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Drug utilisation and adverse drug reaction monitoring in schizophrenic patients: A tertiary care hospital study in India. 精神分裂症患者的药物利用和药物不良反应监测：印度三级医院研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223568
Vipin Kumar Jain, Shilpa N Kaore, Megha Jain, Vaibhav Dubey
{"title":"Drug utilisation and adverse drug reaction monitoring in schizophrenic patients: A tertiary care hospital study in India.","authors":"Vipin Kumar Jain, Shilpa N Kaore, Megha Jain, Vaibhav Dubey","doi":"10.6026/973206300223568","DOIUrl":"10.6026/973206300223568","url":null,"abstract":"<p><p>Inadequate and poorly documented data on psychotropic drug utilization in schizophrenia in India necessitates systematic evaluation of prescribing patterns and associated adverse drug reactions. This prospective observational study assessed drug utilization, prescription rationality and adverse drug reactions among schizophrenia patients attending a tertiary care psychiatric outpatient department using WHO prescribing indicators. A total of 112 prescriptions comprising 285 drugs were analyzed, with atypical antipsychotics prescribed in 87% of first-visit cases, while combination therapies and polypharmacy were frequently observed. Significant dose variations were noted in commonly used antipsychotics such as risperidone, olanzapine and aripiprazole, as well as benzodiazepines like clonazepam and lorazepam (p<0.001). Atypical antipsychotics predominated due to better tolerability and lower extrapyramidal side effects, highlighting evolving prescribing trends. Thus, structured evidence on drug utilization patterns and variability in dosing, help in optimizing rational prescribing practices in schizophrenia management.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3568-3571"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of post-operative infections and antibiotic resistance trends: A clinical study. 术后感染发生率与抗生素耐药趋势的临床研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223594
Vidya Kiran Bammidi, Jagannath Mishra, Dilip Katakam, Shamurailatpam Priyadarshini, Deepthi Nirmal Gavarraju, Neha Akhilesh Kumar Singh, Heena Dixit Tiwari
{"title":"Incidence of post-operative infections and antibiotic resistance trends: A clinical study.","authors":"Vidya Kiran Bammidi, Jagannath Mishra, Dilip Katakam, Shamurailatpam Priyadarshini, Deepthi Nirmal Gavarraju, Neha Akhilesh Kumar Singh, Heena Dixit Tiwari","doi":"10.6026/973206300223594","DOIUrl":"10.6026/973206300223594","url":null,"abstract":"<p><p>Gram-negative organisms, particularly Escherichia coli and Klebsiella species, are predominant pathogens. Therefore, it is of interest to evaluate the microbiological culture reports, antimicrobial susceptibility testing and clinical records of surgical patients who developed post-operative infections. In our study 200 surgical patients were included, among 32 developed post-operative infections, so giving an overall infection incidence of 16%. High resistance rates were observed against commonly prescribed antibiotics including amoxicillin-clavulanate and ceftriaxone, whereas lower resistance was noted for carbapenems. Thus, data shows the increasing burden of antimicrobial resistance in post-operative infections and the importance of continuous microbiological surveillance for effective infection control.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3594-3598"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical significance of biologic width in dentistry. 牙医学生物宽度的临床意义。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223692
Krutika Sangani, Bindiya Trambadiya Bhimani, Ana Cristina Garcia, Kelly J Pedraza Corrales, Zankhana Bhagat, Achalben Patel
{"title":"Clinical significance of biologic width in dentistry.","authors":"Krutika Sangani, Bindiya Trambadiya Bhimani, Ana Cristina Garcia, Kelly J Pedraza Corrales, Zankhana Bhagat, Achalben Patel","doi":"10.6026/973206300223692","DOIUrl":"10.6026/973206300223692","url":null,"abstract":"<p><p>Biologic width (BW) is the distance between the junctional epithelium and the supracrestal connective tissue above the alveolar crest, typically measuring approximately 2.04 mm. It is crucial for the health of periodontal, gingival, and alveolar bone tissues this creates a seal around the tooth's neck to prevent periodontal disease and gingival inflammation. Violation of BW can create a myriad of complications, like gingival inflammation, attachment loss, and bone loss. The article further discusses restorative and implant margin placement strategies, as well as surgical interventions such as crown lengthening, which help preserve BW. New digital tools provide a more precise assessment of BW in dentistry.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3692-3696"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of maxillary arch expansion using clear aligners with and without composite attachments - A finite element study. 有和没有复合附着体的透明矫正器对上颌弓扩展的比较-一项有限元研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223673
Sanitha Dhan, Vinaya S Pai, Mrunmayee Gholap, P Siri Krishna, Manjunath Hegde
{"title":"Comparison of maxillary arch expansion using clear aligners with and without composite attachments - A finite element study.","authors":"Sanitha Dhan, Vinaya S Pai, Mrunmayee Gholap, P Siri Krishna, Manjunath Hegde","doi":"10.6026/973206300223673","DOIUrl":"10.6026/973206300223673","url":null,"abstract":"<p><p>The influence of composite attachment geometry, placement and aligner thickness on maxillary expansion in clear aligner therapy remains inadequately understood. Therefore, it is of interest to evaluated tooth displacement and periodontal ligament stress using different attachment designs (ellipsoidal and rectangular), placements (buccal and lingual) and thermoplastic aligner thicknesses (0.5 mm and 0.75 mm). A three-dimensional finite element model of the maxillary arch was analyzed using ANSYS R18.1 to simulate expansion mechanics. Maximum displacement of the canine and first premolar was observed with a 0.75 mm aligner without attachments, while the second premolar and molar demonstrated greater expansion and higher stress concentrations with rectangular buccal attachments and 0.75 mm aligners. The null hypothesis was rejected, indicating that attachment design, placement and aligner thickness significantly affect maxillary expansion biomechanics.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3673-3680"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the efficacy of A-PRF and I-PRF in mandibular 3rd molar surgery with similar difficulty index: A comparative, split mouth study. 比较A- prf和I-PRF在难度指数相近的下颌第三磨牙手术中的疗效：一项分口比较研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223219
Prashanth Subhash Pawar, Samir Joshi, Sudhir Pawar, Richa Sharma
{"title":"Comparing the efficacy of A-PRF and I-PRF in mandibular 3rd molar surgery with similar difficulty index: A comparative, split mouth study.","authors":"Prashanth Subhash Pawar, Samir Joshi, Sudhir Pawar, Richa Sharma","doi":"10.6026/973206300223219","DOIUrl":"10.6026/973206300223219","url":null,"abstract":"<p><p>In regenerative dentistry, platelet rich fibrin (PRF) has been used as a concentrated autologous growth factors capable of encouraging tissue regeneration. Hence, ten patients requiring bilateral mandibular third molar extraction with similar difficulty index were included in the study. Following surgical extraction, A-PRF and I-PRF prepared using low-speed centrifugation protocols were placed into the extraction sockets during separate appointments conducted at a two-week interval. Following surgical extraction, A-PRF and I-PRF prepared using low-speed centrifugation protocols were placed into the extraction sockets during separate appointments conducted at a two-week interval. Thus, A-PRF and I-PRF prepared without anticoagulants using a low-speed centrifugation protocol in mandibular third molar surgery.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3219-3225"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Data on nutritional awareness among Saudi adults: Al-Ahsa study. 沙特成年人营养意识数据：Al-Ahsa研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223516
BiBi Mariam, Suchithra Koipurathu Rajappan, Fatimah Ahmed AlMubark, Zahra'a Ahmed AlShayeb, Hawra'a Mohammed AlSalman, Zahra Sameer Al Abdi, Kholoud Hamdan Al Rawaili, Latifa Abdullah Al Jafaar
{"title":"Data on nutritional awareness among Saudi adults: Al-Ahsa study.","authors":"BiBi Mariam, Suchithra Koipurathu Rajappan, Fatimah Ahmed AlMubark, Zahra'a Ahmed AlShayeb, Hawra'a Mohammed AlSalman, Zahra Sameer Al Abdi, Kholoud Hamdan Al Rawaili, Latifa Abdullah Al Jafaar","doi":"10.6026/973206300223516","DOIUrl":"10.6026/973206300223516","url":null,"abstract":"<p><p>Nutritional awareness is essential for preventing non-communicable diseases (NCDs) linked to poor diet and sedentary lifestyles. In Saudi Arabia, gender-specific patterns of nutrition knowledge remain inconsistent, necessitating localized evidence to guide health promotion strategies. Therefore, it is of interest to assess and compare awareness of healthy nutritional practices among 538 Saudi adults aged 18-65 years in Al-Ahsa using a validated questionnaire. Overall nutritional awareness was moderate (males: 2.12 ± 0.16; females: 2.13 ± 0.17), while nutrition and physical-activity awareness were high in both genders. Mann-Whitney U tests showed no statistically significant gender differences in awareness scores (p > 0.05). Despite adequate awareness, unhealthy behaviors such as meal skipping (77.9%) and sedentary lifestyle (34.8%) were common. Thus, we show a gap between awareness and practice and support the need for targeted community nutrition interventions.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3516-3520"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of microsurgical versus conventional periodontal flap procedures: A prospective randomized comparison. 显微外科手术与常规牙周瓣手术的评价：一项前瞻性随机比较。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223352
Amit Kumar Upadhyay, Megha Modi, Chandresh Kumar Shukla, Priyanka Jha, Prachi Kapade, Swarnabha Halder
{"title":"Evaluation of microsurgical versus conventional periodontal flap procedures: A prospective randomized comparison.","authors":"Amit Kumar Upadhyay, Megha Modi, Chandresh Kumar Shukla, Priyanka Jha, Prachi Kapade, Swarnabha Halder","doi":"10.6026/973206300223352","DOIUrl":"10.6026/973206300223352","url":null,"abstract":"<p><p>Comparative effectiveness of microsurgical versus conventional flap surgery in periodontal treatment remains inadequately defined. Therefore, it is of interest to compare clinical outcomes of microsurgical and conventional periodontal flap procedures in 100 patients with chronic periodontitis. Hence, patients were allocated to two groups, with assessment of probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), post-operative pain and healing at baseline, 1 month and 3 months. The microsurgical group showed greater reduction in PPD, higher CAL gain, improved healing and reduced post-operative discomfort compared to the conventional group (p<0.05). Thus, we show superior clinical and patient-centered outcomes with microsurgical techniques, supporting their use in periodontal therapy.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3352-3356"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of pioglitazone in correcting ovulatory functions among polycystic ovary syndrome patients. 吡格列酮纠正多囊卵巢综合征患者排卵功能的疗效观察。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223385
Ulvina Khalid, Anam Rashid, Vidhi Janak Shah, Mehwish Saleem, Sadia Detho, Rabia Khursheed
{"title":"Efficacy of pioglitazone in correcting ovulatory functions among polycystic ovary syndrome patients.","authors":"Ulvina Khalid, Anam Rashid, Vidhi Janak Shah, Mehwish Saleem, Sadia Detho, Rabia Khursheed","doi":"10.6026/973206300223385","DOIUrl":"10.6026/973206300223385","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a major cause of infertility due to chronic anovulation, and current treatments like metformin are not effective for all patients. Evidence on pioglitazone's role in restoring ovulation is limited, particularly among South Asian women where PCOS prevalence is high. This study, conducted in Lahore from January to June 2025, evaluated pioglitazone in 95 PCOS patients. After six months of treatment, 72.6% of patients achieved restored ovulation with improved hormonal profiles. Pioglitazone thus emerges as an effective alternative to metformin, improving menstrual cycles, ovulation, hyperandrogenism, and reducing the risk of type 2 diabetes.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3385-3389"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparative study of ultrasound-guided versus landmark-based femoral with sciatic nerve blocks in lower limb surgeries. 超声引导与地标性坐骨神经阻滞在下肢手术中的比较研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223457
Ajita Tiwari, Irfan Ahmad Siddiqui, Sushil Chand Verma
{"title":"A comparative study of ultrasound-guided versus landmark-based femoral with sciatic nerve blocks in lower limb surgeries.","authors":"Ajita Tiwari, Irfan Ahmad Siddiqui, Sushil Chand Verma","doi":"10.6026/973206300223457","DOIUrl":"10.6026/973206300223457","url":null,"abstract":"<p><p>Peripheral nerve blocks are widely used in lower limb surgeries to provide effective anesthesia and post-operative analgesia. Therefore, it is of interest to compare ultrasound-guided and landmark-based femoral with sciatic nerve block techniques in terms of success rate, onset time, duration of analgesia and complications. A prospective comparative study was conducted on 100 patients undergoing elective lower limb surgeries, divided equally into ultrasound-guided and landmark-based groups. Ultrasound-guided blocks demonstrated significantly faster onset, higher success rates, longer duration of analgesia and fewer complications compared to the landmark-based technique (p < 0.05). Thus, data shows that ultrasound guidance improves the safety, accuracy and overall efficacy of peripheral nerve blocks in clinical practice.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3457-3460"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C - reactive protein to albumin ratio as predictor of severity and outcome in acute pancreatitis. C -反应蛋白与白蛋白比值作为急性胰腺炎严重程度和预后的预测因子。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223521
Umesh Pratap Singh, Manzar Hussain Usmani, Mukund Pandey, Pooja Patel
{"title":"C - reactive protein to albumin ratio as predictor of severity and outcome in acute pancreatitis.","authors":"Umesh Pratap Singh, Manzar Hussain Usmani, Mukund Pandey, Pooja Patel","doi":"10.6026/973206300223521","DOIUrl":"10.6026/973206300223521","url":null,"abstract":"<p><p>Early and accurate prediction of severity in acute pancreatitis remains a major clinical challenge, particularly in resource-limited settings. Hence, this cross-sectional study evaluated 100 patients to assess the prognostic value of the CRP/Albumin ratio (CAR) in comparison with BISAP and other parameters. Disease severity was mild in 40%, moderate in 30% and severe in 30%, with ICU admission in 23% and overall mortality of 5%, increasing with severity. Non-survivors had significantly higher age (62.6 ± 7.09 vs 40.41 ± 13.66 years), urea (78.72 ± 66.08 vs 24.09 ± 13.99 mg/dL), creatinine (2.69 ± 1.68 vs 0.84 ± 0.43 mg/dL), CRP (182.61 ± 141.55 vs 75.98 ± 82.76 mg/L), CAR (107.18 ± 106.30 vs 28.09 ± 38.10) and BISAP scores (4.6 ± 0.55 vs 0.85 ± 0.99), along with lower albumin levels (2.11 ± 0.87 vs 3.20 ± 0.98 g/dL). Thus, BISAP showed the highest predictive accuracy (AUC = 1.000), followed by creatinine (0.985), age (0.952) and CAR (0.930).</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3521-3526"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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