{"title":"Evaluation of salivary biomarker interleukin-6 in oral squamous cell carcinoma and its clinical correlation.","authors":"Dipak Chaudhari, Shilpa Motghare, Vikas Pandey, Gunmeek Kaur, Sameer Gupta, Saptadisha Rakshit, Miral Mehta, Bhumika J Patel","doi":"10.6026/973206300211497","DOIUrl":null,"url":null,"abstract":"<p><p>Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy with high morbidity. Hence, this cross-sectional study evaluated salivary interleukin-6 (IL-6) levels in 30 OSCC patients versus 30 healthy controls. IL-6 levels were significantly higher in OSCC patients and increased progressively with advancing clinical stages. A strong positive correlation was found between IL-6 levels and disease stage (r = 0.82, p < 0.001). Salivary IL-6 shows promise as a non-invasive biomarker for OSCC detection and progression monitoring.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1497-1500"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449527/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/973206300211497","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy with high morbidity. Hence, this cross-sectional study evaluated salivary interleukin-6 (IL-6) levels in 30 OSCC patients versus 30 healthy controls. IL-6 levels were significantly higher in OSCC patients and increased progressively with advancing clinical stages. A strong positive correlation was found between IL-6 levels and disease stage (r = 0.82, p < 0.001). Salivary IL-6 shows promise as a non-invasive biomarker for OSCC detection and progression monitoring.
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