BMC Ophthalmology最新文献

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A preliminary comparative study of peripheral capsular linear incision versus circular micro-tear capsulotomy for in situ lens regeneration. 外周囊线性切口与圆形微撕裂囊切开术原位晶状体再生的初步比较研究。
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-05-06 DOI: 10.1186/s12886-026-04824-7
Ming Zhang, Tengyu Xu, Menghan Wang, Wenwen Hou, Yan Wang, Liming Cai, Wei Wang, Suchang Wang
{"title":"A preliminary comparative study of peripheral capsular linear incision versus circular micro-tear capsulotomy for in situ lens regeneration.","authors":"Ming Zhang, Tengyu Xu, Menghan Wang, Wenwen Hou, Yan Wang, Liming Cai, Wei Wang, Suchang Wang","doi":"10.1186/s12886-026-04824-7","DOIUrl":"https://doi.org/10.1186/s12886-026-04824-7","url":null,"abstract":"<p><strong>Background: </strong>In congenital cataract, conventional circular micro-tear capsulotomy often causes loss of anterior capsular lens epithelial cells, thereby impairing the integrity and transparency of the regenerated lens. Based on the concept of minimal capsulorhexis, we performed a preliminary pilot investigation using a 1.5 mm linear incision in the peripheral capsule to evaluate whether this technique could improve lens regeneration outcomes.</p><p><strong>Methods: </strong>Forty 4-week-old New Zealand white rabbits were randomly allocated to two groups: peripheral capsular linear incision (Group A) and circular micro-tear capsulotomy (Group B), with 20 rabbits per group. All surgeries were performed by the same experienced surgeon. Detailed surgical procedures are described below. Postoperatively, regenerated lenses were assessed for morphology, size, weight, transparency, and capsular healing, followed by histological analysis.</p><p><strong>Results: </strong>Successful lens regeneration was observed in both groups. Group A showed superior regenerative outcomes, with more intact lens morphology, higher transparency, and greater lens weight and thickness compared with Group B. Histological examination revealed that epithelial cells in Group A differentiated into well-organized lens fibers with more orderly arrangement, faster capsular healing, smaller scars, and smoother capsular surfaces than those in Group B.</p><p><strong>Conclusions: </strong>Our preliminary pilot study indicates that peripheral capsular linear incision may offer potential advantages over small circular micro-tear capsulotomy in promoting morphological and functional lens regeneration and capsular healing in rabbit eyes. These findings may provide novel surgical strategies for lens regeneration in children with congenital cataracts.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation and comparison of the clinical significance of miR-21-5p levels from different specimen sources in patients with fungal keratitis. 真菌性角膜炎患者不同标本来源miR-21-5p水平的评价及临床意义比较
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-05-05 DOI: 10.1186/s12886-026-04804-x
Qian Liu, Ping Chen, Zhenlan Chen, Hui Liu, Shasha Han
{"title":"Evaluation and comparison of the clinical significance of miR-21-5p levels from different specimen sources in patients with fungal keratitis.","authors":"Qian Liu, Ping Chen, Zhenlan Chen, Hui Liu, Shasha Han","doi":"10.1186/s12886-026-04804-x","DOIUrl":"https://doi.org/10.1186/s12886-026-04804-x","url":null,"abstract":"<p><strong>Background: </strong>Fungal keratitis (FK) is a type of infectious keratitis with a high risk of causing blindness. Therefore, it is crucial to identify effective diagnostic indicators and understand its pathological mechanism.</p><p><strong>Methods: </strong>Quantitative Reverse Transcription polymerase chain reaction (qRT-PCR) was employed to detect miR-21-5p expression in tears, serum, and corneal tissues from patients with FK and non-infectious keratitis (NIK) controls. Pearson correlation analysis was used to assess the expression correlation of miR-21-5p across different sample types. Additionally, the correlations between miR-21-5p and the pro-inflammatory cytokines IL-6, TNF-α, and IL-1β were analyzed.</p><p><strong>Results: </strong>The expression of miR-21-5p in each sample of the FK group was significantly higher than that of the NIK group, and the expression in corneal tissue was higher than that in tears and serum. In the FK group, the expression levels of IL-6, TNF-α and IL-1β varied significantly among the three sample types (all P < 0.001). The expression of miR-21-5p was significantly positively correlated with the levels of IL-6, TNF-α and IL-1β in serum, tear fluid and corneal tissue (all P < 0.001).</p><p><strong>Conclusion: </strong>miR-21-5p is highly expressed in FK serum, tears, and corneal tissues, and the expression of miR-21-5p is positively correlated with the levels of inflammatory factors.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
27-Gauge direct endoillumination-assisted scleral buckling using a heads-up 3D visualization system: surgical feasibility and outcomes in primary rhegmatogenous retinal detachment. 使用平视3D可视化系统测量直接内光辅助巩膜扣合:原发性孔源性视网膜脱离的手术可行性和结果。
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-05-05 DOI: 10.1186/s12886-026-04882-x
Ming-Chieh Hsieh, Yi-Jye Chen, Hung-Yin Lai, Chun-Chi Chiang, Yi-Wen Chen, Jennifer Hui-Chun Ho, Yi-Yu Tsai
{"title":"27-Gauge direct endoillumination-assisted scleral buckling using a heads-up 3D visualization system: surgical feasibility and outcomes in primary rhegmatogenous retinal detachment.","authors":"Ming-Chieh Hsieh, Yi-Jye Chen, Hung-Yin Lai, Chun-Chi Chiang, Yi-Wen Chen, Jennifer Hui-Chun Ho, Yi-Yu Tsai","doi":"10.1186/s12886-026-04882-x","DOIUrl":"https://doi.org/10.1186/s12886-026-04882-x","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the feasibility, anatomical outcomes, visual results, and safety profile of a modified scleral buckling (SB) technique utilizing 27-gauge direct endoillumination under a heads-up three-dimensional (3D) visualization system for primary rhegmatogenous retinal detachment (RRD).</p><p><strong>Methods: </strong>This retrospective case series included consecutive patients with primary RRD who underwent modified SB surgery at a tertiary referral center. Retinal breaks were identified using a 27-gauge endoillumination probe through a valved trocar under a heads-up 3D visualization system with a non-contact wide-angle viewing lens. Anatomical success after a single surgery was the primary outcome. Secondary outcomes included final best-corrected visual acuity (BCVA) and surgical complications.</p><p><strong>Results: </strong>Twenty-seven eyes of 27 patients were included, with a mean age of 34.6 ± 12.1 years. Fifteen eyes (56%) were macula-off at presentation. Single-surgery anatomical success was achieved in all cases during a mean follow-up of 9.4 ± 5.9 months. Mean BCVA improved significantly from 0.57 ± 0.55 logMAR preoperatively to 0.21 ± 0.30 logMAR postoperatively (p < 0.001). Twelve eyes (44.4%) achieved a final visual acuity of 20/20. No major intraoperative or postoperative complications, including endophthalmitis, iatrogenic retinal breaks, cataract formation, or vitreous prolapse, were observed.</p><p><strong>Conclusions: </strong>This modified SB technique using 27-gauge direct endoillumination and heads-up 3D visualization appears to be a feasible and safe approach for selected cases of primary RRD, demonstrating encouraging anatomical and functional outcomes. However, given the retrospective design, small sample size, and absence of a control group, further prospective comparative studies are warranted to validate these findings.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertensive retinopathy as a masquerade neuroretinitis in a child: a case report. 儿童高血压视网膜病变为假面性神经视网膜炎1例报告。
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-05-05 DOI: 10.1186/s12886-026-04791-z
Sarah Gabison, Rym Khellaf, Carl Arndt, Aurélie Bérot, Guillaume Silva, Nathalie Bednarek, Christine Pietrement, Thomas Ferreira de Moura
{"title":"Hypertensive retinopathy as a masquerade neuroretinitis in a child: a case report.","authors":"Sarah Gabison, Rym Khellaf, Carl Arndt, Aurélie Bérot, Guillaume Silva, Nathalie Bednarek, Christine Pietrement, Thomas Ferreira de Moura","doi":"10.1186/s12886-026-04791-z","DOIUrl":"10.1186/s12886-026-04791-z","url":null,"abstract":"<p><strong>Background: </strong>High blood pressure in children is rare and often underdiagnosed, but it can cause irreversible damage to target organs. Ocular signs of hypertensive retinopathy are nonspecific and may resemble those of neuroretinitis or papilledema, which can delay diagnosis.</p><p><strong>Case presentation: </strong>A 9-year-old girl presenting with bilateral visual loss was referred to our emergency department. Best-corrected visual acuity was 20/200 in the right eye and counting fingers in the left. Fundus examination revealed bilateral optic disc swelling with a macular star and flame-shaped hemorrhages. Infectious work-up and neuroimaging were inconclusive. Reassessment showed severe hypertension (165/118 mmHg), hypokalemia, impaired renal and cardiac function. Plasma renin and aldosterone were markedly elevated. Imaging revealed a hypoplastic left kidney with subtotal renal artery stenosis and high-grade vesicoureteral reflux, contributing only 7% of total renal function on DMSA scintigraphy. Antihypertensive therapy with amlodipine, enalapril, and acebutolol normalized blood pressure, improved renal and cardiac function, and restored full visual acuity within six months. A left nephrectomy was subsequently performed to improve long-term blood pressure control.</p><p><strong>Conclusion: </strong>This case demonstrates the importance of systematic blood pressure measurement in children with disc edema or neuroretinitis-like features. Severe hypertension should be considered early on. Pediatric guidelines recommend blood pressure targets below the 90th percentile with ACE inhibitors, angiotensin receptor blockers, calcium channel blockers, or thiazide diuretics as first-line agents. Nephrectomy may be indicated in cases of refractory hypertension when a hypoplastic kidney contributes less than 10% of overall function.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"26 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipemic anterior chamber mimicking uveitis in severe hypertriglyceridemia a case report and literature review. 严重高甘油三酯血症中脂性前房模拟葡萄膜炎1例报告并文献复习。
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-05-05 DOI: 10.1186/s12886-026-04841-6
Jiaying Lei, Xinxin Lu, Qingfeng Liang
{"title":"Lipemic anterior chamber mimicking uveitis in severe hypertriglyceridemia a case report and literature review.","authors":"Jiaying Lei, Xinxin Lu, Qingfeng Liang","doi":"10.1186/s12886-026-04841-6","DOIUrl":"https://doi.org/10.1186/s12886-026-04841-6","url":null,"abstract":"<p><strong>Background: </strong>Diffuse milky-white exudation (lipemic aqueous humor) in the anterior chamber is a rare ocular manifestation associated with metabolic disease-related microvascular dysfunction. Early-onset type 2 diabetes mellitus is characterized by severe metabolic disturbances (e.g., dyslipidemia) and early microvascular injury. We report a young female with poorly controlled hyperglycemia/hyperlipidemia presenting with pseudouveitis and marked milky-white anterior chamber exudation (lipemic aqueous humor), initially mimicking a corneal disorder.</p><p><strong>Case presentation: </strong>A 33-year-old woman with 5-year type 2 diabetes (poor glycemic control), dyslipidemia, chronic sleep disturbances, and a high-fat/high-sugar diet developed acute left-eye pain, photophobia, and decreased vision during menstruation following travel-related fatigue. Slit-lamp examination showed massive homogeneous milky-white anterior chamber exudation (corneal porcelain-like appearance), and B-scan ultrasonography was unremarkable. Fasting blood tests revealed markedly elevated fasting glucose, triglycerides, and total cholesterol. She was diagnosed with pseudouveitis with anterior chamber lipid-protein exudation, and symptoms improved rapidly within 12 h of intensive topical/periocular corticosteroid therapy; intraocular inflammation largely resolved by day 6, with residual posterior synechiae.</p><p><strong>Conclusions: </strong>Early-onset type 2 diabetes patients are prone to metabolic dysregulation under physiological/metabolic stress. Persistent hyperglycemia/hyperlipidemia may compromise microvascular integrity and increase permeability, potentially leading to lipid-protein leakage into the anterior chamber (lipemic aqueous humor)-a hypothetical association due to lack of aqueous humor biochemical analysis. This milky exudate is easily misdiagnosed as infectious keratitis, especially with normal B-scan findings. Meticulous slit-lamp examination, adjunctive AS-OCT/UBM, and systemic metabolic evaluation are crucial for accurate diagnosis. Clinicians should promptly assess serum glucose/lipid levels in young patients with milky anterior chamber opacities to avoid misdiagnosis and unnecessary interventions.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the effects of single and opposite incision techniques on with-the-rule astigmatism in cataract surgery. 单切口与对切口对白内障手术中顺位散光影响的比较。
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-05-05 DOI: 10.1186/s12886-026-04868-9
Emine Seker Un, Tunahan Akyol, Osman Parca, Sevket Oguz Belli
{"title":"Comparison of the effects of single and opposite incision techniques on with-the-rule astigmatism in cataract surgery.","authors":"Emine Seker Un, Tunahan Akyol, Osman Parca, Sevket Oguz Belli","doi":"10.1186/s12886-026-04868-9","DOIUrl":"https://doi.org/10.1186/s12886-026-04868-9","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effects of single clear corneal incision (CCI) and opposite clear corneal incision (OCCI) techniques on corneal and total astigmatism in patients undergoing phacoemulsification cataract surgery.</p><p><strong>Methods: </strong>This retrospective comparative study included 285 eyes of 285 patients with preoperative total astigmatism of 0.75-3.0 diopters and corneal astigmatism of 0.50-2.0 diopters. Patients were divided into two groups: OCCI (141 eyes) and CCI (144 eyes). All surgeries were performed by the same surgeon using a standardized phacoemulsification technique with 2.4-mm clear corneal incisions placed on the steep meridian. In the OCCI group, a second identical incision was created 180° opposite the primary incision. Corneal astigmatism, total astigmatism, spherical equivalent, uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), and intraocular pressure were evaluated preoperatively and during a minimum 12-month follow-up.</p><p><strong>Results: </strong>Preoperative demographic and ocular characteristics were comparable between groups (all p > 0.05). Postoperatively, corneal astigmatism was significantly lower in the OCCI group compared with the CCI group (- 0.71 ± 0.48 D vs. -1.01 ± 0.56 D; p = 0.001). Total astigmatism was also significantly reduced in the OCCI group (- 1.19 ± 1.20 D vs. -1.51 ± 0.71 D; p = 0.004). Spherical equivalent and intraocular pressure did not differ significantly between groups. BCVA outcomes were comparable at all follow-up visits (p > 0.05). However, UCVA was significantly better in the OCCI group at 3 months (p = 0.047) and 12 months (p = 0.031).</p><p><strong>Conclusions: </strong>Opposite clear corneal incisions provide a stronger astigmatic corrective effect than single clear corneal incisions and result in superior uncorrected visual acuity at mid- and long-term follow-up. OCCI represents a simple, safe, and effective technique for correcting mild to moderate astigmatism during routine cataract surgery.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of internal limiting membrane flap and autologous whole blood techniques in complicated macular hole surgery. 内限定膜瓣与自体全血技术在复杂黄斑孔手术中的应用评价。
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-05-04 DOI: 10.1186/s12886-026-04885-8
Büşra Köse, Hidayet Erdöl, Dilek Uzlu, Murat Günay, Mehmet Kola
{"title":"Assessment of internal limiting membrane flap and autologous whole blood techniques in complicated macular hole surgery.","authors":"Büşra Köse, Hidayet Erdöl, Dilek Uzlu, Murat Günay, Mehmet Kola","doi":"10.1186/s12886-026-04885-8","DOIUrl":"https://doi.org/10.1186/s12886-026-04885-8","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate and compare the outcomes of internal limiting membrane (ILM) flap and autologous whole blood application for treatment of complicated macular holes (CMHs).</p><p><strong>Methods: </strong>A retrospective analysis of medical records was performed for patients who underwent vitrectomy for CMHs, including preoperative and postoperative evaluations at 1, 3, and 6 months. Patients were divided into two groups: Group 1 autologous whole blood and Group 2 ILM flap application. The hole parameters were measured using preoperative OCT images. The integrity of the external limiting membrane (ELM)-ellipsoid zone (EZ) and anatomical closure patterns was evaluated on postoperative OCT images. Closure patterns were scored.</p><p><strong>Results: </strong>The study included 37 eyes: 17 (45.9%) in Group 1 and 20 (54.1%) in Group 2. The postoperative closure rate was 94.1% in Group 1 and 100% in Group 2, with an overall rate of 97.3%. No significant differences were found between Groups 1 and 2 in OCT parameters, best-corrected visual acuity, ELM-EZ recovery, or macular edema reduction at any follow-up time point (p > 0.05). The optimal closure score was higher in group 2 at the first month postoperatively (p = 0.036), but no difference was detected at the third and sixth months (p = 0.870 and p = 0.780, respectively).</p><p><strong>Conclusions: </strong>This study demonstrated that both autologous whole blood and ILM flap techniques are effective in the surgical management of CMHs, achieving high closure rates. Given its comparable postoperative results to the ILM flap, autologous whole blood may be a beneficial option in CMH surgery.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Untargeted serum metabolomic profiling in patients with generalized and ocular Myasthenia Gravis. 广泛性和眼性重症肌无力患者的非靶向血清代谢组学分析。
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-05-02 DOI: 10.1186/s12886-026-04843-4
Bin Wei, Haoyu Yuan, Jiawei He, Yuxiang Hu, Jing Li, Xiaorong Wu
{"title":"Untargeted serum metabolomic profiling in patients with generalized and ocular Myasthenia Gravis.","authors":"Bin Wei, Haoyu Yuan, Jiawei He, Yuxiang Hu, Jing Li, Xiaorong Wu","doi":"10.1186/s12886-026-04843-4","DOIUrl":"https://doi.org/10.1186/s12886-026-04843-4","url":null,"abstract":"<p><strong>Background: </strong>Myasthenia Gravis (MG) is divided into ocular (OMG) and generalized (GMG) subtypes. While clinical diagnosis is well-established, understanding the underlying biochemical mechanisms and metabolic shifts during disease progression remains challenging; untargeted metabolomics offers a novel perspective to explore these systemic alterations.</p><p><strong>Objective: </strong>To characterize the serum metabolic landscape of MG patients and identify potential metabolic signatures associated with disease subtypes (OMG and GMG) via untargeted metabolomics.</p><p><strong>Methods: </strong>91 participants (41 GMG, 22 OMG, 28 healthy controls [HC]) were enrolled. Fasting serum samples were analyzed by LC-MS/MS. Multivariate analyses (PCA, PLS-DA/OPLS-DA), differential metabolite screening (VIP > 1.0, p < 0.05), and KEGG pathway enrichment were performed.</p><p><strong>Results: </strong>HC and MG groups showed distinct metabolic profiles. MG had 515 (175 up, 340 down) and 368 (146 up, 222 down) differential metabolites in positive/negative ion modes, respectively. Key perturbed pathways included glycerophospholipid, sphingolipid metabolism, and unsaturated fatty acid biosynthesis. Ten representative metabolites (e.g., ubiquinone, cortisol) differed significantly among groups; clustering analysis revealed distinct metabolite abundance trajectories across HC, OMG, and GMG.</p><p><strong>Conclusion: </strong>MG is associated with notable systemic metabolic dysregulation, particularly in lipid-related pathways. Rather than serving as immediate diagnostic tools, these integrative metabolic signatures provide a crucial biochemical framework for understanding disease pathogenesis and offer valuable clues for future hypothesis-driven research and prospective validation.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormone therapy preserves ocular surface integrity following circadian alignment disturbance in menopausal rats. 激素治疗保留眼表完整性后,昼夜节律紊乱的更年期大鼠。
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-05-02 DOI: 10.1186/s12886-026-04877-8
Semra Acer, Mehmet Argun, Özlem Özmen, Cafer Açıkgöz, Mustafa Yavuz
{"title":"Hormone therapy preserves ocular surface integrity following circadian alignment disturbance in menopausal rats.","authors":"Semra Acer, Mehmet Argun, Özlem Özmen, Cafer Açıkgöz, Mustafa Yavuz","doi":"10.1186/s12886-026-04877-8","DOIUrl":"https://doi.org/10.1186/s12886-026-04877-8","url":null,"abstract":"<p><strong>Background: </strong>This study examines the impact of a light-cycle shift regimen on corneal and conjunctival tissues in menopausal rats and evaluates the protective role of combined hormone therapy.</p><p><strong>Methods: </strong>Twenty-four menopausal female albino rats were randomly assigned to three groups (n = 8) following a 10-day acclimatization period. Group 1 (Control+Saline) was maintained under a 12:12 light/dark cycle. Light-cycle shift regimen was induced in Groups 2 and 3 using a rotating 7-day light-exposure sequence repeated over 21 days; this protocol consisted of 24 h of continuous light, 72 h of inverted dark-light timing, and 72 h of standard light-dark conditions. Groups 1 and 2 received saline, while Group 3 received 17β-Estradiol and drospirenone daily via oral gavage. After 31 days, eyes were enucleated for histological and immunohistochemical analyses of corneal, conjunctival, and palpebral tissues, including caspase-3 (Cas-3), tumor necrosis factor-alpha (TNF-α), and PERIOD-2 (PER2) expression.</p><p><strong>Results: </strong>Light-cycle shift regimen (Group 2) significantly increased corneal thickness (p < 0.001), conjunctival inflammation, and vascular congestion, with marked upregulation of Cas-3 and TNF-α and downregulation of PER2. Hormone therapy (Group 3) attenuated these effects, showing reduced corneal edema, diminished inflammatory infiltration, and partial normalization of molecular markers.</p><p><strong>Conclusions: </strong>Shifting light-dark cycles may aggravate inflammatory and apoptotic changes in the ocular surface during menopause. Estrogen-progestin therapy attenuates these alterations by modulating the expression of the circadian-associated protein PER2 and maintaining structural integrity. These findings suggest that hormone therapy may offer potential benefits for preserving ocular surface homeostasis in menopausal women experiencing sleep or circadian rhythm disturbances.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glaucoma following cataract surgery in pediatric patients: a systematic review of incidence, risk factors, and management strategies. 儿童白内障手术后青光眼:发病率、危险因素和管理策略的系统回顾。
IF 1.7 4区 医学
BMC Ophthalmology Pub Date : 2026-04-30 DOI: 10.1186/s12886-026-04849-y
Seham S Alhemaidi
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