BMC Ophthalmology最新文献

{"title":"Histone H3 lysine 9 tri-methylation is associated with pterygium.","authors":"Dahee Choi, Ann-Yae Na, Seok-Won Jeoung, Yun-Hee Choi, Nayoon Park, Hyun-Sun Park, Hyuk-Kwon Kwon, Hyun-Shik Lee, Dong-Hyung Cho, Dong Hyun Kim, Hong-Yeoul Ryu","doi":"10.1186/s12886-025-03939-7","DOIUrl":"10.1186/s12886-025-03939-7","url":null,"abstract":"<p><strong>Background: </strong>Pterygium, abnormal growths of conjunctival tissue onto the cornea, are common ocular surface conditions with a high risk of recurrence after surgery and potential ophthalmic complications. The exact cause of pterygium remains unclear, and the triggers are still unknown. This study aims to investigate the relationship between pterygium and epigenetics to uncover the cause of pterygium and identify biomarkers for its diagnosis.</p><p><strong>Methods: </strong>We performed a ChIP-seq assay to compare genome-wide histone modification levels between normal conjunctiva and stage 3 pterygium samples.</p><p><strong>Results: </strong>In this study, we investigate the epigenetic profiles of patients with pterygium, focusing on histone H3 lysine 4 (H3K4) and lysine 9 (H3K9) trimethylation (me3). While H3K4me3 levels showed no significant genome-wide change, they were significantly altered in genes related to development and ocular diseases. Conversely, H3K9me3 levels were markedly elevated genome-wide, particularly at the promoters of 82 genes involved in developmental pathways. Furthermore, we identify six genes, ANK2, AOAH, CBLN2, CDH8, CNTNAP4, and DPP6, with decreased gene expression correlated with substantially increased H3K9me3, suggesting their potential as biomarkers for pterygium.</p><p><strong>Conclusion: </strong>This study represents the first report linking histone modification to pterygium progression, providing valuable insights into therapeutic strategies and potential drug targets.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"106"},"PeriodicalIF":1.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Toric Allocation Pathway (TAP): outcomes of a standardised pathway for toric lens allocation at a tertiary referral hospital.","authors":"Muhammad Azaan Khan, Dominic McCall, Chameen Samarawickrama","doi":"10.1186/s12886-025-03907-1","DOIUrl":"10.1186/s12886-025-03907-1","url":null,"abstract":"<p><strong>Aims: </strong>To determine if a standardised Toric Allocation Pathway (TAP) improved visual and refractive outcomes for patients undergoing cataract surgery at a tertiary referral teaching hospital.</p><p><strong>Methods: </strong>Demographic, visual, and refractive data from all patients who underwent cataract surgery and toric intraocular lens (IOL) insertion with an emmetropic target between January 2015 and December 2019 were retrospectively collected and separated into pre-TAP and TAP groups. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), postoperative spherical equivalent refraction (SER) and postoperative cylinder were compared using multivariate regression analysis and Mann-Whitney U testing.</p><p><strong>Results: </strong>A total of 118 eyes were divided into pre-TAP (n = 59, 50%) and TAP (n = 59, 50%) groups. Case-mix and surgeon rank was comparable between the two groups (all variables p > 0.05). The TAP group outperformed the pre-TAP group in postoperative mean UDVA (6/7.5 ± 0.13 LogMAR vs. 6/9 ± 0.19 LogMAR, p = 0.049, respectively) and residual cylinder (0.47 ± 0.54D vs. 0.87 ± 0.78D, p < 0.001). As well, the TAP group was more consistent, with significantly smaller standard deviations for all outcomes. Consequently, a higher proportion of patients achieved a SER of ≤ 0.5D from emmetropia in the TAP group (78% vs. 58%, p < 0.001).</p><p><strong>Conclusions: </strong>The TAP improved the visual and refractive outcomes for patients with regular astigmatism while minimising inappropriate implantation of toric IOLs. It is ideal for large teaching hospitals and provides a framework for developing surgeons in correctly selecting patients who would most benefit from toric IOLs.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"102"},"PeriodicalIF":1.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vivo sclera thickness measurements in experimental myopia of guinea pigs.","authors":"Ruiheng Zhang, Chuyao Yu, Li Dong, Yitong Li, Xuhan Shi, Haotian Wu, Wenda Zhou, Heyan Li, Wenbin Wei","doi":"10.1186/s12886-025-03936-w","DOIUrl":"10.1186/s12886-025-03936-w","url":null,"abstract":"<p><p>The sclera is the target organ of axial elongation during myopia onset and progression. Visualizing the sclera in-vivo is important for monitoring the dynamic changes of the sclera remodeling in experimental myopia. In the present study, three-week-old tricolor guinea pigs were subjected to negative controls (n = 8), monocular negative lens-induced myopia (LIM, n = 10), or combining monocular LIM and intravitreally mTORC1 agonist (MHY1485, 4 µg) injection for inducing high myopia (LIM + MHY1485 group, n = 10) for four weeks. Serial biometric measurements were performed to monitor experimental myopia onset and progression. Swept-source optical coherence tomography (SS-OCT) was performed to measure sclera thickness at the beginning and end of study. The results showed four weeks of LIM and LIM + MHY1485 induced a significant degree of myopia shift, compared to the negative control (Control, -2.04 ± 0.60; LIM - 6.21 ± 0.55; LIM + MHY1485, -9.14 ± 1.11, diopters, P < 0.0001). The cross-sectional SS-OCT showed clear boundaries of the inner and outer boundaries of the sclera. At baseline, the mean sclera thickness was 105.05 ± 5.41 μm. At the end of the study, sclera thickness significantly correlated with axial length (coefficient = -4.49 μm for every 0.1 mm axial length increase, 95%CI: -3.56 to -5.83 μm, P < 0.001) and refractive error (coefficient = -2.77 μm for every 1 diopter myopic shift, 95%CI: -2.06 to -3.47 μm, P < 0.001) among all guinea pigs. Sclera thickness also significantly correlates with choroidal thickness and choroidal vascularity index (%). In conclusion, the present study shows SS-OCT can be used as a non-invasive method to evaluate sclera thickness and monitor myopia progression in the guinea pig model of LIM.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"105"},"PeriodicalIF":1.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in monochromatic aberrations with accommodation in a large adult population.","authors":"María Mechó-García, María Arcas-Carbonell, Elvira Orduna-Hospital, Ana Sánchez-Cano, Vicente Fernández-Sánchez, Rute J Macedo-de-Araújo, Paulo Fernandes, José Manuel González-Méijome, Jos J Rozema","doi":"10.1186/s12886-025-03947-7","DOIUrl":"10.1186/s12886-025-03947-7","url":null,"abstract":"<p><strong>Background: </strong>During accommodation, the eye undergoes significant structural changes, altering wavefront aberrations. So, this study aimed to evaluate changes in Zernike coefficients up to the 6th order with different accommodation demands and ages in a large cohort of young adults, considering the decrease in pupil size with the accommodation.</p><p><strong>Methods: </strong>Aberrometric measurements for 210 healthy subjects aged 18-40 were performed with the irx3 (Imagine Eyes, Orsay, France), stimulating accommodation with the Badal system of the instrument, from 0 to 5 D. Each wavefront was rescaled to a standardized pupil size for each accommodative vergence. Variations of Zernike coefficients were analyzed for each accommodative demand, and the change of Zernike coefficients with age.</p><p><strong>Results: </strong>The most notable changes observed during accommodation was the increase in C(2,0). Both C(2,±2) astigmatism showed a reduction in magnitude during accommodation. C(4,0) became less positive, or more negative, as accommodation increased. C(3,-1) remained constant as the accommodation demand increased, while C(3,1) showed an increase. Changes were observed with accommodation and age, where C(2,0) had a negative linear relationship. The C(4,0) changed gradually with age only for accommodative demands below 3 D. C(3,±1) decreased with age.</p><p><strong>Conclusions: </strong>Wavefront aberration coefficients presented changes during accommodation in people aged 20-40 years. C(2,0) underwent the most pronounced changes and C(4,0) changed more with accommodation than other higher-order aberrations. Zernike coefficients C(2,0), C(4,0) and C(3,±1) decreased with age, and C(2,±2) astigmatisms showed an increase in magnitude with age. These findings were made considering the decrease in pupil size with accommodation, highlighting the importance of accounting for pupil diameter variations when evaluating wavefront aberrations.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"104"},"PeriodicalIF":1.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of factors on the space between the posterior capsule and IOL.","authors":"Xiaohong Liu, Ning Cui, Chuyi Zhou, Jinyi Long, Ping Hu, Xue Wu, Yuhong Ye, Ling Xu, Zhengbing Zhou, Da Long","doi":"10.1186/s12886-025-03917-z","DOIUrl":"10.1186/s12886-025-03917-z","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effect of factors on the space between the posterior capsule and IOL.</p><p><strong>Methods: </strong>A total of 126 patients were included in the study. All patients underwent AS-OCT examinations after surgery. The relationship between the posterior capsule-IOL (PC-IOL) adhesion range and various factors, including IOL type, follow-up period, axial length, and lens thickness, were analyzed.</p><p><strong>Results: </strong>When the follow-up period was shorter than 1 week, the proportion of PC-IOL adhesion range greater than 1/2 in the ZA9003, softec, SN6ATX, and 525 groups was 66.7%, 78.9%, 25%, and 53.8%, respectively. When the follow-up period was longer than 1 month, these proportions increased to 75%, 100%, 40.8%, and 100%, respectively. In the multivariate logistic regression analysis, only the IOL types and follow-up period were statistically significant, while axial length and lens thickness were not statistically significant.</p><p><strong>Conclusion: </strong>The follow-up period and IOL types affect the space between the IOL and the posterior capsule, whereas axial length and lens thickness do not. Among the four IOL types studied, the softec IOL has the strongest adhesive power, while the SN6ATX IOL has the weakest.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"101"},"PeriodicalIF":1.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of phacoemulsification combined with goniosynechi-alysis with goniotomy versus trabeculectomy in patients with angle-closure glaucoma and cataract.","authors":"Mei Li, Yuanhui Jin, Jiangjian Hu","doi":"10.1186/s12886-025-03927-x","DOIUrl":"10.1186/s12886-025-03927-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the effectiveness and safety of phacoemulsification cataract extraction with intraocular lens implantation (PEI) combined with Goniosynechialysis (GSL), Goni-otomy (GT), and PEI combined with Trabeculectomy (TRAB), in managing mid to late-stage Primary Angle-Closure Glaucoma (PACG) combined with cataract.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 42 patients (54 eyes) with mid to late-stage PACG combined with cataracts, who were previously treated at Dongyang People's Hospital from December 3, 2020, to November 30, 2023. Among them, 16 (24 eyes) underwent PEI-GSL-GT, and 26 (30 eyes) underwent PEI-TRAB. After minimum of 6 months of postoperative follow-up, observations were made on intraocular pressure (IOP), best-corrected visual acuity (BCVA), use of antiglaucoma medications, and complications for both surgical procedures.</p><p><strong>Results: </strong>Postoperative BCVA improved significantly in both groups. In the PEI-GSL-GT group, IOP decreased by 26% (from 17.75 to 13.13 mmHg); in the PEI-TRAB group, it decreased by 14.5% (from 17.87 to 15.27 mmHg). At the 6-month follow-up, IOP was significantly lower in the PEI-GSL-GT group compared to the PEI-TRAB group. The number of patients using antiglaucoma medications decreased significantly in both groups. By the 6-month follow-up, no patients in the PEI-GSL-GT group were using antiglaucoma medications.</p><p><strong>Conclusions: </strong>PEI-GSL-GT is more effective than PEI-TRAB in lowering IOP in patients with mid to late-stage PACG, potentially reducing or discontinuing postoperative antiglaucoma medications, decreasing postoperative complications, and improving visual acuity.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"100"},"PeriodicalIF":1.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of fracture and displacement of a previously successful bilateral transconjunctival ab-externo XEN gel stent: a case report.","authors":"Qi Zhang, Chengshou Zhang, Xin Liu, Min Chen, Kaijun Wang","doi":"10.1186/s12886-025-03922-2","DOIUrl":"10.1186/s12886-025-03922-2","url":null,"abstract":"<p><strong>Background: </strong>The XEN45 Gel Stent (XGS) is an innovative, minimally invasive glaucoma surgery device, which is typically inserted via an ab-interno method, avoiding conjunctival dissection. With increasing experience, some surgeons have advocated for a transconjunctival ab-externo approach, with or without conjunctival dissection, for the delivery of XGS.</p><p><strong>Case presentation: </strong>A 33-year-old male patient with a history of primary open-angle glaucoma diagnosed three years ago presented to the clinic with the complaint of visual field loss. This case report presents the initial implantation of XGS in both glaucoma eyes, using the transconjunctival ab-externo technique without conjunctival dissection. However, subsequent follow-up revealed that in the left eye, the XGS had been fractured as a result of external force. Meanwhile, in the right eye, the displacement of the XGS was attributed to the surgical needlework. To facilitate re-implantation, the transconjunctival ab-externo approach with conjunctival dissection was employed to enhance the securement of the XGS.</p><p><strong>Conclusions: </strong>The case highlights that external force and needling can cause XGS fracture and displacement. To reduce this risk, employing a transconjunctival ab-externo approach with conjunctival dissection and securing the XGS with sutures was found to decrease complications, indicating a more effective surgical strategy for XGS implantation.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"98"},"PeriodicalIF":1.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of contrast sensitivity at low spatial frequencies with myopic shift in Chinese children.","authors":"Yuhao Ye, Fang Liu, Yiyong Xian, Meng Li, Lingling Niu, Xingtao Zhou, Jing Zhao","doi":"10.1186/s12886-025-03858-7","DOIUrl":"10.1186/s12886-025-03858-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the correlation of contrast sensitivity function (CSF) with myopic shift in Chinese children.</p><p><strong>Methods: </strong>This prospective case-series study included 62 eyes (31 children) who visited the Eye and ENT Hospital of Fudan University in January 2022 and were followed up for 6 months. Routine ophthalmic examinations and quantitative CSF (qCSF) tests without refractive correction were performed. Differences in CSF parameters, including the area under the log CSF (AULCSF), CSF acuity, and contrast sensitivity (CS) at 1.0-18.0 cpd, were compared between two groups stratified according to the myopic shift based on mydriatic spherical equivalent (<-0.50 D or ≥-0.50 D) during follow-up.</p><p><strong>Results: </strong>The myopia progressed by 0.13 ± 0.24 and 1.18 ± 0.75 D in the stabilized (28 eyes) and advanced (34 eyes) groups, respectively. Compared with the advanced group, the stabilized group showed significantly lower baseline qCSF test results for CSF acuity and CS at 1.0 and 1.5 cpd. The qCSF readings for CSF acuity and CS at 1.0, 1.5, and 3.0 cpd increased significantly during the 6-month follow-up in the stabilized group, while these values showed non-significant decreases in the advanced group. CS at 3.0 cpd was significantly correlated with myopic shift. Compared with the advanced group, participants in the stabilized group with higher myopia showed relatively significantly lower CS (baseline CSF acuity and CS at 1.0, 1.5, and 3.0 cpd).</p><p><strong>Conclusions: </strong>Children with relatively slower myopic shift showed lower contrast sensitivity at low spatial frequencies, which might be an effective factor in myopia control.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"99"},"PeriodicalIF":1.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal variations in corneal biomechanics in healthy young adults.","authors":"DaTian Zhu, LuMeng Wang, ZhanXin Qu, Pu Wang, YongYi Yuan, Lan Yang, XinYu Yao, XiaoBo Zheng, HengLi Lian, Chong Wang, JunJie Wang, YuFeng Ye, Ahmed Elsheikh, FangJun Bao, JunHua Li","doi":"10.1186/s12886-025-03913-3","DOIUrl":"10.1186/s12886-025-03913-3","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the diurnal changes in corneal biomechanics in healthy young adults.</p><p><strong>Methods: </strong>At Wenzhou Medical University Eye Hospital in China, a prospective case series. Each healthy subject had six Corvis ST examinations, from 10:00 on a first day to 6:00 on the following day, at 4-hour intervals. The data collected included the biomechanically corrected IOP (bIOP), the central corneal thickness (CCT) and six dynamic corneal response (DCR) parameters, namely deformation amplitude (DA), the ratio between DA values at the apex and 2 mm from the apex (DAR2), integrated inverse radius (IIR), the stiffness parameter at first applanation (SP-A1), Corvis biomechanical index (CBI) and the updated stress-strain index (SSIv2). A multilevel model was used to assess the changes in DCR parameters of patients over time during the examination period.</p><p><strong>Results: </strong>Sixty-one subjects were included and intra-operator reproducibility was good for most DCR parameters at the 6 time points. DA, DAR2, IIR and CBI showed small fluctuations during the 24-hour cycle with mean values of 0.1, 0.16, 0.34, and 0.04 units, respectively, while SP-A1 showed higher variations averaging 20.57 units and SSIv2 had the least fluctuation within 0.10 units during 24-hour cycle. After correcting for the effects of CCT and bIOP, the diurnal fluctuations in IIR, CBI and SSIv2 were not statistically significant, unlike the fluctuations in DA, DAR2 and SP-A1, which remained significant.</p><p><strong>Conclusions: </strong>Compared with the DA, DAR2, IIR and CBI, SP-A1 was more affected while SSIv2 was the less affected by the diurnal variations and associated corneal edema.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"90"},"PeriodicalIF":1.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143498971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of single-step transepithelial photorefractive keratectomy in myopia, hyperopia and astigmatism-a systematic review.","authors":"Sharmeen Akram, Wardah Moazzum, Khadijah Abid","doi":"10.1186/s12886-024-03830-x","DOIUrl":"10.1186/s12886-024-03830-x","url":null,"abstract":"<p><strong>Background: </strong>This systematic review assesses the efficacy of single-step transepithelial photorefractive keratectomy (tPRK) in terms of postoperative pain, epithelial healing, postoperative haze and visual acuity. It also compares single tPRK to two-step tPRK where data is available.</p><p><strong>Methods: </strong>This systematic review adhered to the PRISMA reporting guidelines (Preferred Reporting Items for Systematic Reviews and Meta-analyses). An electronic literature search was conducted on PUBMED, Scopus, and Google Scholar. The quality of the studies included in this systematic review was evaluated using the Newcastle Ottawa Scale (NOS). The protocol of this systematic review was registered on PROSPERO with ID CRD42024494717.</p><p><strong>Results: </strong>A total of 11 studies published between 2013 and 2023 were included in this systematic review. Studies revealed a significant improvement in visual acuity with both single-step tPRK and two-step tPRK. Two studies showed that single-step tPRK not only offers a better UDVA but also a significant improvement in the manifest sphere, cylinder, and spherical equivalent at various follow-up periods compared to two-step tPRK. One study demonstrated the broad effectiveness of single-step tPRK for myopia correction across low-, moderate-, and high-severity groups. Rapid epithelial healing was a consistent finding. Complete epithelial healing within 72 h was noted in 100% of eyes treated with single-step tPRK in one of the studies. The incidence of corneal haze following tPRK was generally low across the studies. Post-tPRK pain scores were initially lower in the single-step tPRK group. One study reported that the maximum pain level within the first four days after surgery was significantly lower in the single-step tPRK group than in the two-step tPRK group.</p><p><strong>Conclusion: </strong>Both two-step and single-step tPRK are safe refractive procedures. Single-step tPRK, because of less haze formation, lower pain scores, faster healing, and greater effectiveness in improving visual acuity, is superior to the two-step technique.</p><p><strong>Trial registration: </strong>The protocol of this systematic review was registered on PROSPERO with ID CRD42024494717.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"93"},"PeriodicalIF":1.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143498977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}