Effect of estradiol valerate on humoral immune function in BALB/c mice after total hysterectomy.

IF 1.9 4区 医学 Q2 BIOLOGY
Penghuan Chang, Hui Huang, Peijian Huang, Hongru Yi, Wenhua Zhong, Zhaoxin Yang
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引用次数: 0

Abstract

Total hysterectomy is a commonly performed gynecological procedure used to treat uterine pathologies. This study aimed to establish a total hysterectomy mouse model and investigate the effect of estradiol valerate on humoral immune function in BALB/c mice. Our results showed that the ratios of CD4+ and CD8+ subpopulation and hepatitis B virus antibody IgG content were reduced in the total hysterectomy (TH) group compared with the control group (P<0.05). The measured indices showed varying degrees of improvement after estradiol valerate administration. The numbers of CD19+ B lymphocytes significantly increased in the TH group (P<0.05) compared with the control group. There was a significant reduction of the size of germinal centers within lymph nodes in the TH group. This effect was reversed by estrogen supplementation. In summary, reduced estrogen levels following total hysterectomy may impair B lymphocyte activation, IgG secretion, and plasma cell production, leading to compromised immune function. Early treatment with estradiol valerate reverses impaired immune function and enhances antigen-induced antibody production in mice.

戊酸雌二醇对BALB/c小鼠全子宫切除术后体液免疫功能的影响。
全子宫切除术是一种常用的妇科手术,用于治疗子宫病变。本研究旨在建立全子宫切除小鼠模型,探讨戊酸雌二醇对BALB/c小鼠体液免疫功能的影响。结果显示,与对照组相比,全子宫切除术(TH)组CD4+和CD8+亚群比例及乙型肝炎病毒抗体IgG含量降低(P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
129
审稿时长
2 months
期刊介绍: The Brazilian Journal of Medical and Biological Research, founded by Michel Jamra, is edited and published monthly by the Associação Brasileira de Divulgação Científica (ABDC), a federation of Brazilian scientific societies: - Sociedade Brasileira de Biofísica (SBBf) - Sociedade Brasileira de Farmacologia e Terapêutica Experimental (SBFTE) - Sociedade Brasileira de Fisiologia (SBFis) - Sociedade Brasileira de Imunologia (SBI) - Sociedade Brasileira de Investigação Clínica (SBIC) - Sociedade Brasileira de Neurociências e Comportamento (SBNeC).
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