BMC Ophthalmology最新文献

{"title":"Innovator ranibizumab ComparEd to Biosimilar ranibizumab in combination with Expansile gas in submaculaR HemorrhaGe: the ICEBERG study.","authors":"Debdulal Chakraborty, Tushar Kanti Sinha, Soumen Mondal, Subhendu Boral, Arnab Das, Saptorshi Majumbar, Angshuman Mukherjee, Ranabir Bhattacharya, Sumit Randhir Singh","doi":"10.1186/s12886-025-03846-x","DOIUrl":"10.1186/s12886-025-03846-x","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the anatomical and visual outcomes in eyes with submacular hemorrhage (SMH) treated with a combination of ranibizumab (RBZ) either innovator or biosimilar (Razumab) and intravitreal perfluoropropane gas (C₃F₈).</p><p><strong>Methods: </strong>Treatment naïve neovascular age related macular degeneration (n-AMD) patients with SMH were retrospectively analyzed. Patients received either innovator or biosimilar RBZ (3 loading doses followed by pro re nata regimen) and single injection of intravitreal C₃F₈. Optical coherence tomography (OCT) was performed at baseline, 1, 3 and 6 months. Changes in best corrected visual acuity (BCVA) and central macular thickness (CMT) were assessed at 6 months. P value ≤ 0.05 was considered statistically significant.</p><p><strong>Results: </strong>A total of 67 eyes (35 and 32 eyes in innovator and biosimilar group respectively) were analyzed. BCVA improved from 1.15 ± 0.19 to 0.51 ± 0.23 logarithm of minimum angle of resolution (logMAR) in innovator RBZ group (p < 0.001) and from 1.17 ± 0.15 to 0.53 ± 0.20 logMAR in biosimilar RBZ group (p < 0.001). Similarly, mean CMT showed significant reduction in both groups at 6 months (innovator RBZ: 609.5 ± 50.1 μm to 254.3 ± 20.3 μm, p < 0.001; biosimilar RBZ: 602.3 ± 58.9 μm to 251.8 ± 22.3 μm, p < 0.001). Intergroup comparisons between innovator and biosimilar RBZ showed no differences in either BCVA or CMT at all time points (all p values > 0.05). Mean number of intravitreal injections was marginally higher in innovator group compared to biosimilar RBZ (4.37 ± 0.49 vs. 4.22 ± 0.42; p = 0.18).</p><p><strong>Conclusion: </strong>Biosimilar RBZ may act as a viable alternative to innovator RBZ to treat SMH with comparable anatomical and visual outcomes at 6 months.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"41"},"PeriodicalIF":1.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving ROP management: insights from a comparative analysis of screening and treatment modalities in a tertiary hospital, Pakistan.","authors":"Muhammad Moin, Aisha Azam, Lubna Siddiq Mian, Ashal Pal, Rutaab Kareem, Noor Us Sehar","doi":"10.1186/s12886-025-03865-8","DOIUrl":"10.1186/s12886-025-03865-8","url":null,"abstract":"<p><strong>Background: </strong>The principal objective of our study is to evaluate the characteristics of babies with type 1 ROP, screening practices and treatment trends in a tertiary care centre in Pakistan.</p><p><strong>Methods: </strong>This prospective study at Mayo Hospital, Lahore (July 2022-July 2024), included 89 preterm infants with type 1 ROP, selected using non-probability sampling. Infants were categorized based on international (GA < 32weeks or BW < 1500 g) and local screening criteria (GA < 35 weeks or BW < 2000 g), and treatment outcomes were evaluated across three groups: Anti-VEGF, combination therapy (Anti-VEGF followed by laser), and laser therapy. Statistical analysis was performed using SPSS version 27.0, significance was set at p < 0.05.</p><p><strong>Results: </strong>Out of 355 infants screened, 89 (25.1%) met the inclusion criteria for type 1 ROP. The cohort included 55 males (61.8%) and 34 females (38.2%), with a mean gestational age of 31.31 weeks and a mean birth weight of 1602.25 g. Zone 1 ROP was found in 36% of cases, associated with lower birth weight (P = 0.029) and earlier gestational age (P = 0.037), while Zone 2 ROP, found in 64%, was linked to higher birth weight and later gestational age. Zone 1 infants were more likely to receive anti-VEGF or combination therapy, whereas Zone 2 infants predominantly received laser therapy (p < 0.000). Preterm infants (born before 32 weeks) mostly received Anti-VEGF or combination therapy, while those with higher birth weights primarily received laser therapy (p < 0.010). Among the treated babies, 63 (70.8%) met international screening criteria and were more likely to have Zone 1 ROP and receive Anti-VEGF or combination therapy. Conversely, 26 (29.2%) did not meet these criteria, had predominantly Zone 2 ROP and were more likely to receive laser therapy (p = 0.007).</p><p><strong>Conclusion: </strong>International screening criteria effectively identify severe type 1 ROP cases, particularly Zone 1, which often require Anti-VEGF therapy. Local criteria capture additional cases, predominantly Zone 2, which are more likely to need laser treatment. These findings highlight the need for tailored screening and treatment approaches to improve ROP management and outcomes for preterm infants.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"40"},"PeriodicalIF":1.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear metabolomics reveals novel potential biomarkers in epithelial herpes simplex keratitis.","authors":"Jinyu Zhang, Zhenning Wu, Yangqi Zhang, Kaili Wu, Xiaoyi Li, Shiyou Zhou","doi":"10.1186/s12886-025-03875-6","DOIUrl":"10.1186/s12886-025-03875-6","url":null,"abstract":"<p><strong>Background: </strong>Herpes simplex keratitis (HSK) is a recurrent inflammatory disease of cornea primarily initiated by type I herpes simplex virus infection of corneal epithelium. However, early diagnosis of HSK remains challenging due to the lack of specific biomarkers. This study aims to identify biomarkers for HSK through tear metabolomics analysis between HSK and healthy individuals.</p><p><strong>Methods: </strong>We conducted a cross-sectional study enrolling 33 participants. Tear samples were collected from one eye of 18 HSK patients and 15 healthy volunteers using Schirmer-strips. Tear metabolomic profiling was performed using high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS). Metabolites were quantified and matched against entries in the human metabolome database (HMDB) and small molecule pathway database (SMPDB) to identify metabolites and metabolic pathways, respectively. Metabolic differences between HSK and control group were determined using multivariate statistical analysis.</p><p><strong>Results: </strong>A total of 329 metabolites were identified, of which 18 were significantly altered in HSK patients. Notably, 12 metabolites were significantly increased, and 6 were significantly decreased in HSK patients. The changed metabolites were enriched in these pathways: arginine and proline metabolism, phospholipid biosynthesis, alpha linolenic acid and linoleic acid metabolism, retinol metabolism. To assess the potential utility of tear biomarkers, a predictive model was developed combining 4 metabolites (AUC = 0.998 [95%CI: 0.975, 1]): D-proline, linoelaidic acid, plantagonine, and phosphorylcholine.</p><p><strong>Conclusions: </strong>Our study establishes that HSK has a distinctive metabolomic profile, with 4 key elements maybe emerging as potential biomarkers for diagnostic purposes. These findings may provide novel insights into early and rapid diagnosis of HSK.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"43"},"PeriodicalIF":1.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal vascular geometry and its association to silent brain infarction.","authors":"Jing Wang, Tingli Chen, Jing Wang, Xiyun Bian, Xiaowei Zhang, Xiaolong Yang, Xing Qi, Yihan Li, Haixia Huang, Qian Qian, Fei Yuan","doi":"10.1186/s12886-025-03854-x","DOIUrl":"10.1186/s12886-025-03854-x","url":null,"abstract":"<p><strong>Objective: </strong>To examine the relationship between retinal vascular geometry and silent brain infarction (SBI) in the Chinese population.</p><p><strong>Methods: </strong>We conducted a cross-sectional study that retrospectively analyzed the fundus photographs, MRI and other clinical data of 227 SBIs and 227 controls who visited Shanghai Health And Medical Center for physical examination. The retinal vessel fractal dimension (FD), retinal artery fractal dimension (FDa), retinal vein fractal dimension (FDv), central retinal artery diameter in the region from 0.5 ~ 1.0 disc diameter (DD) from the disc margin (CRAEB), central retinal artery diameter in the region from 1.0 ~ 2.0 DD from the disc margin (CRAEC), central retinal vein diameter in the region from 0.5 ~ 1.0 DD from the disc margin (CRVEB), central retinal vein diameter in the region from 1.0 ~ 2.0 DD from the disc margin (CRVEC), retinal arteriovenous diameter ratio in the region from 0.5 ~ 1.0 DD from the disc margin (AVRB), and retinal arteriovenous diameter ratio in the region from 1.0 ~ 2.0 DD from the disc margin (AVRC) were accessed by the Singapore \"I\" Vessel Assessment (SIVA) software.</p><p><strong>Results: </strong>FD, FDa, FDv, CRAEB, CRAEC, CRVEB, CRVEC and AVRB in SBI subjects were 1.25 (1.21-1.28), 1.11 (1.08-1.14), 1.09 (1.06-1.13), 168.78 ± 19.39, 163.55 ± 18.97, 235.77 (222.64-254.08), 224.39 ± 23.29, 0.72 ± 0.06, respectively, significantly lower than those of control subjects [1.30 (1.28-1.32), 1.15 (1.13-1.18), 1.14 (1.12-1.16), 196.81 ± 27.94, 183.81 ± 25.46, 273.03 (247.59-296.30), 249.59 ± 32.03, and 0.73 ± 0.08]. Logistic regression results showed that higher FD (OR, 0.04), FDa (OR, 0.07), FDv (OR, 0.06), CRAEB (OR, 0.02), CRAEC (OR, 0.04), CRVEB (OR, 0.03), CRVEC (OR, 0.06), and AVRB (OR, 0.55) were associated with a lower of SBI. There was no significant difference in AVRC between the two groups.</p><p><strong>Conclusion: </strong>Our study shows the association between retinal vascular geometry and SBI, and the results may provide new biomarkers for the early detection of SBI.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"36"},"PeriodicalIF":1.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy.","authors":"Maximilian Hammer, Amanda Ie, Katharina Eibenberger, Gerd Uwe Auffarth, Kanmin Xue","doi":"10.1186/s12886-024-03834-7","DOIUrl":"10.1186/s12886-024-03834-7","url":null,"abstract":"<p><strong>Purpose: </strong>Proliferative vitreoretinopathy (PVR) is a complication of retinal detachment which requires multiple vitreoretinal surgical interventions and frequent use of oil endotamponade. In this study, we conducted an in-depth analysis of complications associated with the use of heavy silicone oil in the management of inferior PVR.</p><p><strong>Methods: </strong>A retrospective cohort study of 20 eyes that underwent vitrectomy for inferior PVR with use of heavy silicone oil (Densiron 68) between March 2021 and October 2022 at Oxford Eye Hospital. Complications were classified into major categories relating to intraocular pressure, inflammation, lens, and oil emulsification/migration. Visual outcomes and surgical success rate were also evaluated.</p><p><strong>Results: </strong>Fill-induced pressure spikes (> 30 mmHg) within 14 days post-surgery were common after Densiron tamponade, especially in patients previously on glaucoma drops. The number of glaucoma drugs were increased in 45% of patients during Densiron tamponade. In 20% of cases, an increased medication was continued long-term after Densiron removal. Significant cataract progression occurred in all phakic patients. In 25% of pseudophakic cases, posterior capsule opacification was noted. Inflammatory complications, such as anterior uveitis, were rare and any cystoid macular oedema was transient. No unexplained acute loss of vision following Densiron removal was encountered. The anatomical success rate at 30 days after Densiron removal was 70%. The mean (± SD) best-corrected visual acuities were 1.04 (± 0.79), 0.85 (± 0.62) and 0.50 (± 0.51) logMAR prior, during and after Densiron tamponade, respectively.</p><p><strong>Conclusion: </strong>The outcomes in this cohort treated with Densiron 68 were comparable to previously reported anatomical and functional results in cases with inferior PVR. IOP and lens-related complications require additional treatment during or after Densiron tamponade. Inflammatory complications rarely occurred over tamponade durations of around three months.</p><p><strong>Trial registration: </strong>Analyses were conducted as an internal quality improvement audit and as such did not require external IRB review.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"38"},"PeriodicalIF":1.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of 0.1% cyclosporine A in dry eye patients with inadequate responses to 0.05% cyclosporine A: a switching, prospective, open-label, multicenter study.","authors":"Sook Hyun Yoon, Eun Chul Kim, In-Cheon You, Chul Young Choi, Jae Yong Kim, Jong Suk Song, Joon Young Hyon, Hong Kyun Kim, Kyoung Yul Seo","doi":"10.1186/s12886-025-03862-x","DOIUrl":"10.1186/s12886-025-03862-x","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the clinical efficacy of 0.1% cyclosporine A (CsA) in dry eye patients who have shown inadequate responses to previous treatment with 0.05% CsA.</p><p><strong>Design: </strong>This study was designed as a switching, prospective, multicenter, 12-week, open-label study.</p><p><strong>Methods: </strong>Patients with dry eye disease (DED), who experienced inadequate responses to at least 3 months of treatment with 0.05% cyclosporine, were enrolled in this study. Clinical evaluations included the National Eye Institute (NEI) corneal and conjunctival staining scores, tear film break-up time (TF-BUT), Symptom Assessment in Dry Eye (SANDE), ocular discomfort scale (ODS), and tear volume. These parameters were assessed at baseline, and again at 4, 8, and 12 weeks after switching to 0.1% CsA.</p><p><strong>Results: </strong>Ninety-one patients were enrolled in the study, and 70 patients completed the trial. Statistical analysis was performed on the full analysis set (FAS) using the Markov Chain Monte Carlo (MCMC) method to account for missing data. After switching to 0.1% CsA, subjective symptoms assessed by the Symptom Assessment in Dry Eye (SANDE) and Ocular Discomfort Scale (ODS) showed improvement (p < 0.0001). Objective signs of dry eye, including the National Eye Institute (NEI) score, tear film break-up time (TF-BUT), and tear volume also improved (p < 0.0001).</p><p><strong>Conclusions: </strong>In patients with dry eye disease (DED) who exhibited inadequate responses to 0.05% cyclosporine A (CsA), switching to 0.1% CsA resulted in significant improvements in both subjective symptoms and objective clinical signs. This finding suggests that higher concentrations of CsA may be more effective in treating individuals with moderate to severe DED.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"37"},"PeriodicalIF":1.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of corneal transplantation: a review of 8,378 patients.","authors":"Mohammad Nasser Hashemian, Mohammad Javad Zia, Masoud Khorrami-Nejad, Qaysser Sattar Abed, Hesam Hashemian","doi":"10.1186/s12886-024-03826-7","DOIUrl":"10.1186/s12886-024-03826-7","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the outcomes of corneal transplantation procedures over a 13-year period at Farabi Eye Hospital, Tehran, Iran, to identify trends and determinants influencing the frequency and success of primary and re-transplantations.</p><p><strong>Methods: </strong>Utilizing a comprehensive dataset from the hospital's Hospital Information System, the study reviewed the records of 8,378 patients who underwent corneal transplants between 2009 and 2022. This analysis included demographic information, surgical details, and follow-up data. Statistical methods were applied to assess the impact of variables such as age, gender, surgeon experience, and surgical techniques on the likelihood of re-transplantation.</p><p><strong>Results: </strong>Of the 8,378 transplants, 7,660 (91.4%) were primary procedures while 718 (8.6%) involved re-transplantation. The most common primary transplant was penetrating keratoplasty (PKP, 50.3%), followed by Descemet's stripping endothelial keratoplasty (DSAEK, 29.3%), and deep anterior lamellar keratoplasty (DALK, 18.5%). Analysis revealed no significant association between re-transplantation rates and patient gender or nationality. Older recipient age correlates with higher re-transplantation rates, likely due to reduced regenerative capacity and increased comorbidities in older patients. Pre-transplant comorbidities (e.g., keratoconus, ulcers), concurrent surgeries (e.g., vitrectomy), and prior procedures (e.g., glaucoma surgeries, IOL implantation) significantly increase re-transplantation risk, likely due to additional ocular stress and inflammation.</p><p><strong>Conclusion: </strong>The study highlights the importance of patient age, surgeon experience, and the choice of surgical technique in the success rates of corneal transplants. These factors are crucial for optimizing patient outcomes and minimizing the necessity for re-transplantations.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"39"},"PeriodicalIF":1.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the correlations between changes in posterior segment and anterior chamber segment after implantable collamer lens implantation in highly myopic patients.","authors":"Yifei Peng, Lu Xiong, Haokun Qu, Yang Liu, Zheng Wang","doi":"10.1186/s12886-025-03863-w","DOIUrl":"10.1186/s12886-025-03863-w","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of Implantable Collamer Lens (ICL) implantation on anterior chamber angle parameters and posterior segment structures in highly myopic eyes and explore potential correlations between these changes. The study aimed to assess alterations in superficial and deep vessel density (SVD, DVD), foveal avascular zone (FAZ) area, and retinal nerve fiber layer (RNFL) thickness to clarify the safety profile of ICL implantation.</p><p><strong>Methods: </strong>Prospective observational study, included 36 highly myopic eyes undergoing ICL implantation in surgery group and 23 non-surgical control eyes in non-surgery group. Anterior chamber parameters were assessed using AS-OCT, and posterior segment changes, including SVD, DVD, FAZ, and RNFL, were evaluated using OCT and OCTA preoperatively and at intervals up to 3 months postoperatively. Statistical analyses included paired t-tests, Wilcoxon tests, and Spearman correlation.</p><p><strong>Results: </strong>ICL implantation significantly improved uncorrected distance visual acuity (UDVA) (p < 0.01). Anterior chamber depth (ACD) and angle parameters, such as AOD and TISA, decreased initially but stabilized by 3 months. SVD and DVD showed early postoperative fluctuations, returning to baseline by 3 months, while the FAZ area and subfoveal choroidal thickness remained stable. Significant correlations were identified between anterior segment narrowing and posterior vascular changes, particularly in the pericentral region.</p><p><strong>Conclusions: </strong>ICL implantation effectively and safely corrects high myopia, with stable anterior and posterior structural changes by 3 months. Transient vascular density fluctuations correlated with anterior chamber angle alterations, highlighting the need for long-term studies to further understand these dynamics and ensure retinal safety postoperatively.</p><p><strong>Trial registration: </strong>The study was approved by the ethics committee of Aier Eye Hospital, Jinan University (No. GZAIER2023IRB25; China Clinical Trial Record No. MR-44-24-009241).</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"33"},"PeriodicalIF":1.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of several toric intraocular lens calculators for predicting postoperative refractive astigmatism in cataract surgery: a real-world study.","authors":"Haocheng Xian, Bingzhen Li, Ziyao Xia, Chun Zhang, Xuemin Li","doi":"10.1186/s12886-025-03856-9","DOIUrl":"10.1186/s12886-025-03856-9","url":null,"abstract":"<p><strong>Background: </strong>This study aims to comprehensively evaluate the predictive accuracy of six widely used toric intraocular lens (IOL) calculators in eyes undergoing cataract surgery with toric IOL implantation.</p><p><strong>Methods: </strong>This retrospective study reviewed 53 eyes of 53 patients that underwent cataract extraction with toric IOL implantation using Zeiss 709 M. Six toric IOL calculators were evaluated: Barrett toric calculator (with predicted PCA, measured PCA, and TK), Kane formula (predicted PCA), and EVO 2.0 formula (predicted and measured PCA). Postoperative refractive astigmatism prediction errors were comprehensively calculated and analyzed using vector analysis.</p><p><strong>Results: </strong>The mean absolute prediction error (APE) ranged from 0.56 ± 0.37 D (Barrett TK) to 0.63 ± 0.46 D (Barrett predicted PCA, PPCA). The proportions of eyes achieving APE ≤ 1.0 D were highest for Barrett TK and Kane predicted PCA (90.6%). The highest proportions of eyes achieving APE ≤ 0.25 D and ≤ 0.50 D were observed with Barrett measured PCA (18.9% and 56.6%, respectively), while the lowest with Barrett PPCA (9.4% and 50.9%, respectively). The study found no statistically significant differences in mean absolute prediction error (APE) among the six calculators (χ² = 6.88, P = 0.23) and the centroid of PE (P = 0.93). A difference in mean APE was observed between the Barrett predicted PCA and Barrett TK calculators (P = 0.02).</p><p><strong>Conclusion: </strong>The study confirms the importance of considering posterior corneal astigmatism remains essential to achieving precise refractive outcomes but also underscores the need for ongoing refinement and evaluation to optimize surgical outcomes.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"35"},"PeriodicalIF":1.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of OCT imaging-based reoperations in strabismus.","authors":"Savleen Kaur, Jaspreet Sukhija, Srishti Raj, Shweta Chaurasia, Shubhi Singh M Optom","doi":"10.1186/s12886-024-03816-9","DOIUrl":"10.1186/s12886-024-03816-9","url":null,"abstract":"<p><strong>Purpose: </strong>Reoperations in strabismus are reportedly needed in 20-40% of cases undergoing surgery. The present study investigated the outcomes of reoperations based on preoperative imaging of extraocular muscle insertions, and whether the Anterior Segment Optical Coherence Tomography (ASOCT) was of value.</p><p><strong>Methods: </strong>Patients with strabismus requiring reoperation with/without previous surgical records at the Advanced Eye Centre, PGIMER, Chandigarh were recruited. All patients underwent a thorough clinical examination and imaging of extraocular muscle insertions on the Swept Source Anterior Segment Optical Coherence Tomography. The accuracy of measuring muscle insertions with the ASOCT was compared with intraoperative caliper readings.</p><p><strong>Results: </strong>Forty-seven muscles (28 patients) were imaged on ASOCT with confirmation intraoperatively during re-operation. The mean age of the patients was 21.6 ± 5.6 years. After looking at the imaging findings, the decision of which muscle to operate on changed in eleven patients (39.2%). The accuracy of ASOCT to measure muscle insertion ± 1 mm was seen in 78.7% (38/47 muscles). The ASOCT could give additional information, such as a slipped muscle and stretched scar in three patients.</p><p><strong>Conclusions: </strong>Imaging can be beneficial in achieving successful results in strabismus reoperations with high accuracy. It can be pivotal in surgical planning in reoperations (~ 40%).</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"34"},"PeriodicalIF":1.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}