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A comparative evaluation of corticotomy-assisted and conventional maxillary anterior en-masse retraction: A clinical study. 皮质切开术与常规上颌前牙整体牵开的临床比较研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223400
Ruchi Raval, Surendra Lodha, Anand Mohan, Sanket Sheth, Sangita Bhalodi, Tejomaya Shastry
{"title":"A comparative evaluation of corticotomy-assisted and conventional maxillary anterior en-masse retraction: A clinical study.","authors":"Ruchi Raval, Surendra Lodha, Anand Mohan, Sanket Sheth, Sangita Bhalodi, Tejomaya Shastry","doi":"10.6026/973206300223400","DOIUrl":"10.6026/973206300223400","url":null,"abstract":"<p><p>Orthodontic patients often experience prolonged treatment duration and anchorage loss during maxillary anterior en-masse retraction. This drawback has prompted the need for techniques that can accelerate tooth movement. Therefore, it is of interest to evaluate the effectiveness of corticotomy-assisted versus conventional maxillary anterior en-masse retraction in adult patients. It was conducted in the Department of Orthodontics and Dentofacial Orthopaedics, Manipal College of Dental Sciences, Manipal, Karnataka, India. Twelve patients with Class I bimaxillary protrusion were divided equally into two groups and treated with identical orthodontic mechanics. The rate of tooth movement, anchorage loss and incisor torque control were assessed at defined time intervals during space closure. Corticotomy-assisted retraction showed a significantly higher rate of tooth movement and reduced overall treatment time with less anchorage loss. No significant difference in torque control was observed between the two treatment modalities.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3400-3404"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between comorbid conditions and disease severity in COVID-19 patients: A retrospective study from a government medical college hospital of Central India. COVID-19患者合并症与疾病严重程度之间的关系：来自印度中部一所政府医学院医院的回顾性研究
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223640
Rakesh Kumar Sisodia, Tarunendra Kumar Mishra, Mahesh Kumar Patidar, Mahendra Chouhan, Umesh Sinha
{"title":"Association between comorbid conditions and disease severity in COVID-19 patients: A retrospective study from a government medical college hospital of Central India.","authors":"Rakesh Kumar Sisodia, Tarunendra Kumar Mishra, Mahesh Kumar Patidar, Mahendra Chouhan, Umesh Sinha","doi":"10.6026/973206300223640","DOIUrl":"10.6026/973206300223640","url":null,"abstract":"<p><p>The COVID-19 pandemic has posed a major global health challenge, with emerging evidence showing worse outcomes among patients with pre- existing comorbidities. Therefore, it is of interest to examine the association between comorbidity status and disease severity among 384 laboratory-confirmed COVID-19 patients admitted to a government medical college in Central India. Patients were divided into comorbid(n=192) and non-comorbid (n=192) groups, with hypertension (69.27%), diabetes mellitus (36.98%) and cardiac disease (13.54%) being most prevalent. Fever (67.45%), cough (55.47%) and shortness of breath (36.20%) were predominant symptoms, while severe illness occurred in 29.69% of comorbid versus 11.46% of non-comorbid patients (x<sup>2</sup>=24.83, p<0.00001). Thus, we show that hypertension and diabetes markedly increase COVID-19 severity, emphasizing prioritized care and aggressive management of high-risk populations.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3640-3646"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anemia of chronic disease: Evaluating iron markers and bone marrow findings. 慢性疾病贫血：评估铁标记物和骨髓检查结果。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223576
Preeti Nigotia, Madhur Gupta, Abhishek Yadav, Lakshya Pruthi
{"title":"Anemia of chronic disease: Evaluating iron markers and bone marrow findings.","authors":"Preeti Nigotia, Madhur Gupta, Abhishek Yadav, Lakshya Pruthi","doi":"10.6026/973206300223576","DOIUrl":"10.6026/973206300223576","url":null,"abstract":"<p><p>Anemia of chronic disease (ACD) is a common condition associated with chronic inflammation, characterized by disordered iron metabolism and impaired erythropoiesis. This study evaluated iron metabolism markers and correlated them with bone marrow iron stores in 100 patients with anemia in chronic disease settings. Parameters including serum iron, ferritin, total iron-binding capacity (TIBC), transferrin saturation (TSAT) and soluble transferrin receptor (sTfR) were analyzed alongside bone marrow iron grading using Perls' Prussian blue staining. Most patients demonstrated low serum iron and TSAT with normal to elevated ferritin levels, while increased sTfR in some cases suggested coexisting iron deficiency. Data shows that integrating serum ferritin and sTfR with bone marrow iron grading provides a more reliable framework for distinguishing anemia of chronic disease from coexisting iron deficiency, supporting a dual biochemical-morphological approach over single-marker evaluation in routine clinical practice.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3576-3580"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of used Mango and Karanj chewing stick (Datun) on Streptococcus mutans: An in vitro study. 用过的芒果和卡兰吉咀嚼棒（大屯）对变形链球菌作用的体外研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223245
Soni Soni, Dhananjay Kumar, Garima Mangal, Nirmala Kumari
{"title":"Effect of used Mango and Karanj chewing stick (Datun) on <i>Streptococcus mutans</i>: An <i>in vitro</i> study.","authors":"Soni Soni, Dhananjay Kumar, Garima Mangal, Nirmala Kumari","doi":"10.6026/973206300223245","DOIUrl":"10.6026/973206300223245","url":null,"abstract":"<p><p>Dental caries remains a major oral health problem, necessitating effective natural antimicrobial alternatives targeting <i>Streptococcus Mutans</i>. Chewing sticks from <i>Mangifera indica</i> and <i>pongamia pinnata</i> contain bioactive compounds with established antiseptic and bactericidal properties. Aqueous extracts (5%, 10% and 50% w/v) were prepared and tested against <i>Streptococcus mutans</i> using agar diffusion to assess zones of inhibition. <i>Mangifera indica</i> showed maximum antimicrobial efficacy at 50% concentration, followed by lower but notable effects at 10% and 5%. Thus, we show <i>Mangifera indica</i> as a potent natural anti-cariogenic agent with potential integration into preventive oral healthcare strategies.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3245-3247"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of CD10 expression in prostate adenocarcinoma and its clinic-pathological correlation at tertiary care hospital. 三级医院前列腺癌组织中CD10表达及临床病理相关性的研究
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223380
Hukam Singh Meena, Radhika Rai, Aashita Thakur, Shashi Kant, Ashok Panchonia, Meena Mittal, Chandrashekhar Chhatrasal
{"title":"Evaluation of CD10 expression in prostate adenocarcinoma and its clinic-pathological correlation at tertiary care hospital.","authors":"Hukam Singh Meena, Radhika Rai, Aashita Thakur, Shashi Kant, Ashok Panchonia, Meena Mittal, Chandrashekhar Chhatrasal","doi":"10.6026/973206300223380","DOIUrl":"10.6026/973206300223380","url":null,"abstract":"<p><p>Prostate adenocarcinoma is the second most common cancer in men worldwide and ranks sixth in cancer-related mortality, with more than 95% of cases arising from prostatic acini. CD10, an immunohistochemical marker, has emerged as a potential prognostic indicator, as its high expression is linked to aggressive tumor behavior and early lymph node metastasis, and tumor grading is performed using the WHO Grade Group system based on the Gleason score. Hence, this study included 40 cases of prostate adenocarcinoma diagnosed between January 2023 and December 2024 at the Department of Pathology, MGM Medical College, Indore, involving patients aged 45-95 years with a mean age of 68.5 years. Among the cases evaluated, CD10 expression was negative in 30% (n=12), diffuse in 27.5% (n=11), cytoplasmic in 22.5% (n=9), and membranous in 20% (n=8), and these patterns were correlated with Gleason score. Thus, we show that the pattern of CD10 immunoexpression, particularly diffuse and cytoplasmic positivity, correlates significantly with higher Gleason scores in prostate adenocarcinoma, supporting its incorporation as an adjunct immunohistochemical marker to refine histopathological risk stratification beyond conventional Gleason grading.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3380-3384"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between periodontal maintenance compliance and implant survival following fixed prosthodontic restorations. 固定义齿修复后牙周维护依从性与种植体存活的关系。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223681
Gatha Mohanty, Ramnath Revankar, Vipul Asopa, Shivalika S Asopa, Garima Rani, P Arun Kumar, Guljot Singh
{"title":"Correlation between periodontal maintenance compliance and implant survival following fixed prosthodontic restorations.","authors":"Gatha Mohanty, Ramnath Revankar, Vipul Asopa, Shivalika S Asopa, Garima Rani, P Arun Kumar, Guljot Singh","doi":"10.6026/973206300223681","DOIUrl":"10.6026/973206300223681","url":null,"abstract":"<p><p>Periodontal maintenance compliance plays a crucial role in the long-term success of implant-supported fixed prosthodontic restorations. This retrospective cohort study evaluated the correlation between periodontal maintenance compliance and implant survival among 100 patients with fixed implant-supported prostheses. The overall implant survival rate was 93%, with compliant patients demonstrating significantly higher survival rates (96.8%) compared to non-compliant patients (86.8%) (P < 0.05), along with a moderate positive correlation between maintenance compliance and implant survival (r = 0.41, p < 0.01). Logistic regression analysis identified periodontal maintenance compliance as a significant independent predictor of implant survival. The findings suggest that regular supportive periodontal therapy and patient adherence to maintenance programs are essential for improving long-term implant success and minimizing biological complications.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3681-3685"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of silver diamine fluoride versus fluoride varnish in arresting early childhood caries: A clinical study. 氟化二胺银与氟化物清漆防治儿童早期龋齿的临床研究
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223585
Riddhi Jadeja, Debadrita Ghosh, Devashree Shukla, Sanjana Bhargava, Dhanuja Rani J, Srinivas Murthy S T
{"title":"Effect of silver diamine fluoride versus fluoride varnish in arresting early childhood caries: A clinical study.","authors":"Riddhi Jadeja, Debadrita Ghosh, Devashree Shukla, Sanjana Bhargava, Dhanuja Rani J, Srinivas Murthy S T","doi":"10.6026/973206300223585","DOIUrl":"10.6026/973206300223585","url":null,"abstract":"<p><p>The comparative effectiveness of silver diamine fluoride and fluoride varnish in arresting early childhood caries remains insufficiently established. Therefore, it is of interest to evaluate caries arrest among 90 children treated with either silver diamine fluoride or fluoride varnish. Hence, participants were divided into two groups, with clinical assessment of caries arrest at baseline and follow-up using standardized criteria. Silver diamine fluoride showed a higher caries arrest rate than fluoride varnish, reflecting its combined antimicrobial and remineralization effects. Thus, we show comparative clinical evidence supporting silver diamine fluoride as a more effective minimally invasive approach for managing early childhood caries.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3585-3589"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of blended learning versus conventional didactic teaching in pathology education outcomes. 混合学习与传统教学对病理学教育效果的影响。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223781
Puja Singh, Jyoti Namdev, Jyoti Shukla
{"title":"Effectiveness of blended learning versus conventional didactic teaching in pathology education outcomes.","authors":"Puja Singh, Jyoti Namdev, Jyoti Shukla","doi":"10.6026/973206300223781","DOIUrl":"10.6026/973206300223781","url":null,"abstract":"<p><p>Traditional didactic lectures in pathology often promote passive learning, limiting students' ability to apply knowledge clinically. Therefore, it is of interest to compare the learner outcomes between blended learning and traditional didactic lectures among 110 second-year MBBS students. The blended learning group demonstrated significantly superior performance in application-based scores (mean difference 4.5, p<0.001, d=1.85), total examination scores (difference 5.5, p<0.001, d=1.48) and all learner engagement domains (p<0.001) with large effect sizes. Student satisfaction was also markedly higher with blended learning (4.32±0.51 versus 3.48±0.62, p<0.001). Thus, data shows the blended learning enhances higher-order cognitive skills, engagement and satisfaction into competency-based medical curricula for pathology education.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3781-3785"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periodontal maintenance therapy: A comparative study of frequent scaling versus standard check-up regimes in preventing periodontal disease recurrence. 牙周维持治疗：频繁洗牙与标准检查在预防牙周病复发方面的比较研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223231
Manali Patil, Lynette Fernandes, Ipsita Jayanti, Neha Bhalla, Gaurav Singh, Sachidananda Chungkham
{"title":"Periodontal maintenance therapy: A comparative study of frequent scaling versus standard check-up regimes in preventing periodontal disease recurrence.","authors":"Manali Patil, Lynette Fernandes, Ipsita Jayanti, Neha Bhalla, Gaurav Singh, Sachidananda Chungkham","doi":"10.6026/973206300223231","DOIUrl":"10.6026/973206300223231","url":null,"abstract":"<p><p>The optimal frequency of periodontal maintenance visits remains uncertain despite their critical role in preventing recurrence of periodontal disease after active therapy. Therefore, it is of interest to compare the effectiveness of 1-month scaling intervals with standard 3-month maintenance visits in 100 patients with treated chronic periodontitis. Clinical parameters including PI, GI, PPD, CAL and BOP were assessed at baseline, 3, 6 and 12 months and recurrence was defined by increased probing depth and clinical attachment loss. Both groups improved over time but the 1-month maintenance group showed significantly greater reductions in periodontal parameters and a lower recurrence rate than the 3-month group. Thus, we show more frequent and individualized periodontal maintenance protocols for better long-term clinical outcomes and reduced disease recurrence.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3231-3235"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of ease in dental treatment using midazolam versus midazolam-ketamine in uncooperative children. 咪达唑仑与咪达唑仑-氯胺酮在不合作儿童牙科治疗中的易用性比较评价。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223305
Vaishali Sharma, Shalu Majreti, Naina Agarwal, Yihan Fu, Indushree Saini, Prakhyath P S, Kapil Paiwal, Manish Jain
{"title":"Comparative evaluation of ease in dental treatment using midazolam versus midazolam-ketamine in uncooperative children.","authors":"Vaishali Sharma, Shalu Majreti, Naina Agarwal, Yihan Fu, Indushree Saini, Prakhyath P S, Kapil Paiwal, Manish Jain","doi":"10.6026/973206300223305","DOIUrl":"10.6026/973206300223305","url":null,"abstract":"<p><p>Effective sedation strategies for non-cooperative children in dental care remain a significant clinical challenge. Therefore, it is of interest to compare the effectiveness of midazolam alone versus midazolam combined with ketamine in managing uncooperative pediatric dental patients. Hence, seventy children were equally divided into two groups, with assessment of behavioral response, treatment compliance and operator comfort. The combination regimen demonstrated improved sedation quality, better compliance and enhanced operator comfort compared to midazolam alone. Thus, we show combination sedation as a more effective approach for pediatric dental management, optimizing clinical outcomes and procedural efficiency.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3305-3309"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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