BMC Ophthalmology最新文献

{"title":"Effects of matrix metalloproteinase inhibition in cultured human Tenon's capsule fibroblasts.","authors":"Na Hyun Kim, Kyung Eun Han, Roo Min Jun, Seongsoo Sohn, Changwon Kee, Wool Suh","doi":"10.1186/s12886-025-04258-7","DOIUrl":"10.1186/s12886-025-04258-7","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the characteristics of anterior and posterior human Tenon's capsule fibroblasts and determine the effect of matrix metalloproteinase (MMP) inhibition on cultured human Tenon's capsule fibroblasts.</p><p><strong>Methods: </strong>Tissues obtained from the anterior and posterior Tenon's capsules were partially incised, cultured, and subjected to microarray analysis. Electrophoresis was performed on the cells treated with Ilomastat (MMP-9 inhibitor), and collagen 1, 3, and 6. Antibodies against transforming growth factor-beta (TGF-β) and vimentin were used as probes to compare the expression levels.</p><p><strong>Results: </strong>There were no differences between anterior and posterior Tenon's capsule fibroblasts in the microarray. Western blot analysis showed similar expression of collagen 1, 3, and 6, TGF-β, and vimentin between anterior and posterior Tenon's capsule fibroblast. Ilomastat did not affect the proliferation of cultured human Tenon's capsule.</p><p><strong>Conclusions: </strong>No differences in characteristics were observed between anterior and posterior Tenon's capsule fibroblasts, and inhibition of MMPs did not affect the proliferation of cultured human Tenon's capsule fibroblasts.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"434"},"PeriodicalIF":1.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of 7 intraocular lens power calculation formulas in primary angle-closure glaucoma eyes, according to axial length and anterior chamber depth.","authors":"Han Xu, Yuanjin Zheng, Xinlei Lu, Longyuan Liu, Rui Wan, Shaodan Zhang, Guoxing Li, Rongrong Le, Yuanbo Liang","doi":"10.1186/s12886-025-04238-x","DOIUrl":"10.1186/s12886-025-04238-x","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the impact of Axial Length (AL) and anterior chamber depth (ACD) on the performance of the Kane, EVO 2.0, Barrett Universal II (BU II), SRK/T, Haigis, Holladay 2 and Hoffer Q formulas when calculating intraocular lens power in primary angle-closure glaucoma (PACG) patients.</p><p><strong>Setting: </strong>Eye hospital, Wen Zhou Medical University, Zhejiang, China.</p><p><strong>Design: </strong>Retrospective, consecutive case series.</p><p><strong>Methods: </strong>Patients who underwent cataract surgery diagnosed with PACG or not were included. The main outcome measures comprised mean prediction error (ME), mean absolute refractive error (MAE), median absolute refractive error (MedAE). Additionally, the proportions of eyes with postoperative refractive errors within ± 0.25 diopter (D), ± 0.50 D, ± 0.75 D, and ± 1.00 D were calculated. Subgroup analyses were conducted based on AL and ACD.</p><p><strong>Results: </strong>A total of 116 eyes were included, with 66 in the PACG group and 50 in the control group. The PACG group showed significantly larger MAEs compared to the control group. In PACG eyes, the BUII formula tends to cause negative residual refractive errors, while the Kane, EVO, and Holladay 2 formulas often lead to positive ones (P < 0.01). Notably, the SRK/T and Haigis formulas demonstrated better predictability for ME (P < 0.01). PACG patients with an AL under 22 mm or an ACD under 2.5 mm have lower IOL power calculation predictability (P < 0.05). Subgroup analysis shows that PACG eyes with both AL under 22 mm and ACD under 2.5 mm have the lowest predictability and are most prone to significant prediction errors (P < 0.05). A negative correlation was found between postoperative prediction error and AL.</p><p><strong>Conclusions: </strong>PACG eyes showed lower prediction accuracy, especially in short ALs and shallow ACD cases. SRK/T and Haigis formulas had better ME predictability. The study stresses optimizing IOL power calculation formulas for PACG eyes, considering AL and ACD effects.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"431"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of SPEED and OSDI questionnaires for dry eye symptom in Chinese college students: a cross-sectional study.","authors":"Xiaohong Meng, Ruojun Geng, Kaili Yang, Jingjing Wei, Zepeng Xu, Menghan Wang, Shengwei Ren","doi":"10.1186/s12886-025-04255-w","DOIUrl":"10.1186/s12886-025-04255-w","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the suitability of the Standard Patient Evaluation of Eye Dryness (SPEED) and the Ocular Surface Disease Index (OSDI) among Chinese college students, and to further validate the SPEED questionnaire by using the OSDI in a non-clinical sample.</p><p><strong>Methods: </strong>This cross-sectional study involved 1,084 students from Nanyang Medical College, aged 18 to 21 years. The students completed the OSDI and SPEED questionnaires to assess dry eye symptoms. The correlation between the scores of the two questionnaires was analyzed to assess criterion validity. Based on the OSDI scores, a receiver operating characteristic curve was constructed to determine the area under the ROC curve and the cut-off point for evaluating the diagnostic threshold of the SPEED questionnaire.</p><p><strong>Results: </strong>The Cronbach's alpha values for the OSDI and SPEED questionnaires were 0.943 and 0.911, respectively. Notably, only 281 participants (25.92%) completed all 12 questions in the OSDI questionnaire, whereas all participants completed the SPEED questionnaire without omitting any questions. The mean SPEED scores Full were 3.71, 11.57, 13.84, and 19.72 for each subgroup. Posthoc testing revealed statistically significant differences between all groups (P < 0.05). A significant correlation was observed between the OSDI score, the SPEED score, and the SPEED score Full, particularly between the SPEED score and the SPEED score Full.</p><p><strong>Conclusion: </strong>In comparison to the OSDI questionnaire, the SPEED questionnaire demonstrates a favorable response rate, reliability, and validity in differentiating dry eye symptoms among Chinese college students. It may be more appropriate for diagnosing dry eye and conducting epidemiological studies within this population.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"425"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endophthalmitis following inadvertent intravitreal injection of botulinum toxin: a case report and literature review.","authors":"Saud Mohammed Aljohani, Amal Salem Alharbi, Raid Mohammed Alhayaza","doi":"10.1186/s12886-025-04269-4","DOIUrl":"10.1186/s12886-025-04269-4","url":null,"abstract":"<p><strong>Background: </strong>Botulinum toxin A (BTA) injection is a well-established, minimally invasive treatment for strabismus, offering an alternative to traditional surgery. While generally safe, rare complications like globe penetration and inadvertent intraocular injection have been reported. These can lead to retinal detachment, vitreous hemorrhage, and retinal toxicity. Although most intraocular BTA injection complications are well-documented, endophthalmitis remains extremely rare, with only one previously reported case resulting in total vision loss.</p><p><strong>Case presentation: </strong>A 3-year-old boy with esotropia received a botulinum toxin A injection into the left medial rectus muscle. A globe penetration from the needle was suspected. The dilated fundus exam was unremarkable. However, one week later, he presented with eye pain, redness, and photophobia. Clinical examination confirmed the diagnosis of acute post-operative endophthalmitis. The patient underwent urgent vitreous tap, pars plana vitrectomy, Endolaser, intravitreal antibiotic injection, and silicone oil injection. Subsequently, the silicone oil with epiretinal membrane removal was performed, and the patient's vision was maintained postoperatively, CUSNM in both eyes.</p><p><strong>Conclusion: </strong>This case emphasizes the rare yet serious complications of Inadvertent Intravitreal Injection of Botulinum Toxin. It underscores the importance of early detection of endophthalmitis and timely intervention for an optimal outcome and to prevent irreversible ocular damage.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"429"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the intraocular total IgE level and its ratio with serum IgE level for the diagnosis of ocular toxocariasis in children and adults: a retrospective comparative study.","authors":"Shuang Zhang, Li Chen, Xiaofeng Hu, Hui Wang, Jing Feng, Yong Tao","doi":"10.1186/s12886-025-04252-z","DOIUrl":"10.1186/s12886-025-04252-z","url":null,"abstract":"<p><strong>Background: </strong>Ocular Toxocariasis (OT) is characterized by complicated clinical manifestations, which makes it difficult to diagnose. In this study, we mainly evaluated the diagnostic values of intraocular fluid (IF) total IgE level and IF/Serum IgE ratio in OT and compared the differences between child and adult patients.</p><p><strong>Methods: </strong>76 patients with 52 children (< 16 years) and 24 adults of clinically-diagnosed OT and 64 patients with non-OT uveitis were enrolled in this study. The paired IF and serum samples were collected for total IgE, total IgG and specific IgG testing. The IF IgE levels and IF/Serum IgE ratios were compared between child and adult patients. The area under the curve (AUC) was generated to assess the diagnostic performances of the above indicators.</p><p><strong>Results: </strong>The IF IgE level was significantly higher in child patients than in adult patients (1671.79 ± 1425.97 versus 784.44 ± 544.73 ng/ml, p = 0.015). Besides, the IF/Serum IgE ratio showed similar trend with 24.02 ± 6.10 in children and 7.68 ± 5.05 in adults (p = 0.001). The best cutoff value of the IF IgE concentration was 10.65 ng/ml, yielding 77.6% (95%CI, Confidence Interval, 66.4-86.1%) sensitivity and 98.4% (95%CI, 90.5-99.9%) specificity. The IF IgE level showed lower AUC than that of IF specific IgG level (0.925 versus 0.975, p = 0.037). However, the AUC of IF/Serum IgE ratio for OT was significantly higher than that of GWC (0.934 versus 0.527, p < 0.0001). The best cutoff value of IF/Serum IgE ratio was 0.48 with the sensitivity of 78.4% (95%CI, 67.0-86.8%) and specificity of 98.4% (95%CI, 90.5-99.9%). For the diagnosis of child OT, the cutoff value of IF IgE level of child OT was 13.10 ng/ml with the high sensitivity of 82.7% (95%CI, 69.2-91.3%) while the best cutoff value of 10.65 ng/ml for adult OT yielded only 66.7% (95%CI, 44.7-83.6%) sensitivity. However, the sensitivity of IF/Serum IgE ratio for child OT (86.3%, 95%CI, 73.1-93.8%) was close to that for adult OT (87.0%, 95%CI, 65.3-96.6%).</p><p><strong>Conclusions: </strong>Both IF IgE level and IF/Serum IgE ratio demonstrated good diagnostic performance for ocular toxocariasis and higher sensitivity of IF IgE level was noted for the diagnosis of child OT.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"428"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical research on the application of AI-assisted computing systems in the treatment of intermittent exotropia.","authors":"Tao Li, Zihao Han, Silun Xiong, Chuanqiang Dai, Tianyang Hu, Juan Tang","doi":"10.1186/s12886-025-04240-3","DOIUrl":"10.1186/s12886-025-04240-3","url":null,"abstract":"<p><strong>Objective: </strong>To explore the impact of AI-assisted computing systems on the effects of surgery, stereoscopic vision, and quality of life in patients with intermittent exotropia after treatment.</p><p><strong>Methods: </strong>Data from a total of 108 children with intermittent exotropia were collected and randomly divided into Group A and Group B. Group A used the traditional prism calculation method, whereas Group B used the AI-assisted calculation system method. The success rate of surgery, the strabismus correction effect, postoperative stereoscopic function, far strabismus, near strabismus, horizontal and vertical perceptual eye positions, externally skewed deviation, and quality of life (Child-IXTQ score) were compared between the two groups.</p><p><strong>Results: </strong>At different time points (1 day, 1 month, 3 months, and 6 months after surgery), the success rate of surgery in Group B was significantly higher than that in Group A, with an average difference in the success rate of 8.47 ± 1.92% (all P < 0.05). Compared with those at 1 day after surgery, the incidence rates of 6-m strabismus and 33-cm strabismus in the two groups of children were significantly lower at 1, 3, and 6 months after surgery (all P < 0.05). Compared with the preoperative conditions, the central stereoscopic vision of the two groups of children significantly increased at 1, 3, and 6 months after surgery, whereas the proportion of children without stereoscopic vision significantly decreased (all P < 0.05). Moreover, compared with preoperative conditions and 1 month postoperatively, the proportion of far-standing stereopsis gradually increased in both groups of patients at 3 and 6 months postoperatively (all P < 0.05). However, in terms of both central and far-standing stereoscopic vision, the rate of increase displayed by children in Group B was significantly greater than that in Group A (all P < 0.05). At various postoperative time points, the Child-IXTQ score of Group B was higher than that of Group A. At 6 months after surgery, the Child-IXTQ score of Group B reached its highest value (84.57 ± 5.32) (all P < 0.05).</p><p><strong>Conclusion: </strong>AI-assisted computing systems can effectively improve the success rate of paediatric surgery, enhance the establishment of stereoscopic vision function, improve visual quality, and significantly improve quality of life.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"432"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image of ''sudden block by the iris'' before completion of traumatic aniridia: indirect partial support for Navon's hypothesis.","authors":"Atsuhide Takesue, Shintaro Nakao","doi":"10.1186/s12886-025-04280-9","DOIUrl":"10.1186/s12886-025-04280-9","url":null,"abstract":"","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"430"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in choriocapillaris blood flow density and associated factors affecting axial elongation in Chinese children and adolescents with mild to moderate myopia: a cross-sectional study.","authors":"Xin Cui, Liping Chen, Hui Zheng, Xin Meng, Lu Tian, Bin Wu, Shiyong Xie, Wei Wang, Xuefeng Shi","doi":"10.1186/s12886-025-04272-9","DOIUrl":"10.1186/s12886-025-04272-9","url":null,"abstract":"<p><strong>Background: </strong>To investigate changes in choriocapillaris blood flow density (CFD) and identify factors influencing axial elongation in Chinese children and adolescents with mild to moderate myopia.</p><p><strong>Methods: </strong>A hospital-based cross-sectional study was conducted. A total of 288 participants aged 8 to 15 years were recruited from Tianjin Eye Hospital, including 186 children and adolescents with myopia and 102 age-matched participants without refractive error who served as the control group. Based on cycloplegic spherical equivalent (SE), the myopic participants were further categorized into moderate and mild myopia groups. Refractive power was determined through refraction tests, while various parameters-including axial length (AL) and choriocapillaris flow density (CFD)-were obtained through ophthalmic examinations. Statistical analyses were performed to examine changes in CFD and to identify factors associated with axial length.</p><p><strong>Results: </strong>AL and SE differed significantly among all three groups (all P < 0.001). SFCT was significantly lower in the moderate myopia group compared to the mild myopia and control groups (P < 0.05 for both comparisons), while no significant differences in SFCT or FRT were found between the mild myopia and control groups(all P > 0.05).CFD-peri was significantly lower in the moderate myopia group compared to both the mild myopia and control groups (P = 0.006 and P < 0.001, respectively), while no significant differences were found in CFD-fovea or CFD-para among the three groups(P > 0.05).Spearman correlation analysis revealed significant negative correlations between AL and SE (r = -0.770), SFCT (r = -0.170), CFD-fovea (r = -0.347), CFD-para (r = -0.368), and CFD-peri (r = -0.359) (all P < 0.01). Hierarchical regression analysis identified SE (β = -0.751, P < 0.001) and CFD-peri (β = -0.118, P = 0.005) as independent predictors of axial length, with the final model explaining 71.5% of its variance (R² = 0.715).</p><p><strong>Conclusion: </strong>Choriocapillaris blood flow density in the macular region changes in the early stages of myopia, showing decreases in the perifoveal region. Both SE and CFD-peri may serve as potential biomarkers for predicting axial length elongation in the early stage of myopia.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"426"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeatability, reproducibility, and agreement for three optical coherence tomography instruments.","authors":"Jiali Zhang, Muhan Zhong, Shuqi Fan, Xindan Chang, Xue Li, Hao Chen, Jinhua Bao, Yingying Huang","doi":"10.1186/s12886-025-04257-8","DOIUrl":"10.1186/s12886-025-04257-8","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the repeatability, reproducibility and agreement for three optical coherence tomography (OCT) in measuring retinal (RT) and choroidal thickness (ChT).</p><p><strong>Methods: </strong>Sixty-eight eyes were included. The average RT and ChT were obtained with VG200I and Triton, while only the subfoveal RT (SFRT) and ChT (SFChT) were measured with RTVue. Operator 1 conducted two examinations to assess repeatability, and operator 2 conducted one for reproducibility. Built-in software was used to calculate RT-auto and ChT-auto, and custom-designed algorithms were used to calculate ChT-custom to assess interanalysis and intermachine agreements.</p><p><strong>Results: </strong>The intraclass correlation coefficients for the repeatability and reproducibility were larger than 0.760 and 0.940 with VG200I, 0.890 and 0.910 with Triton, and 0.960 and 0.975 with RTVue, respectively. The intermachine differences for SFRT and SFChT were - 8.82 ± 3.15 μm and - 41.89 ± 8.21 μm (VG200I vs. RTVue), -26.86 ± 3.15 μm and - 56.60 ± 7.81 μm (Triton vs. RTVue), and 18.04 ± 2.01 μm and 14.71 ± 3.02 μm (VG200I vs. Triton), respectively. The mean differences between VG200I and Triton in RT, ChT-auto and ChT-custom across the different regions ranged between 16.34 and 27.80 μm, 66.53 and 96.93 μm, and 4.48 and 18.32 μm, respectively. The mean differences between ChT-auto and ChT-custom across the different regions ranged between 29.06 and 43.71 μm for VG200I and - 48.73 and - 27.98 μm for Triton. The intermachine correlations were high, with ρ > 0.655 for all parameters.</p><p><strong>Conclusion: </strong>The three OCT devices all showed great repeatability and reproducibility, while the agreements between them were poor.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"427"},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serous retinal detachment with retinal pigment epithelium tear after PreserFlo MicroShunt surgery: a case report.","authors":"Ayako Sadahide, Yosuke Harada, Hirokazu Sakaguchi, Ayako Sadahide","doi":"10.1186/s12886-025-04259-6","DOIUrl":"10.1186/s12886-025-04259-6","url":null,"abstract":"<p><strong>Background: </strong>The PreserFlo MicroShunt is a minimally invasive glaucoma drainage device designed to lower intraocular pressure (IOP) with fewer complications compared with those of traditional filtration surgery. Hypotony and choroidal detachment (CD) are known postoperative risks. However, retinal pigment epithelium (RPE) tears and serous retinal detachment following PreserFlo MicroShunt have not been reported previously. We report a case of retinal detachment with an RPE tear under hypotony following minimally invasive glaucoma surgery using a drainage device that required surgical intervention to elevate the IOP and achieve resolution.</p><p><strong>Case presentation: </strong>A 53-year-old man with a history of ocular hypertension and cataract surgery with intraocular lens suturing developed uncontrolled IOP in his right eye. PreserFlo MicroShunt surgery was performed but resulted in hypotony and subsequent CD. Despite initial management with atropine eye drops and oral steroids, retinal detachment with RPE tears developed. Scleral drainage and pars plana vitrectomy with sulfur hexafluoride (SF6) gas tamponade were performed to elevate IOP and stabilize the retinal condition, leading to the successful resolution of the detachment. Postoperatively, the IOP stabilized within the mid-teens without observing recurrence.</p><p><strong>Conclusions: </strong>This is the first reported case of RPE tears and serous retinal detachment following Preserflo MicroShunt surgery. These findings highlight that a rapid and significant reduction in IOP, even without reaching absolute hypotony, might disrupt choroidal circulation and RPE integrity, particularly in eyes with predisposing factors, such as atopic dermatitis and long-term steroid use. Early recognition of CD and timely intervention to elevate IOP are crucial for preventing vision-threatening complications.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"424"},"PeriodicalIF":1.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}