BMC Ophthalmology最新文献

{"title":"The retrograde suture needle threading technique for in-situ repositioning of dislocated intraocular lenses with eyelets.","authors":"XiaoJia Huang, Zhou Zhou, ShanShan Huang, Wenjing He, Qi Chen, Chaolan Shen, Haibin Zhong, Ke Yang, Ling Cui, Fan Xu, Gang Yao","doi":"10.1186/s12886-025-04105-9","DOIUrl":"10.1186/s12886-025-04105-9","url":null,"abstract":"<p><strong>Background: </strong>Rescuing dislocated intraocular lenses (IOLs) with eyelets after scleral suture fixation presents technical challenges and risks of ocular tissue damage. We propose a novel in-situ rescue technique for repositioning dislocated IOLs with fixation eyelets. This approach avoids large incisions, accommodates dislocations in any direction, and offers a safer, more efficient alternative to traditional methods.</p><p><strong>Methods: </strong>The technique was performed on four patients with dislocated IOLs following scleral suture fixation. Under retrobulbar anesthesia, a retrograde suture-guided approach was employed. A double-armed polypropylene suture was introduced retrogradely into the eye via a puncture site. The suture arms were threaded through the fixation eyelet of the IOL haptic. One arm was then cut and hooked out through the eyelet. The broken ends of the two sutures were tied together. The IOL was adjusted to its proper position, and the suture was tightened to secure it to the sclera.</p><p><strong>Results: </strong>All four patients underwent successful in-situ IOL refixation without intraoperative complications. Postoperative examinations confirmed well-centered IOLs in all cases. Postoperative vision has significantly improved compared to preoperative vision. Over a follow-up period of 11-36 months, no redislocation or major complications were observed.</p><p><strong>Conclusion: </strong>This in-situ rescue technique provides a safe, effective, and straightforward solution for fixing dislocated perforated IOLs. Its simplicity and positive outcomes position it as a promising option for managing these complex cases.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"290"},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of childhood overweight in meibomian gland dysfunction and dry eye disease in Chinese children.","authors":"Zhen Xu, Lulu Bao, Xiaomin Wang, Haihang Ying, Jianbo Mao","doi":"10.1186/s12886-025-04086-9","DOIUrl":"https://doi.org/10.1186/s12886-025-04086-9","url":null,"abstract":"<p><strong>Aim: </strong>To explore the factors causing structural abnormalities of meibomian gland in the pediatric population.</p><p><strong>Methods: </strong>Two-hundred children were enrolled to evaluate the morphology of meibomian gland. Demographic and clinical information were collected. Symptoms of dry eye disease (DED) were assessed with the ocular surface disease index (OSDI) questionnaire. Meibography was performed and grading of images was performed by a 5-point meiboscale (0-4) for gland atrophy and a 3-point score (0-2) for gland tortuosity.</p><p><strong>Results: </strong>200 eyes of 200 participants aged 10-18 years (13.10 ± 2.39 years) were imaged. Most patients had a score of 1, 130 (65%) in meiboscore and 138 (69%) in gland tortuosity. The meiboscore showed significant difference with the increase of weight, BUT and BMI percentile ranking. The gland tortuosity showed significant difference with the increase of age, and BMI percentile ranking. Besides, shorter BUT corresponds to larger percentage of meibomian gland atrophy and higher OSDI score. Gender had no significant effect on gland dysfunction. The gland meiboscore was significantly correlated with weight, OSDI score, BUT, BMI percentile and BMI percentile ranking. And the gland tortuosity was significantly correlated with weight, BMI percentile and OSDI score.</p><p><strong>Conclusion: </strong>In this pediatric population, the meiboscore become higher with the increase of weight, BMI percentile, OSDI and the decrease of BUT, and gland tortuosity became more serious with the increase of age and BMI percentile. Therefore, clinicians should be aware that being overweight is a risk factor for changes in meibomian gland structure.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"285"},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the influencing factors on subjective evaluation in initial and end-of-day silicone hydrogel contact lens wear.","authors":"Han-Yin Sun, Ren-Yu Yang, Ya-Yu Chen","doi":"10.1186/s12886-025-04110-y","DOIUrl":"https://doi.org/10.1186/s12886-025-04110-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the factors influencing subjective ratings of comfort, vision quality, dryness, and satisfaction at both initial and end-of-day wear among young Asian wearers of silicone hydrogel contact lenses.</p><p><strong>Methods: </strong>Participants aged 20 to 24 years who were satisfied wearers of silicone hydrogel daily disposable contact lenses were recruited. Each participant attended two scheduled visits. During the first visit (Day 1), ocular health, refractive error, visual acuity, first and average non-invasive tear break-up time (F-NITBUT and A-NITBUT), and subjective ratings were measured without lenses and 15 min after wearing Somofilcon A daily disposable lenses. On the second visit (Day 7), follow-up data were collected after seven consecutive days of lens wear.</p><p><strong>Results: </strong>A total of 59 healthy participants (mean age: 20.86 ± 1.29 years) participated in this study. Visual acuity demonstrated a significant negative correlation with comfort, vision quality, and satisfaction after 15 min of Somofilcon A lens wear on Day 1 and a positive correlation with dryness. Additionally, A-NITBUT was significantly positively correlated with vision quality. On Day 7, visual acuity was negatively correlated with overall vision quality after 8 h of wear. However, residual refraction and F-NITBUT showed no significant correlation with comfort, vision quality, dryness, or satisfaction after 15 min of wear on Day 1-8 h on Day 7.</p><p><strong>Conclusions: </strong>The results suggest that higher visual acuity at initial lens wear was strongly associated with improved subjective comfort, vision quality, and overall satisfaction, as well as reduced dryness. Furthermore, a longer average tear break-up time was associated with improved vision quality. For prolonged lens use, visual acuity was only associated with vision quality. Visual acuity plays a significant role in subjective ratings at the initial lens wear, while tear break-up time may serve as a predictor for subjective vision quality.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"287"},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of SS-OCTA to evaluate the effects of long-term hydroxychloroquine treatment on retinal structure and microcirculation in patients with systemic lupus erythematosus.","authors":"Xuemei Li, Chao Xiong, Shuilin Luo, Yunxiu Chen, Min Li, Siyi Wang, Yaohua Wang, Zhilin Wang, Rui Wu, Hongfei Liao","doi":"10.1186/s12886-025-04083-y","DOIUrl":"10.1186/s12886-025-04083-y","url":null,"abstract":"<p><strong>Propose: </strong>The application of swept-source optical coherence tomography angiography (SS-OCTA) technique is used to detect the effects of long-term use of hydroxychloroquine (HCQ) on retinal structure and microcirculation in patients with systemic lupus erythematosus (SLE) before visual dysfunction occurs.</p><p><strong>Methods: </strong>Retrospective case-control study. A total of 73 SLE patients (73 eyes) who had taken HCQ regularly for a long period of time were included as the SLE patient group, while 21 healthy individuals (21 eyes) were included as the control group. Based on the duration of HCQ use (HCQ course), the SLE patient group was divided into baseline group (6 months ≤ medication time < 1 year), low-risk group ( 1 year ≤ medication time < 5 years), and high-risk group (medication time ≥ 5 years). All participants underwent bilateral SS-OCTA macular imaging (6 mm*6 mm), slit-lamp examination, non-contact tonometry, computerized visual field (30 - 2) test, and fundus autofluorescence imaging (FAF).</p><p><strong>Results: </strong>Compared among the groups, the full-layer retinal thickness and superficial blood vessel density of the fovea, below the inner circle, temporal side of the outer circle and above the outer circle decreased in the macular area (6 mm*6 mm) in high-risk group of SLE patients, while the area and circumference of FAZ increased (P < 0.0125). Correlation analysis suggested that the duration of SLE disease and HCQ cumulative dose were negatively correlated with superficial retinal capillary plexus vessel density (SCP-VD) in the three regions of inner retina, full-layer retinal thickness in the fovea, fovea, temporal side of the inner circle, and above the inner circle (r < 0,P < 0.05), and positively correlated with the area and circumference of FAZ (r > 0,P < 0.05).</p><p><strong>Conclusion: </strong>Analysis by SS-OCTA examination showed that long-term HCQ treatment had adverse effects on the inner retina, SCP-VD and FAZ parameters in subclinical SLE patients without visual impairment.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"288"},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muller's muscle fibrosis is a possible predictive factor in the outcome of Muller's muscle-conjunctival resection.","authors":"Hassan Asadigandomani, Mohammad Taher Rajabi, Navid Mohsenzadeh Kermani, Zohreh Nozarian, Mohammadreza Ghaedamini, Seyed Mohsen Rafizadeh","doi":"10.1186/s12886-025-04115-7","DOIUrl":"https://doi.org/10.1186/s12886-025-04115-7","url":null,"abstract":"<p><strong>Background: </strong>The purpose of our prospective study is to investigate the histopathology of Muller's muscle extracted after Muller's Muscle-Conjunctival Resection (MMCR) and to find the relationship between histopathological findings and the outcomes of ptosis surgery.</p><p><strong>Methods: </strong>Forty-seven patients with mild to moderate ptosis underwent MMCR surgery and pathological samples including conjunctiva and Muller's muscle were stained with Hematoxylin and Eosin (H/E) and Masson trichrome. The degree of muscle fibrosis and hypertrophy were evaluated.</p><p><strong>Results: </strong>The results indicated that an increase in the severity of fibrosis (for example, increase from mild to moderate), increases the 1 mm correction effect by 0.027 (CI = 0.002-0.052 and p-value = 0.033). There is no association between the 1 mm correction effect (p-value = 0.67), ptosis correction (p-value = 0.60), and post-operation difference between ptotic and normal eye (p-value = 0.90) with Muller's muscle hypertrophy. Also, there is no statistically significant association between Muller's muscle hypertrophy and 1 mm correction effect, ptosis correction, and post-operation difference according to the type of pathogenesis (aponeurotic; p-value = 0.123, congenital; p-value = 0.286, horner syndrome; p-value = 0.667).</p><p><strong>Conclusions: </strong>Following the increase in Muller's muscle fibrosis, the ptosis correction effect of MMCR surgery increases, but the presence or absence of hypertrophy of Muller's muscle is not correlated to the outcomes of surgery.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"284"},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of bilateral stellate nonhereditary idiopathic foveomacular retinoschisis with 14-month follow-up: clinical features, OCT findings and treatment outcome.","authors":"Narges Hassanpoor, Ali Tahmasebi, Ehsan Aminsobhani, Mohamadreza Niyousha","doi":"10.1186/s12886-025-04116-6","DOIUrl":"https://doi.org/10.1186/s12886-025-04116-6","url":null,"abstract":"<p><strong>Background: </strong>Stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) is a relatively recent and rare classification introduced. Currently, there is no reliable treatment for the disease.</p><p><strong>Case presentation: </strong>We discussed an additional case multimodal imaging including Optical coherence tomography (OCT), fluorescein angiography and Optical coherence tomography angiography (OCTA) as well as treatment result. The case was a healthy, non-myopic woman, where foveal cystic changes persisted despite 9 months of topical dorzolamide and an additional 5 months of oral acetazolamide. Genetic testing for Congenital X-linked retinoschisis (CXLR) was negative. ERG results were near normal. Optical coherence tomography showed no vitreomacular traction, while fluorescein angiography ruled out vascular disease.</p><p><strong>Conclusions: </strong>Our findings suggest that bilateral SNIFR can occur in non-myopic females, although this patient did not respond to systemic and topical carbonic anhydrase inhibitors.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"282"},"PeriodicalIF":1.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy analysis of microinvasive glaucoma surgery alone or in combination with phacoemulsification in patients with normal tension glaucoma: a systematic review and meta-analysis.","authors":"Zhen Yu, Mengfan Wu, YuFei Tao, Zihan Huang, Mingmin Yang, Xiaohua Pan, Dimitrios Ntentakis, Ning Fan","doi":"10.1186/s12886-025-04104-w","DOIUrl":"10.1186/s12886-025-04104-w","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of minimally invasive glaucoma surgery (MIGS) as monotherapy, or in combination with phacoemulsification, in the management of normal tension glaucoma (NTG).</p><p><strong>Methods: </strong>A systematic literature review and meta-analysis were conducted. The literature search was performed using four electronic databases, including Pubmed, Embase, Web of science, and Cochrane Central Register of Controlled Trials, to identify studies evaluating the efficacy of MIGS on patients with NTG, published from October 1, 2019 to October 1, 2024. The articles meeting our inclusion criteria were independently screened and assessed by three reviewers. Effect estimates associated with NTG were pooled and evaluated via meta-analysis. The articles retrieved from the databases were systematically analyzed using Citespace 6.2.R3.</p><p><strong>Results: </strong>A total of 11 English-language studies involving 413 eyes from 327 NTG patients were included. Follow-up ranged from 6 to 60 months. MIGS alone reduced IOP by 2.62 mmHg (95% CI: -3.70 to -1.54; Z = 4.77, P < 0.00001), while MIGS with cataract surgery reduced IOP by 2.09 mmHg (95% CI: -2.83 to -1.35; Z = 5.53, P < 0.00001). The number of IOP-lowering medications decreased by 1.47 with MIGS alone (95% CI: -2.16 to -0.77; Z = 4.07, P < 0.0001) and by 1.13 with combined surgery (95% CI: -1.75 to -0.52; Z = 3.63, P = 0.0003). No significant differences were observed between the two surgical approaches.</p><p><strong>Conclusion: </strong>The meta-analysis demonstrated that either MIGS alone or combined with phacoemulsification effectively reduced the IOP and the requirement for IOP-lowering medications in NTG patients. MIGS alone or combined with phacoemulsification reduced the IOP most at 12 months, and the lowest IOP-lowering medications at 24 months in postoperative patients with NTG.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"283"},"PeriodicalIF":1.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of corneoscleral mixed hemangioma by intrastromal lenticule transplantation in a case of xeroderma pigmentosum: a case report.","authors":"Yingwei Wang, Li Cai, Hua Feng, Xiaofei Wu, Hongmin Ke, Jerry Ma, Wanmei Tang, Kunling Chen, Qiong Wang","doi":"10.1186/s12886-025-04087-8","DOIUrl":"10.1186/s12886-025-04087-8","url":null,"abstract":"<p><strong>Background: </strong>Xeroderma pigmentosum (XP) is a rare autosomal recessive skin disease. The ocular manifestations in XP patients usually include severe photophobia, conjunctivitis, corneal opacification, ocular surface squamous neoplasia (OSSN) which often appears in the palpebral fissure area. In addition, there are other accompanying ocular surface lesions that require clinical attention.</p><p><strong>Case presentation: </strong>We report a unique case of Xeroderma Pigmentosum (XP) with a progressive corneoscleral neoplasm, which become bigger during 6 years of follow-up. The patient was diagnosed with corneoscleral mixed hemangioma with XPC genotype, and was successfully treated by intrastromal lenticule transplantation obtained from small-incision lenticule extraction.</p><p><strong>Conclusions: </strong>The corneoscleral neoplasm of XP is rarely reported before, treatment should be personalized according to the disease condition.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"277"},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between myopia and relative peripheral refraction in children with monocular Tilted disc syndrome.","authors":"Jiawei Wang, Shangzhu Zhang, Huijun Jiang, Jialiang Duan, Ruijie Xi, Shaoyi Wang, Jiangnan Wang, Song Chai","doi":"10.1186/s12886-025-04108-6","DOIUrl":"https://doi.org/10.1186/s12886-025-04108-6","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the refractive error and relative peripheral refraction in pediatric patients with monocular tilted disc syndrome.</p><p><strong>Methods: </strong>This single-center, prospective, cross-sectional, observational study included 49 patients from the Pediatric Ophthalmology Department of the Second Hospital of Hebei Medical University aged 5-17 years with monocular tilted disc syndrome. Eyes with tilted optic discs formed the study group, and contralateral eyes with normal discs served as controls, with mean spherical equivalents of - 3.24 D and - 0.47 D, respectively. Best-corrected visual acuity, spherical equivalent, axial length, tilt ratio, defined as the ratio of maximum to minimum disc diameters, and relative peripheral refraction, assessing myopia-related defocus were compared between groups. Pearson's correlation analysis assessed associations between optic disc tilt and spherical equivalent, axial length, and the total refraction difference value.</p><p><strong>Results: </strong>Tilted optic discs were associated with significantly greater myopia (- 3.24 ± 1.83 D in tilted eyes and - 0.47 ± 0.72 D in non-tilted eyes, P <.001), longer axial length (24.59 ± 1.04 mm in tilted eyes and 23.45 ± 0.78 mm in non-tilted eyes, P <.001), and a higher tilt ratio (1.43 ± 0.05 in tilted eyes and 1.14 ± 0.04 in non-tilted eyes, P <.001). Discrepancies between tilted and non-tilted eyes were observed in the superior, inferior, and nasal quadrants, and the total refraction difference value (P <.001). In eyes with tilted disc syndrome, a negative correlation was found between the total refraction difference value and the spherical equivalent (P <.001). The tilt ratio of optic disc eyes was significantly greater than that of contralateral eyes and was negatively correlated with the spherical equivalent. There was a positive correlation between the tilt ratio and axial length (P <.001).</p><p><strong>Conclusions: </strong>Pediatric patients with monocular tilted disc syndrome exhibited longer axial lengths, more myopic spherical equivalent, and more positive relative peripheral refraction. A greater tilt ratio is associated with larger relative peripheral refraction and axial length, corresponding to more severe myopia.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"275"},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for vitreous hemorrhage and recurrent hemorrhage after vitrectomy in patients with diabetic retinopathy.","authors":"Shuwen Lu, Haoyu Li, Chao Ma, Xian Li","doi":"10.1186/s12886-025-04112-w","DOIUrl":"https://doi.org/10.1186/s12886-025-04112-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the risk factors associated with recurrent hemorrhage following vitrectomy surgical intervention for diabetic retinopathy (DR).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 579 eyes diagnosed with DR necessitating surgical intervention. These cases were categorized into two groups: recurrent hemorrhage and non-recurrent hemorrhage. Comparative, random forest (RF), and regression analyses were subsequently performed to evaluate variables pertaining to patients' demographic information, clinical examination and blood test results, treatment approaches, lifestyle habits, and overall health status.</p><p><strong>Results: </strong>This study compared patients with recurrent and non-recurrent hemorrhages, revealing significant differences in factors such as endodiathermy, anticoagulant use, cerebrovascular diseases, smoking status, glycosylated hemoglobin levels and BMI. Patients with no recurrent hemorrhage have faster vision recovery. The univariable logistic regression analysis indicated that cerebrovascular disease (OR = 7.87, P < 0.001), anticoagulant use (OR = 16.72, P < 0.001), and elevated glycated hemoglobin levels (OR = 21.22, P < 0.001) exhibited strong associations with recurrent hemorrhage. The multivariable logistic regression analysis indicated that recurrent hemorrhage risk factors include anticoagulant use (OR = 120.77, P = 0.020) and glycated hemoglobin levels (OR = 18.41, P = 0.001).</p><p><strong>Conclusions: </strong>Recurrent postoperative hemorrhage is influenced by several factors, notably the use of intraoperative endodiathermy, adjustments in ocular therapy, and management of the patient's systemic condition. In clinical practice, careful consideration of these factors is essential to mitigate postoperative hemorrhage in patients.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"274"},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}