BMC OphthalmologyPub Date : 2025-10-09DOI: 10.1186/s12886-025-04388-y
Çiğdem Coşkun, Sebile Çomçalı, Celil Orman
{"title":"Evaluation of corneal densitometry using Pentacam in patients with type 2 diabetes mellitus: a controlled cross-sectional study.","authors":"Çiğdem Coşkun, Sebile Çomçalı, Celil Orman","doi":"10.1186/s12886-025-04388-y","DOIUrl":"10.1186/s12886-025-04388-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to analyze corneal densitometry (CD) values in individuals diagnosed with Type 2 Diabetes Mellitus (DM) using the Pentacam Scheimpflug imaging system and to compare the obtained data with those from a control group consisting of healthy individuals.</p><p><strong>Methods: </strong>The study included 74 eyes of 37 patients diagnosed with Type 2 Diabetes Mellitus (DM) and 54 eyes of 27 healthy volunteers matched for age and gender. All participants underwent measurements of flat keratometry (K1), steep keratometry (K2), maximum keratometry (Kmax), central corneal thickness (CCT), thinnest corneal thickness (TCT), average anterior and posterior elevation at the corneal apex (AAE and APE), corneal volume (CV) and CD. All measurements were performed using the Pentacam HR device (Oculus, Germany), which operates based on the Scheimpflug imaging principle. CD was evaluated in detail according to radial zones (0-2 mm, 2-6 mm, 6-10 mm, 10-12 mm) and corneal depths (anterior, central, posterior, and total). Only newly diagnosed Type 2 DM patients were included in the study, while those with diabetic retinopathy or maculopathy were excluded. HbA1c levels of all patients were recorded. Statistical analysis of the data was conducted using SPSS software version 22.0, and a p-value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean age of the Type 2 Diabetes Mellitus (DM) group was 50.51 ± 8.93 years, while the mean age of the healthy control group was 50.89 ± 5.71 years. There were no statistically significant differences between the two groups in terms of age and gender distribution (p = 0.42 and p = 0.20, respectively). Similarly, no significant differences were observed between the groups in terms of K1, K2, Kmax, CCT, TCT, AAE,APE and CV (p = 0.51; p = 0.50; p = 0.48; p = 0.95; p = 0.99; p = 0.50; p = 0.29; p = 0,58 respectively). In contrast, CD values were significantly higher in the Type 2 DM group compared to the healthy control group across all zones (0-2 mm, 2-6 mm, 6-10 mm, 10-12 mm) and at all corneal depths (anterior, central, posterior, total) (p < 0.01). A low-level positive correlation was found between HbA1c levels and AAE (r = 0.281; p = 0.015). In addition, a very weak negative correlation was observed between HbA1c levels and CD values in the anterior 2-6 mm zone (r = -0.240; p = 0.035).</p><p><strong>Conclusion: </strong>In this study, CD values were found to be significantly higher in patients with Type 2 DM compared to healthy individuals. This finding suggests that chronic hyperglycemia may lead to both morphological and functional changes in the corneal tissue.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"558"},"PeriodicalIF":1.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differentially expressed profiles of LncRNAs in pterygium.","authors":"Jiusheng Zheng, Zhixin Ding, Lixin Mei, Huixiang Jin, Pengfei Zhang, Jinghong Yao, Guangming Liu, Shuting Li, Yinping Liu","doi":"10.1186/s12886-025-04321-3","DOIUrl":"10.1186/s12886-025-04321-3","url":null,"abstract":"<p><strong>Objective: </strong>To do the differential expression of long noncoding RNAs (lncRNAs) in pterygium was screened by gene chip technology, and the differentially expressed lncRNAs HOTTIP and RP1-261G23.7 were studied to explore their possible mechanisms in the pathogenesis of pterygium.</p><p><strong>Methods: </strong>Collected 40 specimens from June 2016 to May 2017 that underwent surgery in the Ophthalmology Department of Yanjishan Hospital of Wannan Medical College, including 20 pterygium tissue specimens (6 males and 14 females, aged 47-84 years, mean age 68.1 years), 20 cases of normal nasal bulbar conjunctival tissue in patients with strabismus (9 males and 11 females, aged 41-88 years, mean age 61.6 years). Four samples from each group were randomly selected to detect lncRNA expression by high-throughput gene chip detection technology; lncRNA HOTTIP, RP1-261G23.7 and corresponding target genes HOXA13, VEGFA were screened by quantitative real time polymerase chain reaction (qRT-PCR) to verify whether there is a significant difference between the two groups, and to analyze the correlation between the expression of the target genes HOXA13 and VEGFA.</p><p><strong>Results: </strong>(1) SPSS17.0 software was used for data processing in the experimental group and the control group. Gender and age were analyzed by the chi-square test. The statistical results were all P > 0.05, and there was no significant difference in statistics, (2) A total of 8271 differential lncRNAs were detected by high-throughput gene chip detection and compared with normal nasal bulbar conjunctival tissue in patients with strabismus. Among them, lncRNAs with a P-value < 0.05 and log fold change > 2 and Benjamini-Hochberg FDR correction (FDR < 0.05) had 612 upregulated genes and 743 downregulated genes. (3) The two highly differential lncRNAs were selected and verified by qRT-PCR. The results showed that lncRNAs HOTTIP and RP1-261 G23.7 and the corresponding target genes HOXA13 and VEGFA were highly consistent and highly expressed in the control group.</p><p><strong>Conclusions: </strong>(1) LncRNAs are differentially expressed in pterygium; (2) Key lncRNA HOTTIP, RP1-261G23.7 may be new gene targets for pterygium.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"557"},"PeriodicalIF":1.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC OphthalmologyPub Date : 2025-10-09DOI: 10.1186/s12886-025-04417-w
Fatemeh Sanie-Jahromi, Masoomeh Eghtedari, Mahmood Nejabat, Ramin Salouti, Hossein Jamali, Shahram Bamdad, Mohammad Hassan Jalalpour, Amir Khosravi
{"title":"Limbal stem cell sheet bandage for short-term treatment of corneal regeneration.","authors":"Fatemeh Sanie-Jahromi, Masoomeh Eghtedari, Mahmood Nejabat, Ramin Salouti, Hossein Jamali, Shahram Bamdad, Mohammad Hassan Jalalpour, Amir Khosravi","doi":"10.1186/s12886-025-04417-w","DOIUrl":"10.1186/s12886-025-04417-w","url":null,"abstract":"<p><p>This study investigates a novel short-term treatment for Limbal Stem Cell Deficiency (LSCD) using a limbal stem cell (LSC) sheet bandage. The method utilizes polytetrafluoroethylene (PTFE) membranes to harvest and transplant LSC sheets for corneal surface regeneration. In cases where autologous tissue was not available, limbal biopsies obtained from patients' relatives were cultured to generate LSC sheets, which were subsequently transferred onto PTFE scaffolds using a bottom-up cell transfer technique. Eight patients with treatment-resistant, end-stage LSCD underwent the procedure and examined during a six-months follow-up. Pre-transplantation assessments confirmed the viability and marker expression of the LSCs. Immunocytochemistry and microscopy validated the structural integrity of the LSC sheets on PTFE, and toxicity assays indicated the scaffold's biocompatibility. Post-operative evaluations showed improvements or stabilization in visual acuity, along with a reduction in the use of lubricating eye drops during a 1-month period. No immediate severe complications were observed. Short-term outcomes were promising, showing corneal surface regeneration and improved patient satisfaction and quality of life. However, long-term success varied at the 6- month follow-up. This LSC sheet bandage acted as a cellular bandage, rapidly restoring the corneal surface and facilitating further therapeutic procedures. The technique may serve as a potential interim solution for patients ineligible for conventional corneal transplants. TRIAL REGISTRATION: The study was registered in the Iranian Registry of Clinical Trials (IRCT) on 2020-05-06 (approval number: IRCT20180724040574N1).</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"555"},"PeriodicalIF":1.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC OphthalmologyPub Date : 2025-10-09DOI: 10.1186/s12886-025-04399-9
Lijuan Xu, Juan Gu, Wenqing Ye, Xinyao Zhang, Yin Zhao, Tao Zhou, Jialing Han, Ruiyi Ren, Yuanbo Liang
{"title":"Incidence and risk factors for early transient intraocular pressure elevation after penetrating canaloplasty in patients with glaucoma.","authors":"Lijuan Xu, Juan Gu, Wenqing Ye, Xinyao Zhang, Yin Zhao, Tao Zhou, Jialing Han, Ruiyi Ren, Yuanbo Liang","doi":"10.1186/s12886-025-04399-9","DOIUrl":"10.1186/s12886-025-04399-9","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the incidence and risk factors for early transient intraocular pressure (IOP) elevation after penetrating canaloplasty (PCP) in patients with primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG) and secondary glaucoma (SG).</p><p><strong>Methods: </strong>This retrospective study included 198 eyes of 198 patients with glaucoma. Participants were classified as normal IOP, early transient high IOP (E-HIOP [Tst]), early persistent IOP elevation, late transient high IOP, and late persistent IOP elevation, based on the period and persistence of postoperative IOP elevation.</p><p><strong>Results: </strong>E-HIOP (Tst) developed in 34.8%, 33.3%, and 40.9% of eyes with POAG, PACG, and SG, respectively. In comparison with normal IOP group, we observed the following variations in E-HIOP (Tst) cohorts: 8 - 10 years younger in patients with POAG and PACG; higher prevalence of hyphema (45.5% vs. 20.5%) in POAG; higher baseline IOP in PACG and SG (7 - 8 mmHg); higher preoperative IOP maximum (IOP<sub>pre-max</sub>) in SG (all p < 0.05). Higher IOP<sub>pre-max</sub> was a risk factor for E-HIOP (Tst) in PACG and SG (p < 0.05).</p><p><strong>Conclusions: </strong>Nearly 30 - 40% of eyes developed E-HIOP (Tst) after PCP. E-HIOP (Tst) tended to develop in younger participants and those with higher preoperative IOP. A higher IOP<sub>pre-max</sub> was a risk factor for E-HIOP (Tst) in PACG and SG.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"559"},"PeriodicalIF":1.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC OphthalmologyPub Date : 2025-10-08DOI: 10.1186/s12886-025-04395-z
Saadia Zohra Farooqui, Shazia Khan, Silpi Biswas
{"title":"Predictors of Chlamydia trachomatis conjunctivitis in neonates: a 10-Year retrospective study.","authors":"Saadia Zohra Farooqui, Shazia Khan, Silpi Biswas","doi":"10.1186/s12886-025-04395-z","DOIUrl":"10.1186/s12886-025-04395-z","url":null,"abstract":"<p><strong>Background: </strong>Ophthalmia neonatorum (ON) is a common neonatal ocular condition with potentially serious ocular and systemic complications. The spectrum of causative organisms varies by geographical regions, maternal health practices, and over time. Chlamydia trachomatis remains a significant pathogen with non-specific symptoms that overlap with other infections. This study aims to assess local burden of Chlamydia trachomatis and identify clinical predictors.</p><p><strong>Methods: </strong>We conducted a 10-year retrospective review (2014-2023) of neonates presenting with suspected ON at a tertiary paediatric eye centre in Singapore. Clinical and microbiological data were analysed to determine etiological trends and identify predictors of C. trachomatis conjunctivitis. Diagnostic methods included Gram stain, culture, immunofluorescence, and PCR testing. Multivariate logistic regression was used to assess associations.</p><p><strong>Results: </strong>A total of 797 neonates were included; 140 (17.5%) tested positive for Chlamydia trachomatis followed by Staphylococcus aureus (10.2%) and MRSA (4.1%), while Neisseria gonorrhoeae was rare (0.75%). Ten-year trend showed a consistent pattern with Chlamydia trachomatis been the highest causative organism followed by Methicillin-sensitive Staphylococcus aureus. The presence of bloody discharge was the strongest predictor for Chlamydia infection (OR = 20.99, 95% CI: 6.09-72.29, p < .001), followed by vaginal delivery (OR = 17.63, 95% CI: 5.59-55.51, p < .001). Additional significant predictors included eyelid swelling (OR = 3.04, 95% CI: 1.58-5.83, p < .001) and conjunctival redness (OR = 2.73, 95% CI: 1.73-4.29, p < .001).</p><p><strong>Conclusions: </strong>Chlamydia trachomatis remains the leading cause of ON in our cohort. Key clinical predictors-bloody discharge, eyelid swelling, conjunctival redness, and unilateral involvement-can assist clinicians in early recognition and timely initiation of targeted testing and therapy. These findings support the development of predictive diagnostic frameworks in settings with limited access to molecular diagnostics.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"554"},"PeriodicalIF":1.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC OphthalmologyPub Date : 2025-10-08DOI: 10.1186/s12886-025-04370-8
Amirabbas Safaripour, Sina Baghi Keshtan, Elahe Boumeri, Motahare Alisofi, Ali Rabiei, Shahin Dehvari, Mahmoud Reza Rahimi Barghani, Akram Soltanzadeh
{"title":"Absorbable versus non-absorbable sutures in upper eyelid blepharoplasty: a systematic review of clinical outcomes and follow-up burden.","authors":"Amirabbas Safaripour, Sina Baghi Keshtan, Elahe Boumeri, Motahare Alisofi, Ali Rabiei, Shahin Dehvari, Mahmoud Reza Rahimi Barghani, Akram Soltanzadeh","doi":"10.1186/s12886-025-04370-8","DOIUrl":"10.1186/s12886-025-04370-8","url":null,"abstract":"<p><strong>Background: </strong>Upper eyelid blepharoplasty is a common surgical procedure requiring meticulous wound closure. The choice between absorbable and non-absorbable sutures remains debated, with implications for clinical outcomes, patient comfort, and postoperative follow-up burden.</p><p><strong>Objective: </strong>This systematic review aims to compare absorbable and non-absorbable sutures in upper eyelid blepharoplasty, focusing on clinical outcomes (scar quality, complications) and postoperative burden (follow-up visits, discomfort).</p><p><strong>Method: </strong>Following PRISMA 2020 guidelines, a comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and Google Scholar. Included studies were randomized controlled trials, prospective/retrospective cohort studies, or case series directly comparing suture types. Data were extracted and synthesized qualitatively due to heterogeneity.</p><p><strong>Results: </strong>Eleven studies met inclusion criteria. Absorbable and non-absorbable sutures demonstrated equivalent scar quality and complication rates. While absorbable sutures theoretically reduce follow-up burden by eliminating removal needs, no included study provided quantitative data on visit numbers or resource utilization. A potential reduction in patient discomfort is often cited, but was also not quantitatively measured. Suture technique (running vs. interrupted) influenced early edema but not long-term outcomes. Risk factors for adverse events were technique-dependent rather than suture material-dependent.</p><p><strong>Conclusion: </strong>Both suture types are clinically viable, with absorbable sutures offering logistical advantages. The choice should consider patient preferences and surgical context. Future research should quantify follow-up burden and evaluate newer suture technologies.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"553"},"PeriodicalIF":1.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical coherence tomography angiography in identifying aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.","authors":"Jing Dong, Xiaogang Wang, Huiru Xue, Yuxian Zeng, Hongda Gong, Junhong Li","doi":"10.1186/s12886-025-04394-0","DOIUrl":"10.1186/s12886-025-04394-0","url":null,"abstract":"<p><strong>Background: </strong>Optical coherence tomography angiography (OCTA) has shown promise in assessing microvascular and structural alterations in the retina and optic nerve. This study primarily aimed to evaluate the utility of OCTA in distinguishing aquaporin-4 antibody-positive (AQP4-Ab+) neuromyelitis optica spectrum disorder (NMOSD) patients from healthy controls (HC). Additionally, exploratory analyses were conducted to examine differences between AQP4-Ab + and AQP4-Ab-, all MOG-Ab-negative(double-seronegative) groups in NMOSD patients.</p><p><strong>Methods: </strong>We retrospectively analyzed clinical data from NMOSD patients admitted to the Neurology Department of our First Hospital from January 2018 to December 2020. Patients were categorized into AQP4-Ab-positive (AQP4-Ab+) and double-seronegative groups, with an age-matched normal control group. OCTA examinations were conducted to compare differences in optic nerve fiber layer thickness, macular central thickness, optic disc, macular blood flow, and clinical characteristics among the three groups.</p><p><strong>Results: </strong>There were statistically significant gender differences among the three groups, with a higher proportion of females in the AQP4-Ab + group compared to the other two groups (P < 0.05). Structurally, significant differences were observed in all parameters between the AQP4-Ab + group and healthy controls (HC), as well as between the double-seronegative group and HC (all P < 0.05). Direct comparison between AQP4-Ab + and double-seronegative NMOSD patients revealed significant differences in specific OCTA parameters, including optic disc central vessel density (P < 0.001), inner optic disc ring vessel density (P = 0.010), inner optic disc ring superior vessel density (P = 0.008), and outer macular ring nasal vessel density (P = 0.042). However, most other OCTA parameters showed no statistically significant differences between the antibody-positive and antibody-negative subgroups (P > 0.05). The optic disc vessel density demonstrated the highest diagnostic efficiency overall, with the nasal side vessel density of the optic disc achieving an AUC of 0.829.</p><p><strong>Conclusion: </strong>OCTA exhibits significant clinical utility in diagnosing AQP4-Ab + NMOSD. Differences between AQP4-Ab + and double-seronegative patients were explored and may provide further insight, although further research is required.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"551"},"PeriodicalIF":1.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC OphthalmologyPub Date : 2025-10-07DOI: 10.1186/s12886-025-04402-3
Lixing Zhou, Jieli Mao, Min Cao, Chuanyan Wu, Mengyu Zhu, Stephen J Vincent, Aiqin Xu, Ruzhi Deng
{"title":"Corneal eccentricity and related factors in Chinese children and adolescents with astigmatism.","authors":"Lixing Zhou, Jieli Mao, Min Cao, Chuanyan Wu, Mengyu Zhu, Stephen J Vincent, Aiqin Xu, Ruzhi Deng","doi":"10.1186/s12886-025-04402-3","DOIUrl":"10.1186/s12886-025-04402-3","url":null,"abstract":"<p><strong>Objective: </strong>To quantify the distribution of anterior corneal eccentricity (e value) and identify associated factors in Chinese children and adolescents with astigmatism.</p><p><strong>Methods: </strong>Corneal topography data obtained using the Medmont E300 were retrieved from 961 participants aged 3 to 18 years, with corneal astigmatism (ΔK) ≥ 2.00 D. Data analysis included anterior corneal e values along both flat and steep meridians at 1-10 mm chord lengths, as well as the device-reported mean e values for the flat and steep meridians (9.35 mm chord dimater); anterior corneal keratometry readings (flat/steep K); ΔK; and refractive error. Demographic factors, including age and sex, were also analyzed.</p><p><strong>Results: </strong>This study included 961 right eyes (mean age: 7.9 ± 2.9 years; 56% male). The mean e values were 0.73 ± 0.10 for the flat meridian and 0.51 ± 0.21 for the steep meridian. Along the flat meridian, e values decreased and stabilized with increasing chord length, while along the steep meridian, a U-shaped trend was observed. The mean flat e was correlated with the flat K (β = -0.013, P < 0.001) and ΔK values (β = 0.037, P < 0.001), whereas the mean steep e was only associated with sex (β = -0.043, P = 0.001) in multivariate analyses.</p><p><strong>Conclusion: </strong>In Chinese children and adolescents with moderate to high corneal astigmatism, the anterior cornea demonstrates aspheric characteristics with distinct meridional asymmetry. The flat e value may was associated with corneal curvature (flat K and ΔK values), whereas the steep e value was not associated with these parameters.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"550"},"PeriodicalIF":1.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC OphthalmologyPub Date : 2025-10-07DOI: 10.1186/s12886-025-04406-z
Jieli Wu, Qian Tan, Wang Cai, Ding Lin, Libei Zhao
{"title":"Effects of crystalline lens characteristics on vault after implantable collamer lens implantation.","authors":"Jieli Wu, Qian Tan, Wang Cai, Ding Lin, Libei Zhao","doi":"10.1186/s12886-025-04406-z","DOIUrl":"10.1186/s12886-025-04406-z","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between crystalline lens characteristics and postoperative vault in highly myopic eyes following implantation of Implantable Collamer Lens V4c (ICL V4c; STAAR Surgical).</p><p><strong>Setting: </strong>Changsha Aier Eye Hospital, Aier Eye Hospital Group, Changsha, China.</p><p><strong>Design: </strong>Retrospective observational study.</p><p><strong>Methods: </strong>This retrospective study included 199 eyes from 199 patients who underwent ICL implantation. Crystalline lens Dimensional parameters were quantified using CASIA 2 swept-source anterior segment optical coherence tomography. Based on vault height measured 3 months postoperatively, eyes were classified into low (< 250 µm), optimal (250-750 µm), or high (> 750 µm) vault groups. Group comparisons, Spearman correlation, and multivariate logistic regression analyses were performed to identify factors associated with low vault outcomes.</p><p><strong>Results: </strong>Significant differences were observed in white-to-white (WTW), anterior chamber depth (ACD), anterior radius of curvature (ARC), posterior radius of curvature (PRC), lens thickness (LT), and decentration among the different vault groups (all P < 0.001). Multivariate logistic regression analysis identified a significant negative association between low vault and both ARC and lens tilt, after adjusting for age, gender and spherical equivalent (all P < 0.05).</p><p><strong>Conclusions: </strong>Crystalline Lens parameters play a critical role in determining postoperative vault following ICL implantation. Steeper anterior curvature and greater lens tilt may be anatomic indicators of a predisposition to low postoperative vault outcomes.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"552"},"PeriodicalIF":1.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}