Bioinformation最新文献

{"title":"Stability analysis of elastomeric impression materials after antimicrobial disinfection.","authors":"Santosh T, Pushkar Gupta, Omar Basheer Altaher Mohammed, Aditi M Paranjpe, Harsh Chansoria, Abhishek Pathak, Dayanand Huddar, Sanchari Bhowmick","doi":"10.6026/9732063002001070","DOIUrl":"10.6026/9732063002001070","url":null,"abstract":"<p><p>Impression materials used for replication of dental structures frequently come into touch with blood and saliva during the impression operation. Hence, disinfection of impression mistrials is needed. Therefore, it is of interest to evaluate the effects of three different disinfectants on the antibacterial activity and dimensional stability of the elastomeric impression material. According to American Dental Association (ADA) specification number 19 compliant, a stainless steel master die was constructed. Using vinyl polysiloxanes (VPS) impression medium, thirty samples were produced on this die in accordance with the manufacturer's instructions. To finish the disinfection process, thirty samples were randomly assigned to each of the three groups: Group I consisted of diluted water (control group), Group II consisted of 5.25 percent sodium hypochlorite (NaOCl), and Group III consisted of ozone gas and Group IV - UV radiation. The dimensional stability was evaluated using a stereomicroscope with a 20x magnification and image research software. The antibacterial efficacy of each disinfectant was assessed. In the VPS impression material, the control group exhibited the greatest number of dimensional changes, with ozone gas and 5.25% NaOCl showing the least amount of dimensional changes. The groups were found to differ statistically significantly from one another. The results of the investigation indicate that the VPS elastomeric impression showed very minor dimensional changes when submerged in different disinfectants. In a clinical setting, samples cleaned with 5.25% hypochlorite can be kept for a long time because the consequent dimensional changes are minimal. Ozone gas, UV radiation and sodium hypochlorite showed a reduction in the amount of bacteria.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1070-1074"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vivo</i> evaluation of apical third enlargements to twice and thrice larger than initial apical binding file in final treatment outcome.","authors":"Kranti Rajesh Khadse, Rana K Varghese, Malwika Sisodia, Naveen Kumar Gupta, Priyanka Damodhar Ippar, Anushri Arvind Uge","doi":"10.6026/9732063002001116","DOIUrl":"10.6026/9732063002001116","url":null,"abstract":"<p><p>Root canal treatment is a critical procedure in endodontics, aimed at eliminating microorganisms and pathological debris from the root canal system to prevent reinfection and ensure the health of the periradicular tissues. A total of 180 patients with asymptomatic apical periodontitis (PAI score >3) were included in this randomized clinical trial. Patients were divided into two main groups, each with three subgroups based on the biomechanical preparation of the canals using different file sizes and tapers. Biomechanical preparation was followed by intracanal medicament placement, and patients were recalled for obturation and final restoration. Postoperative pain was assessed using the Visual Analog Scale (VAS) at 6, 12, 24, 48 and 72 hours post-treatment. Periapical healing was evaluated using the Periapical Index (PAI) at 3,6 and 12 months post-treatment. While larger apical preparation sizes and tapers can enhance periapical healing, excessive enlargement beyond three sizes larger than the IABF does not significantly improve outcomes. Optimal root canal treatment should balance adequate cleaning and disinfection with the preservation of tooth structure.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1116-1119"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride enigma in end stage renal disease.","authors":"Paramaturi Sharon Rose, Kurpad Nagaraj Shashidhar, Uppalamethi Munilakshmi, Muthyala Meghanath","doi":"10.6026/973206300200998","DOIUrl":"10.6026/973206300200998","url":null,"abstract":"<p><p>Fluoride is an essential micro-mineral. Chronic exposure to fluoride affects collagen biosynthesis, insulin resistance, diabetes mellitus and kidney damage. Present prospective study, include 142 subjects categorised into group I and II. Serum samples was separated and stored appropriately. Statistical significant values were observed in urea, creatinine, calcium, magnesium, fluoride and IL6 in DN. Serum fluoride, total proteins, and calcium showed a positive correlation in group I versus group II. Fluoride is one of the key adjunct and surrogate molecule in causation of micro-vascular complications of diabetes.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"998-1001"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>Cocos nucifera oil</i> on tensile strength of two different tissue conditioners at different time intervals.","authors":"Pushkar Gupta, Abhishek Pathak, Sneha S Mantri, Harsh Chansoria, Shivakshi Chansoria, Swati Solanki","doi":"10.6026/9732063002001191","DOIUrl":"10.6026/9732063002001191","url":null,"abstract":"<p><p>Tissue conditioners are a short-term soft liner that is frequently used in dentistry to improve the condition of abused denture-bearing tissues, particularly in patients with denture stomatitis. Topical application of antifungal agent has multiple disadvantages which can be negated by incorporation of an herbal agent like <i>Cocos nucifera oil</i> into the tissue conditioner, which can enhance its mechanical properties like tensile strength, while aiding in reduction of <i>C.albicans</i> count in the oral cavity. Therefore, it is of interest to evaluate the tensile strength of Visco-gel and GC soft liner with and without 10% w/w <i>Cocos nucifera oil</i> on different time intervals. 32 dumb-belled shaped samples of each Visco-gel and GC soft liner were divided into two groups of 16 each (with and without 10% w/w Cocos nucifera oil). All the samples were stored in sterile glass jars with distilled water at 37°C. 4 samples from each group were tested for tensile strength on day 1, day 3, day 7 and day 14. Tensile strength test was performed on a Universal testing machine with computer control, data acquisition, and data analysis software. Incorporation of 10% w/w <i>Cocos nucifera oil</i> statistically increases the tensile strength of Visco-gel and GC soft liner, from day 1 to day 14, after immersion in distilled water.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1191-1195"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking and dynamics analysis of flavonoids from Retama monosperma with drug-resistant GIST mutations.","authors":"Kaoutar El Khattabi, Jihane Akachar, Sanaa Lemriss, Rachid El Jaoudi, Fouad Zouaidia","doi":"10.6026/973206300200966","DOIUrl":"10.6026/973206300200966","url":null,"abstract":"<p><p>Gastrointestinal stromal tumors (GISTs), the most prevalent mesenchymal tumors of the gastrointestinal tract, are predominantly driven by activating mutations in receptor tyrosine kinases such as c-Kit and PDGFRα. Resistance to tyrosine kinase inhibitors (TKIs) poses a substantial therapeutic challenge, underscoring the need for novel treatments. Consequently, investigating the potential of natural compounds, specifically flavonoids from Retama monosperma, known for their diverse bioactivities, is of significant interest. Molecular docking and simulations revealed that Luteolin exhibited high binding affinities for PDGFRα (-8.1 kcal/mol) and c-KIT (-9.6 kcal/mol), comparable to Avapritinib and Sunitinib. The compound demonstrated favorable ADMET properties and formed notable hydrogen bonds and hydrophobic interactions with key residues in both targets. Molecular dynamic simulation over 100 ns revealed stable complexes with consistent RMSD and RMSF values. Additionally, Luteolin showed strong binding affinities to the resistant mutations c-Kit (D816H) and PDGFRα (T674I), with enhanced stability. These findings suggest that Luteolin has significant potential as a dual inhibitor and offers a promising alternative to conventional TKIs for addressing GIST resistance.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"966-973"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-heating effect on micro-hardness and depth of cure for three bulk-fill composite resins: An <i>in vitro</i> study.","authors":"Alakesh Singha, Archan Dhanesha, Sruthi Nair, Ruchi Patel, Subasish Behera, Soumyaranjan Nanda","doi":"10.6026/9732063002001128","DOIUrl":"10.6026/9732063002001128","url":null,"abstract":"<p><p>This study aimed to evaluate the effect of preheating on the micro-hardness and depth of cure of three different bulk-fill composite resins: Filtek Bulk Fill (3M ESPE), Tetric EvoCeram Bulk Fill (Ivoclar Vivadent), and SDR (Dentsply Sirona). Three bulk-fill composite resins, Filtek Bulk Fill (3M ESPE), Tetric EvoCeram Bulk Fill (Ivoclar Vivadent), and SDR (Dentsply Sirona), were tested in this <i>in vitro</i> study. Each resin was divided into two groups: preheated and non-preheated. The preheating process was performed using a composite warmer at 68°C for 5 minutes. Micro-hardness was measured using a Vickers hardness tester, and the depth of cure was evaluated by measuring the hardness ratio at different depths (0.5 mm, 1 mm, and 2 mm). Pre-heating significantly increased the micro-hardness of all three bulk-fill composite resins (p < 0.05). For Filtek Bulk Fill, the micro-hardness value increased from 60 to 70 HV, for Tetric EvoCeram Bulk Fill from 55 to 65 HV, and for SDR from 58 to 68 HV. The depth of cure was also enhanced in the preheated groups. The hardness ratio at 2 mm depth was 0.85 for Filtek Bulk Fill, 0.80 for Tetric EvoCeram Bulk Fill, and 0.83 for SDR in the preheated groups, compared to 0.75, 0.70 and 0.72 in the non-preheated groups, respectively. Pre-heating bulk-fill composite resins improves their micro-hardness and depth of cure. This suggests that preheating could be beneficial in clinical settings to enhance the physical properties of composite restorations.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1128-1131"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health care concerns among autism patients: A review.","authors":"Sibani Sarangi, Rajeev Ranjan Raj, Anurag Rawat, Sajjad Salam, Shubham Tripathi, Dipanshu Aggarwal, Ritik Kashwani","doi":"10.6026/9732063002001017","DOIUrl":"10.6026/9732063002001017","url":null,"abstract":"<p><p>Autism is a developmental disorder mostly affecting neural and developmental skills with problems in learning, communication and repetitive behaviour. It has become more highlighted over the past few decades because of the increasing awareness, survey tools and research worldwide. Existing worldwide, this disorder affects the normal lifestyle of the affected people since childhood and continues with the same pace through lifetime. Due to poor neuromuscular coordination, it also affects the normal orofacial dynamics of an individual and manifests as multiple oral disorders. Therefore it's of interest to report known data on the oral manifestations of this spectral disorder and various approaches at varied levels to maintain a harmonious oral environment.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1017-1021"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Up-cycling the dental waste materials: Going green in dentistry.","authors":"Kranti Rajesh Khadse, Swati Priya, Rana K Varghese, Malwika Sisodia, Naveen Kumar Gupta, Anita Chandrakar","doi":"10.6026/9732063002001124","DOIUrl":"10.6026/9732063002001124","url":null,"abstract":"<p><p>The depletion of natural resources due to the extensive use of various materials in dentistry is a growing concern. A significant contributor to this issue is the lack of recycling practices, leading to the continuous exploitation of these resources. This research aims to explore simple yet effective scientific techniques to up-cycle common dental materials while maintaining their properties. The focus of modern practices should align with the 3R's-Reduce, Reuse, and Recycle. In dental institutions and clinics, materials like dental plaster and dental stone, extensively used for pouring impressions, are completely discarded as waste. This study involves collecting these waste products and evaluating their properties for potential reuse. Additionally, endodontic materials such as stainless steel hand files and rotary Ni-Ti files, typically discarded, can be recycled in metallurgical departments and repurposed into custom-made cast posts and titanium posts, respectively. The wisdom tooth crush technique is explored for its application as autologous graft material in filling bone defects. Discarded alginate impressions, widely used in Prosthodontics, are heated and repurposed as a denture polishing agent and as a fertilizer in agriculture. Excess glass ionomer cement, a common restorative material, can be repurposed into polishing cones and powders, or used as a polishing agent with rubber cups and buffs. Modeling wax, predominantly used in occlusal rim fabrication, can be collected and purified, with 90% of it recoverable without compromising its properties. Finally, discarded dental burs can be repurposed to splint implant impression copings, aiding in the accurate transfer of orientation, a critical step in implant prosthodontics. This study advocates for the adoption of recycling practices in dental colleges and among practitioners to manage and reuse the waste generated in the field. By doing so, the treatment cost can be reduced by 30-40%, and natural resources can be conserved, contributing to the preservation of the Earth's resources.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1124-1127"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender determination from ridges using dermatoglyphics techniques.","authors":"Manasi Patra, Niva Mahapatra, Shyam Sundar Behura, Lipsa Bhuyan, Girish Ms, Samir Pv, Pratik Surana","doi":"10.6026/9732063002001008","DOIUrl":"10.6026/9732063002001008","url":null,"abstract":"<p><p>Fingerprint analysis for gender determination in Ganjam District, Southern Odisha is of interest in forensic science. Dermatoglyphics, the study of fingerprint patterns, leverages their genetic uniqueness and stability to identify individuals in forensic and disaster scenarios. Left thumb prints were collected and analyzed under magnification, followed by statistical evaluation. Results showed significant differences in fingerprint patterns between genders, confirming the method's accuracy. Thus, fingerprint pattern analysis is a valuable tool for gender identification in forensic medicine, criminal investigations, and during mass disasters.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1008-1011"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation N-Telopeptide (NTx) and calprotectin level in crevicular fluid with peri-implantitis.","authors":"Ashwini Narayankar, Sagar Kumar Kashyap, Suman Yadav, Anas Abdul Khader, Anjaneya Dube, Pushkar Gupta, Nureldeen An Elhammali, Abhaya Chandra Das","doi":"10.6026/9732063002001183","DOIUrl":"10.6026/9732063002001183","url":null,"abstract":"<p><p>Following inflammation and bone loss near the implant site, peri-implantitis develops. N-Telopeptide (NTx) and Calprotectin are abundant in the crevicular fluids found in that area and are thought to be possible biomarkers. Therefore, it is of interest to evaluate the amounts of calprotectin and NTx in the peri-implant sulcular fluid (PISF) from implant sites with or without peri-implantitis. Twenty healthy individuals and twenty patients with peri-implantitis who had a single dental implant were included in the total of forty participants. For every patient, the peri-implant clinical parameters of gingival index (GI), probing depth (PD) and bleeding on probing (BOP) were ted. To evaluate the bone loss (BL), radiographic pictures of every implant were acquired. Using sterile paper strips, PISF was gathered in order to use the ELISA technique to measure the amounts of NTx and calprotectin. We examined the correlations between the levels of PISF, NTx and calprotectin with the peri-implant clinical indicators. In comparison to the healthy group, the peri-implantitis group had increased levels of NTx and calprotectin. In individuals with peri-implantitis, the levels of NTx and calprotectin in the PISF may be a promising indicator for bone loss and peri-implant inflammation.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1183-1186"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}