Incidence and risk factors for early transient intraocular pressure elevation after penetrating canaloplasty in patients with glaucoma.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

BMC Ophthalmology Pub Date : 2025-10-09 DOI:10.1186/s12886-025-04399-9

Lijuan Xu, Juan Gu, Wenqing Ye, Xinyao Zhang, Yin Zhao, Tao Zhou, Jialing Han, Ruiyi Ren, Yuanbo Liang

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Abstract

Background: This study aimed to evaluate the incidence and risk factors for early transient intraocular pressure (IOP) elevation after penetrating canaloplasty (PCP) in patients with primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG) and secondary glaucoma (SG).

Methods: This retrospective study included 198 eyes of 198 patients with glaucoma. Participants were classified as normal IOP, early transient high IOP (E-HIOP [Tst]), early persistent IOP elevation, late transient high IOP, and late persistent IOP elevation, based on the period and persistence of postoperative IOP elevation.

Results: E-HIOP (Tst) developed in 34.8%, 33.3%, and 40.9% of eyes with POAG, PACG, and SG, respectively. In comparison with normal IOP group, we observed the following variations in E-HIOP (Tst) cohorts: 8 - 10 years younger in patients with POAG and PACG; higher prevalence of hyphema (45.5% vs. 20.5%) in POAG; higher baseline IOP in PACG and SG (7 - 8 mmHg); higher preoperative IOP maximum (IOP_pre-max) in SG (all p < 0.05). Higher IOP_pre-max was a risk factor for E-HIOP (Tst) in PACG and SG (p < 0.05).

Conclusions: Nearly 30 - 40% of eyes developed E-HIOP (Tst) after PCP. E-HIOP (Tst) tended to develop in younger participants and those with higher preoperative IOP. A higher IOP_pre-max was a risk factor for E-HIOP (Tst) in PACG and SG.

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青光眼患者穿透性小管成形术后早期一过性眼压升高的发生率及危险因素。

背景：本研究旨在评价原发性开角型青光眼（POAG）、原发性闭角型青光眼（PACG）和继发性青光眼（SG）患者行穿透性青光眼成形术（PCP）后早期一过性眼压（IOP）升高的发生率及危险因素。方法：对198例青光眼患者198只眼进行回顾性研究。根据术后IOP升高的时间和持续时间，将参与者分为正常IOP、早期一过性高IOP （E-HIOP [Tst]）、早期持续IOP升高、晚期一过性高IOP和晚期持续IOP升高。结果：POAG、PACG和SG组患者发生E-HIOP （Tst）的比例分别为34.8%、33.3%和40.9%。与正常IOP组相比，我们观察到E-HIOP （Tst）队列的以下变化：POAG和PACG患者年轻8 - 10岁；POAG患者前房积血患病率较高（45.5%比20.5%）；PACG和SG的基线眼压升高（7 - 8 mmHg）；SG患者术前最大IOP （IOPpre-max）较高（所有p -max均为PACG和SG患者E-HIOP （Tst）的危险因素）。结论：PCP术后近30 - 40%的眼睛发生E-HIOP （Tst）。E-HIOP （Tst）倾向于在年轻和术前IOP较高的参与者中发展。较高的IOPpre-max是PACG和SG患者E-HIOP （Tst）的危险因素。

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来源期刊

BMC Ophthalmology OPHTHALMOLOGY-

CiteScore

3.40

自引率

5.00%

发文量

441

审稿时长

6-12 weeks

期刊介绍： BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.