Bioinformation最新文献

{"title":"Oral health care concerns among autism patients: A review.","authors":"Sibani Sarangi, Rajeev Ranjan Raj, Anurag Rawat, Sajjad Salam, Shubham Tripathi, Dipanshu Aggarwal, Ritik Kashwani","doi":"10.6026/9732063002001017","DOIUrl":"10.6026/9732063002001017","url":null,"abstract":"<p><p>Autism is a developmental disorder mostly affecting neural and developmental skills with problems in learning, communication and repetitive behaviour. It has become more highlighted over the past few decades because of the increasing awareness, survey tools and research worldwide. Existing worldwide, this disorder affects the normal lifestyle of the affected people since childhood and continues with the same pace through lifetime. Due to poor neuromuscular coordination, it also affects the normal orofacial dynamics of an individual and manifests as multiple oral disorders. Therefore it's of interest to report known data on the oral manifestations of this spectral disorder and various approaches at varied levels to maintain a harmonious oral environment.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1017-1021"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-heating effect on micro-hardness and depth of cure for three bulk-fill composite resins: An <i>in vitro</i> study.","authors":"Alakesh Singha, Archan Dhanesha, Sruthi Nair, Ruchi Patel, Subasish Behera, Soumyaranjan Nanda","doi":"10.6026/9732063002001128","DOIUrl":"10.6026/9732063002001128","url":null,"abstract":"<p><p>This study aimed to evaluate the effect of preheating on the micro-hardness and depth of cure of three different bulk-fill composite resins: Filtek Bulk Fill (3M ESPE), Tetric EvoCeram Bulk Fill (Ivoclar Vivadent), and SDR (Dentsply Sirona). Three bulk-fill composite resins, Filtek Bulk Fill (3M ESPE), Tetric EvoCeram Bulk Fill (Ivoclar Vivadent), and SDR (Dentsply Sirona), were tested in this <i>in vitro</i> study. Each resin was divided into two groups: preheated and non-preheated. The preheating process was performed using a composite warmer at 68°C for 5 minutes. Micro-hardness was measured using a Vickers hardness tester, and the depth of cure was evaluated by measuring the hardness ratio at different depths (0.5 mm, 1 mm, and 2 mm). Pre-heating significantly increased the micro-hardness of all three bulk-fill composite resins (p < 0.05). For Filtek Bulk Fill, the micro-hardness value increased from 60 to 70 HV, for Tetric EvoCeram Bulk Fill from 55 to 65 HV, and for SDR from 58 to 68 HV. The depth of cure was also enhanced in the preheated groups. The hardness ratio at 2 mm depth was 0.85 for Filtek Bulk Fill, 0.80 for Tetric EvoCeram Bulk Fill, and 0.83 for SDR in the preheated groups, compared to 0.75, 0.70 and 0.72 in the non-preheated groups, respectively. Pre-heating bulk-fill composite resins improves their micro-hardness and depth of cure. This suggests that preheating could be beneficial in clinical settings to enhance the physical properties of composite restorations.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1128-1131"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Up-cycling the dental waste materials: Going green in dentistry.","authors":"Kranti Rajesh Khadse, Swati Priya, Rana K Varghese, Malwika Sisodia, Naveen Kumar Gupta, Anita Chandrakar","doi":"10.6026/9732063002001124","DOIUrl":"10.6026/9732063002001124","url":null,"abstract":"<p><p>The depletion of natural resources due to the extensive use of various materials in dentistry is a growing concern. A significant contributor to this issue is the lack of recycling practices, leading to the continuous exploitation of these resources. This research aims to explore simple yet effective scientific techniques to up-cycle common dental materials while maintaining their properties. The focus of modern practices should align with the 3R's-Reduce, Reuse, and Recycle. In dental institutions and clinics, materials like dental plaster and dental stone, extensively used for pouring impressions, are completely discarded as waste. This study involves collecting these waste products and evaluating their properties for potential reuse. Additionally, endodontic materials such as stainless steel hand files and rotary Ni-Ti files, typically discarded, can be recycled in metallurgical departments and repurposed into custom-made cast posts and titanium posts, respectively. The wisdom tooth crush technique is explored for its application as autologous graft material in filling bone defects. Discarded alginate impressions, widely used in Prosthodontics, are heated and repurposed as a denture polishing agent and as a fertilizer in agriculture. Excess glass ionomer cement, a common restorative material, can be repurposed into polishing cones and powders, or used as a polishing agent with rubber cups and buffs. Modeling wax, predominantly used in occlusal rim fabrication, can be collected and purified, with 90% of it recoverable without compromising its properties. Finally, discarded dental burs can be repurposed to splint implant impression copings, aiding in the accurate transfer of orientation, a critical step in implant prosthodontics. This study advocates for the adoption of recycling practices in dental colleges and among practitioners to manage and reuse the waste generated in the field. By doing so, the treatment cost can be reduced by 30-40%, and natural resources can be conserved, contributing to the preservation of the Earth's resources.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1124-1127"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride enigma in end stage renal disease.","authors":"Paramaturi Sharon Rose, Kurpad Nagaraj Shashidhar, Uppalamethi Munilakshmi, Muthyala Meghanath","doi":"10.6026/973206300200998","DOIUrl":"10.6026/973206300200998","url":null,"abstract":"<p><p>Fluoride is an essential micro-mineral. Chronic exposure to fluoride affects collagen biosynthesis, insulin resistance, diabetes mellitus and kidney damage. Present prospective study, include 142 subjects categorised into group I and II. Serum samples was separated and stored appropriately. Statistical significant values were observed in urea, creatinine, calcium, magnesium, fluoride and IL6 in DN. Serum fluoride, total proteins, and calcium showed a positive correlation in group I versus group II. Fluoride is one of the key adjunct and surrogate molecule in causation of micro-vascular complications of diabetes.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"998-1001"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender determination from ridges using dermatoglyphics techniques.","authors":"Manasi Patra, Niva Mahapatra, Shyam Sundar Behura, Lipsa Bhuyan, Girish Ms, Samir Pv, Pratik Surana","doi":"10.6026/9732063002001008","DOIUrl":"10.6026/9732063002001008","url":null,"abstract":"<p><p>Fingerprint analysis for gender determination in Ganjam District, Southern Odisha is of interest in forensic science. Dermatoglyphics, the study of fingerprint patterns, leverages their genetic uniqueness and stability to identify individuals in forensic and disaster scenarios. Left thumb prints were collected and analyzed under magnification, followed by statistical evaluation. Results showed significant differences in fingerprint patterns between genders, confirming the method's accuracy. Thus, fingerprint pattern analysis is a valuable tool for gender identification in forensic medicine, criminal investigations, and during mass disasters.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1008-1011"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation N-Telopeptide (NTx) and calprotectin level in crevicular fluid with peri-implantitis.","authors":"Ashwini Narayankar, Sagar Kumar Kashyap, Suman Yadav, Anas Abdul Khader, Anjaneya Dube, Pushkar Gupta, Nureldeen An Elhammali, Abhaya Chandra Das","doi":"10.6026/9732063002001183","DOIUrl":"10.6026/9732063002001183","url":null,"abstract":"<p><p>Following inflammation and bone loss near the implant site, peri-implantitis develops. N-Telopeptide (NTx) and Calprotectin are abundant in the crevicular fluids found in that area and are thought to be possible biomarkers. Therefore, it is of interest to evaluate the amounts of calprotectin and NTx in the peri-implant sulcular fluid (PISF) from implant sites with or without peri-implantitis. Twenty healthy individuals and twenty patients with peri-implantitis who had a single dental implant were included in the total of forty participants. For every patient, the peri-implant clinical parameters of gingival index (GI), probing depth (PD) and bleeding on probing (BOP) were ted. To evaluate the bone loss (BL), radiographic pictures of every implant were acquired. Using sterile paper strips, PISF was gathered in order to use the ELISA technique to measure the amounts of NTx and calprotectin. We examined the correlations between the levels of PISF, NTx and calprotectin with the peri-implant clinical indicators. In comparison to the healthy group, the peri-implantitis group had increased levels of NTx and calprotectin. In individuals with peri-implantitis, the levels of NTx and calprotectin in the PISF may be a promising indicator for bone loss and peri-implant inflammation.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1183-1186"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of endothelin-1 and interleukin-1β as a biomarker for diagnosing peri-implant disorders.","authors":"Pranav V Manek, Arpita Srivastava, Rahul Shrivastava, Miloni Bhatt, Naina Pattnaik, Manish Kumar","doi":"10.6026/9732063002001148","DOIUrl":"10.6026/9732063002001148","url":null,"abstract":"<p><p>Endothelin-1 (ET-1) and interleukin-1β (IL-1β) is increased in periodontitis and is linked to inflammatory cytokines among other variables. The purpose of this study was to ascertain if ET-1 and IL-1β are utilized as an early indicator for peri-implant mucositis (PM) and peri-implantitis (PI), as well as to look into the relationship between ET-1 and IL-1β levels and peri-implant illnesses. 58 patients (30 males and 28 females) with a total of 152 implants were included for final analyses. Three groups were formed from the 152 qualifying implants. A plastic probe was used at low pressure of 0.25N to assess the peri-implant parameters like probing pocket depth (PPD), modified gingival index (mGI), BOP being present or absent and modified plaque index (mPI). Mean bone loss (MBL) and the average annual bone loss (ABL) were evaluated. The values were significantly greater in PI group and PM group as compared to healthy subjects. ET-1 and IL-1β levels are significantly increased in peri-implant illnesses. ET-1 and IL-1β may be utilized as diagnostic indicator for peri-implant disorders.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1148-1153"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the wear resistance of different artificial teeth materials in removable dentures.","authors":"Atul Bhandari, Sneha Saraf, Nabarun Chakraborty, Arpita Srivastava, Ishan Roy Choudhury, Kritika Rajan","doi":"10.6026/9732063002001159","DOIUrl":"10.6026/9732063002001159","url":null,"abstract":"<p><p>This study aimed to evaluate and compare the wear characteristics of acrylic resins, composite resins and ceramic materials used in removable dentures. A total of 88 samples (n = 88) were subjected to simulated chewing cycles using a wear-testing apparatus. The wear depths were measured using profilometry and statistical analyses were performed to assess the differences among the materials. Ceramics exhibited superior wear resistance compared to acrylic and composite resins in removable dentures. These findings highlight the importance of material selection for the optimization of denture longevity and patient satisfaction.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1159-1163"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave versus conventional sintering on mechanical properties of 3Y-TZP - A systematic review.","authors":"Padmapriya Puppala, Gaurang Mistry, Vidhi Desai, Rajeev Singh, Mayuri Bachhav, Sanpreet Singh Sachdev","doi":"10.6026/9732063002001086","DOIUrl":"10.6026/9732063002001086","url":null,"abstract":"<p><p>This systematic review evaluates the mechanical properties of yttria-stabilized zirconia (3Y-TZP) processed by microwave sintering compared to conventional sintering methods. Zirconia, known for its excellent strength and esthetics, has seen advancements in sintering techniques to enhance its properties. Conventional sintering, while effective, is time-consuming and less energy-efficient. In contrast, microwave sintering, introduced in 1999, offers rapid heating and improved control over temperature and shrinkage. This review, adhering to PRISMA guidelines, included studies from 2000 to 2023 that compared the effects of both sintering methods on relative density, flexural strength, Young's modulus and hardness of zirconia. Results indicate that microwave sintering improves hardness and reduces processing time, whereas conventional sintering provides higher relative density, flexural strength, and Young's modulus. The findings suggest that the choice of sintering technique should align with specific material property requirements, with each method offering distinct advantages for zirconia applications.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"1086-1094"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking and simulation analysis of c-KIT and PDGFRα with phytochemicals as dual inhibitors for GIST.","authors":"Kaoutar El Khattabi, Sanaa Lemriss, Rachid El Jaoudi, Fouad Zouaidia","doi":"10.6026/973206300200974","DOIUrl":"10.6026/973206300200974","url":null,"abstract":"<p><p>Mutations in the c-KIT or PDGFRα genes primarily drive gastrointestinal stromal tumors (GISTs). While tyrosine kinase inhibitors (TKIs) such as Imatinib have improved outcomes, resistance due to secondary mutations remains a significant challenge. This study used computational methods to identify phytochemicals from Moroccan plants as dual inhibitors of c-KIT and PDGFRα. Screening 545 phytochemicals, 6-Hydroxygenistein (6-OHG), a derivative of Genistein, showed high binding affinities (-10.3 kcal/mol for PDGFRα and -10.5 kcal/mol for c-KIT), comparable to Imatinib. 6-OHG demonstrated competitive binding affinities, favorable ADMET properties, good solubility, and oral bioavailability. Its antioxidant properties suggest a potentially lower toxicity profile. Interaction analysis revealed significant hydrogen bonds and hydrophobic interactions with key residues in both targets. Molecular dynamics simulations over 30 ns indicated stable complexes with consistent RMSD values, radius of gyration, solvent-accessible surface area, and hydrogen bonding patterns. Free binding energy calculations using the MM-PBSA method highlighted strong binding efficacy, with total binding energies of -278.0kcal/mol for PDGFRα and -202.1kcal/mol for c-KIT, surpassing Imatinib. These findings suggest that 6-OHG is a promising dual inhibitor for GIST therapy, potentially overcoming resistance mechanisms associated with current TKIs. However, further experimental validation is necessary to fully understand it's potential.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 9","pages":"974-979"},"PeriodicalIF":1.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}