BioinformationPub Date : 2025-06-30eCollection Date: 2025-01-01DOI: 10.6026/973206300211593
Vutukuri Kiranmai, Amoolya Rao Amaravadhi, Vaishnavi Jamched, Kosmita Karki, Navneeth Jayaprakash, Angel Pratapsingh Chavan, James Joseph Rajan
{"title":"Impact of sleep apnea severity on left ventricular remodelling.","authors":"Vutukuri Kiranmai, Amoolya Rao Amaravadhi, Vaishnavi Jamched, Kosmita Karki, Navneeth Jayaprakash, Angel Pratapsingh Chavan, James Joseph Rajan","doi":"10.6026/973206300211593","DOIUrl":"10.6026/973206300211593","url":null,"abstract":"<p><p>Sleep apnea is a common but often overlooked condition strongly associated with cardiovascular dysfunction, particularly left ventricular (LV) remodeling. This longitudinal study assessed changes in LV structure and function over time across sleep apnea severity groups defined by the apnea-hypopnea index (AHI). Serial echocardiographic evaluations revealed that moderate-to-severe sleep apnea was significantly correlated with increased LV mass index, systolic and diastolic dysfunction. Greater AHI severity and lack of treatment were linked to more progressive LV impairment. These results emphasize the need for early diagnosis and management of sleep apnea to reduce its long-term cardiac impact.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1593-1596"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In vitro analysis of the sealing ability of different root canal sealers under thermo-mechanical stress.","authors":"Antriksh Azad, Vaishali Mashalkar, Ruchi Agrawal, Yihan Fu, Dipak Chaudhari, Abhishek Haldia, Miral Mehta","doi":"10.6026/973206300211518","DOIUrl":"10.6026/973206300211518","url":null,"abstract":"<p><p>The ability to create a proper seal by testing three root canal sealers under conditions that replicated thermal and mechanical stresses is of interest. A total of sixty human single-rooted teeth received epoxy resin-based and calcium silicate-based and bioceramic-based sealers before thermocycling and mechanical loading procedures. Microleakage examinations demonstrated that bioceramic sealer allowed the least dye penetration at 0.45 ± 0.12 mm while calcium silicate sealer permitted 0.71 ± 0.18 mm penetration and epoxy resin sealer ended with 1.02 ± 0.21 mm penetration. The statistical analysis using a One-way ANOVA method established significant differences at a p value less than 0.05. The use of bioceramic sealers leads to high-quality apical barriers which enhances continued endodontic treatment success.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1518-1521"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of salivary biomarker interleukin-6 in oral squamous cell carcinoma and its clinical correlation.","authors":"Dipak Chaudhari, Shilpa Motghare, Vikas Pandey, Gunmeek Kaur, Sameer Gupta, Saptadisha Rakshit, Miral Mehta, Bhumika J Patel","doi":"10.6026/973206300211497","DOIUrl":"10.6026/973206300211497","url":null,"abstract":"<p><p>Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy with high morbidity. Hence, this cross-sectional study evaluated salivary interleukin-6 (IL-6) levels in 30 OSCC patients versus 30 healthy controls. IL-6 levels were significantly higher in OSCC patients and increased progressively with advancing clinical stages. A strong positive correlation was found between IL-6 levels and disease stage (r = 0.82, p < 0.001). Salivary IL-6 shows promise as a non-invasive biomarker for OSCC detection and progression monitoring.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1497-1500"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral health awareness: Periodontitis among diabetic patients in Chhattisgarh, India.","authors":"Shashank Agrawal, Vineeta Gupta, Manisha Kumari, Deepesh Kumar Gupta, Komal Sihani, Neha Sahu","doi":"10.6026/973206300211304","DOIUrl":"10.6026/973206300211304","url":null,"abstract":"<p><p>Awareness on diabetes-periodontitis association among 300 patients (150 diabetic, 150 non-diabetic) attending a tertiary care center in Chhattisgarh is of interest. Only 36% of diabetic participants recognized this link, while 76% of all respondents were unaware of the systemic impact of poor oral hygiene. A mere 24.7% of diabetic individuals had ever been referred to a dentist by a physician. Oral hygiene practices and perceived risk awareness were notably low among both groups. These findings underscore the need for inter-disciplinary efforts and targeted awareness programs to address oral-systemic health gaps.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1304-1309"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Awareness and attitudes towards dental implants among dental patients in India: A questionnaire-based survey.","authors":"Monal Karkar, Rik Chatterjee, Shashidevi Haranal, Jasleen Kaur, Nitesh Naresh, Nimish Nimeya, Ritik Kashwani","doi":"10.6026/973206300211351","DOIUrl":"10.6026/973206300211351","url":null,"abstract":"<p><p>Dental patients' awareness and impressions on dental implants is of interest using a standard questionnaire. Out of the three hundred individuals, 48% correctly identified dental implants as a fixed prosthesis replacing a tooth root and 72% had heard of them. Despite obstacles, including significant cost, anxiety and ignorance, still exist, most respondents had positive impressions; 66% of them highly rated dental implants. Strongly correlated were higher degrees of education and growing acceptance of dental implants, as well as awareness. These results highlight the need for improved patient education and focused communication techniques to raise acceptability and informed decision-making about dental implant treatments.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1351-1356"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health belief model based predictors and perceptions of COVID-19 vaccination amongst frontline health workers.","authors":"Jitendra Majhi, Paramita Sengupta, Preetika Banerjee, Aloke Biswas, Kayur Mehta, Anita Shet, Ninad Vilas Nagrale","doi":"10.6026/973206300211404","DOIUrl":"10.6026/973206300211404","url":null,"abstract":"<p><p>COVID-19 pandemic presented with a scenario wherein the healthcare delivery system was overwhelmed by unprecedented COVID morbidities. Vaccines were made available in a short span of time during the pandemic for the public that required the frontline workers especially the ASHAs to overcome their own hesitancies of the newer vaccine before convincing the community for vaccination. A cross-sectional survey on the perceptions of COVID vaccination was conducted wherein 74 ASHAs participated in the interview involving Likert scale responses on vaccine acceptance which were modelled on Health Belief Model (HBM) to find predictors of vaccine acceptance by performing ordinal regression analysis. It was seen that the domains of 'Benefit', 'Barrier' and 'Modifying Variable' appeared to increase the acceptance of the vaccine whereas the domains of 'Susceptibility' and 'Severity' had decreasing effect on acceptance, of which only 'Severity' domain significantly had a negative effect on COVID vaccine acceptance amongst the frontline workers. HBM is a useful tool which can provide information about the facilitating and negating factors of newer vaccines introduction which can be utilized by public health researchers to better understand the perceptions and accordingly vaccine introduction approaches can be modified.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1404-1415"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2025-06-30eCollection Date: 2025-01-01DOI: 10.6026/973206300211429
Vikram Jhamb, Ameer Akhil Ahmed Shaik, Priyanka Vinay Agrawal, Shamolie Shailesh Deshmukh, Indu Kumari, Harish Kumar, Hasina Khan, Pratik Surana
{"title":"Instrumentation timing for manual K file and different pedatric rotary files systems in deciduous mandibular molars.","authors":"Vikram Jhamb, Ameer Akhil Ahmed Shaik, Priyanka Vinay Agrawal, Shamolie Shailesh Deshmukh, Indu Kumari, Harish Kumar, Hasina Khan, Pratik Surana","doi":"10.6026/973206300211429","DOIUrl":"10.6026/973206300211429","url":null,"abstract":"<p><p>Pulpectomy has been the standard treatment for necrotic primary teeth. However, hand files often results in longer chairside times. Pediatric rotary files made especially for primary teeth have been made possible by technological advancements, improving the effectiveness of pulpectomy. Therefore, it is of interest to compare instrumentation timing between Hand K files and pediatric rotary files (Prime Pedo<sup>TM</sup> and Pro AF Baby Gold) in deciduous lower molars. Thirty deciduous molars in all were separated into three groups: Group I utilized Hand K-files, Group II employed Prime Pedo<sup>TM</sup> and Group III utilized Pro AF Baby Gold. Examination revealed that the rotary and manual methods for treating deciduous teeth differed significantly in instrumentation time.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1429-1432"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2025-06-30eCollection Date: 2025-01-01DOI: 10.6026/973206300211651
Thasnim Jawhar Kallayil, Francis P G, Joseph Sebastian, Biju Kalarickal, Arun Bosco Jerald, Terry Thomas Edathotty
{"title":"Effect of various chemical disinfectants on the mechanical properties of elastomeric chains.","authors":"Thasnim Jawhar Kallayil, Francis P G, Joseph Sebastian, Biju Kalarickal, Arun Bosco Jerald, Terry Thomas Edathotty","doi":"10.6026/973206300211651","DOIUrl":"10.6026/973206300211651","url":null,"abstract":"<p><p>Different cleaning procedures affected the mechanical characteristics of elastomeric chains. Hence, 255 samples, divided into 17 groups of 15 samples each, were tested for bacterial contamination and tensile strength using five disinfection procedures. Colonies on culture plates indicated contamination, while the universal testing machine determined ultimate tensile strength. The samples disinfected with 70% isopropyl alcohol (IPA) remained contaminated, as shown by colony growth, even though there was a statistically significant reduction in colonies compared to the controls. All samples examined after 1 and 10 cycles in the disinfectants had higher ultimate tensile strengths than controls.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1651-1657"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2025-06-30eCollection Date: 2025-01-01DOI: 10.6026/973206300211310
Sai Krishna Athota, K Varun Reddy, Harikrishna Modalavalasa, Bhargavi Katta, Ravi Shankar Yalavarthy, Prachi Krishna Kant Pandey
{"title":"Patient perspectives on tooth replacement: A cross-sectional survey.","authors":"Sai Krishna Athota, K Varun Reddy, Harikrishna Modalavalasa, Bhargavi Katta, Ravi Shankar Yalavarthy, Prachi Krishna Kant Pandey","doi":"10.6026/973206300211310","DOIUrl":"10.6026/973206300211310","url":null,"abstract":"<p><p>Awareness, attitudes, knowledge and preferences regarding tooth replacement among 200 adults aged 30-70 years using a validated 26-item questionnaire is of interest. Results showed that 66% of participants had a positive attitude towards treatment and 5% of participants showed negative awareness, while 38% demonstrated good awareness and 29% had poor understanding of available options. Socio-demographic factors are including age, education, affordability, influenced decisions and expectations. The findings highlight the need for targeted awareness programs to improve knowledge and encourage early adoption of dental prosthetic care in adult population.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1310-1316"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction of cardiovascular disease risk using biomarkers in blood.","authors":"Sruthi Vempatapu, Daleena Prathiba Madda, Akhil N, Kongara Sree Nischal Chowdary","doi":"10.6026/973206300211547","DOIUrl":"10.6026/973206300211547","url":null,"abstract":"<p><p>Prediction of cardiovascular disease risk using biomarkers in blood is of interest. Hence, evaluation of blood biomarkers as predictors of cardiovascular disease (CVD) among 300 participants is completed. C-reactive protein (CRP), Troponin I, LDL, HDL, and IL-6 levels were measured, showing significant differences between CVD and non-CVD groups. CRP and Troponin I demonstrated the highest predictive accuracy with AUCs of 0.89 and 0.85. A combined model using CRP, Troponin I, and LDL showed 88% sensitivity and 84% specificity. These biomarkers may aid early CVD detection and risk stratification in clinical practice.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1547-1550"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}