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Delayed versus immediate surgical intervention for perforated appendicitis. 穿孔阑尾炎的延迟与即刻手术治疗。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/973206300211612
J Naveen Bose, Rhea Khamitkar, Emilda Ambrose, Kaushik Nattamai Rameshbabu, Priyanka Perumal, Toufique Khan, Keerthika Muniasamy, Shoraf P
{"title":"Delayed versus immediate surgical intervention for perforated appendicitis.","authors":"J Naveen Bose, Rhea Khamitkar, Emilda Ambrose, Kaushik Nattamai Rameshbabu, Priyanka Perumal, Toufique Khan, Keerthika Muniasamy, Shoraf P","doi":"10.6026/973206300211612","DOIUrl":"10.6026/973206300211612","url":null,"abstract":"<p><p>Perforating appendicitis is a critical condition that needs urgent surgery. However, there is controversy exists regarding early versus delayed surgery. Hence, we assessed 100 patients with immediate surgery in 50 cases and delayed intervention in the remaining 50 cases. The patients were followed up for one year to determine postoperative complications, hospital stay, and recovery. Results indicated that early surgery decreased complications and hospital stay very significantly. These results underscore the significance of prompt surgical intervention in enhancing outcomes and lowering healthcare costs.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1612-1615"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking pseudo-exfoliation and serum uric acid among cataract patients. 白内障患者假性去角质与血清尿酸的关系。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/973206300211328
Haneela N L, Chaitra M C, Apoorva N, Sasankadhar Reddy
{"title":"Linking pseudo-exfoliation and serum uric acid among cataract patients.","authors":"Haneela N L, Chaitra M C, Apoorva N, Sasankadhar Reddy","doi":"10.6026/973206300211328","DOIUrl":"10.6026/973206300211328","url":null,"abstract":"<p><p>Pseudo-exfoliation syndrome (PXF), an age-related condition causing fibrillar deposits in the eye, may involve metabolic factors like uric acid. Therefore, it is of interest to compare blood uric acid levels in 80 cataract patients (over 45 years) at R.L. Jalappa Hospital, Kolar, from January to December 2024, splitting them into 40 with PXF and 40 without, excluding those with secondary PXF, other eye conditions, systemic diseases affecting uric acid, or prior eye surgery and collecting age, sex and uric acid data from medical records. No significant differences were found in mean age (70.83 years for PXF vs. 69.15 years for controls; p=0.332) or sex distribution (p=0.809). However, uric acid was higher in the PXF group (4.513 mg/dL) than controls (3.908 mg/dL; p=0.016), rising with PXF severity: 3.76 mg/dL (mild), 4.49 mg/dL (moderate) and 5.29 mg/dL (severe; p=0.001). Elevated uric acid is linked to PXF presence and severity, suggesting a role in its development, though further studies are needed to confirm clinical significance.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1328-1331"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimally invasive versus open surgery among colorectal cancer patients. 结直肠癌患者微创手术与开放手术的比较。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/973206300211635
Rahul Mathew, Kaushik J, Sailesh I S Kumar, Shakthiyan Gopal, Ajeet Saoji, Priyanka Perumal, Shoraf P
{"title":"Minimally invasive versus open surgery among colorectal cancer patients.","authors":"Rahul Mathew, Kaushik J, Sailesh I S Kumar, Shakthiyan Gopal, Ajeet Saoji, Priyanka Perumal, Shoraf P","doi":"10.6026/973206300211635","DOIUrl":"10.6026/973206300211635","url":null,"abstract":"<p><p>Minimally Invasive Surgery has become an acceptable substitute for Open Surgery in the management of colorectal cancer, with the claimed benefits of reduced morbidity and quicker recovery. Therefore it is of interest to compare the clinical and oncological results of MIS and OS among 200 patients with colorectal cancer over five years. The patients were evaluated for operative time, complications, hospital stay and disease-free survival. MIS has been demonstrated to be linked to markedly reduced stays in hospital (6 vs. 10 days) and decreased complication rates (15% vs. 25%) versus Open Surgery with similar oncologic outcomes: clearance of margins, as well as five-year disease- free survival, p > 0.05. Thus, data support MIS as an effective and safe method within suitably chosen patients with cancer of the colon and rectum, with advantage at recovery duration and complications.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1635-1638"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the effect of polymer and titanium abutments on peri-implant tissues: A comparative clinical study. 聚合物基台与钛基台对种植体周围组织影响的临床比较研究。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/973206300211514
Piyush Javiya, Chinju Punnen, Dipak Chaudhari, Paridhi Sharma, Snehamoy Pradhan, Deepak Sharma, Miral Mehta
{"title":"Evaluating the effect of polymer and titanium abutments on peri-implant tissues: A comparative clinical study.","authors":"Piyush Javiya, Chinju Punnen, Dipak Chaudhari, Paridhi Sharma, Snehamoy Pradhan, Deepak Sharma, Miral Mehta","doi":"10.6026/973206300211514","DOIUrl":"10.6026/973206300211514","url":null,"abstract":"<p><p>The evaluation between titanium and polymer abutments regarding peri-implant soft tissue health took place in a study involving 40 patients with posterior implants. Therefore, it is of interest to evaluate the plaque index (PI), Bleeding on probing (BOP) and Probing depth (PD) together with radiographic bone level assessments at three specified time points: baseline and 3 months as well as 6 months. The clinical assessment of Group B (polymer) at 6 months revealed superior outcomes including a decreased PI score to 0.88 alongside reduced BOP to 10% and contractions in PD up to 2.6 mm compared to 0.92 PI, 15% BOP and 2.9 mm PD. Group B participants showed smaller marginal bone loss than Group A with differences at 0.38 mm vs. 0.45 mm although results were not statistically meaningful. Patients obtained better results from polymer abutments although both types of abutment functioned properly.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1514-1517"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anxiety among patients with single versus multiple visits for root canal treatment. 单次与多次根管治疗患者的焦虑。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/973206300211563
Saicharan G, Joel Mathew, Renjith Madhavan, Ajeesha Nair J S, Sonam Dubey, Udipta Sahoo
{"title":"Anxiety among patients with single versus multiple visits for root canal treatment.","authors":"Saicharan G, Joel Mathew, Renjith Madhavan, Ajeesha Nair J S, Sonam Dubey, Udipta Sahoo","doi":"10.6026/973206300211563","DOIUrl":"10.6026/973206300211563","url":null,"abstract":"<p><p>RCT treatment makes patients feel nervous often and the option to do the procedure in one session or divided across multiple visits affects both patients' peace of mind during the process and the treatment results. The investigators split 60 individuals with irreversible pulpitis into two groups that received RCT as one continuous session or performed across several visits. Patients who had single-visit treatment experienced greater anxiety decrease from 18.6 points to 11.2 points whereas patients receiving multiple sessions showed less significant anxiety reduction from 19.1 points to 13.7 points. Single-visit RCT led to lower pain scores in patients compared to multiple-visit RCT at one week yet success rates between both groups remained similar at 93% versus 90% (p>0.05). Patient anxiety improved better after single-visit RCT procedures despite achieving comparable treatment outcomes.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1563-1566"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prompt engineering and diagnostic accuracy of multimodal large language models in thyroid fine-needle aspiration cytology. 甲状腺细针穿刺细胞学中多模态大语言模型的快速工程和诊断准确性。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/97320630021317
Bibhas Saha Dala, Kaushik Mukhopadhyay, Dwaipayan Roy, Souvik Bhattacharya, Indranil Chakrabarti, Santosh Kumar Mondal
{"title":"Prompt engineering and diagnostic accuracy of multimodal large language models in thyroid fine-needle aspiration cytology.","authors":"Bibhas Saha Dala, Kaushik Mukhopadhyay, Dwaipayan Roy, Souvik Bhattacharya, Indranil Chakrabarti, Santosh Kumar Mondal","doi":"10.6026/97320630021317","DOIUrl":"10.6026/97320630021317","url":null,"abstract":"<p><p>Role of Large language models (LLMs) in fine-needle aspiration cytology (FNAC) image analysis remain uncertain. We evaluated two LLMs - Chat GPT-4o (OpenAI) and Claude 3.5 Sonnet (Anthropic) on 63 thyroid FNAC cases, each represented by eight microscopic images (Pap and MGG, 10x/40x), using generic and structured prompts. Structured prompts improved Bethesda concordance and near-match rates but inter-rater agreement remained poor (κ ≤ 0.09). Specificity reached 100% with structured prompts, but sensitivity dropped to ≤11.8% and misclassification persisted. LLMs show potential, but domain-specific training and validation are necessary for clinical use.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1317-1323"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and efficacy of Modified Delorme's procedure for rectal prolapse. 改良Delorme手术治疗直肠脱垂的安全性和有效性。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/973206300211585
Nandram Dhakariya, Bhupesh Kushram, Bharti Badlani, Anjulika Sachan, Abhay Kumar
{"title":"Safety and efficacy of Modified Delorme's procedure for rectal prolapse.","authors":"Nandram Dhakariya, Bhupesh Kushram, Bharti Badlani, Anjulika Sachan, Abhay Kumar","doi":"10.6026/973206300211585","DOIUrl":"10.6026/973206300211585","url":null,"abstract":"<p><p>Modified Delorme's Procedure is a safe and effective perineal approach to treat complete rectal prolapse, especially in the elderly and high-risk patients unfit for trans-abdominal surgery. Hence, a total of 65 patients (mean age 62.3 years; female: male ratio 6:1) underwent Modified Delorme's Procedure. The present prospective study of 65 patients with a mean age of 62.3 years, with a female to male ratio of 6:1, demonstrated a 92.3% success rate, with marked improvement in obstructed defecation and fecal continence on validated scales. Minimal postoperative complications included a recurrence rate of 7.7% and transient anal stenosis in 4.6%. The combination of mucosal stripping, muscular plication and adjunct postanal repair offers durable relief of symptoms with less morbidity than abdominal procedures.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1585-1588"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychiatric morbidity among ICU patients at a general hospital in India. 印度一家综合医院重症监护病房患者的精神病发病率。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/973206300211438
S Sarath Ajay Kumar, Anil Kumar Pidikiti, Vaidyanath Gottumukkula
{"title":"Psychiatric morbidity among ICU patients at a general hospital in India.","authors":"S Sarath Ajay Kumar, Anil Kumar Pidikiti, Vaidyanath Gottumukkula","doi":"10.6026/973206300211438","DOIUrl":"10.6026/973206300211438","url":null,"abstract":"<p><p>Psychiatric morbidity among ICU patients at a general hospital in India is of interest. Psychiatric diagnosis was assessed using the Mini International Neuropsychiatric Interview (MINI), while illness severity was measured with the APACHE-II scale for 400 ICU patients. The results revealed that, 65.5% prevalence of psychiatric disorders were 2 times higher than the primary care settings 23-42.5% and the parameters like mood 28.2% and anxiety 24.5%. Disorders predominated, with 72.4% prevalence in CNS patient's vs 42.1% in others and the results also showed that, there was 82.3% morbidity in >70yr vs 36.4% in <30yr (p<0.001). These findings mandate protocolized psychiatric screening for ICU patients, particularly targeting elderly males, those with CNS/respiratory disorders and APACHE-II scores >30. The research findings had suggested that, implementing brief MINI assessments during ICU rounds could significantly improve the detection and management of comorbid mental health conditions in critical care settings.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1438-1442"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P300 response among children and adolescents: Age and stimulus effects. 儿童和青少年的P300反应：年龄和刺激效应。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/973206300211332
Sangeeta Gupta, Arun Prasad, Gaurav Gupta
{"title":"P300 response among children and adolescents: Age and stimulus effects.","authors":"Sangeeta Gupta, Arun Prasad, Gaurav Gupta","doi":"10.6026/973206300211332","DOIUrl":"10.6026/973206300211332","url":null,"abstract":"<p><p>The association between age and P300 components and also the influence of stimulus-related variations, particularly intensity and probability in children and adolescents is of interest. P300 amplitude and latency and the effects of stimulus variation on P300 components were measured in 60 subjects in the age-group of 5-18 years and analysed with one-way ANOVA. P < 0.05 was considered as statistically significant. Mean P300 latency decreased and mean N2-P3 amplitudes increased with statistical significance (p<0.001) (one-way ANOVA) with substantially greater changes till 8-11 years of age. P300 latency varied inversely with stimulus intensity and probability while N2-P3 amplitude varied positively with stimulus intensity and adversely with change in the probability in all the age-groups (p<0.001) (one-way ANOVA). Age affects both P300 latency and amplitude in the children and adolescents in a characteristic pattern and stimulus variations affect the P300 responses relatively uniformly in different younger age-groups.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1332-1339"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming personality traits (Gunas) through meditation: A randomized controlled trial. 通过冥想改变人格特征（Gunas）：一项随机对照试验。
IF 1.9
Bioinformation Pub Date : 2025-06-30 eCollection Date: 2025-01-01 DOI: 10.6026/973206300211340
Chanchal Surywanshi, Kawal Krishan, Danish Javed
{"title":"Transforming personality traits (<i>Gunas</i>) through meditation: A randomized controlled trial.","authors":"Chanchal Surywanshi, Kawal Krishan, Danish Javed","doi":"10.6026/973206300211340","DOIUrl":"10.6026/973206300211340","url":null,"abstract":"<p><p>Medical students often experience stress and maladaptive personality traits that affect mental health. This randomized controlled trial evaluated the impact of a six-week Trimurti <i>Dhyana</i> (Meditation) Yoga intervention on personality traits (<i>Gunas</i>) in 70 male medical students aged 18-30 years. The intervention group practiced daily meditation for 20 minutes, while the control group continued routine activities. Post-intervention, the meditation group showed a significant increase in <i>Sattva</i> and reductions in <i>Rajas</i> and <i>Tamas</i> scores as measured by the Vedic Personality Inventory. These findings suggest that <i>Trimurti Dhyana Yoga</i> is an effective, non-invasive strategy for enhancing psychological resilience in high-stress populations.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1340-1345"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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