of AIS patients with mRS score >2 at M3 was reduced in CBSM group vs RC group (P=0.045). Hospital anxiety depression scale (HADS)-anxiety score at M3 (P=0.016), HADS-depression score at M3 (P=0.005), and depression rate at M3 (P=0.021) were decreased in the CBSM group vs the RC group. EuroQol-5 dimension scores at M1 (P=0.024) and M3 (P=0.012) were decreased, while EuroQol-visual analogue scale score at M3 (P=0.026) was increased in the CBSM group vs the RC group. By subgroup analyses, CBSM had favorable outcomes in AIS patients with age ≤65 years. CBSM was beneficial to neurologic recovery and distress relief in AIS patients with an education level of middle school or above, and to health status in those with an education level of primary school or uneducated. In conclusion, CBSM benefitted neurologic recovery and psychosomatic health in AIS patients with minor neurological deficits, however, further studies should verify these results with a larger sample size and longer follow-up.","PeriodicalId":9088,"journal":{"name":"Brazilian Journal of Medical and Biological Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0