Bioinformation最新文献_第3页

In vivo analysis of puerarin from Pueraria tuberosa as a promising galactagogue. 葛根中葛根素作为催乳剂的体内分析。

IF 1.9

Bioinformation Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001574

Kiran R Giri, Kamlesh M Palandurkar, Ved Prakash, Amit Singh, Anshuman Trigunayat

{"title":"In vivo analysis of puerarin from Pueraria tuberosa as a promising galactagogue.","authors":"Kiran R Giri, Kamlesh M Palandurkar, Ved Prakash, Amit Singh, Anshuman Trigunayat","doi":"10.6026/9732063002001574","DOIUrl":"10.6026/9732063002001574","url":null,"abstract":"Breastfeeding is crucial for maternal and infant health, yet global rates vary, with India having the highest at 43.2% and the lowest at 35.8%.To evaluate the galactagogue properties of Pueraria tuberosa in a female rat model, assess its safety through acute toxicity studies and examine its impact on hormone regulation. Secondary objectives included analyzing its effect on serum prolactin levels and conducting molecular docking and GC-MS analyses. Ethical approval was obtained (Letter No. Dean/2019/IEAC/1614). Charles Foster rats were housed under standard conditions and divided into four groups: vehicle, Pueraria tuberosa extracts, 15 mg/kg/day of Puerarin in DMSO and saline and from day three today fifteen of parturition, 2.7 mg/kg of domperidone. Weekly body weights and milk yield were recorded. Serum prolactin levels were measured using the Rat Prolactin ELISA Kit. GC-MS analysis identified Pueraria tuberosa extract constituents. Imaging with the Vevo LAZR System evaluated breast areas and molecular docking studies targeted the 5-HT2AR and D2 receptors. Significant differences in milk yield were observed between the 3rd and 14th days across treatment groups, with Puerarin and domperidone significantly increasing serum prolactin levels. Imaging indicated increased breast blood flow in Puerarin-treated rats, suggesting enhanced lactation. Molecular docking showed high affinity of Puerarin for D2 and 5HT2A receptors, indicating potential hormonal regulation mechanisms. This research provides a comprehensive preclinical evaluation of Puerarin's efficacy and safety as a galactagogue, addressing gaps in understanding herbal lactation aids and laying the foundation for future clinical trials and comparisons with established galactagogues.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 11","pages":"1574-1581"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of ultrasonic activation on four different sealers for intra-tubular penetration to root dentin. 超声激活对四种不同管内牙本质渗透密封剂的影响。

IF 1.9

Bioinformation Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001593

Bhardwaj Nikhil, Jain K Rajnish, Khetarpal Ambica, Suri Shally, Arora Rachita, Singh Avishek

引用次数: 0

Exploring root canal outcomes and periodontal disease in diabetic patients: A review. 糖尿病患者根管预后与牙周病的关系研究综述

IF 1.9

Bioinformation Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001570

Abdo Mohammed Mohammed Abdulrazzaq, Ali Mohammed Alyami, Fayez Hamad Al Aqil, Abdullah Mohammed Al-Khomsan, Sulaiman Mana Al Hutaylah, Hamad Mohammed Al Khamssan, Meshal Hussain Alhammami

引用次数: 0

Incidence of oral cancer due to tobacco and alcohol use. 吸烟和饮酒引起的口腔癌发病率。

IF 1.9

Bioinformation Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001650

Ashutosh Pandey, Imran Md, Anjana Bharti, Satya Prakash, Sweety Kumari, Sumit Verma, Manoj Mittal

引用次数: 0

Integrating MICRORNA941 and T cell subset research into public health strategies for managing inflammaging in elderly and immune-compromised patients. 将MICRORNA941和T细胞亚群研究整合到老年和免疫功能低下患者炎症管理的公共卫生策略中。

IF 1.9

Bioinformation Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001529

Lily Fotovat, Kathleen Wang, Francesco Chiappelli

{"title":"Integrating MICRORNA941 and T cell subset research into public health strategies for managing inflammaging in elderly and immune-compromised patients.","authors":"Lily Fotovat, Kathleen Wang, Francesco Chiappelli","doi":"10.6026/9732063002001529","DOIUrl":"10.6026/9732063002001529","url":null,"abstract":"As of 2022, the Centers for Disease Control and Prevention (CDC) reported that the average life expectancy for both sexes in the United States is 77.5 years. While new advances in health have increased life expectancy, aging comes with complications that impact the development of diseases like cancer, senile dementia (non-Alzheimer), diabetes and Parkinson's. Through aging, the body's immune system declines, a process recognized as immunosenescence and which contributes to inflammaging, a state of chronic, though non-productive, inflammation that progresses with advancing age in the absence of overt infection and that contributes to the onset and progression of a spectrum of age-related pathologies. MicroRNAs are small forms of RNA that control gene expression by binding to messenger RNA (mRNA) in the cell cytoplasm. In particular, microRNA-941 (miR-941) has been found to play a critical role in the regulation of differentiation of cell populations, certain T cell subsets responsible for maintaining efficient immune surveillance in normal subjects, immune compromised individuals as well as the elderly. We propose that concerted research designed to define and characterize interventions targeting the regulatory effects of miRNA-941 specifically on T-cell subsets will benefit treatment of infectious (e.g., CoViD-19, H5N1 infection) and chronic illnesses (e.g., diabetes II, diabetes III, Long Covid [i.e., Post-Acute Covid-19 Syndrome, PACS], autoimmune disease), which are most common among the aging and the immune compromised population. It is possible and even probable that active research in this specific area will proffer new horizons for finding cures, aid in disease management and improved accessibility and affordability of public health services.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 11","pages":"1529-1531"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral hygiene with age: A comprehensive study. 口腔卫生与年龄关系的综合研究。

IF 1.9

Bioinformation Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001555

Saba Anwar Kondkari, Sneha Masne Deshpande, Haritha Nimmagadda, Uttam Shetty, Sumeet Agarwal, Laresh Mistry, Prasad Mhaske, Pratibha Kavle

引用次数: 0

An update on attachment systems for mandibular implant overdentures: A review. 下颌种植覆盖义齿附着体系统研究进展综述。

IF 1.9

Bioinformation Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001623

Charushila Sardar, Gaurang Mistry, Nimrat Kaur Randhawa, Padmapriya Puppala, Ankita Chitnis, Sanpreet Singh Sachdev

{"title":"An update on attachment systems for mandibular implant overdentures: A review.","authors":"Charushila Sardar, Gaurang Mistry, Nimrat Kaur Randhawa, Padmapriya Puppala, Ankita Chitnis, Sanpreet Singh Sachdev","doi":"10.6026/9732063002001623","DOIUrl":"10.6026/9732063002001623","url":null,"abstract":"The present systematic review aims to evaluate the global use of attachment systems for mandibular implant overdentures, focusing on their impact on clinical outcomes, patient satisfaction and prosthesis stability. Mandibular overdentures supported by implants have become a standard of care for edentulous patients, with various attachment systems such as bar, ball and locators being commonly utilized. The review synthesizes findings from numerous studies, examining differences in retention, ease of maintenance, cost-effectiveness and long-term success rates across different attachment modalities. The analysis also delves into patient-centered outcomes, including comfort, ease of use and quality of life, providing a comprehensive overview of the efficacy of each system. By comparing and contrasting these systems, the review identifies trends and preferences in clinical practice, highlighting the benefits and drawbacks of each approach. The findings indicate that while all systems show promise in enhancing the functionality of mandibular overdentures, patient-specific factors and clinician preferences play crucial roles in the selection process.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 11","pages":"1623-1628"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of emotional intelligence in shaping self-esteem among Indian nurses at Trichy, Tamilnadu. 泰米尔纳德邦特里希印度护士情商在塑造自尊中的作用。

IF 1.9

Bioinformation Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001564

Rajathi A, Christena P, Rose Infantina J, Anitha Catherine M

{"title":"Role of emotional intelligence in shaping self-esteem among Indian nurses at Trichy, Tamilnadu.","authors":"Rajathi A, Christena P, Rose Infantina J, Anitha Catherine M","doi":"10.6026/9732063002001564","DOIUrl":"10.6026/9732063002001564","url":null,"abstract":"Nursing is a multifaceted profession that requires a blend of technical skills and emotional intelligence (EI) to manage various responsibilities, from patient care to team supervision. EI is closely connected to self-esteem, a psychological construct representing an individual's self-worth and competence. Self-esteem significantly influences how nurses perceive their abilities and engage with their work environment. The current study adopted the non-experimental descriptive correlational survey design to assess the emotional intelligence and self-esteem among the nurses. The study was conducted for a period of two months, among 301 Nurses working in various departments of the hospital, Trichy, Tamilnadu. The assessment of the samples was done using the background variables, TEIQue-SF- (Trait Emotional Intelligence questionnaire- short form) and Rosenberg's self-esteem scale. The data was collected through the Google Form for 4 weeks. The study results show that 81.1% of the nurses had average emotional intelligence only, 18.9% of the nurses had a high level of emotional intelligence and none of the nurses had a low level of emotional intelligence. In the aspects of self-esteem 76.4% of nurses had moderate level of self-esteem, 21.3% had high level of self-esteem and 2.3% had low level of self-esteem, there was a weak positive correlation between the level of Emotional intelligence and the level of Self- esteem with \"r\" value 0.321 & \"p\" value 0.01. Nurses render care to those who are emotionally heightened for patients and families. The persons exhibit confidence when they are emotionally intelligent, capable of understanding and stabilize their emotions. Self-esteem can be shaped by individuals' relationships with others, experiences and accomplishments in life.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 11","pages":"1564-1568"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geno-toxic risk assessment of locally produced bovine pericardium (LYOLEMB) for guided tissue regeneration. 本地生产的牛心包（LYOLEMB）用于引导组织再生的基因毒性风险评估。

IF 1.9

Bioinformation Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001489

Abdo Mohammed Mohammed Abdulrazzaq, Sultan Alanazi, Ali M Alyami, Abdullah Awad Alshehri, Turki Fahad Al Mansour, Yazeed Saleh Al-Ghwaynim

引用次数: 0

Molecular docking analysis of breast cancer target RAC1B with ligands. 乳腺癌靶点RAC1B与配体的分子对接分析。

IF 1.9

Bioinformation Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI: 10.6026/9732063002001467

Kajal Verma, Lakshmi Pillai

引用次数: 0