Ehab Mohamed Elsayed Saad, Hazem Elbadry Mohammed Mohammed, Mohamed Mohamed-Aly Ibrahim, Omar Hassan Salama Selim, Sayed Mostafa Elsayed Abdelhafeez, Ahmed Mohammed Sakr, Fathy Mohamed Abo Elftouh Elsalhy, Ahmed Abdelmohsen Ali Ayoub, Ehab Abdelsamea Alazab, Ehab Tharwat, Tamer Gamal El Sayed Mostafa
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This study aimed to evaluate the outcomes of perfluorocarbon liquid (PFCL) versus posterior retinotomy (PR) during pars plana vitrectomy (PPV) for RRD, focusing on anatomical success, visual acuity, intraocular pressure (IOP), and complications.</p><p><strong>Methods: </strong>This is a prospective randomized controlled trial that included 58 eyes with RRD, divided into Group A (PFCL, n = 29) and Group B (PR, n = 29). Preoperative assessments included best-corrected visual acuity (BCVA), IOP, axial length, lens status, macula status, and PVR grade. Outcomes were evaluated at 1 week, 1 month, 2 months, and 3 months postoperatively. Primary outcomes included retinal reattachment rates and the number of operations; secondary outcomes included BCVA, IOP changes, complications like cataract development, retinal redetachment, epiretinal membrane (ERM) formation, and single-surgery success.</p><p><strong>Results: </strong>Retinal reattachment rates were comparable (76% in Group A vs. 66% in Group B, p = 0.387), as well as the number of operations (p = 0.375). Moreover, BCVA improved significantly in both groups (p < 0.05), with no intergroup differences. IOP increased postoperatively in both groups (p < 0.001), with no significant differences. No differences were observed in cataract formation or retinal redetachment. However, ERM incidence was significantly higher in the PR group (27% vs. 11%, p = 0.049).</p><p><strong>Conclusion: </strong>PFCL and PR are effective for RRD repair, with similar anatomical and visual outcomes. However, PFCL may reduce ERM risk, making it preferable in certain cases. 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Primary outcomes included retinal reattachment rates and the number of operations; secondary outcomes included BCVA, IOP changes, complications like cataract development, retinal redetachment, epiretinal membrane (ERM) formation, and single-surgery success.</p><p><strong>Results: </strong>Retinal reattachment rates were comparable (76% in Group A vs. 66% in Group B, p = 0.387), as well as the number of operations (p = 0.375). Moreover, BCVA improved significantly in both groups (p < 0.05), with no intergroup differences. IOP increased postoperatively in both groups (p < 0.001), with no significant differences. No differences were observed in cataract formation or retinal redetachment. However, ERM incidence was significantly higher in the PR group (27% vs. 11%, p = 0.049).</p><p><strong>Conclusion: </strong>PFCL and PR are effective for RRD repair, with similar anatomical and visual outcomes. However, PFCL may reduce ERM risk, making it preferable in certain cases. 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引用次数: 0
摘要
目的：孔源性视网膜脱离（RRD）是一种威胁视力的疾病，需要及时的手术干预。采用各种辅助技术来增强视网膜下液引流和视网膜再附着。本研究旨在评估全氟化碳液体（PFCL）与后视网膜切开术（PR）在治疗RRD的玻璃体切除术（PPV）中的效果，重点关注解剖成功、视力、眼压（IOP）和并发症。方法：采用前瞻性随机对照试验，纳入58只RRD眼，分为a组（PFCL, n = 29）和B组（PR, n = 29）。术前评估包括最佳矫正视力（BCVA）、IOP、眼轴长度、晶状体状态、黄斑状态和PVR等级。分别在术后1周、1个月、2个月和3个月对结果进行评估。主要结局包括视网膜再附着率和手术次数；次要结局包括BCVA、IOP改变、白内障发展、视网膜再脱离、视网膜前膜（ERM）形成等并发症和单次手术成功。结果：两组视网膜再附着率比较（A组76%，B组66%，p = 0.387），手术次数比较（p = 0.375）。此外，两组患者的BCVA均有显著改善(p)。结论：PFCL和PR对RRD修复有效，解剖和视觉效果相似。然而，PFCL可以降低ERM风险，使其在某些情况下更可取。这些发现指导了手术决策，并强调了进一步研究的必要性。试验注册：该研究于2025年4月4日在ClinicalTrials.gov （NCT06919211）上回顾性注册。
Outcomes of perfluorocarbon liquid vs. posterior retinotomy as adjuncts during pars-plana vitrectomy for the surgical repair of rhegmatogenous retinal detachment: a randomized clinical trial.
Purpose: Rhegmatogenous retinal detachment (RRD) is a sight-threatening condition requiring prompt surgical intervention. Various adjunctive techniques are employed to enhance subretinal fluid drainage and retinal reattachment. This study aimed to evaluate the outcomes of perfluorocarbon liquid (PFCL) versus posterior retinotomy (PR) during pars plana vitrectomy (PPV) for RRD, focusing on anatomical success, visual acuity, intraocular pressure (IOP), and complications.
Methods: This is a prospective randomized controlled trial that included 58 eyes with RRD, divided into Group A (PFCL, n = 29) and Group B (PR, n = 29). Preoperative assessments included best-corrected visual acuity (BCVA), IOP, axial length, lens status, macula status, and PVR grade. Outcomes were evaluated at 1 week, 1 month, 2 months, and 3 months postoperatively. Primary outcomes included retinal reattachment rates and the number of operations; secondary outcomes included BCVA, IOP changes, complications like cataract development, retinal redetachment, epiretinal membrane (ERM) formation, and single-surgery success.
Results: Retinal reattachment rates were comparable (76% in Group A vs. 66% in Group B, p = 0.387), as well as the number of operations (p = 0.375). Moreover, BCVA improved significantly in both groups (p < 0.05), with no intergroup differences. IOP increased postoperatively in both groups (p < 0.001), with no significant differences. No differences were observed in cataract formation or retinal redetachment. However, ERM incidence was significantly higher in the PR group (27% vs. 11%, p = 0.049).
Conclusion: PFCL and PR are effective for RRD repair, with similar anatomical and visual outcomes. However, PFCL may reduce ERM risk, making it preferable in certain cases. These findings guide surgical decision-making and highlight the need for further research.
Trial registration: The study was retrospectively registered at ClinicalTrials.gov (NCT06919211) on April 4, 2025.
期刊介绍：
BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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