BMC Ophthalmology最新文献

{"title":"Multiple choroidal granulomas in lymphomatoid granulomatosis: a case report.","authors":"Ryo Taguchi, Yoshiaki Tanaka, Machiko Shimmura, Hiroko Takano, Akihiro Kakehashi, Toshikatsu Kaburaki","doi":"10.1186/s12886-025-04030-x","DOIUrl":"https://doi.org/10.1186/s12886-025-04030-x","url":null,"abstract":"<p><strong>Background: </strong>Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder predominantly affecting middle-aged men. The disease occurs primarily in the lungs; however, reports of lesions in intraocular regions are scarce. Herein, we report a case of choroidal granulomas in a patient with LYG.</p><p><strong>Case presentation: </strong>A 55-year-old male patient presented to a respiratory specialist with pneumonia of unknown cause. His serum-soluble IL-2 receptor level was highly elevated, and transbronchial lung biopsies revealed granulomatous lesions. Sarcoidosis was suspected, and an ophthalmological examination was performed. The best-corrected visual acuity was 1.2 in both eyes. Although no cells were present in the anterior chambers or anterior vitreous in either eye, multiple large yellowish-white exudates on the fundus of the right eye and soft exudates around the optic disc in the left eye were observed. Optical coherence tomography revealed choroidal granulomas consistent with the yellowish-white lesions in the right eye. Fluorescein angiography revealed tissue staining in the right eye consistent with granulomatous choroidal lesions. Both eyes showed capillaritis, mainly in the nasal retina. Subsequently, a thoracoscopic left lung biopsy led to a pathological diagnosis of LYG, and chemotherapy was initiated. Thereafter, the yellowish-white exudates gradually scarred, and the choroidal granulomas and soft exudates disappeared; thus, a vitreous biopsy was not performed. After autologous hematopoietic stem cell transplantation, the LYG was in remission. No ocular lesion recurrence was observed in the subsequent 18 months.</p><p><strong>Conclusions: </strong>LYG may cause multiple large choroidal granulomas.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"223"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of blood-count-derived inflammatory markers in patients with idiopathic epiretinal membrane.","authors":"Serdar Bilici, Kardelen Ezgi Şahin Elarslan, Numan Küçük, Suat Hayri Uğurbaş","doi":"10.1186/s12886-025-04047-2","DOIUrl":"https://doi.org/10.1186/s12886-025-04047-2","url":null,"abstract":"<p><strong>Background: </strong>To assess the role of inflammation in the pathogenesis of idiopathic epiretinal membrane (iERM) by evaluating blood-count-derived inflammatory marker levels.</p><p><strong>Methods: </strong>The medical records of patients diagnosed with iERM and cataract patients with normal fundus examinations were analyzed retrospectively. Levels of neutrophils, monocytes, lymphocytes, and thrombocytes were obtained from blood samples. Systemic inflammatory markers, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were calculated and compared between the two groups. The receiver operating characteristic curve (ROC) analysis was performed to determine the best cutoff value of NLR, PLR, SII, and SIRI in iERM.</p><p><strong>Results: </strong>In total, 91 iERM cases and 95 controls were included in the study. iERM patients had significantly higher NLR (2.25 vs. 1.91, p = 0.003), PLR (117.22 vs. 113.33, p = 0.042), SII (529.45 vs. 472.57, p = 0.003), and SIRI (1.25 vs. 0.90, p < 0.001). The area under the curve of NLR, PLR, SII, and SIRI in differentiating patients with iERM and controls was 0.637, 0.608, 0.645 and 0.660, respectively, according to ROC analysis. The best cutoff values (with sensitivity and specificity) were 1.95 (60.4% and 52.6%) for NLR, 116.7 (54.9% and 55.7%) for PLR, 498.03 (58.2% and 58.9%) for SII, and 1.07 (62.6% and 64.6%) for SIRI.No significant differences in inflammatory markers were found across iERM stages.</p><p><strong>Conclusion: </strong>Patients with iERM exhibit higher levels of blood-count-derived inflammatory markers, suggesting a link between systemic subclinical inflammation and iERM development. However, these markers do not correlate with iERM severity. Further research with larger cohorts and broader inflammatory marker analysis is needed to elucidate the role of systemic inflammation in iERM pathogenesis.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"228"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our results of the quadruple procedure in combined vitrectomy.","authors":"Mehmet Ozgur Zengin, Yusuf Ziya Güven, Mehmet Vural, Gozde Sahin Vural, Eyyup Karahan","doi":"10.1186/s12886-025-04018-7","DOIUrl":"https://doi.org/10.1186/s12886-025-04018-7","url":null,"abstract":"<p><strong>Purpose: </strong>To reveal the outcomes of combined phacovitrectomy and supplementary scleral buckling (SB) surgery in patients with inferior break retinal detachment (RD) and proliferative vitreoretinopathy (PVR) ≥ Stage-C.</p><p><strong>Methods: </strong>In this retrospective study, 22 eyes of 22 patients who underwent surgery in Bozyaka Training and Research Hospital between 2018 and 2020 were included. The demographic data, follow-up duration, preoperative & postoperative best-corrected visual acuity (BCVA) (Snellen), intraocular pressure (IOP), final anatomic status, and the recurrence rate of RD were recorded from the files of patients.</p><p><strong>Results: </strong>The mean age of the patients was 56.9 ± 15.2 years, and follow-up duration was 16.6 ± 10.2 months. The internal tamponade was silicone oil (SO) in 16 patients (72.7%), and perfluoropropane (C₃F₈) in 6 patients (27.2%). The BCVA was improved from 0.0065 ± 0.014 to 0.26 ± 0.17 after surgery (p:0,0001), and IOP changed from 12.3 ± 2.5 mmHg to 15.3 ± 2.4 mmHg. During follow-up period, the recurrent RD was only found in one patient (4.50%) and following to second surgery, anatomical success was achieved in all of the patients (100%) in final visit.</p><p><strong>Conclusion: </strong>The combined phacovitrectomy and SB is an effective and reliable surgical method in patients with inferior quadrant RD and advanced stage PVR.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"222"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing scleral wound suturing and non-suturing in 23-gauge vitrectomy combined with cataract phacoemulsification for the management of proliferative diabetic retinopathy.","authors":"Wu Hongyan, Zhao Guangjin, Zhou Hangshuai","doi":"10.1186/s12886-025-04068-x","DOIUrl":"https://doi.org/10.1186/s12886-025-04068-x","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the outcomes of scleral wound suturing and non-suturing in 23-gauge vitrectomy combined with cataract phacoemulsification on eyes with severe proliferative diabetic retinopathy.</p><p><strong>Methods: </strong>This retrospective cohort study enrolled patients with proliferative diabetic retinopathy who underwent a 23-step vitrectomy combined with cataract phacoemulsification. Scleral wounds were either sutured or left unsutured in sutured group and unsutured group, respectively. All patients were monitored for 6 months, undergoing slit-lamp examination, intraocular pressure measurement, fundus examination, and vision assessment.</p><p><strong>Results: </strong>A total of 79 eyes were enrolled in sutured group and 85 eyes in unsutured group. Both groups were well-matched for factors such as age, sex, intraocular pressure (IOP), hypertension, diabetes duration, HbA1c levels, visual acuity, retinal detachment, neovascular glaucoma, and preoperative pan-retinal photocoagulation. Despite scleral incision sutures in sutured group, there was no significant difference in surgical time between the groups. Silicone oil and gas tamponade were similarly used, and no significant differences in postoperative complications were found, except that scleral suturing potentially exacerbated conjunctival or scleral scarring. Sutured group had a lower incidence of hypotony, though IOP was not significantly different between groups after one week. For silicone oil tamponade, IOP was comparable between groups, while for gas tamponade, early postoperative IOP was significantly lower in unsutured group. The incidence of postoperative hypotension was higher in unsutured group with gas tamponade. Visual acuity recovery showed no disparity between the groups.</p><p><strong>Conclusion: </strong>For patients with proliferative diabetic retinopathy undergoing vitrectomy combined with cataract surgery, scleral incision suturing appeared to be more effective in maintaining intraocular pressure in the early stage, especially for those who had gas as the vitreous tamponade. However, this might worsened conjunctival or scleral scarring. There were no significant differences observed in postoperative complications and visual acuity recovery between patients with and without scleral wound suturing.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"226"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral sequential bacterial dacryoadenitis with abscess- a case report.","authors":"Lydia Lam, James Pietris, Clare Quigley, Garry Davis, James Slattery, Dinesh Selva","doi":"10.1186/s12886-025-04063-2","DOIUrl":"https://doi.org/10.1186/s12886-025-04063-2","url":null,"abstract":"<p><strong>Background: </strong>Acute dacryoadenitis is characterized by inflammation of the lacrimal gland, and is typically viral. Bacterial dacryoadenitis is rare, with Staphylococcus and Streptococcus species being the most common pathogens. The bilateral sequential onset of dacryoadenitis has not been described in the literature to date.</p><p><strong>Case presentation: </strong>A 54-year-old immunocompetent female presented to the emergency department with a 1-week history of left-sided periorbital swelling, erythema, and pain. Orbital computed tomography demonstrated significant soft tissue thickening and swelling surrounding the left orbit and a lacrimal gland abscess. Culture swabs were negative for microorganisms. Despite initial management with intravenous antibiotics and surgical drainage, the condition recurred post-discharge. Three years later, the patient experienced similar symptoms in the right eye. Cultures were repeatedly negative for microorganisms. Despite courses of intravenous antibiotics and surgical drainage, the patient experienced recurrences of abscesses in the right eye, highlighting the challenges in managing this rare condition.</p><p><strong>Conclusions: </strong>We describe a unique case of bilateral sequential bacterial dacryoadenitis with abscess formation. This case highlights the need for prompt diagnosis and management, including surgical intervention, to prevent complications and recurrences.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"227"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scleral tunneling combined with the Tenon's capsule coverage in Glaucoma Drainage Valve surgery.","authors":"Yihua Yao, Jinping Gong, Nuozhou Wu, Sinan Liu, Yan Lin, Qin Ye, Biting Zhou, Yihua Zhu, Xiaohui Wang","doi":"10.1186/s12886-025-04052-5","DOIUrl":"https://doi.org/10.1186/s12886-025-04052-5","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of an modified surgical technique using scleral tunneling and Tenon's capsule for implantation of the Ahmed Glaucoma Drainage Valve (AGV) in refractory glaucoma.</p><p><strong>Methods: </strong>This research involved the retrospective collection of data from 78 patients diagnosed with refractory glaucoma who underwent implantation of the AGV using a modified technique combining scleral tunneling with autologous Tenon's capsule. The analysis focused on preoperative and 60-month postoperative indices, which included the surgical technique employed, intraocular pressure (IOP) measurements, the utilization of antiglaucoma medications, rates of surgical success, and the incidence of postoperative complications.</p><p><strong>Results: </strong>The findings suggest that the modified surgical technique exhibited an accuracy in the placement of implants. It also achieved remarkable postoperative control of IOP. The average IOP of the enrolled patients decreased from a preoperative maximum of 44.5 mmHg to 18.62 mmHg at 60 months postoperatively. Additionally, the usage of antiglaucoma medications decreased from an average of 2.88 preoperative medications to 1.76 medications at 60 months postoperatively. The rates of surgical success were recorded at 85.90% at 12 months, 82.54% at 24 months, 76.60% at 36 months, 71.88% at 48 months, and 66.67% at 60 months following the surgical procedure. It is noteworthy that no severe complications, including drain valve exposure and endophthalmitis, were reported.</p><p><strong>Conclusions: </strong>The modified AGV implantation technique effectively regulated IOP, reduced medication dependence, and minimized severe complications. However, limitations such as small sample size and lack of a control group necessitate further large-scale trials to confirm its efficacy.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"224"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network meta-analysis of intraocular lens power calculation formulas based on artificial intelligence in short eyes.","authors":"Xin Zheng, Meng Li, Zhao-Xing Guo, Zhi-Yong Tian, Jing-Shang Zhang, Ying-Yan Mao, Peng Zhao, Zhong-Yan Li, Xiu-Hua Wan","doi":"10.1186/s12886-025-04066-z","DOIUrl":"https://doi.org/10.1186/s12886-025-04066-z","url":null,"abstract":"<p><strong>Purpose: </strong>To systematically assess and compare the accuracy of artificial intelligence (AI) -based intraocular lens (IOL) power calculation formulas with traditional IOL formulas in patients with short eye length.</p><p><strong>Design: </strong>A systematic review and network meta-analysis.</p><p><strong>Methods: </strong>We performed an exhaustive search of the PubMed, Embase, Web of Science, and Cochrane Library databases to identify relevant studies published until February 2024. The extracted data comprised the mean absolute error (MAE) and the percentage of eyes with refractive prediction errors (PE) within ± 0.50 and ± 1.00 diopters (D). Network meta-analysis was performed using Review Manager 5.3 and StataSE 16.0.</p><p><strong>Results: </strong>A network meta-analysis of 21 formulas was carried out in 10 studies, including 756 eyes with axial length (AL) < 22 mm. The results showed that the top AI-based formula was Pearl-DGS. For the percentage of eyes with PE within ± 0.50 D, the Pearl-DGS formula demonstrated the highest accuracy. In terms of the percentage of eyes with PE within ± 1.00 D, the FullMonte IOL formula performed poorly, and no significant differences were observed among the other formulas.</p><p><strong>Conclusions: </strong>The Pearl-DGS formula emerged as the leading AI-based method for determining IOL power in patients with short eye lengths, demonstrating superior accuracy compared to conventional vergence formulas.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"225"},"PeriodicalIF":1.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The therapeutic effect of IPL on children with refractory seasonal allergic conjunctivitis.","authors":"Jiao Jiang, Xiaoge Yang, Feifan Du, Wei Zheng, Jiancang Wang","doi":"10.1186/s12886-025-04058-z","DOIUrl":"https://doi.org/10.1186/s12886-025-04058-z","url":null,"abstract":"<p><strong>Objective: </strong>To observe the effectiveness of intense pulsed light(IPL) treatment as an adjuvant treatment of refractory seasonal allergic conjunctivitis in children.</p><p><strong>Methods: </strong>A total of 31 patients with refractory seasonal allergic conjunctivitis who did not respond well to anti-allergic drug treatment were randomly selected to receive drug therapy combined with IPL treatment (17 patients) and drug treatment alone (14 patients) for 1 week, and the ocular surface symptom questionnaire and ocular surface sign score were performed before and after treatment, respectively.</p><p><strong>Result: </strong>After treatment, the IPL group had significantly lower scores in eye rubbing, blinking, eye itching, discharge, tearing, and total scores than before treatment (P < 0.05), while there was no significant difference in foreign body sense scores before and after treatment (P > 0.05). There were no significant differences in eye rubbing, blinking, eye itching, discharge, foreign body sensation, tearing, and total score between the control group after treatment (P > 0.05). After treatment, the scores of ocular signs in the IPL group and the control group were lower than those before treatment, and the difference was statistically significant (P < 0.01).</p><p><strong>Conclusion: </strong>IPL therapy is effective in improving ocular surface symptoms in children with refractory seasonal allergic conjunctivitis, especially in suppressing eye itching, with good results.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"217"},"PeriodicalIF":1.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myopi-X lenses vs. low-dose atropine in myopia control: a Turkish retrospective study : Study design: retrospective observational study.","authors":"Nilay Akagun, Ugur Emrah Altiparmak","doi":"10.1186/s12886-025-04009-8","DOIUrl":"https://doi.org/10.1186/s12886-025-04009-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The global prevalence of myopia is rising rapidly, with projections indicating that by 2050, half of the world's population will be affected. High myopia is associated with an increased risk of sight-threatening complications, contributing to a substantial public health burden. Atropine 0.01% has been widely used for myopia control in non-Asian populations, supported by evidence demonstrating its efficacy. Myopi-X&lt;sup&gt;®&lt;/sup&gt; lenses, designed to induce myopic defocus, represent an optical alternative to pharmacological intervention. Given that atropine requires monthly preparation, long-term adherence, and may cause mild side effects, (Myopi-X&lt;sup&gt;®&lt;/sup&gt; Novax&lt;sup&gt;®&lt;/sup&gt;) lenses offer a non-pharmacological option that may be preferable for some patients. This study compares the effectiveness of these two treatment strategies in comparison with single vision lenses to provide further insights into their role in myopia management.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective observational study was conducted at Acıbadem Hospital, Ankara, between September 2022 and September 2023. A total of 128 patients aged 5 to 16 years with myopia were included and divided into three groups: peripheral progressive addition lenses (Myopi-X&lt;sup&gt;®&lt;/sup&gt; Novax&lt;sup&gt;®&lt;/sup&gt;), atropine 0.01%, and single vision lenses. Baseline characteristics, including age, gender, and axial length, were recorded. Cycloplegic autorefraction and axial length measurements were performed, and statistical analyses were conducted to assess changes in spherical equivalent refraction and axial length over 12 months. Additionally, the potential effects of baseline axial length, gender, and age group on spherical equivalent progression and axial length elongation were evaluated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Significant differences were observed among the treatment groups in changes in spherical equivalent refraction and axial length (p &lt; 0.001). Both the Myopi-X&lt;sup&gt;®&lt;/sup&gt; lenses and atropine 0.01% groups exhibited significantly less myopia progression compared to the single vision lenses group (p &lt; 0.001 for both). However, no significant difference was observed between the Myopi-X&lt;sup&gt;®&lt;/sup&gt; lenses and atropine 0.01% groups at 12 months (p = 0.79), and axial length changes remained comparable between these two groups (p = 0.76). Regarding potential confounding factors, age had a significant effect on spherical equivalent refraction progression, with older children experiencing less myopic progression (p = 0.02), whereas no significant effect was observed on axial length change (p = 0.11). Gender was not significantly associated with changes in spherical equivalent (p = 0.21) or axial length (p = 0.32). Similarly, baseline axial length showed no significant association with changes in spherical equivalent (p = 0.17) or axial length (p = 0.36).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Both Myopi-X&lt;sup&gt;®&lt;/sup&gt; lenses and atropine 0.01% effectively slowed m","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"220"},"PeriodicalIF":1.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periorbital necrotizing fasciitis: the Manchester experience.","authors":"Abigail Hopkins, Jonathan K Y Ng, Jae Yee Ku, Adam Bull, Qistina Pilson, Anne Cook","doi":"10.1186/s12886-025-04062-3","DOIUrl":"https://doi.org/10.1186/s12886-025-04062-3","url":null,"abstract":"<p><strong>Background: </strong>To describe the presentation and management of patients with periorbital necrotizing fasciitis (PONF) through an observational retrospective case series. The clinical notes of twelve consecutive patients managed by the Oculoplastic and Orbital Service and Maxillofacial Service of the Manchester University NHS Foundation Trust between 2018 and 2023 were reviewed. Five of these patients were contactable and gave informed consent for inclusion in the study.</p><p><strong>Methods: </strong>Retrospective review of patient characteristics, risk factors, clinical findings, Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score, imaging results, microbiology and histology results, patient management and mortality.</p><p><strong>Results: </strong>The majority of the patients were male (n = 3) with a median (IQR) age of 63 (51-71) years. The median (IQR) number of risk factors per patient was 1 (0-1.5). All patients had periorbital swelling at presentation. Median (IQR) LRINEC score was 5 (3-8.5). Group A Streptococcus was isolated from at least one sample (wound swab, tissue sampling, blood culture) in 4 cases. Histology was consistent with PONF in the remaining case. All patients received intravenous antibiotics and had between 1 and 4 surgical debridements. The median (IQR) time from the onset of symptoms to antibiotic treatment was 24 (17-42) hours, and the time of suspected diagnosis to debridement was 4 (2.3-6) hours. The median (IQR) final best recorded visual acuity (BRVA) was 2.0 (0.23-3) logMAR. Three patients developed orbital compartment syndrome; 2 of these had a final BRVA of no perception of light (NPL). The median (IQR) time from the initial surgery to the most recent follow-up was 4 (2.5-42) months. There was no mortality.</p><p><strong>Conclusions: </strong>This study showed no mortality in PONF due to early antibiotic treatment and surgical debridement. A high index of clinical suspicion for PONF using the LRINEC score and other parameters combined with a low threshold for treatment should be maintained, especially in high-risk groups. Urgent referral to specialist surgical teams to ensure prompt diagnosis and treatment is essential to optimise outcomes in the face of this destructive infection.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"221"},"PeriodicalIF":1.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}