BMC Ophthalmology最新文献

{"title":"High BMI, silicone oil tamponade, and recurrent vitreous hemorrhage predict poor visual outcomes after pars plana vitrectomy in proliferative diabetic retinopathy.","authors":"Zhi-Gang Wang, Ping Li, Xiu-Min Yang, Zi-Qi Wang, Pei-Ran Zhang","doi":"10.1186/s12886-025-03954-8","DOIUrl":"10.1186/s12886-025-03954-8","url":null,"abstract":"<p><strong>Background: </strong>Proliferative diabetic retinopathy (PDR) is a serious microvascular complication of diabetes and a leading cause of global vision loss. Pars plana vitrectomy (PPV) is the primary surgical treatment for PDR, but visual outcomes vary due to multiple influencing factors. This study aims to evaluate the factors predicting visual prognosis in patients with PDR after PPV.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 112 eyes from 87 patients with PDR who underwent PPV between May 2020 and May 2024. Data collected included patient demographics, preoperative and postoperative best-corrected visual acuity (BCVA), and other baseline clinical data. Data analysis was performed with IBM SPSS Statistics Version 24.0. Univariate and multivariate linear regression models were applied to assess the relationship between the final BCVA and various clinical parameters.</p><p><strong>Results: </strong>The mean BCVA improved significantly, from 1.94 ± 0.89 logMAR preoperative to 0.76 ± 0.70 logMAR postoperatively (P < 0.001). Multivariate linear regression identified body mass index (BMI) (B = 0.035; 95% CI 0.003-0.066; P = 0.033), silicone oil (SO) tamponade (B = 0.354; 95% CI 0.005-0.643; P = 0.029), and recurrent vitreous hemorrhage (VH) (B = 0.585; 95% CI 0.304-0.867; P < 0.001) as significant negative predictors of final BCVA.</p><p><strong>Conclusions: </strong>While PPV improves visual outcomes in PDR patients, factors such as high BMI, SO tamponade, and recurrent VH negatively affect prognosis and could serve as predictors of poor visual outcomes following the procedure. This study emphasizes the importance of tailored management strategy for PDR, including early intervention, optimal BMI control, and minimizing SO tamponade duration.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"148"},"PeriodicalIF":1.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between longitudinal serum vitamin D levels and myopia in children: a prospective birth cohort analysis.","authors":"Ju-Hsien Li, Ho-Min Chen, Kuan-Wen Su, Yu-Kai Kuo, Cheng-Hsiu Wu, Nan-Ni Chen, Pei-Wei Huang, Chi-Chin Sun","doi":"10.1186/s12886-025-03960-w","DOIUrl":"10.1186/s12886-025-03960-w","url":null,"abstract":"<p><strong>Background: </strong>Myopia is an increasingly prevalent visual impairment associated with severe ocular complications. Risk factors for childhood myopia include genetics, East Asian ethnicity, age, parental myopia, and various environmental factors. The relationship between vitamin D levels, outdoor activity, and myopia remains inconclusive. This study aims to investigate the correlation between longitudinal serum vitamin D levels and myopia in Taiwanese children.</p><p><strong>Methods: </strong>The study measured serum 25-hydroxyvitamin D (25(OH)D) concentrations in children from the Prediction of Allergies in Taiwanese Children (PATCH) study at multiple time points, including umbilical cord blood and ages 1, 3, and 5 years. Refractive error under cycloplegic conditions and axial length were assessed from January 2021 to April 2022. Myopia was defined as a mean spherical equivalent in both eyes ≤ -0.5 diopter. Independent sample t-tests, partial correlation analyses, and generalized estimating equation (GEE) analyses were conducted to examine the relationship between serum vitamin D concentrations and myopia.</p><p><strong>Results: </strong>A total of 126 eyes from 63 children (mean age: 8.90 ± 2.24 years) were analyzed. The lowest serum vitamin D level (19.11 ± 9.10 ng/mL) was observed in umbilical cord blood, while the highest level (37.01 ± 12.61 ng/mL) occurred at 1 year of age. No significant differences in serum vitamin D concentrations were found between children with and without myopia during gestation, at birth, or at ages 1, 3, and 5 years (all P > 0.05). Additionally, GEE analysis revealed that serum vitamin D levels were not significantly associated with cycloplegic spherical equivalent or axial length after adjusting for age and sex.</p><p><strong>Conclusions: </strong>This prospective birth cohort study found no association between serum vitamin D concentrations at birth, 1, 3, or 5 years of age and the development of myopia in Taiwanese children. These findings suggest that other factors, such as ethnicity, near work activities, or lighting conditions, may play more significant roles in myopia development, particularly among East Asian populations.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"143"},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical findings and management of intraocular foreign bodies (IOFB) in third-world country eye hospital.","authors":"Made Indra Widyanatha, Henry Santosa Sungkono, Grimaldi Ihsan, Rova Virgana, Erwin Iskandar, Arief Sjamsulaksan Kartasasmita","doi":"10.1186/s12886-025-03903-5","DOIUrl":"10.1186/s12886-025-03903-5","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the demoFigurey and clinical characteristics of intraocular foreign body as open globe injury type at National Eye Center Cicendo Eye Hospital.</p><p><strong>Methods: </strong>This descriptive-retrospective study is based on medical records of patients admitted to National Eye Center Cicendo Eye Hospital diagnosed with intraocular foreign bodies from January 2019 to June 2023.</p><p><strong>Results: </strong>A total of twenty-one cases of ocular trauma specifically intraocular foreign bodies were recorded based on medical records. A total of 20 cases (95.2%) were male. The incidence of 15 cases (71.4%) of trauma in outdoor activities with the whole mechanism (100%) of penetrations. Most cases were referred cases (57.1%). 11 cases had surgery under 24 h prior to trauma (52.4%). The entry site of the foreign body was on the cornea (17 cases, 81%). Metallic foreign bodies account for 16 (76.2%); most locations are found on the retina (71.4%). More than three fourths of patients had single IOFB (76.2%). Visual acuity is mostly present between counting fingers- 0.1 Snellen. Patients showed to have had retinal breaks (61.9%).</p><p><strong>Conclusion: </strong>The majority of IOFB patients were working-age males. The nature of IOFBs is mostly metallic and retained in the posterior segment.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"142"},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual function deficits in dyslexic children: a case-control study.","authors":"Azam Darvishi, Negar Sangsefidi, Javad Heravian Shandiz, Davood Sobhani Rad, Foroozan Narooie-Noori, Masoud Khorrami-Nejad","doi":"10.1186/s12886-025-03959-3","DOIUrl":"10.1186/s12886-025-03959-3","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the ophthalmic findings between dyslexic and non-dyslexic children aged 7-10 years.</p><p><strong>Methods: </strong>A matched case-control study was conducted on 32 dyslexic children as a case group and 32 non-dyslexics as a control group. Both groups underwent complete ophthalmic examinations to measure corrected distance visual acuity, refractive errors, latent and manifest deviations, stereoacuity, near point of accommodation (NPA), and contrast sensitivity (CS).</p><p><strong>Results: </strong>The mean age of the participants in our study was 8.1 ± 0.8 (range 7-10) years. Both dyslexic and non-dyslexic groups consisted of 17(53.1%) boys and 15(46.9%) girls. There was no significant difference in visual functions (P > 0.05) except for stereoacuity and contrast sensitivity between the two groups. Contrast sensitivity (CS) was decreased and aggravated in dyslexics versus controls. The mean score of binocular CS in the case and control group was 115.8 ± 40.6 and 175.6 ± 44.3 cycle per degree, respectively (P < 0.001). Notably, stereoacuity was increased in dyslexics versus controls (94.2 ± 73.6 vs. 60.94 ± 12.01 s/arc, P = 0.017).</p><p><strong>Conclusion: </strong>Dyslexic children exhibited decreased contrast sensitivity and impaired stereoacuity compared to controls. These findings support the theory of magnocellular system deficits in dyslexia. Further research is required to elucidate the role of contrast sensitivity and its impact on dyslexic vision.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"144"},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis: clinical outcomes of laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) in hyperopia.","authors":"Mohammed Naji Almutairi, Abdullrahman M Alshehri, Abdulrahman Y Alhoumaily, Osamah Alnahdi, Mohammed A Taha, Shiji Gangadharan","doi":"10.1186/s12886-025-03956-6","DOIUrl":"10.1186/s12886-025-03956-6","url":null,"abstract":"<p><strong>Background: </strong>To evaluate differences in clinical outcome, safety, and efficacy of photorefractive keratectomy (PRK) and laser-assisted in situ keratomileusis (LASIK) in the correction of hyperopic refractive errors.</p><p><strong>Methods: </strong>We have adhered to PRISMA criteria in this systematic review, which is registered with PROSPERO (CRD42023469543). Our search with studies comparing PRK and LASIK for hyperopia was conducted through the databases PubMed, EMBASE, Web of Science, and the Cochrane Library. We used the Cochrane method to assess bias and evaluated variables like uncorrected distance visual acuity and mean spherical equivalent. Using fixed- or random-effects models, a meta-analysis was performed using RevMan 5.4 for evaluating heterogeneity and significance. Sensitivity analysis addressed the causes of heterogeneity to assure stability.</p><p><strong>Results: </strong>We included 6 articles (419 participants, 585 eyes) in this review five were retrospective and 1 case-series. The final mean refractive SE (WMD, -0.05; 95% confidence interval [CI], 0.42 to 0.31; P = 0.06). patients achieving uncorrected distance visual acuity (UDVA) of 20/20 or better (OR, 0.58; 95% CI, 0.39-0.78; P = 0.33). final UDVA of 20/40 or better (OR, 1.40; 95% CI, 0.65-3.02; P = 0.81) were analyzed.</p><p><strong>Conclusions: </strong>In this meta-analysis, LASIK had no significant benefits over PRK in relation to clinical outcomes. Less corneal haze was observed in LASIK-treated eyes at 1 to 3 months after surgery.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"140"},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal cross-linking effects on ocular surface parameters and corneal topographic and optical characteristics in progressive keratoconus cases: a prospective single-arm study.","authors":"Nazli Taheri, Afshin Lotfi Sadigh, Salar Abed Nikmanesh, Amir Tarkavani, Peyman Ghodraty, Amin Arasteh, Tahereh Attar Gharamaleki","doi":"10.1186/s12886-025-03968-2","DOIUrl":"10.1186/s12886-025-03968-2","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the effects of epithelial-off corneal cross-linking (CXL) on the ocular surface and corneal topographic and optical parameters in progressive keratoconus (KCN) cases.</p><p><strong>Study design: </strong>Prospective single-arm interventional study.</p><p><strong>Methods: </strong>Thirty eyes of 25 progressive KCN cases needing corneal CXL entered the study. All the included eyes underwent an epi-off corneal CXl procedure following the Dresden protocol. The ocular surface parameters, including tear break-up time (TBUT), Schirmer I test, and Ocular surface disease index (OSDI), were evaluated at baseline, one and 6 months after the procedure. The corneal imaging with Pentacam (Oculus Inc.) was conducted at these visits, measuring topographic parameters (e.g., K_max, K₁, K₂, and corneal thickness), indices (e.g., ISV, IVA, KI IHA), and aberrations.</p><p><strong>Results: </strong>The median age of the patients was 24.0 (IQR:21.0-26.5) with a baseline BCVA of 0.045 LogMAR (IQR:0.000-0.301). The BCVA had no significant change in the last follow-up (p:1.000). The baseline median values for TBUT, Schirmer test, and OSDI were 11.0s, 13.0mm, and 28.12, demonstrating a significant ocular surface malfunction. These ocular surface parameters showed no significant change 6 months after CXL (p: 0.662, 0.534, and 0.372, respectively). The K₁ and K₂ values decreased significantly at the last follow-up compared to the baseline (44.4 vs. 45.6 (p:0.019) and 48.0 vs. 48.1 (p:0.008), respectively). The only topographic indices that improved 6 months after CXL was the index of surface variance (ISV) (70.50 vs. 61.70, p:0.036). The corneal front surface higher-order aberrations, including spherical aberration, coma, and trefoil, showed no significant change 6 months after CXL.</p><p><strong>Conclusion: </strong>Progressive KCN cases cope with some ocular surface problems, such as dry eye, but the corneal CXL is safe for these cases without causing any deterioration in the ocular surface problems. The corneal CXL might not improve the topographic indices and corneal aberrations 6 months after the procedure.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"141"},"PeriodicalIF":1.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal quantitative assessment of retinal crystalline deposits in bietti crystalline dystrophy.","authors":"Seung Jun You, Chang Ki Yoon, Un Chul Park, Kyu Hyung Park, Eun Kyoung Lee","doi":"10.1186/s12886-025-03962-8","DOIUrl":"10.1186/s12886-025-03962-8","url":null,"abstract":"<p><strong>Background: </strong>This study aims to quantitatively analyze retinal crystalline deposits in patients with Bietti Crystalline Dystrophy (BCD) and examine their progression over time in a longitudinal study.</p><p><strong>Methods: </strong>We retrospectively reviewed consecutive patients diagnosed with BCD at a single center. Retinal crystalline deposits were quantified from fundus photographs using semi-automated software, which divided the macular area into a central foveal circle, inner ring, and outer ring. We then analyze changes in the area and area fraction of these deposits over a two-year period.</p><p><strong>Results: </strong>The study included 30 eyes from 16 patients. Over the two-year study period, the inner ring demonstrated the statistically significant decrease in both crystal area and crystal area fraction from baseline to one year (P = 0.044 for area; P = 0.003 for area fraction) and two years (P = 0.003 for area; P < 0.001 for area fraction). Mean crystal area fraction was 1.042 ± 0.295% in the central foveal circle, 1.056 ± 0.208% in the inner ring, and 1.001 ± 0.155% in the outer ring, with no significant differences observed between the regions (all P > 0.05). The genotype-phenotype correlation showed that exon7del homozygotes had significantly lower baseline crystal area and area fraction, suggesting an association with more severe disease.</p><p><strong>Conclusions: </strong>The use of semi-automated software to analyze fundus photographs provided a quantitative method for assessing retinal crystalline deposits in BCD. This longitudinal study enhanced our understanding of the disease's natural progression.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"139"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in aqueous humor cytokines and metabolomics in contralateral eye after unilateral cataract surgery.","authors":"Yang Li, Taiying Cheng, Sujun Zhou, Fayuan Li, Wenjun Guo, Mingbo Li, Taixiang Liu","doi":"10.1186/s12886-025-03961-9","DOIUrl":"10.1186/s12886-025-03961-9","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;For patients with bilateral age-related cataracts, sequential phacoemulsification and intraocular lens implantation is a common treatment. However, it remains unclear whether surgery on the first eye has an impact on the second eye, as current research results are inconsistent. This study will explore whether surgery on one eye affects the non-operated eye through aqueous humor cytokines and metabolomic analyses in the second eye.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A rabbit model of unilateral phacoemulsification and intraocular lens implantation was established. The experimental group consisted of 15 rabbits undergoing this procedure. Postoperatively, rabbits were divided into five subgroups (three rabbits per subgroup), and aqueous humor was collected from both the operated and non-operated eyes at 1 day, 3 days, 1 week, 2 weeks, and 3 weeks after surgery. Additionally, 5 rabbits were selected as a control group, from which aqueous humor was extracted. Levels of IL-1a, IL-1β, IL-2, IL-4, IL-6, IL-8, IFN-γ, TNF-α, MCP-1, and VEGF in the aqueous humor were compared. In the clinical study, preoperative aqueous humor samples were collected from 22 patients undergoing bilateral phacoemulsification and intraocular lens implantation. Among them, 11 patients were tested for the aforementioned 10 cytokines, while the other 11 patients underwent untargeted metabolomics research.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the animal experiment, levels of all 10 cytokines in the operated eyes were significantly higher compared to both the control and non-operated eyes groups (P &lt; 0.05). In the non-operated eyes, IL-1β and IL-2 levels were also elevated compared to the control (P &lt; 0.05); however, no statistically significant differences were observed between the non-operated eyes and the control group at postoperative time points of 1 day, 3 days, 1 week, 2 weeks, and 3 weeks. In the clinical study, no significant differences were found in cytokine levels between the two eyes. In the untargeted metabolomics analysis, 354 metabolites showed differential expression, 280 were upregulated and 74 were downregulated. Notably, Adenine and 2-Aminopurine were significantly downregulated, highlighting Purine metabolism as the most impacted pathway.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Animal experiments showed a significant increase in IL-1β and IL-2 levels in the non-operated eyes postoperatively, reflecting systemic and local inflammatory responses. In clinical experiments, although no significant changes in cytokines were observed in the aqueous humor of both eyes, differential expression of metabolites indicated metabolic adjustments in the non-operated eye following surgery on the first eye. These findings reveal that unilateral cataract surgery may affect the stability of the intraocular environment in the contralateral eye, suggesting that in staged bilateral surgeries, potential metabolic changes in the non-operated eye and their clinical","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"137"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The role of the KEAP1-NRF2 signaling pathway in form deprivation myopia guinea pigs.","authors":"Zhiming Gu, Jiayu Meng, Weiqi Zhong, Changjun Lan, Qingqing Tan, Xiaoling Xiang, Hong Zhou, Xuan Liao","doi":"10.1186/s12886-025-03967-3","DOIUrl":"10.1186/s12886-025-03967-3","url":null,"abstract":"","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"136"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accidental diode laser-induced full-thickness macular hole: a case report.","authors":"Nazanin Zeinali Nezhad, Atiye Moradi, Shiva Pouradeli, Mohammad Rezaei Zadeh Rukerd, Mahdi Sharifzadeh Kermani","doi":"10.1186/s12886-025-03970-8","DOIUrl":"10.1186/s12886-025-03970-8","url":null,"abstract":"<p><p>Accidental ocular injuries caused by laser devices used in non-medical settings are rare but potentially vision-threatening. This case report describes a 24-year-old woman who sustained a full-thickness macular hole (FTMH) in the right eye following accidental diode laser exposure during a hair removal procedure at a beauty center. The injury occurred when the laser probe was inadvertently activated, striking the patient's unprotected eye. The patient presented with profound visual loss in the affected eye, with visual acuity reduced to the level of hand motion. Comprehensive ophthalmological examination revealed a FTMH in the right eye, confirmed by optical coherence tomography (OCT), which showed complete disruption of the foveal retinal layers and cystic changes at the margins of the hole. The patient underwent surgical intervention with pars plana vitrectomy (PPV), internal limiting membrane (ILM) peeling, and gas tamponade to promote macular hole closure and restore retinal integrity. Despite successful anatomical closure of the macular hole, the patient's visual prognosis remained guarded due to extensive photothermal damage to the retinal pigment epithelium and photoreceptor layers. This case underscores the devastating consequences of inadequate laser safety protocols in non-medical environments, the critical role of OCT in diagnosing and managing laser-induced retinal injuries, and the importance of timely surgical intervention.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"135"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}