BMC Ophthalmology最新文献

{"title":"Frontal osteomyelitis presenting as chronic preseptal abscess: an unusual scenario.","authors":"Rawan Hosny, Abanoub Younan, Rania A Ahmed","doi":"10.1186/s12886-025-04207-4","DOIUrl":"10.1186/s12886-025-04207-4","url":null,"abstract":"<p><p>Preseptal cellulitis is characterized by local inflammation anterior to the orbital septum. This case is being reported to highlight a rare cause of a chronic form of preseptal inflammation: Frontal osteomyelitis. The patient initially presented with a chronic left upper lid swelling preceded by minor blunt trauma of four-month duration. Condition did not respond to medical treatment. Drainage of swelling was done and pus was sent for culture and sensitivity, results of which were negative. It rapidly recollected following drainage. Patient had no nasal complaints or constitutional manifestations. Computed tomography and magnetic resonance imaging diagnosed extent of sinus involvement and frontal osteomyelitis. Clindamycin therapy was given for four weeks following which the patient markedly improved.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"342"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced quality of life in corneal dystrophy - a prospective case control study.","authors":"Carolin Elhardt, Ahmad Zia Aamoon, Lennart Maximilian Hartmann, Clara Marie Sophie Grün, Armin Wolf, Christian Maximilian Wertheimer","doi":"10.1186/s12886-025-04200-x","DOIUrl":"10.1186/s12886-025-04200-x","url":null,"abstract":"<p><strong>Background: </strong>Corneal dystrophies are a group of rare eye diseases that can cause visual impairment and affect social well-being, independence, and active participation in society. This study presents data on the impact of corneal dystrophies on quality of life compared to a healthy control group.</p><p><strong>Methods: </strong>This prospective case control study was conducted at the Department of Ophthalmology at the University Hospital Ulm in Germany. The study included 45 patients with corneal dystrophy (excluding Fuchs endothelial dystrophy) between 2021 and 2024, and a control group of 45 healthy patients. All patients completed two questionnaires on quality of life (NEI-VFQ and VF-14). The quality of life was correlated with visual acuity and Scheimpflug imaging parameters, such as higher order aberrations as well as corneal astigmatism, densitometry and pachymetry.</p><p><strong>Results: </strong>Thirteen different corneal dystrophies were included; genetic testing confirmed the dystrophies in thirteen patients (13/36 tested; 13/45 total). Mean age was 57 ± 16 years, 60% were female. Compared to the control group, patients with corneal dystrophies reported a significantly worse overall quality of life in the VF-14 (p < 0.001) and in all categories of the NEI-VFQ (p < 0.02). There was a high correlation of the quality of life in patients with corneal dystrophy with visual acuity, higher order aberrations and corneal astigmatism, and no correlation with corneal densitometry and pachymetry.</p><p><strong>Conclusions: </strong>Our data indicate that corneal dystrophies have a significant impact on an individual's quality of life in many ways. These findings highlight the importance of identifying and treating these diseases to enhance overall well-being and active participation in daily life.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"341"},"PeriodicalIF":1.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of trabeculectomy versus canaloplasty in open-angle glaucoma - an 11-year follow-up of the TVC study cohort.","authors":"Raoul Verma-Fuehring, Juliane Matlach, Thomas Klink, Jost Hillenkamp, Franz Grehn","doi":"10.1186/s12886-025-04183-9","DOIUrl":"10.1186/s12886-025-04183-9","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the long-term outcomes of the Trabeculectomy versus Canaloplasty (TVC) study cohort after 11 years. The TVC study was a prospective, single-center, randomized clinical trial comparing the 24-month surgical outcomes of trabeculectomy and canaloplasty in patients with open-angle glaucoma.</p><p><strong>Methods: </strong>This prospective follow-up study included only patients from the original 2015 TVC cohort. Primary endpoints were complete (without glaucoma medication) and qualified success (with or without glaucoma medication), defined as intraocular pressure (IOP) ≤ 18 mmHg (Definition 1) or IOP ≤ 21 mmHg with ≥ 20% reduction from baseline (Definition 2). Secondary endpoints included changes in IOP, medication use, complications, and revision surgeries.</p><p><strong>Results: </strong>Mean follow-up was 11.9 ± 1.1 years for trabeculectomy (TE) and 11.0 ± 2.0 years for canaloplasty (CP) (15 TE and 13 CP patients). Complete success rates for TE vs. CP were 53.3% vs. 15.4% (Definition 1, p = 0.06) and 46.7% vs. 15.4% (Definition 2, p = 0.22). Qualified success was achieved by 73.3% vs. 69.2% (Definition 1, p = 1.0) and 66.7% vs. 76.9% (Definition 2, p = 0.69). Median IOP was 10.0 (6.0-12.0) mmHg for TE and 14.0 (11.5-17.75) mmHg for CP (p < 0.01). Mean number of compounds was 1.0 ± 1.4 in TE and 1.9 ± 1.5 in CP (p = 0.17). Revision surgeries were needed in 26.7% (TE) vs. 23.1% (CP). The only long-term complication, hypotony maculopathy, occurred in two TE patients (15.4%).</p><p><strong>Conclusion: </strong>After 11 years, trabeculectomy still demonstrated greater IOP reduction and higher complete success rates but was associated with a higher complication rate. In contrast, canaloplasty offers a safe alternative when slightly higher IOPs and moderate medication use are acceptable.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"340"},"PeriodicalIF":1.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of myopic retinopathy and its awareness in adults: a hospital-based comparative study.","authors":"Ajay Deep Syal, Jasmita Satapathy, Pradeep Kumar Panigrahi","doi":"10.1186/s12886-025-04175-9","DOIUrl":"10.1186/s12886-025-04175-9","url":null,"abstract":"<p><strong>Background: </strong>The present study assessed the characteristics of retinal degenerations in myopic patients and compared their occurrence with that of emmetropic patients. It also studied the awareness of myopic retinopathy among myopic patients.</p><p><strong>Methods: </strong>This cross-sectional comparative study included patients of either gender, aged 18 to 40 years, diagnosed with either myopia or emmetropia. Patients with myopia and emmetropia constituted the study and control groups, respectively. A comprehensive ophthalmic evaluation was done in every case. Myopia was divided into three categories: mild (0.5- 5 D), moderate (> 5 to 10 D), and severe (> 10 D). A pre-designed questionnaire was prescribed to the myopic patients, and their responses to the questions were noted.</p><p><strong>Results: </strong>The study included 400 (800 eyes) myopic and 200 (400 eyes) emmetropic patients. Mean age in the myopic and emmetropic groups was 23.59 ± 5.96 and 24.13 ± 6.62 years, respectively. The mean axial length in the myopia group was 24.53 ± 1.61 mm compared to 22.21 ± 0.84 mm in the emmetropia group (P < 0.0001). Peripheral retinal changes were present in 304 (38.0%) and 23 (5.8%) eyes with myopia and emmetropia, respectively (P = 0.0001). White without pressure was the most common peripheral retinal degeneration in the myopia group (25.4%), followed by lattice degeneration (12.6%). Around 50.7% of myopic patients were unaware of vision-threatening complications of myopia. Only 48.8% of the participants knew the importance of regular retinal check-ups. Older age, increased axial length, and higher myopia grades were found to be statistically significant predictors of peripheral retinal degeneration (P < 0.005).</p><p><strong>Conclusion: </strong>Myopic patients have a higher prevalence of peripheral retinal degeneration than emmetropics. Majority of myopic patients are unaware of the sight-threatening potential of the disease. Increasing awareness and promoting regular eye examinations can reduce the effect of the progression of the disease and major complications.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"339"},"PeriodicalIF":1.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined femtosecond intrastromal lenticular implantation and corneal crosslinking to treat advanced keratoconus: a 6-month observation including epithelial remodeling.","authors":"Yahui Dong, Jing Zhang, Yafei Xu, Lihong Xu, Fangfang Sun, Jie Hou, Zhixing Ma, Yulin Lei","doi":"10.1186/s12886-025-04141-5","DOIUrl":"10.1186/s12886-025-04141-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To evaluate the effect of combined femtosecond intrastromal lenticular implantation (FILI) and corneal crosslinking (CXL) in advanced keratoconus by reporting visual quality, biomechanics, curvature, and corneal epithelial remodeling.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Nine eyes from eight patients with advanced keratoconus were included in this retrospective study. All involved eyes underwent combined FILI and CXL. A femtosecond laser was used to create an intrastromal pocket with a 4 mm incision in the recipient cornea. A convex stromal lenticule, obtained by small incision lenticule extraction (SMILE) for myopia treatment, was then gently inserted into the intrastromal pocket through the 4 mm incision and flattened. Following this, the CXL procedure was performed on the operative eye. Follow-up evaluations were conducted before surgery and at 1,3, and 6 months postoperatively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;We collected data before surgery and at 1, 3, and 6 months postoperatively for all involved keratoconus patients. Corneal biomechanical properties in all eyes improved significantly; SP-A1 increased from the preoperative value (36.17 ± 4.70) to 6 months postoperatively (53.47 ± 3.55, P = 0.008). ARTh increased from the preoperative value (129.19 ± 8.63) to 6 months postoperatively (320.61 ± 54.47, P = 0.015). The integrated radius decreased from the preoperative value (17.18 ± 3.26) to 6 months postoperatively (13.36 ± 2.64, P = 0.015). There was no statistical difference in DAR-2 mm and A1 velocity between preoperative and 1, 3, and 6 months postoperative time points (P = 0.651, P = 0.397). The central corneal thickness of all patients increased significantly and remained stable after surgery. The uncorrected distance visual acuity (UDVA) did not change significantly, but some patients wore rigid gas permeable contact lenses (RGPs) over 6 months after surgery and achieved a best-corrected visual acuity (BCVA) of LogMAR 0.2 to 0.0. The absolute value of spherical aberration in the 6th month decreased than that before the surgery (P = 0.028), and there was no significant change in higher-order aberrations and coma aberrations before and after the surgery. Following the surgery, the epithelium became thicker in both central 0-1 mm and peripheral 3.5-4.5 mm zones of the cornea, but showed no significant disparities within the paracentral 1-2.5 mm and 2.5-3.5 mm regions. The corneal epithelial thickness (CET) became more uniform overall.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Combined FILI and CXL appear to effectively thickened the cornea and improved the corneal biomechanics of advanced keratoconus, and prevented further development of keratoconus. The corneal epithelium thickened in both central and peripheral regions, and the distribution of corneal epithelial thickness became more uniform after surgery. We suggest that this change in the corneal epithelium may be related to a moderate rate of corneal thickness chang","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"338"},"PeriodicalIF":1.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of corneal epithelial remodeling on visual quality after SMILE and FS-LASIK for high myopia.","authors":"Yunjing Ma, Qi Li, Qian Guo, Yue Huang, Ruibo Yang, Hui Liu, Chen Zhang, Shaozhen Zhao","doi":"10.1186/s12886-025-04168-8","DOIUrl":"10.1186/s12886-025-04168-8","url":null,"abstract":"<p><strong>Background: </strong>To investigate the corneal epithelial remodeling profile after small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK) for high myopia, as well as its possible consequence for subjective and objective changes in visual quality.</p><p><strong>Methods: </strong>This prospective observational study included 72 eyes with high myopia, divided into two groups, who underwent either SMILE or FS-LASIK. In addition to standard evaluation, anterior segment optical coherence tomography was used to assess central 6-mm corneal epithelial thickness (ET) before surgery and at 1 week, 1, 3, and 6 months after surgery; ET inhomogeneity across the central 5- and 6-mm cornea was quantified using the coefficient of variance (CV). The objective optical quality includes the modulation transfer function cut off frequency (MTF cut off), Strehl ratio, objective scatter index (OSI), and mean OSI obtained using the Optical Quality Analysis System-II. Patient-reported quality of vision was determined with a modified National Eye Institute Refractive Error Quality of Life questionnaire. The correlation of postoperative ET and treatment parameters with visual quality related parameters was analyzed.</p><p><strong>Results: </strong>Both ET and CV were significantly increased in the SMILE and FS-LASIK groups at 6 months postoperatively (P < 0.001). Paracentral ET was positively correlated with changes in MTF cut off and Strehl ratio at 1 week after SMILE (0.338, 0.405, separately, P < 0.05). For FS-LASIK, ET was negatively correlated with MTF cut off change at 1, 3, 6 months postoperatively (-0.334, -0.385, -0.375, separately, P < 0.05); Central 6-mm CV and Strehl ratio significant correlated at 6 months (-0.427, P = 0.01); ET was significantly correlated with patient-reported quality of vision (P < 0.05). No correlation was found between preoperative spherical equivalent, keratometry values, total corneal thickness, optical zone, and ablation depth and changes in visual quality parameters.</p><p><strong>Conclusions: </strong>Correction of high myopia with SMILE and FS-LASIK induced epithelial remodeling involved an increase in ET and ET inhomogeneity. Epithelial changes in different regions have different effects on subjective and objective visual quality, which may have a certain clinical relevance of the corneal epithelial thickness measurement for visual quality assessment after refractive surgery.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"336"},"PeriodicalIF":1.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmologic abnormalities in institutionalized Congolese children with cognitive impairment.","authors":"Therese M Lungambi, Justin Mbusa-Kombi, Christian K Onankoy, Ange Mubiala, Gloria M Elongo, Jean-Claude Mwanza","doi":"10.1186/s12886-025-04180-y","DOIUrl":"10.1186/s12886-025-04180-y","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the frequency and types of ophthalmologic anomalies in children with cognitive impairment, identify the causes of visual impairment in these children, and assess the relationship between the severity of cognitive impairment and ophthalmologic anomalies.</p><p><strong>Methods: </strong>A cross-sectional study was carried out between October 2023 and June 2024 on 80 children 7 to 17 years old with cognitive impairment and institutionalized in two centers in Kinshasa. Participants underwent a complete ophthalmologic examination and cognitive assessment using the Montreal Cognitive Assessment (MoCA) test.</p><p><strong>Results: </strong>The median (interquartile range) age of the children was 14 (11-16) years. 55% were boys. Cognitive impairment was mild in 41.2%, moderate in 33.8%, and severe in 25% of the children. Overall, 74 (92.5%) children had at least one ophthalmologic abnormality, and 43.8% had multiple ophthalmologic abnormalities. Refractive errors (82.5%), stereoscopic disorders (22.5%) and strabismus (12.6%) were the most frequent disorders. Twenty-seven (33.7%) children had vision impairment. The causes of vision impairment were refractive errors (46.7%), strabismus amblyopia (20%), and cataract (13.3%). There was a significant association between the severity of cognitive impairment and both visual impairment and defective stereopsis (p = 0.035).</p><p><strong>Conclusions: </strong>Ophthalmologic manifestations are frequent in children with cognitive deficits. They are dominated by ametropia. A substantial proportion of these children are visually impaired. Periodic ophthalmologic screening of these children via conventional pediatric health system or school health services is recommended.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"337"},"PeriodicalIF":1.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of posterior segment characteristics in high myopic Turkish patients.","authors":"Mustafa Kayabaşı, Ali Osman Saatci, Neslihan Demirel, Ziya Ayhan, Mahmut Kaya, Zeynep Özbek, Taylan Öztürk","doi":"10.1186/s12886-025-04167-9","DOIUrl":"10.1186/s12886-025-04167-9","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the structural characteristics of high myopia (HM) in a Turkish cohort using spectral domain optical coherence tomography (OCT) and evaluate the relationship between axial length (AL) and various retinal, choroidal, and scleral parameters.</p><p><strong>Methods: </strong>A retrospective analysis of medical records and imaging data was conducted in HM patients examined at Dokuz Eylül University between January 2019 and January 2023. Eyes were categorized into three groups based on AL: Group 1 (26.00-27.49 mm), Group 2 (27.50-28.99 mm), and Group 3 (≥ 29.00 mm). Retinal, choroidal, and scleral parameters were quantitatively assessed, and posterior segment findings were analyzed across these groups.</p><p><strong>Results: </strong>A total of 146 eyes from 91 patients (mean age: 46.55 ± 17.05 years) were included. Central foveal thickness was significantly lower in Group 1 compared to Group 2 (p = 0.017). Moreover, Group 1 exhibited lower values for average macular thickness, average macular volume, and scleral sink, along with higher subfoveal choroidal thickness values compared to both Group 2 and Group 3 (p < 0.05 for all comparisons). The most common posterior segment findings were peripapillary atrophy (91.8%), tilted disc (47.3%), vitreomacular adhesion (39.0%), and posterior staphyloma (PS, 27.4%). Group 3 exhibited the most advanced stages of myopic maculopathy among the groups (p = 0.001). 'Plus' lesions, defined as the presence of macular neovascularization (MNV), Fuchs spots, or lacquer cracks, were detected in 14.4% of eyes. Pathologic myopia was diagnosed in 49.3% of eyes, including 47.2% based on myopic maculopathy stage and 0.7% each on the presence of PS, active MNV, or scarred MNV. Active MNV was more frequent in Group 3, while scarred MNV was predominant in Group 2.</p><p><strong>Conclusions: </strong>Present findings highlight the progressive nature of structural changes associated with increasing AL in HM patients, emphasizing the importance of early detection and monitoring of posterior segment complications. This study provides valuable insights into the prevalence and distribution of myopia-related complications in a Turkish population, aiding in the clinical management of HM.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"335"},"PeriodicalIF":1.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictability of visual outcome based on injury size and location following penetrating ocular trauma in children.","authors":"Xiaoxin Lyu, Han Zhang","doi":"10.1186/s12886-025-04122-8","DOIUrl":"10.1186/s12886-025-04122-8","url":null,"abstract":"<p><strong>Background: </strong>Penetrating ocular trauma is the most common form of open globe injury in children. However, the open globe classification may not accurately reflect the impact of different anterior ocular injuries on visual prognosis. This study aimed to analyze the factors influencing the prognosis of pediatric patients with penetrating ocular trauma in Shandong Province and evaluate the applicability of OTS and POTS.</p><p><strong>Methods: </strong>Sixty-six pediatric patients from Shandong Provincial Hospital Affiliated to Shandong First Medical University, between January 2017 and September 2024, were included in this retrospective study. Patient characteristics, injury causes, initial visual acuity (IVA), final visual acuity (FVA), and treatment were recorded. Injuries in the anterior ocular were reclassified into zones I, II, III, I_a, and II_a, FVA were analyzed about different zones, and the prognostic factors for visual outcomes were assessed. Each patient was evaluated using the OTS and POTS and followed for at least 3 months, with final visual outcomes compared with the predicted outcomes.</p><p><strong>Results: </strong>A total of 66 patients (mean age 6.9 ± 3.1 years) were included, with 49 males (74.2%) and 17 females (25.8%). OTS and POTS both correlated with FVA (r = -0.313, p = 0.032; r = -0.270, p = 0.028) but underestimated good outcomes in the ≥ 0.5 group (p = 0.029, p = 0.016, p < 0.05). FVA ≥ 0.5 was defined as a successful outcome, and the best outcomes were in zones II and III (100% success), and the poorest outcomes were in zone I_a (71.4% success). In multivariable analysis, older age (B=-0.031, p = 0.037), zone III (B=-0.307, p = 0.011), or zone II_a (B=-0.235, p = 0.042) injuries were independently associated with better outcomes when compared with zone I_a.</p><p><strong>Conclusion: </strong>Larger and more centrally located injuries are associated with worse prognoses, older age and more peripherally located injuries are associated with better prognoses. OTS and POTS tend to underestimate the probability of good visual outcomes, indicating limitations in their applicability.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"334"},"PeriodicalIF":1.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical retrospective analysis of 218 cases of infectious endophthalmitis.","authors":"Chunhui Li, Zheyi Yan, Guohong Zhou, Yan Gao, Peini Cheng","doi":"10.1186/s12886-025-04142-4","DOIUrl":"10.1186/s12886-025-04142-4","url":null,"abstract":"<p><strong>Purpose: </strong>Endophthalmitis is a serious medical condition that needs immediate antibiotic therapy. There are few studies analyzing the pathogenic bacteria of endophthalmitis in China recently. This study was conducted to analyze the pathogenic factors, pathogenic bacteria and prognosis of infectious endophthalmitis.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from January 2016 to December 2020 in Shanxi Eye Hospital. Statistical analysis by using Logistic regression analysis were performed to evaluate of independent risk factor for prognostic factors for poor visual acuity.</p><p><strong>Results: </strong>Positive case of specimen culture was detected in 96 cases, accounting for 44.04%. Staphylococcus epidermidis, the most common bacteria, accounted for 32.98% (31/94), mainly in traumatic endophthalmitis and postoperative endophthalmitis, and was extremely sensitive to vancomycin (96.77%). The Gram-positive bacteria were highly sensitive to vancomycin (87.01%) and relatively sensitive to levofloxacin (68.83%). Gram-negative bacteria were highly sensitive to levofloxacin (88.24%). 12.39% of patients with visual acuity > 0.02 at admission and 27.98% at discharge, the difference was statistically significant (χ² = 17.449, P < 0.001). Logistic regression analysis of traumatic endophthalmitis group showed that intraocular foreign body was an independent risk factor for poor visual acuity after post-operation (OR = 2.215. P = 0.016).</p><p><strong>Conclusions: </strong>As society progresses and hygiene concepts increase in China, the bacteria that cause infection are changing, and factors that influence prognosis may also be changing. Clarifying the different causative factors and etiological characteristics of infectious endophthalmitis are important to provide appropriate clinical treatment.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"332"},"PeriodicalIF":1.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}