BioinformationPub Date : 2026-06-30eCollection Date: 2026-01-01DOI: 10.6026/973206300223245
Soni Soni, Dhananjay Kumar, Garima Mangal, Nirmala Kumari
{"title":"Effect of used Mango and Karanj chewing stick (Datun) on <i>Streptococcus mutans</i>: An <i>in vitro</i> study.","authors":"Soni Soni, Dhananjay Kumar, Garima Mangal, Nirmala Kumari","doi":"10.6026/973206300223245","DOIUrl":"10.6026/973206300223245","url":null,"abstract":"<p><p>Dental caries remains a major oral health problem, necessitating effective natural antimicrobial alternatives targeting <i>Streptococcus Mutans</i>. Chewing sticks from <i>Mangifera indica</i> and <i>pongamia pinnata</i> contain bioactive compounds with established antiseptic and bactericidal properties. Aqueous extracts (5%, 10% and 50% w/v) were prepared and tested against <i>Streptococcus mutans</i> using agar diffusion to assess zones of inhibition. <i>Mangifera indica</i> showed maximum antimicrobial efficacy at 50% concentration, followed by lower but notable effects at 10% and 5%. Thus, we show <i>Mangifera indica</i> as a potent natural anti-cariogenic agent with potential integration into preventive oral healthcare strategies.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3245-3247"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of CD10 expression in prostate adenocarcinoma and its clinic-pathological correlation at tertiary care hospital.","authors":"Hukam Singh Meena, Radhika Rai, Aashita Thakur, Shashi Kant, Ashok Panchonia, Meena Mittal, Chandrashekhar Chhatrasal","doi":"10.6026/973206300223380","DOIUrl":"10.6026/973206300223380","url":null,"abstract":"<p><p>Prostate adenocarcinoma is the second most common cancer in men worldwide and ranks sixth in cancer-related mortality, with more than 95% of cases arising from prostatic acini. CD10, an immunohistochemical marker, has emerged as a potential prognostic indicator, as its high expression is linked to aggressive tumor behavior and early lymph node metastasis, and tumor grading is performed using the WHO Grade Group system based on the Gleason score. Hence, this study included 40 cases of prostate adenocarcinoma diagnosed between January 2023 and December 2024 at the Department of Pathology, MGM Medical College, Indore, involving patients aged 45-95 years with a mean age of 68.5 years. Among the cases evaluated, CD10 expression was negative in 30% (n=12), diffuse in 27.5% (n=11), cytoplasmic in 22.5% (n=9), and membranous in 20% (n=8), and these patterns were correlated with Gleason score. Thus, we show that the pattern of CD10 immunoexpression, particularly diffuse and cytoplasmic positivity, correlates significantly with higher Gleason scores in prostate adenocarcinoma, supporting its incorporation as an adjunct immunohistochemical marker to refine histopathological risk stratification beyond conventional Gleason grading.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3380-3384"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2026-06-30eCollection Date: 2026-01-01DOI: 10.6026/973206300223248
Kiran Mendhe, Praveen Kumar, Pallavi Kadve
{"title":"Long term effect of structured aerobic training versus structured resistance training program on glycaemic control in type 2 diabetes mellitus.","authors":"Kiran Mendhe, Praveen Kumar, Pallavi Kadve","doi":"10.6026/973206300223248","DOIUrl":"10.6026/973206300223248","url":null,"abstract":"<p><p>The absence of clear evidence regarding the long-term comparative effectiveness of structured aerobic versus resistance training in improving lipid profile and metabolic parameters in type 2 diabetes mellitus remains a significant clinical challenge. Hence, this randomized controlled trial evaluated 60 patients with T2DM assigned to aerobic or resistance training groups over an extended follow-up period. Both interventions demonstrated improvements in glycaemic control, lipid profile, cardiovascular parameters and behavioral outcomes, with resistance training showing superior early-phase benefits in diet-related behaviors and metabolic adaptation. However, long-term outcomes between the two groups converged, indicating comparable efficacy over time. Thus, date shows that both exercise modalities are beneficial, with modality-specific temporal advantages. By providing controlled longitudinal evidence, this study advances knowledge by clarifying the time-dependent differential impacts of aerobic and resistance training on metabolic and behavioral outcomes in T2DM.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3248-3253"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2026-06-30eCollection Date: 2026-01-01DOI: 10.6026/973206300223369
Durgesh Kumar, Mohammad Kaleem Ahmad, Anveshika Manoj, Gautam Prasad, Ravindra Kumar Garg, Abbas Ali Mahdi
{"title":"Lead and cadmium levels in blood among painters and battery workers: A case control study.","authors":"Durgesh Kumar, Mohammad Kaleem Ahmad, Anveshika Manoj, Gautam Prasad, Ravindra Kumar Garg, Abbas Ali Mahdi","doi":"10.6026/973206300223369","DOIUrl":"10.6026/973206300223369","url":null,"abstract":"<p><p>Occupational exposure to heavy metals like lead and cadmium remains a significant health concern due to poor workplace awareness and unsafe practices. Therefore, it is of interest to evaluated blood levels of lead, cadmium and oxidative stress markers in occupationally exposed workers (painters and battery workers) compared to controls. Analysis using ICP-MS revealed significantly elevated metal levels in exposed workers, along with decreased antioxidant enzyme activities and increased lipid peroxidation (p < 0.001). Total antioxidant capacity was also significantly reduced, indicating impaired defense against oxidative stress in exposed individuals. Thus, we report the mechanistic link between heavy metal exposure and oxidative imbalance, emphasizing the need for improved occupational safety and preventive strategies.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3369-3374"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2026-06-30eCollection Date: 2026-01-01DOI: 10.6026/973206300223562
Soni Soni, Ravishankar Kumar, Garima Mangal, Nirmala Kumari
{"title":"Periodontal status and oral health-related quality of life among rural population in Patna, India.","authors":"Soni Soni, Ravishankar Kumar, Garima Mangal, Nirmala Kumari","doi":"10.6026/973206300223562","DOIUrl":"10.6026/973206300223562","url":null,"abstract":"<p><p>Periodontal disease is highly prevalent in rural India, yet data linking clinical periodontal status with oral health-related quality of life (OHRQoL) in these communities remain scarce. Hence, a descriptive cross-sectional study was conducted among 550 rural adults in Patna using the WHO Oral Health Assessment Form (2013), modified CPI and OHIP-14 questionnaire from September 2020 to February 2021. Gingival bleeding was found in 48.73%, periodontal pockets (4-5 mm) in 60.36% and loss of attachment predominantly in the 0-3 mm range, with higher severity in females and older age groups. Higher OHIP-14 scores were significantly associated with gingival bleeding, periodontal pockets and loss of attachment (P < 0.001), confirming that worsening periodontal status adversely affects OHRQoL. This study provides novel region-specific evidence from rural Bihar by integrating clinical periodontal indicators with subjective OHIP-14 outcomes, supporting targeted oral health promotion and integration of dental care into primary healthcare for underserved populations.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3562-3567"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical and lateral cephalometric evaluation of class II elastic therapy in skeletal class II malocclusion cases indicated for fixed functional appliance: An <i>in vivo</i> study.","authors":"Priyanshi Mahajan, Purva Joneja, Neelam Dhakar, Julius Mary, Rishabh Joneja, Priyanka Jaiswal","doi":"10.6026/973206300223545","DOIUrl":"10.6026/973206300223545","url":null,"abstract":"<p><p>Management of skeletal Class II malocclusion remains a persistent orthodontic challenge, particularly in selecting an effective alternative to fixed functional appliances. Therefore, it is of interest to evaluate the clinical and cephalometric effects of Class II elastics in 10 patients with skeletal Class II malocclusion. Pre- and post-treatment cephalometric parameters, including SNA, SNB, ANB and overjet, were compared using paired t-test analysis. Data shows significant improvement in cephalometric angles and overjet reduction, with dentoalveolar changes being more pronounced than skeletal changes. Thus, we show Class II elastics as a clinically effective alternative in borderline skeletal Class II cases, with outcomes comparable to fixed functional therapy in selected patients.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3545-3550"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2026-06-30eCollection Date: 2026-01-01DOI: 10.6026/973206300223469
Habibatou Diabate, Clifton Mason Perry, Sajidha Nizamudeen, Oluwatobi Onalaja, Sabah Fatima, Ram Vikas Reddy, Mohammed Hady Albitar, Abdullah Almahmoud, Alana Rivera Negrón, Harsh Vijay Sanghvi, Mohammed Abdul Mateen
{"title":"Associations of vitamin D, hepatic function and inflammatory biomarkers with obesity: A cross-sectional analysis.","authors":"Habibatou Diabate, Clifton Mason Perry, Sajidha Nizamudeen, Oluwatobi Onalaja, Sabah Fatima, Ram Vikas Reddy, Mohammed Hady Albitar, Abdullah Almahmoud, Alana Rivera Negrón, Harsh Vijay Sanghvi, Mohammed Abdul Mateen","doi":"10.6026/973206300223469","DOIUrl":"10.6026/973206300223469","url":null,"abstract":"<p><p>Obesity is associated with hepatic dysfunction, chronic inflammation and vitamin D deficiency, but their interrelationship remains incompletely understood. Therefore, it is of interest to compare the liver function, inflammatory and vitamin D-PTH biomarkers between 100 obese adults (BMI ≥30 kg/m<sup>2</sup>) and 100 age-matched non-obese controls. Obese participants showed significantly higher ALT, AST, ALP, GGT, CRP, IL-6, fibrinogen and PTH levels, with lower serum 25(OH)D concentrations. Regression analysis identified CRP (OR=1.38, 95% CI: 1.24-1.54) and GGT (OR=1.35, 95% CI: 1.20-1.52) as the strongest positive predictors, while 25(OH)D showed a significant inverse association with obesity (OR=0.79, 95% CI: 0.68-0.91). Thus, data shows the combined contribution of hepatic dysfunction, systemic inflammation and vitamin D imbalance to obesity-related metabolic disturbances and support their early clinical assessment.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3469-3475"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correlation of serum ferritin, D dimer and CRP levels with disease severity among hospitalized patients in India.","authors":"Madhur Gupta, Girish Dubey, Ritesh Yadav, Ramesh Prasad Agrawal","doi":"10.6026/973206300223572","DOIUrl":"10.6026/973206300223572","url":null,"abstract":"<p><p>Delayed recognition of severe disease in hospitalized patients remains a major challenge and contributes to increased morbidity and mortality. Therefore, it is of interest to evaluate the correlation of serum ferritin, C-reactive protein (CRP) and D-dimer levels with disease severity in hospitalized patients. Hence, a hospital-based cross-sectional study was conducted on 100 adult patients and biomarker levels were measured using standard laboratory methods. The results showed a significant increase in serum ferritin, CRP and D-dimer levels with increasing disease severity (p < 0.001). A strong positive correlation was observed between these biomarkers and disease severity, with D-dimer showing the highest correlation and elevated levels were significantly associated with ICU admission and mortality. Thus, combined assessment of ferritin, CRP and D-dimer is a simple and reliable approach for early risk stratification and prognostication in hospitalized patients.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3572-3575"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2026-06-30eCollection Date: 2026-01-01DOI: 10.6026/973206300223723
Shivani Rawat, Anu Narang, Santosh Kumar Singh, Gayatri H Giramkar, Sadhvi Pateriya, Naman Keshwani
{"title":"Microleakage of zinc oxide eugenol, resin, calcium hydroxide, bioceramic and bioactive glass sealers using stereomicroscope: An <i>in vitro</i> study.","authors":"Shivani Rawat, Anu Narang, Santosh Kumar Singh, Gayatri H Giramkar, Sadhvi Pateriya, Naman Keshwani","doi":"10.6026/973206300223723","DOIUrl":"10.6026/973206300223723","url":null,"abstract":"<p><p>Microleakage is a major cause of endodontic treatment failure due to inadequate sealing ability of root canal sealers. Therefore, it is of interest to evaluate the microleakage of five different root canal sealers using stereomicroscope. Seventy extracted premolars were divided into five groups (n=14) and obturated using respective sealers. Bioactive glass sealer showed lowest microleakage (1.6400 ± 0.3908 mm), while zinc oxide eugenol showed highest microleakage (5.8200 ± 0.6820 mm). Differences were statistically significant (p<0.0001), bioactive glass and bioceramic sealers demonstrated superior sealing ability compared to conventional sealers. Thus, data shows the enhanced sealing efficacy of contemporary bioactive glass and bioceramic sealers compared to traditional root canal sealers, underscoring their potential to improve long-term endodontic treatment results by minimizing microleakage.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3723-3727"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of endodontic treatment on periodontal healing in Grade III EPL without root damage.","authors":"Meetu Mathur, Shreyansh Ahirwar, Dhanuja Rani J, Srinivas Murthy S T, Aseem Jolly Garg, Micky Kumari, Miral Mehta","doi":"10.6026/973206300223328","DOIUrl":"10.6026/973206300223328","url":null,"abstract":"<p><p>Periodontal and endodontic infection, with or without root damage, go in conjunction with destruction of periodontal bone structure. Therefore, it is of interest to evaluate the effect of non-surgical endodontic treatment of periodontal healing in Grade 3 endo-periodontal lesions (EPL) without root damage. Hence, a total of 100 patients received standardized root canal therapy and were followed for six months. Significant improvement was observed in probing depth, clinical attachment level and tooth mobility. Thus, we show endodontic treatment as an effective approach for managing such lesions conservatively.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3328-3331"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}