BMC Ophthalmology最新文献

{"title":"Retinal atrophy and eccentric macular hole after internal limiting membrane peeling: a case report.","authors":"Shu Zhang, Zhiyan Liu, Chenjia Zhang, Xiangli Wang","doi":"10.1186/s12886-025-04074-z","DOIUrl":"https://doi.org/10.1186/s12886-025-04074-z","url":null,"abstract":"<p><strong>Background: </strong>Postoperative eccentric macular hole (MH) formation is a relatively rare complication after pars plana vitrectomy (PPV) with internal limiting membrane(ILM) peeling for epiretinal membrane (ERM) or MH treatment. Herein, we report a case of eccentric MH formation following PPV with ILM peeling for MH.</p><p><strong>Case presentation: </strong>A 62-year-old male presented with a 3-month history of blurred vision and metamorphopsia in the left eye. Preoperative optical coherence tomography (OCT) confirmed a full-thickness MH (minimum linear diameter: 675 μm). The patient underwent 25-gauge PPV with ILM peeling using indocyanine green (ICG, 0.25%) and inverted ILM flap placement. Postoperative OCT at one week confirmed MH closure. However, subsequent follow-ups revealed progressive inner retinal disorganization, atrophy, and cavitation. At five months, a parafoveal full-thickness eccentric macular hole (EMH) developed inferiorly. No additional interventions were pursued due to stable hole size and absence of retinal detachment.</p><p><strong>Conclusions: </strong>This case highlights rare postoperative retinal atrophy and EMH formation following ILM peeling for MH repair. Potential contributors include ICG-induced photochemical toxicity, Müller cell damage from ILM peeling, and fluid shear stress. The findings underscore the need to optimize ICG protocols (reduced concentration, shorter exposure) and prioritize safer alternatives like brilliant blue G (BBG). Long-term postoperative monitoring is critical to detect delayed complications, emphasizing the balance between surgical efficacy and minimizing iatrogenic retinal injury.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"237"},"PeriodicalIF":1.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management and challenges of femtosecond laser-assisted cataract surgery in patients with cataracts secondary to reverse-implanted posterior chamber phakic intraocular lens: a case report.","authors":"Shuaishuai Liu, Yong Liu","doi":"10.1186/s12886-025-04055-2","DOIUrl":"https://doi.org/10.1186/s12886-025-04055-2","url":null,"abstract":"<p><strong>Background: </strong>Posterior chamber phakic intraocular lens are widely recognized as an effective treatment for refractive errors, yet they are not without risks. One notable complication that can emerge years after reverse implantation is cataract formation. In these intricate scenarios, femtosecond laser-assisted cataract surgery presents itself as a remarkably precise and safer approach for the extraction of cataracts, especially when the ICL is in a reverse position.</p><p><strong>Case presentation: </strong>This report details the extraordinary case of a 33-year-old woman who, ten years after undergoing posterior chamber phakic intraocular lens implantation, experienced a decline in visual acuity in her left eye. She chose to undergo femtosecond laser-assisted cataract surgery in conjunction with posterior chamber phakic intraocular lens removal to address an anterior subcapsular cataract. The procedure encountered unique challenges, including biometric inaccuracies caused by the pre-existing posterior chamber phakic intraocular lens and difficulties in laser targeting. Manual adjustments were necessitated during the laser application. A trifocal intraocular lens was successfully inserted. At her three-month follow-up, the patient exhibited a remarkable improvement, achieving an uncorrected visual acuity of 20/20 in the treated eye. She expressed high satisfaction with the outcome, acknowledging only minor occurrences of halo effects.</p><p><strong>Conclusions: </strong>This report confirms the feasibility of FLACS in treating cataracts in patients with reversely implanted posterior chamber phakic intraocular lens. Compared to typical cataract cases, the surgical procedure did not present significant additional challenges. However, meticulous preoperative measurements, laser scanning, and intraoperative alignment remain essential. With thorough preoperative preparation and precise posterior intraocular lens power calculation, the surgical outcomes can fully meet.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"241"},"PeriodicalIF":1.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of dry eye patients with thyroid disorders: a cross-sectional study.","authors":"Yiteng Lu, Xichen Wan, Han Ye, Pei Yang, Shuyun Zhou, Zhi Chen, Changchang Xin, Xujiao Zhou, Qihua Le, Jiaxu Hong","doi":"10.1186/s12886-025-04084-x","DOIUrl":"https://doi.org/10.1186/s12886-025-04084-x","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the clinical findings in dry eye disease (DED) patients with thyroid disorders and explore their associations with DED symptoms and signs.</p><p><strong>Methods: </strong>In this retrospective cross-sectional chart review study, 99 patients who were diagnosed as DED and subjected to thyroid function screening were included. Corneal fluorescein staining (CFS), Schirmer 1 test (S1T), tear meniscus height (TMH), the first noninvasive breakup time (NIBUT-first), the average noninvasive breakup time (NIBUT-avg), and meibomian gland (MG) dropout ratio were tested and their correlations with thyroid function were analyzed.</p><p><strong>Results: </strong>Overall, the average age and gender distribution of DED patients with or without thyroid disorders were similar (p = 0.391 and 0.804). DED patients with thyroid disorders had shorter NIBUT-first(p < 0.001) and NIBUT-avg( p = 0.0042), and higher MG dropout ratio (p = 0.001). Among thyroid function assessments, elevated levels of anti-thyroid peroxidase antibody (Anti-TPO) and anti-thyroglobulin antibody (Anti-Tg) had significant correlation with reduced NIBUT and increased MG dropout ratio. When either NIBUT-first or MG dropout ratio was used as a predicting factor for thyroid disorders, ROC curve demonstrated a cut-off value of 5.255(NIBUT-first AUC 0.770, sensitivity 85.7%, specificity 58.8%, p < 0.001) and 0.229 (MG dropout ratio AUC 0.784, sensitivity 70.6%, specificity 79.6%, p < 0.001). When combining them together, an AUC area of 0.841(sensitivity 88.2%, specificity 66.2%, p < 0.001) was reached.</p><p><strong>Conclusion: </strong>Shorter NIBUT and higher MG dropout ratio correlated with abnormally elevated levels of Anti-TPO and Anti-Tg in DED patients. A combination of NIBUT and MG dropout assessment may have diagnostic potential as a predictive biomarker of possible thyroid disorders.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"229"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the interchangeability of keratometry measurements from four biometric devices in intraocular lens power calculations: insights into the predictive accuracy of five modern IOL formulas.","authors":"Shan Ma, Cheng Li, Jing Sun, Jun Yang, Kai Wen, Xiteng Chen, Fangyu Zhao, Xuequan Sun, Fang Tian","doi":"10.1186/s12886-025-04067-y","DOIUrl":"https://doi.org/10.1186/s12886-025-04067-y","url":null,"abstract":"<p><strong>Background: </strong>Achieving accurate intraocular lens (IOL) power calculation is crucial for successful refractive outcomes in cataract surgery. This study aimed to evaluate the interchangeability of keratometry (K) values obtained from four biometric devices (IOLMaster 700, CASIA2, Pentacam, and iTrace) and assess the predictive accuracy of five modern IOL calculation formulas (Barrett Universal II, Cooke K6, EVO 2.0, Kane, and PEARL-DGS) when using K values from these different devices.</p><p><strong>Methods: </strong>This prospective study included K values obtained from four biometric devices for use in five IOL power calculation formulas. Predictive accuracy was assessed using multiple statistical parameters, including standard deviation (SD), mean absolute error (MAE), median absolute error (MedAE) and root mean square absolute error (RMSAE). The interchangeability of devices was evaluated by comparing predictive outcomes across devices and formulas, with statistical analyses focusing on consistency and agreement.</p><p><strong>Results: </strong>Predictive accuracy across the five IOL formulas was stable and showed no statistically significant differences when using keratometry measurements from the same biometric device. However, significant variability was noted when comparing K values from different devices using the same formula. The SS-OCT-based devices (IOLMaster 700 and CASIA2) showed higher consistency in predictive accuracy compared to Scheimpflug-based Pentacam and ray-tracing-based iTrace. Despite this inter-device variability, all five IOL formulas showed overall robust performance across different devices.</p><p><strong>Conclusions: </strong>Our findings indicate that keratometry measurements from different biometric devices are not fully interchangeable. SS-OCT-based devices (IOLMaster 700 and CASIA2) provided superior consistency in refractive prediction accuracy. Therefore, clinicians should carefully select biometric device-formula combinations based on the specific measurement principles and desired refractive outcomes. Further research involving larger sample sizes, additional IOL types and biometric devices, as well as assessment of surgeon-related factors, is warranted to optimize refractive accuracy in cataract surgery.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"236"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial disparities in patients with proliferative diabetic retinopathy treated with pars plana vitrectomy in an underserved population.","authors":"Krista Thompson, Ahmed Alshaikhsalama, Angeline L Wang","doi":"10.1186/s12886-025-04037-4","DOIUrl":"10.1186/s12886-025-04037-4","url":null,"abstract":"<p><strong>Background: </strong>Proliferative diabetic retinopathy (PDR) is a serious microvascular complication of diabetes that can lead to irreversible vision loss. Prior research studies have documented how racial minorities with PDR experience less routine screening, less frequent treatment, and more complications. Although pars plana vitrectomy (PPV) is a widely used treatment modality for PDR, minimal research is currently available addressing how race impacts surgical presentation and outcomes.</p><p><strong>Methods: </strong>This study is a retrospective case series involving a sample of patients who underwent PPV for PDR at a county hospital between January 1, 2014, and December 30, 2019. Patients were included if they had a follow-up period of at least six months. The data collection included demographic data, medical history, surgical indications, operative outcomes, and complications. Snellen best corrected visual acuity (BCVA) was converted to logMAR for data analysis. Statistical analysis included chi-square testing, analysis of variance, generalized linear modeling, and multivariate analysis.</p><p><strong>Results: </strong>The study cohort consisted of 715 patients (915 eyes) receiving PPV for the treatment of PDR. In the patient cohort, 576 patients were Hispanic (80.6%), 103 patients were Black (14.4%), and 36 patients were Non-Hispanic White (5.0%). The majority of the patient cohort (75%) received charity insurance. Black patients had significantly higher pre-operative HbA1c levels than Hispanic patients (8.779 vs. 8.271, p = 0.011). Black patients were more likely to undergo surgery for a TRD than Hispanic patients (OR: 0.901, p < 0.001) and White patients (OR: 0.870, p < 0.001) and were more likely to have macula-involving TRDs compared to Hispanic patients (OR: 1.194, p < 0.001) and White patients (OR: 1.289, p = 0.005). Based on the multivariate analysis performed, race did not impact surgical outcomes, including post-operative visual acuity, anatomic success rate, and the need for a repeat surgery.</p><p><strong>Conclusions: </strong>The main findings of this study indicate that Black patients are receiving surgery when they have more advanced diabetic retinopathy. However, there were no significant differences in surgical outcomes.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"232"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year outcomes of trabeculo-canalectomy for Chinese PACG patients: a retrospective study.","authors":"Zhan Xie, Tianhao Xiao, Junlong Huang, Mulong Du, Ping Zhang, Ying-Ting Zhu, Ping Xie, Hong Sun","doi":"10.1186/s12886-025-04051-6","DOIUrl":"https://doi.org/10.1186/s12886-025-04051-6","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the 5-year outcomes of trabeculo-canalectomy in the treatment of primary angle-closure glaucoma (PACG) among Chinese patients.</p><p><strong>Methods: </strong>A retrospective study was designed, involving 46 PACG patients (50 eyes) treated with trabeculo-canalectomy at the First Affiliated Hospital of Nanjing Medical University from January 2016 to December 2018. The patients were followed up at 1 week, 1 month, 3 months, 6 months, 12 months, 1 year, 2 years and 5 years. Surgical success was defined as intraocular pressure (IOP) ≤ 21 mmHg (1 mmHg = 0.133 kPa) under glaucoma medication (qualified success) and without any glaucoma medication (absolute success). Main outcomes were measured according to IOP, number of medication regimens, surgical success rate, complications, and filtering bleb status.</p><p><strong>Results: </strong>A total of 46 PACG patients (50 eyes) were finally included for statistical analysis, with a mean age of 56.68 ± 6.75 years (range, 41-69 years). The mean preoperative IOP was 30.72 ± 10.26 mmHg with a median number of medication regimens of 2 (range, 0 to 4). Compared to those before the operation, the mean IOP decreased to 12.15 ± 3.11, 14.33 ± 4.10, 15.68 ± 4.24, 16.45 ± 4.14, 16.95 ± 3.51, 17.67 ± 3.15 and 17.04 ± 3.78 mmHg at 1 week, 1 month, 3 months, 6 months, 12 months, 1 year, 2 years and 5 years, respectively. The median (range) numbers of medication regimens were 0 (0 ~ 1), 0 (0 ~ 2), 0 (0 ~ 2), 0 (0 ~ 2), 0 (0 ~ 2), 0 (0 ~ 3), 0 (0 ~ 3), 0 (0 ~ 3) at the eight time points, respectively. The mean postoperative IOP and the number of medication regimens at each time point were significantly lower than those before operation (all P < 0.01). The 5-year total success rate was 89%, and the absolute success rate was 78%. Shallow anterior chamber (10%) and hyphema (12%) were the most common complications early after surgery. At 3 months, anterior segment slit-lamp photography and ultrasound biomicroscopy showed no obvious filtering blebs in 50 eyes (100%). IOP increased transiently in 6 eyes (12%) within 1 month after surgery.</p><p><strong>Conclusion: </strong>Simple and cost-saving trabeculo-canalectomy provides favorable 5-year outcomes in the treatment of medically uncontrolled PACG, as shown by more effective IOP control, more obvious drug reduction, as well as fewer post-operative interventions compared to trabeculectomy.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"234"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quorum-Sensing inhibition by furanone compounds and therapeutic effects on Pseudomonas aeruginosa keratitis rabbit model.","authors":"Aleyna Dal, Rümeysa Hekimoğlu, Bilge Sümbül, Fatmanur Babalı Balıbey, Zeynep Özman Gökçe, Ersin Akbulut, Ahmet Elbay","doi":"10.1186/s12886-025-04061-4","DOIUrl":"https://doi.org/10.1186/s12886-025-04061-4","url":null,"abstract":"<p><strong>Background: </strong>To investigate Quorum-Sensing inhibition by furanone compounds in Pseudomonas aeruginosa keratitis rabbit model.</p><p><strong>Methods: </strong>Thirty adult New Zealand White rabbits were used. Anesthetized rabbits were intrastromally injected with Pseudomonas aeruginosa (P. aeruginosa). The rabbits were divided into six groups: the control group (infected only with P. aeruginosa), group A (50 mg/mL ceftazidime), group B (0.1 mg/mL furanone), group C (0.2 mg/mL furanone), group D (0.3 mg/mL furanone), and group E (20% dimethyl sulfoxide). One drop of the treatment was applied every hour for 3 days, starting 1-h post-inoculation. Rabbits were then sacrificed, and corneas were analysed clinically, microbiologically, histologically, and biochemically. One-way analysis of variance was used for the mean comparison of independent groups. The Least Significant Difference method was used as a post-hoc test for pairwise comparisons.</p><p><strong>Results: </strong>In all evaluations, the antibiotic group (group A) showed the best therapeutic response. The slit-lamp examination score of group C was significantly lowered than those compared of to the control (p = 0.009) and E groups (p = 0.014). Histological evaluation showed that inflammation is decreased in groups B, C, and D. Levels of cyclooxygenase-2 (COX-2), superoxide dismutase-1, and reactive oxygen species (ROS) were lowest in the antibiotic-treated group, whereas the highest levels were detected in the control group. Notably, the COX-2 levels in group B and ROS levels in groups B and C were significantly lower than in control group. (p = 0.045, p = 0.039 and p = 0.045, respectively).</p><p><strong>Conclusion: </strong>Furanone compounds may have minimal therapeutic effects against Pseudomonas keratitis. Its therapeutic effect has not been observed to be sufficient compared with that of antibiotics. Further studies are needed to investigate their protective effects and mechanisms.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"231"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of retinal microstructure and electrophysiology in eyes following pars plana vitrectomy and membrane peeling for vitreomacular interface disorders.","authors":"I-Hsien Chen, Meng-Syuan Li, Chia-Li Tseng, Hung-Pin Tu, Shwu-Jiuan Sheu","doi":"10.1186/s12886-025-04042-7","DOIUrl":"https://doi.org/10.1186/s12886-025-04042-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between retinal structural biomarkers using spectral-domain optical coherence tomography (SD-OCT) and macular function before and after surgery.</p><p><strong>Methods: </strong>Forty-four eyes of 44 patients were included. Ophthalmological examinations included visual acuity (VA), intraocular pressure, OCT angiography (OCTA), and multi-focal electroretinography (mf-ERG) at baseline (pre-surgery) and post-operative follow-up. The ILM texture during peeling was graded by the surgeon as follows: Grade 1, fragile; Grade 2, easy to peel in a sheet; and Grade 3, sticky. The cross-sectional area of the ganglion cell layer and central retinal thickness in the fovea were evaluated using ImageJ software of SD-OCT. The presence of a dissociated optic nerve fiber layer (DONFL) was evaluated using en face OCTA images. mf-ERG results are shown as the ratio between the average amplitudes from rings 1 and 2 (central) and rings 4 and 5 (peripheral): the P1 ratio.</p><p><strong>Results: </strong>Based on the SD-OCT morphological characteristics of the foveal area, 14 cases were classified into ERM group 1 (mainly outer retinal thickening or more tenting of the outer retina), 11 into ERM group 2 (prominent inner retinal thickening), 9 into ERM group 3 (ERM with macular hole), and 10 into ERM group 4 (full thickness macular hole without ERM and vitreomacular traction without ERM). Morphological characteristics were correlated with ILM texture (p = 0.0031) and DONFL (p < 0.0001). Group 2 and group 3 ERM had a stickier ILM when peeling and showed DONFL in 100% of the cases. Group 1 ERM had a more fragile ILM when peeling and did not result in DONFL. ILM texture was also correlated with DONFL (p < 0.0001), in which sticky ILM resulted in DONFL after the operation. Eyes with DONFL showed a greater decrease in ganglion cell complex/central retinal thickness in the foveal area, slow P1 ratio recovery, and slower VA improvement.</p><p><strong>Conclusions: </strong>ERM with prominent inner retinal structural changes are likely to have a stickier ILM when peeled, leading to a subsequently DONFL. The appearance of DONFL results in an initial decrease in macular function recovery and slower post-operative visual improvement. Surgeons should be more delicate when peeling sticky ILM, especially in eyes with ERM with prominent inner retinal thickening or macular holes.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"235"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transvitreal endoresection of peripheral exudative hemorrhagic chorioretinopathy: a clinicopathological study.","authors":"Satoru Kase, Ai Shimizu, Susumu Ishida","doi":"10.1186/s12886-025-04070-3","DOIUrl":"https://doi.org/10.1186/s12886-025-04070-3","url":null,"abstract":"<p><strong>Background: </strong>To report a rare case of presumed early-stage peripheral exudative hemorrhagic chorioretinopathy (PEHCR), which was removed by transvitreal approach, and analyze the histological findings.</p><p><strong>Case presentation: </strong>A 76-year-old Japanese woman presented with a fundus lesion in her left eye, and was referred to our university hospital. Her best-corrected visual acuity was 1.0 with normal intraocular pressure in both eyes. The color fundus revealed a whitish elevated lesion, measuring about 2 disc diameters, in the inferior fundus. Fluorescein angiography depicted hyperfluorescence and fluorescein leakages in the lesion in the early and late phases, respectively. Indocyanine green angiography demonstrated the hypofluorescence in the lesion without any hyperfluorescent spots. Swept-source optical coherence tomography of the lesion demonstrated a subretinal solid mass with subretinal fluid and pigment epithelial detachments. Since clinical diagnosis of the fundus lesion could not be made, transvitreal endoresection of the lesion was conducted by pars plana vitrectomy. Her visual acuity remained good with no any complications 1 year after vitrectomy. Histopathologically, the lesion was made up of AE1/AE3 (an epithelial marker)-positive retinal pigment epithelial cells, with CD34 and alpha-smooth muscle actin-positive vessel walls, which were consistent with choroidal neovascularization (CNV). These clinicopathological findings led to the diagnosis of PEHCR.</p><p><strong>Conclusion: </strong>This is the first reported case of transvitreal endoresection of PEHCR, and the histopathology indicated that the origin was peripheral CNV.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"233"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phaeoacremonium iranianum - a new corneal pathogen.","authors":"Xiaona Liu, Xiuhai Lu, Juanjuan Zheng, Shujuan Liu, Man Li","doi":"10.1186/s12886-025-04064-1","DOIUrl":"https://doi.org/10.1186/s12886-025-04064-1","url":null,"abstract":"<p><strong>Background: </strong>Phaeoacremonium is typically found in the environment and can cause diseases in woody plants. It is rarely responsible for infections in humans.</p><p><strong>Case presentation: </strong>In this report, we present a case of corneal infection caused by Phaeoacremonium iranianum. Caused a fan-shaped grayish-white ulcer measuring approximately 4 mm×3 mm inferior nasal cornea. The ulcer appeared relatively dry, with noticeable swelling and cloudiness in the surrounding cornea. The visual acuity after infection was 0.25. We started an aggressive antifungal therapy. Our antifungal susceptibility testing revealed the Minimum Inhibitory Concentration of anifengin was 4 µg/ml, Micafengin and carpofungin exceeding 8 µg/ml, fluorocytosine was 32 µg/ml, posaconazole was 1 µg/ml, voriconazole was 0.5 µg/ml, itraconazole was 2 µg/ml, fluconazole was 64 µg/ml, and amphotericin was 0.05 µg/ml. The patient underwent keratectomy combined with antifungal therapy. A month later, the conjunctiva of the right eye was congested, and a 4*4 mm corneal opacity was visible inferior nasal cornea, with local obvious thinning and a little keratic precipitates on the inner skin, and the infection has been controlled.</p><p><strong>Conclusions: </strong>We detail the progression and treatment of this infection to contribute to the clinical understanding and management of such cases.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"230"},"PeriodicalIF":1.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}