BMC Ophthalmology最新文献

{"title":"Comparison of eyelid contour symmetry after ptosis repair via centralized versus temporally biased levator suturing techniques.","authors":"Emre Ayintap, Hasan Aytogan","doi":"10.1186/s12886-025-04318-y","DOIUrl":"https://doi.org/10.1186/s12886-025-04318-y","url":null,"abstract":"","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"486"},"PeriodicalIF":1.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early diagnosis of primary open-angle glaucoma using isolated-check visual evoked potential with blue-on-yellow perimetry.","authors":"Qiang Li, Dongyue Liu, Min Zhang","doi":"10.1186/s12886-025-04319-x","DOIUrl":"https://doi.org/10.1186/s12886-025-04319-x","url":null,"abstract":"<p><strong>Background: </strong>Early detection of primary open-angle glaucoma (POAG) is crucial, as current diagnostic methods often miss early-stage damage. Combining blue-on-yellow perimetry with isolated-check visual evoked potential (Ic-VEP) could enhance the sensitivity and specificity of early POAG detection.</p><p><strong>Objective: </strong>To evaluate the diagnostic efficacy of Ic-VEP combined with blue-on-yellow perimetry for early POAG detection.</p><p><strong>Methods: </strong>This study included 66 POAG patients and 35 healthy controls, all of whom underwent comprehensive ophthalmologic assessments, including intraocular pressure (IOP), fundus examination, and optical coherence tomography (OCT) to measure retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness. Ic-VEP and Humphrey 24 - 2 blue-on-yellow perimetry were performed to assess the sensitivity, specificity, and ROC curve for early POAG diagnosis. The correlation between Ic-VEP. results, GCC thickness, and visual field loss was also analyzed.</p><p><strong>Results: </strong>Ic-VEP demonstrated 74% sensitivity and 91% specificity for detecting POAG, with an area under the ROC curve (AUC) of 0.785, indicating reliable diagnostic performance. The Ic-VEP signal-to-noise ratio (SNR) showed significant correlation with the mean deviation (MD) of blue-on-yellow perimetry and GCC thickness (p < 0.05). The Kappa coefficient for consistency between Ic-VEP and blue-on-yellow perimetry was 0.226 in early-stage POAG, increasing to 0.672 in moderate to severe stages suggesting enhanced diagnostic value in later stages.</p><p><strong>Conclusion: </strong>Combining Ic-VEP with blue-on-yellow perimetry shows promise for enhancing the early diagnosis of POAG, with Ic-VEP's high specificity (91%) complementing the sensitivity of perimetry. This approach could lead to earlier diagnosis and improved patient outcomes.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"483"},"PeriodicalIF":1.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term surgical outcome of high myopic full-thickness macular hole without retinoschisis.","authors":"Sung Do Cho, Eun Kyoung Lee, Chang Ki Yoon, Un Chul Park","doi":"10.1186/s12886-025-04325-z","DOIUrl":"https://doi.org/10.1186/s12886-025-04325-z","url":null,"abstract":"<p><strong>Background: </strong>To examine the clinical features and long-term surgical results of highly myopic full-thickness macular hole (FTMH) without retinoschisis.</p><p><strong>Methods: </strong>We retrospectively assessed surgical outcomes of highly myopic patients who underwent vitrectomy with internal limiting membrane peeling and gas tamponade to treat FTMH without retinoschisis. Post-operative examinations were conducted at 1, 3, 6, and 12 months after surgery, with further follow-up intervals adjusted based on physician's discretion. Clinical features related to visual acuity and anatomical success, defined as hole closure without developing foveal atrophy, were assessed.</p><p><strong>Results: </strong>Thirty-three eyes (30 patients) were included, and the mean follow-up period was 61.1 ± 48.8 months. Macular hole closure was achieved in 31 (93.9%) eyes, of which 16 (51.6%) developed foveal atrophy during follow-up. Eyes with anatomical success exhibited a significant better visual prognosis than those without during whole follow-up period (P ≤ 0.031), showing a significant postoperative visual improvement from baseline at 6 months, 12 months and final visit (P = 0.002, P < 0.001 and P = 0.013, respectively). Greater minimal macular hole diameter (P = 0.002) and the presence of posterior staphyloma (P = 0.040) were significantly related to anatomical failure, whereas longer axial length was significantly related to poorer final best-corrected visual acuity (P < 0.001).</p><p><strong>Conclusions: </strong>Hole closure rate after vitrectomy in highly myopic patients with FTMH without retinoschisis was high. However, the postoperative development of foveal atrophy hindered vision improvement. Posterior staphyloma, greater minimal hole diameter, and longer axial length were predictive of poor prognosis.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"485"},"PeriodicalIF":1.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal biomechanics and tomographic parameters for different corneal diameters in Chinese patients with myopia.","authors":"Li Li, Qizhi Zhou","doi":"10.1186/s12886-025-04304-4","DOIUrl":"https://doi.org/10.1186/s12886-025-04304-4","url":null,"abstract":"","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"482"},"PeriodicalIF":1.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Hyperacute Panuveitis from the highest reported altitude: co-occurrence with scleritis - an unusual presentation.","authors":"Ranju Kharel Sitaula, Pratap Karki, Prabin Poudel, Prakash Jha, Daya Ram Bhusal, Ananda Kumar Sharma, Sagun Narayan Joshi, Andrea Battisti, Madan Prasad Upadhyay","doi":"10.1186/s12886-025-04316-0","DOIUrl":"https://doi.org/10.1186/s12886-025-04316-0","url":null,"abstract":"<p><strong>Purpose: </strong>Seasonal Hyperacute Panuveitis (SHAPU) is a severe, rapid-onset panuveitis primarily affecting children, often linked to the setae released in the air or by contact with female moths of the genus Gazalina (Lepidoptera, Notodontidae), or with their egg masses laid on various substrates. This study aims to report a rare case of SHAPU from the higher altitude of Nepal with an alpine climate, with concurrence of necrotising scleritis. To the best of our knowledge, this is the first report of SHAPU at high elevation.</p><p><strong>Case report: </strong>A 27-year-trekker male from an alpine climatic region of eastern Nepal was referred to our department, tertiary eye care in Nepal, with a history of sudden onset of redness, pain and decreased vision in his left eye following an indirect contact with a female Gazalina moth resting in his trekking bag during an ascent from 2,364 to 4,371 m above sea level. Circumcorneal congestion and cells, and flare were observed on clinical examination in the anterior chamber. A necrotising patch was present at the anterior sclera. The details of the lens, vitreous and retina were obscured because of hazy media. Ocular ultrasonography showed hyperechoic shadows in the vitreous with a thickening retina-choroid-sclera complex, suggestive of vitritis. He underwent treatment with antibiotics and steroids via all possible routes (topical, intraocular, periocular and systemic), and the scleral perforation could be prevented, but the visual rehabilitation was not possible.</p><p><strong>Conclusion: </strong>SHAPU primarily affects the uveal tissue, but its spread of uveal inflammation to the scleral tissue must be borne in mind. This SHAPU case from a high altitude with intense ocular pain suggests new aspects of SHAPU's pathophysiology, contrasting with its typical painless presentation, warranting further research on the study moth's habitat at higher altitudes.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"484"},"PeriodicalIF":1.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative UBM-guided direct cyclopexy for traumatic cyclodialysis cleft: a four-case series.","authors":"Fei Wang, Xin Jin, Xiang Chen, Bing Chen, Qing-Li Kong, Bao-Ke Hou","doi":"10.1186/s12886-025-04250-1","DOIUrl":"https://doi.org/10.1186/s12886-025-04250-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the feasibility and effectiveness of intraoperative ultrasonic biomicroscopy (UBM)-guided direct cyclopexy for treating traumatic cyclodialysis clefts.</p><p><strong>Methods: </strong>Intraoperative UBM-guided direct cyclopexy was performed on a total of four eyes. Prior to the conjunctival incision, UBM evaluation was facilitated with a self-designed eye cup. Scleral flaps were generated according to their respective locations. Before the scleral flaps and conjunctiva were closed, UBM was used to promptly assess the repositioning status.</p><p><strong>Results: </strong>1.UBM-guided direct cyclopexies were performed on four male patients (mean age: 39.7 years). In all instances, the cyclodialysis cleft resulted from blunt ocular trauma, with an average time interval between injury and surgical treatment of 29.5 days. 2. A simple cyclodialysis cleft was observed in two patients. One patient had retinal detachment and subluxation of the lens, and one presented with a shallow anterior chamber, iridodialysis, cataract, vitreous hemorrhage, papilledema, and hypotony maculopathy. 3. Prior to surgery, the mean IOP in all four patients was 7 mmHg (range: 6-9 mmHg), which increased to an average of 16.5 mmHg on postsurgical day three (range: 11-22 mmHg). 4. UBM examination confirmed successful closure of the cleft in all patients.</p><p><strong>Conclusion: </strong>During the procedure, UBM-guided direct cyclopexies can accurately assess cyclodialysis cleft repair without being affected by the optical clarity of the refractive media. Preliminary findings demonstrate the feasibility of this approach.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"479"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ganglion cell layer changes following the idiopathic macular hole surgery using inverted limiting membrane flap technique.","authors":"Mehmet Önen, Muzaffer Şahin, Gökhan Çelik","doi":"10.1186/s12886-025-04317-z","DOIUrl":"https://doi.org/10.1186/s12886-025-04317-z","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to compare the ganglion cell layer changes following temporal inverted internal limiting membrane flap (i-ILMF) surgery for idiopathic macular hole (IMH).</p><p><strong>Methods: </strong>This retrospective study included 50 eyes that underwent vitrectomy with a 2.5-disc-diameter temporal inverted internal limiting membrane flap (i-ILMF) technique. Demographic, functional, and anatomical data were collected before and after the surgery. The best corrected visual acuity (BCVA) and optical coherence tomography (OCT) findings such as ganglion cell layer -inner plexiform layer (GCL-IPL) thickness and hole related parameters/indexes were compared in the preoperative period and 6th month after surgery.</p><p><strong>Results: </strong>The average age of the patients was 68.8 ± 10.31 years, and the average duration of visual loss was 10.95 ± 6.54 months. The average GCL-IPL thickness increased significantly from 57.98 ± 21.43 μm to 68.74 ± 13.62 μm at 6 months after surgery (p < 0.001). The nasal GCL-IPL thickness was significantly increased from 56.94 ± 24.18 μm to 73.10 ± 15.39 μm after 6 months after surgery (p < 0.001).</p><p><strong>Conclusion: </strong>The temporal i-ILMF technique not only leads to high anatomical success and visual improvement but also results in a significant increase in GCL-IPL thickness postoperatively, suggesting a unique structural response to this method.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"481"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the correlation between corneal and meibomian gland morphology and glycated hemoglobin levels in type 2 diabetes patients.","authors":"Kejun Li, Yize Han, Yin Zhang, QingMin Ma, Jia Lin Niu, Fang Fan, JianMin Wang","doi":"10.1186/s12886-025-04273-8","DOIUrl":"https://doi.org/10.1186/s12886-025-04273-8","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the correlation between corneal nerve and meibomian gland morphological changes and glycated hemoglobin (HbA1c) levels in type 2 diabetes mellitus (T2DM) patients, and to provide an objective basis for early detection of diabetic peripheral neuropathy.</p><p><strong>Methods: </strong>A total of 150 subjects were enrolled, including 130 T2DM patients and 20 healthy controls. T2DM patients were divided into two groups based on HbA1c levels: well-controlled group (HbA1c < 7.0%, n = 65) and poorly-controlled group (HbA1c ≥ 7.0%, n = 65). All subjects underwent comprehensive ophthalmic examinations, including in vivo confocal microscopy (IVCM) for corneal nerve analysis and infrared meibography for meibomian gland evaluation. Disease duration, medication history, and microvascular complications were recorded for all diabetic patients. Age-related meibomian gland changes were controlled by age-matching between groups. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), and meibomian gland parameters were measured and compared among groups. Correlation analysis was performed between HbA1c levels and ocular surface parameters.</p><p><strong>Results: </strong>Compared with the healthy control group, T2DM patients showed significantly reduced CNFD, CNBD, CNFL, and increased meibomian gland dropout (all P < 0.05). These parameters were significantly worse in the poorly-controlled group compared to the well-controlled group (all P < 0.01). Multiple regression analysis showed that HbA1c levels were independently associated with corneal nerve parameters (CNFD: β = -0.462, P < 0.001; CNBD: β = -0.437, P < 0.001; CNFL: β = -0.443, P < 0.001) and meibomian gland dropout (β = 0.389, P < 0.001) after adjusting for age, disease duration, medication types, and presence of microvascular complications.</p><p><strong>Conclusion: </strong>Corneal nerve fiber and meibomian gland morphology are significantly correlated with HbA1c levels in T2DM patients. These ocular surface changes may serve as early, non-invasive biomarkers for diabetic peripheral neuropathy and could potentially be incorporated into routine diabetic follow-up examinations. Longitudinal studies are needed to establish the causality and evaluate the clinical significance of these findings for individualized ocular surface management in diabetic patients.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"480"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative Summation (CUSUM)-as a tool for objective analysis of learning curve for surgeons in acquiring competency in phacoemulsification.","authors":"Emily Ming Choo Ng, Mohamad Aziz Salowi, Othmaliza Othman, Rosmawati Uthman, Nor Fariza Ngah","doi":"10.1186/s12886-025-04246-x","DOIUrl":"10.1186/s12886-025-04246-x","url":null,"abstract":"","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"475"},"PeriodicalIF":1.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of perfluorocarbon liquid vs. posterior retinotomy as adjuncts during pars-plana vitrectomy for the surgical repair of rhegmatogenous retinal detachment: a randomized clinical trial.","authors":"Ehab Mohamed Elsayed Saad, Hazem Elbadry Mohammed Mohammed, Mohamed Mohamed-Aly Ibrahim, Omar Hassan Salama Selim, Sayed Mostafa Elsayed Abdelhafeez, Ahmed Mohammed Sakr, Fathy Mohamed Abo Elftouh Elsalhy, Ahmed Abdelmohsen Ali Ayoub, Ehab Abdelsamea Alazab, Ehab Tharwat, Tamer Gamal El Sayed Mostafa","doi":"10.1186/s12886-025-04271-w","DOIUrl":"10.1186/s12886-025-04271-w","url":null,"abstract":"<p><strong>Purpose: </strong>Rhegmatogenous retinal detachment (RRD) is a sight-threatening condition requiring prompt surgical intervention. Various adjunctive techniques are employed to enhance subretinal fluid drainage and retinal reattachment. This study aimed to evaluate the outcomes of perfluorocarbon liquid (PFCL) versus posterior retinotomy (PR) during pars plana vitrectomy (PPV) for RRD, focusing on anatomical success, visual acuity, intraocular pressure (IOP), and complications.</p><p><strong>Methods: </strong>This is a prospective randomized controlled trial that included 58 eyes with RRD, divided into Group A (PFCL, n = 29) and Group B (PR, n = 29). Preoperative assessments included best-corrected visual acuity (BCVA), IOP, axial length, lens status, macula status, and PVR grade. Outcomes were evaluated at 1 week, 1 month, 2 months, and 3 months postoperatively. Primary outcomes included retinal reattachment rates and the number of operations; secondary outcomes included BCVA, IOP changes, complications like cataract development, retinal redetachment, epiretinal membrane (ERM) formation, and single-surgery success.</p><p><strong>Results: </strong>Retinal reattachment rates were comparable (76% in Group A vs. 66% in Group B, p = 0.387), as well as the number of operations (p = 0.375). Moreover, BCVA improved significantly in both groups (p < 0.05), with no intergroup differences. IOP increased postoperatively in both groups (p < 0.001), with no significant differences. No differences were observed in cataract formation or retinal redetachment. However, ERM incidence was significantly higher in the PR group (27% vs. 11%, p = 0.049).</p><p><strong>Conclusion: </strong>PFCL and PR are effective for RRD repair, with similar anatomical and visual outcomes. However, PFCL may reduce ERM risk, making it preferable in certain cases. These findings guide surgical decision-making and highlight the need for further research.</p><p><strong>Trial registration: </strong>The study was retrospectively registered at ClinicalTrials.gov (NCT06919211) on April 4, 2025.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"476"},"PeriodicalIF":1.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}