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Protein disorder - function paradigm: Putative role in inflammation. 蛋白质紊乱-功能模式：在炎症中的假定作用。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210169
Francesco Chiappelli
{"title":"Protein disorder - function paradigm: Putative role in inflammation.","authors":"Francesco Chiappelli","doi":"10.6026/973206300210169","DOIUrl":"https://doi.org/10.6026/973206300210169","url":null,"abstract":"<p><p>Traditional protein biochemistry defends the intimate interdependence between protein function and structure, the latter being consisting of four distinct levels: premary sstructure: <i>viz,</i> the sequence of its constituent amino acids linked by peptides bonds - the polypeptide chain; ssecondary structure: <i>viz,</i> localized folding patterns (<i>e.g.</i>, a α-helix, β-sheets) of the polypeptide chain held by hydrogen bonds between amino acid backbones; tertiary structure: <i>viz,</i> three-dimensional folding of the protein held by interactions between amino acid side chains mediated by disulfide bridges, hydrogen bonds, ionic bonds and hydrophobic interactions; and quaternary structure: <i>viz,</i> attachment of subunits, when appropriate, by means of similar chemical interactions to form a functional protein complex. Research evidence in the last decade has described intrinsically disordered proteins (IDPs) as polypeptides that lack a well-defined three/four-dimensional structure under physiological conditions, appear structurally unstable and manifest in a dynamic set of possible conformations. IDPs are a major component of the \"dark\" proteome, genome protein products not yet characterized through experimental structure determination and existing homology modeling. Dark proteome in general and IDPs specifically define and characterize the novel disorder - function paradigm, which critically mediate and modulate key cellular organelles and pathways and influence physiopathological processes from aging to chronic diseases and pathogen infection. The role of the disorder-function paradigm in the immunome and the inflammasome in general and specifically in the process of chronic metabolic inflammation observed in aging - <i>i.e.</i>, inflammAging - could be elucidated through diverse AI platforms.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"169-172"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pilates exercises for managing premenstrual syndrome among adolescent girls. 普拉提运动对青春期女孩经期前综合症的管理。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210127
Vaghela Payalben Tejmalji, Mahalakshmi B, Siva Subramanian N
{"title":"Pilates exercises for managing premenstrual syndrome among adolescent girls.","authors":"Vaghela Payalben Tejmalji, Mahalakshmi B, Siva Subramanian N","doi":"10.6026/973206300210127","DOIUrl":"https://doi.org/10.6026/973206300210127","url":null,"abstract":"<p><p>Premenstrual Syndrome (PMS) is a common condition among adolescent girls, characterized by physical, emotional and behavioural symptoms that significantly impact their quality of life. Therefore, it is of interest to evaluate the impact of pilates exercises on alleviating PMS symptoms among adolescent girls, providing evidence for its use as a holistic intervention. A quasi-experimental pretest-posttest design was employed; involving 231 adolescent girls aged 13-17 years from selected schools in North Gujarat. Participants underwent a six-week pilates exercise program, conducted five times weekly. Data were collected using a demographic questionnaire and the Modified PMS Scale to assess pre- and post-intervention symptoms the intervention led to a significant reduction in PMS severity, with mild PMS cases increasing from 50 to 164 and severe cases decreasing from 22 to 10 post-intervention. Paired t-tests revealed a highly significant mean difference in PMS scores (T = 13.122, p < 0.001).</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"127-131"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactate dehydrogenase (LDH) as an indicator of pre-eclampsia. 乳酸脱氢酶（LDH）作为先兆子痫的指标。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210116
Kapil Raghuwanshi, Bhupesh Kushram, Dileep Dandotiya, Sudhakar Petkar, Swapnali Tambade, Mahendra Gandhe
{"title":"Lactate dehydrogenase (LDH) as an indicator of pre-eclampsia.","authors":"Kapil Raghuwanshi, Bhupesh Kushram, Dileep Dandotiya, Sudhakar Petkar, Swapnali Tambade, Mahendra Gandhe","doi":"10.6026/973206300210116","DOIUrl":"https://doi.org/10.6026/973206300210116","url":null,"abstract":"<p><p>High blood pressure (higher than 140/90 mm Hg), proteinuria and swelling due to fluid retention are symptoms of preeclampsia, a disease that affects pregnant women after the 20th week of pregnancy. The cytoplasm of cells undergoing anaerobic glycolysis contains the enzyme lactate dehydrogenase or LDH. Therefore, it is of interest to ascertain the blood lactate dehydrogenase levels of pre-eclamptic women, to assess and analyze these levels, to compare lactate dehydrogenase levels in different groups of preeclampsia patients and healthy controls and to examine the role of lactate dehydrogenase in preeclampsia severity ratings. Increased blood lactate dehydrogenase levels are associated with more severe preeclampsia, according to this study's results. Thus, it is crucial to determine lactate dehydrogenase levels in pre-eclamptic women early on so that these patients may get the right medicine and reduce the morbidity and mortality associated with these disorders.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"116-120"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial effect of various herbal root canal irrigants. 各种草药根管冲洗液的抗菌效果。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210165
Vathsala N, Saikiran Bahadur, Aseem Sharma, Nisha Gupta, Ahmed Ali Ahmed Almuntashiri, Reshma Rajan, Arpita Mohapatra, Awadhesh Gupta
{"title":"Antibacterial effect of various herbal root canal irrigants.","authors":"Vathsala N, Saikiran Bahadur, Aseem Sharma, Nisha Gupta, Ahmed Ali Ahmed Almuntashiri, Reshma Rajan, Arpita Mohapatra, Awadhesh Gupta","doi":"10.6026/973206300210165","DOIUrl":"https://doi.org/10.6026/973206300210165","url":null,"abstract":"<p><p>Root canal irrigation is crucial in endodontics. Therefore, it is of interest to evaluate the antibacterial efficacy of various herbal root canal irrigants (Triphala, Neem (<i>Azadiracta indica</i>, green tea and <i>Curcuma longa</i> (Turmeric)) against <i>Enterococcus faecalis</i>. Antimicrobial efficacy of the herbal irrigants and sodium hypochlorite was done using a brain-heart infusion method. The tested herbal irrigants had antibacterial efficacy against <i>E faecalis</i>. Hence, these herbal irrigants are alternative to sodium hypochlorite.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"165-168"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of microRNAs in chronic hepatitis E viral infection. microrna在慢性戊型肝炎病毒感染中的作用。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210240
Zoya Shafat, Murshad Ahmed, Anam Farooqui, Nazim Khan, Shama Parveen
{"title":"Role of microRNAs in chronic hepatitis E viral infection.","authors":"Zoya Shafat, Murshad Ahmed, Anam Farooqui, Nazim Khan, Shama Parveen","doi":"10.6026/973206300210240","DOIUrl":"https://doi.org/10.6026/973206300210240","url":null,"abstract":"<p><p>Hepatitis E virus (HEV) is an emerging zoonotic pathogen and it is associated with chronic hepatitis E virus infection (CHE) in immuno-suppressed patients due to failure of viral clearance. A network of the CHE-associated-differentially expressed genes (DEGs) is known. Hence, a comprehensive assessment of the known protein-protein interaction (PPI) network is of interest. After network clustering, the hub gene-associated microRNAs (miRNAs) were explored and subsequently, these identified miRNAs (miR-129-2-3p, miR-130a-3p, miR-138-5p, miR-212-3p, miR-221-3p, miR-27b-3p and miR-29c-3p) were undertaken for enrichment analysis. It should be noted that these miRNAs are significantly associated with Hepatitis E virus infection for further validation and analysis.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"240-252"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of various interventions for smoked tobacco cessation among Indians in Chhattisgarh. 各种干预措施对恰蒂斯加尔邦印度人戒烟的影响。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210225
Milind Wasnik, Bhavna Dave, Virendra Vadher
{"title":"Effect of various interventions for smoked tobacco cessation among Indians in Chhattisgarh.","authors":"Milind Wasnik, Bhavna Dave, Virendra Vadher","doi":"10.6026/973206300210225","DOIUrl":"https://doi.org/10.6026/973206300210225","url":null,"abstract":"<p><p>A prospective, single-blind, randomized controlled trial was conducted among 150 adult tobacco users attending the Tobacco Cessation Centre, Government Dental College, Raipur and Chhattisgarh, India. Participants were randomized into three groups: Group I (NRT alone), Group II (NRT + counseling) and Group III (NRT + mCessation). Interventions lasted 12 weeks, with follow-ups at 1 and 3 months. The overall quit rate was 34%. Group II demonstrated the highest success rate (44%), followed by Group III (30%) and Group I (28%). Significant reductions in nicotine dependence, CO levels and cigarette consumption were observed in all groups, with Group II showing the most marked improvements. Behavioral counseling combined with pharmacotherapy is the most effective strategy for smoking cessation.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"225-230"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unmasking yamaguchi syndrome: A rare case of apical hypertrophic cardiomyopathy in a young African - American male. 揭露山口综合征：一例罕见的顶端肥厚性心肌病在一个年轻的非洲裔美国男性。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210257
Sharanya Rajgopa, Yashkumar Chauhan, Keerthi Talluri, Safa Kaleem, Salman Sajid, Tejashwini Reddy, Ankur Shah
{"title":"Unmasking yamaguchi syndrome: A rare case of apical hypertrophic cardiomyopathy in a young African - American male.","authors":"Sharanya Rajgopa, Yashkumar Chauhan, Keerthi Talluri, Safa Kaleem, Salman Sajid, Tejashwini Reddy, Ankur Shah","doi":"10.6026/973206300210257","DOIUrl":"https://doi.org/10.6026/973206300210257","url":null,"abstract":"<p><p>Yamaguchi syndrome, also known as apical hypertrophic cardiomyopathy (AHCM), is a genetic disorder predominantly affecting the apex of the left ventricle and often presenting similarly to acute coronary syndrome, making precise imaging crucial for diagnosis. This condition, first identified in Japanese populations, is more common in Asian communities but varies in frequency across different populations. We are presenting the case of a 30-year-old African-American male patient with a history of hyper-lipidemia, asthma and obesity, who reported palpitations, dizziness and chest pain radiating to the left arm and jaw, particularly under stress. Echocardiography and cardiovascular magnetic resonance (CMR) revealed severe left ventricular hypertrophy, mild valvular regurgitation and marked apical obliteration, confirming the diagnosis of apical hypertrophic cardiomyopathy. This case highlights the need to consider apical hypertrophic cardiomyopathy in the differential diagnosis of patients with hypertrophic features, especially when conventional imaging findings are unclear.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"257-261"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress distribution during orthodontic maxillary canine retraction using 3D finite element analysis. 正畸上颌犬齿收拔过程中应力分布的三维有限元分析。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210220
Parul Singh, Chinki Bansal, Gunjan Kaushik, Utkarsh Shrivas, Kuldip Singh, Ramesh Kumar
{"title":"Stress distribution during orthodontic maxillary canine retraction using 3D finite element analysis.","authors":"Parul Singh, Chinki Bansal, Gunjan Kaushik, Utkarsh Shrivas, Kuldip Singh, Ramesh Kumar","doi":"10.6026/973206300210220","DOIUrl":"https://doi.org/10.6026/973206300210220","url":null,"abstract":"<p><p>The stress distribution in the periodontium during maxillary canine retraction between the forces applied at canine orthodontic bracket and at power arm using 3D finite element analysis (FEA). 3D FEA for power arm, archwire, orthodontic bracket and periodontium was built independently using the ANSYS software. Maximum stress areas in periodontium was after 150 gm force application at power arm soldered to canine bracket at 13 mm and minimum stress area in periodontium was with force application at canine bracket hook. Maximum principle stress (tension side) and minimum principle stress (compression side) observed in the periodontium at power arm soldered to canine bracket at 9mm and minimum at canine bracket hook.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"220-224"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Qi Gong therapy for managing premenstrual syndrome among adolescent girls. 气功疗法对青春期少女经前期综合征的影响。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210132
Vaghela Payalben Tejmalji, Mahalakshmi B, Siva Subramanian N
{"title":"Impact of Qi Gong therapy for managing premenstrual syndrome among adolescent girls.","authors":"Vaghela Payalben Tejmalji, Mahalakshmi B, Siva Subramanian N","doi":"10.6026/973206300210132","DOIUrl":"https://doi.org/10.6026/973206300210132","url":null,"abstract":"<p><p>Premenstrual Syndrome (PMS) is a prevalent condition among adolescent girls, causing significant physical and emotional distress. Therefore, it is of interest to evaluate the impact of Qi Gong therapy on alleviating PMS symptoms among adolescent girls in North Gujarat. A quasi-experimental pretest-posttest design was implemented with 231 adolescent girls aged 13-17 years. Participants underwent a 4-week Qi Gong therapy program, with five 45-minute sessions weekly. Data were collected using a demographic questionnaire and Modified PMS Scale, analysing pre - and post-intervention symptoms through descriptive statistics, paired t-tests and chi-square tests. The intervention significantly reduced PMS severity, with mild PMS cases increasing from 48 (20.78%) to 166 (71.86%) post-intervention. Paired t-tests revealed a highly significant mean difference in PMS scores (T = 12.251, p < 0.001).</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"132-136"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profilometric evaluation of root surface roughness using pumice and zirconium silicate polishing agents. 用浮石和硅酸锆抛光剂测量根表面粗糙度。
IF 1.9
Bioinformation Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.6026/973206300210268
Devadharshini Chandrasekar, C Burnice Nalina Kumari, Nikita Ravi, Jaideep Mahendra, Vijayalakshmi Rajaram
{"title":"Profilometric evaluation of root surface roughness using pumice and zirconium silicate polishing agents.","authors":"Devadharshini Chandrasekar, C Burnice Nalina Kumari, Nikita Ravi, Jaideep Mahendra, Vijayalakshmi Rajaram","doi":"10.6026/973206300210268","DOIUrl":"https://doi.org/10.6026/973206300210268","url":null,"abstract":"<p><p>Periodontitis is a chronic inflammatory disease that leads to tooth loss with dental plaque and calculus as key risk factors. Periodontal prophylaxis including polishing plays a crucial role in reducing plaque deposition and maintaining periodontal health. Therefore, it is of interest to compare the root surface roughness produced by pumice polishing powder and zirconium silicate prophylaxis paste using a profilometric analysis on the extracted teeth. The results show that zirconium silicate paste produced a smooth root surface compared to pumice powder which exhibited a rough texture. Thus, zirconium silicate paste is preferable for preserving root surface integrity during periodontal prophylaxis.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 2","pages":"268-273"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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