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Network toxicology and single-cell analysis reveal molecular mechanisms of DEHP-induced colorectal cancer. 网络毒理学和单细胞分析揭示了dehp诱导结直肠癌的分子机制。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223430
Yingyi Wei, Weixue Li, Wenhua Huang, Zhai Cai
{"title":"Network toxicology and single-cell analysis reveal molecular mechanisms of DEHP-induced colorectal cancer.","authors":"Yingyi Wei, Weixue Li, Wenhua Huang, Zhai Cai","doi":"10.6026/973206300223430","DOIUrl":"10.6026/973206300223430","url":null,"abstract":"<p><p>Di(2-ethylhexyl) phthalate (DEHP) is a common environmental pollutant associated with colorectal cancer (CRC), but its molecular mechanisms remain unclear. Hence, we integrated toxicological target screening, weighted gene co-expression network analysis (WGCNA), and 113 machine learning algorithms to construct a diagnostic model for DEHP-related CRC. Single-cell transcriptomics and molecular docking were further applied to analyze the cellular distribution of key genes and the interactions between DEHP and target proteins. Five core genes (MMP7, CDK4, MMP1, CNR1, and TNFRSF1A) were identified and linked to inflammation, cell cycle regulation, and PI3K-Akt signaling. Thus, we report the molecular basis of DEHP-induced CRC progression providing a novel strategy for identifying environmental carcinogenic biomarkers and therapeutic targets.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3430-3436"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal obstructional outcome in paediatric age group: A general surgeon's prospective. 儿童年龄组肠梗阻的结局：普通外科医生的前瞻性。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223732
Ritesh Yadav, Akhilesh Ratnakar, Sourabh Jain, Talha Saad, Harsh Kumar Goyal, Amar Gangwani, Shashi Marko
{"title":"Intestinal obstructional outcome in paediatric age group: A general surgeon's prospective.","authors":"Ritesh Yadav, Akhilesh Ratnakar, Sourabh Jain, Talha Saad, Harsh Kumar Goyal, Amar Gangwani, Shashi Marko","doi":"10.6026/973206300223732","DOIUrl":"10.6026/973206300223732","url":null,"abstract":"<p><p>Intestinal obstruction is one of the most common surgical emergencies seen in children. Therefore, it of interest to evaluate the pattern of disease occurrence, clinical presentation and treatment outcomes in children with intestinal obstruction. Infants (31.3%) are highly affected by intestinal obstruction than other age groups. Boy child exhibits number cases of intestinal obstruction than girl child. Imperforated anus (52.2%) is the most common congenital types of lesions causing the disease; Intussusception (69.5%) is the commoner acquired lesion and abdominal distention (32.8%) is the typical feature which was exhibited by many child cases. Thus, data shows the best outcome, early diagnosis and intervention are key essentials and hence will facilitate in enhancing knowledge on reduction of mortality rate of the cases.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3732-3735"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum bilirubin level in predicting the severity of acute appendicitis. 血清胆红素水平对急性阑尾炎严重程度的预测。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223773
Prasheelkumar Premnarayan Gupta, Vrashabhan Ahirwar, Kaushlendra Singh Narwariya, Talha Saad, Prakash Bhuriya, Satyendra Mishra, Satyendra Uike
{"title":"Serum bilirubin level in predicting the severity of acute appendicitis.","authors":"Prasheelkumar Premnarayan Gupta, Vrashabhan Ahirwar, Kaushlendra Singh Narwariya, Talha Saad, Prakash Bhuriya, Satyendra Mishra, Satyendra Uike","doi":"10.6026/973206300223773","DOIUrl":"10.6026/973206300223773","url":null,"abstract":"<p><p>Late diagnosis of acute appendicitis escalates the plausibility of appendicular perforation emerging in inflammation of peritoneum. Therefore, it is of interest to determine the levels of serum bilirubin help in prediction of acute inflammation of appendix. A moderately positive association was seen among the levels of serum bilirubin and seriousness of disease with spearman analysis (ρ = 0.41, p < 0.001). Augmented values of bilirubin exhibit a powerful link with appendix inflammation and a prognostic marker for governing complicated cases like perforation. Thus, data shows the bilirubin values as everyday diagnostic workup may assist in the premature identification of appendix inflammation boosting the clinical outcomes.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3773-3776"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring complications of botulinum toxin in community practice: A pharmacological study. 社区实践中监测肉毒杆菌毒素并发症：一项药理学研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223718
Ambili Remesh, Taskeen Kaur Sethi, Sree Ram Subba Reddy Gudimetla, J Dhanuja Rani, Debanti Giri, Rahul Tiwari, Heena Dixit Tiwari, Afroz Kalmee Syed
{"title":"Monitoring complications of botulinum toxin in community practice: A pharmacological study.","authors":"Ambili Remesh, Taskeen Kaur Sethi, Sree Ram Subba Reddy Gudimetla, J Dhanuja Rani, Debanti Giri, Rahul Tiwari, Heena Dixit Tiwari, Afroz Kalmee Syed","doi":"10.6026/973206300223718","DOIUrl":"10.6026/973206300223718","url":null,"abstract":"<p><p>Botulinum toxin is widely used for cosmetic wrinkle reduction, hyperhidrosis, chronic migraine and facial muscle disorders, but concerns persist regarding adverse effects related to injection technique, toxin diffusion and practitioner variability. Therefore, it is of interest to evaluate the complication rates of community-based botulinum toxin therapy and characterize the clinical presentations of its associated adverse effects. A prospective pharmacological observational study was conducted on 120 patients receiving botulinum toxin type A injections. Majority of complications were mild and transient, with injection-site pain and bruising representing the most common local adverse effects. Thus, data shows the botulinum toxin injections performed by trained practitioners have a favorable safety profile in community practice.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3718-3722"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective management of congenital preauricular sinus to reduce recurrence. 先天性耳前窦的有效治疗，减少复发。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223273
Nitin Kumar Jain, Suryakant Tiwari, Salabh Kumar Agrawal, Abhay Kumar Sinha
{"title":"Effective management of congenital preauricular sinus to reduce recurrence.","authors":"Nitin Kumar Jain, Suryakant Tiwari, Salabh Kumar Agrawal, Abhay Kumar Sinha","doi":"10.6026/973206300223273","DOIUrl":"10.6026/973206300223273","url":null,"abstract":"<p><p>Congenital preauricular sinus is a common developmental anomaly with frequent recurrence and post-operative complications despite surgical management. Therefore, it is of interest to compare simple sinusectomy and the supra-auricular approach regarding recurrence, infection, operative time, healing, cosmetic outcomes and patient satisfaction. Hence, eighty-six patients were prospectively assigned to either simple sinusectomy (n=42) or supra-auricular excision (n=44) and followed for 12 months. The supra-auricular approach showed zero recurrence, better cosmetic satisfaction and higher patient approval, despite a longer operative time. Thus, we support the supra-auricular approach as the preferred technique for effective and cosmetically superior management of preauricular sinus.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3273-3276"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and cephalometric comparison: TMA versus AJ wilcock MBT intrusion arches. 临床与头颅测量比较：TMA与AJ wilcock MBT侵入弓。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223539
Shivani Gupta, Purva Joneja, Richa Sharma, Sachin Jayaraj V, Ulrika Diana Pereira Kalia, Rishabh Joneja
{"title":"Clinical and cephalometric comparison: TMA versus AJ wilcock MBT intrusion arches.","authors":"Shivani Gupta, Purva Joneja, Richa Sharma, Sachin Jayaraj V, Ulrika Diana Pereira Kalia, Rishabh Joneja","doi":"10.6026/973206300223539","DOIUrl":"10.6026/973206300223539","url":null,"abstract":"<p><p>Deep bite is one of the most challenging malocclusions to correct orthodontically, yet the comparative effectiveness of available wire materials for intrusion arch fabrication remains insufficiently studied. Therefore, it is of interest to assess the rate of maxillary incisor intrusion achieved with each wire type over a defined period, analyzing the efficiency of force application and biomechanical properties. Ten patients in the age group of 15-30 years were assigned to two groups: Group A (0.017\" x 0.025\" TMA wire) and Group B (0.018\" Special + AJ Wilcock wire). Clinical and radiographic evaluations were conducted at baseline (T0) and after 3 months of active intrusion (T2). Thus, data shows the understanding of AJ Wilcock wire's potential in improving deep bite correction outcomes in specific orthodontic cases.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3539-3544"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological and clinicopathological profile of pancytopenia: A cross-sectional study. 全血细胞减少症的流行病学和临床病理特征：一项横断面研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223348
Chethan N, Divyansh Badole, Zeeshan Farooqui, Manoj Gupta, Sachin Parmar
{"title":"Epidemiological and clinicopathological profile of pancytopenia: A cross-sectional study.","authors":"Chethan N, Divyansh Badole, Zeeshan Farooqui, Manoj Gupta, Sachin Parmar","doi":"10.6026/973206300223348","DOIUrl":"10.6026/973206300223348","url":null,"abstract":"<p><p>Broad etiology of pancytopenia also makes it regionally heterogeneous, requiring a multifaceted clinico-haematological assessment. ence, this cross-sectional study at MGM medical college and Maharaja Yeshwantrao hospital in Indore involved 200 patients whose CBC, peripheral smear, LFT/RFT, vitamin B12/folate levels and bone marrow were measured within a period of 12 months and had to be above 15 years old with pancytopenia (not under chemotherapy/radiotherapy). Severe anaemia (53.5%), moderate leucopenia (34%), severe thrombocytopenia (25.5%) and 31-40 year-olds had the highest (21.5%) were severe cases; pallor (60%) and dyspnoea (32.5%) were most common. Top causes were vitamin B12 deficiency (28.5%), hypersplenism (12%) and dimorphic anaemia (10.5%) and gender-B12 association had a significant value (p=0.028). Thus, the major reversible cause is nutrition deficiencies, especially the vitamin B12 deficiency, which should be screened and supplemented by communities.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3348-3351"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of anemia severity with maternal cardiac function during third trimester - An observational study. 妊娠晚期贫血严重程度与母体心功能的相关性——一项观察性研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223277
Sarita Jalodiya, Nidhi Narrey, Sarita Shah
{"title":"Correlation of anemia severity with maternal cardiac function during third trimester - An observational study.","authors":"Sarita Jalodiya, Nidhi Narrey, Sarita Shah","doi":"10.6026/973206300223277","DOIUrl":"10.6026/973206300223277","url":null,"abstract":"<p><p>Maternal anemia is a common pregnancy condition that can considerably impair cardiovascular adaption throughout the third trimester. Therefore, it is interest to report. The relationship between anemia severity and maternal cardiac function in third-trimester pregnant women using echocardiographic measures. Hence, a total of 120 pregnant women were divided into mild, moderate, and severe anemia groups based on hemoglobin levels, and cardiac function parameters such heart rate, cardiac output, and left ventricular ejection fraction were measured. An increasing severity of anemia was associated with considerably greater heart rate and cardiac output, as well as minor impairments in diastolic cardiac function. Thus, we report that increasing severity of maternal anemia in the third trimester produces measurable compensatory cardiac changes rising heart rate and cardiac output with early diastolic impairment underscoring the need for routine echocardiographic surveillance in anemic pregnant women.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3277-3280"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing urinary tract infection outcomes: nitrofurantoin versus fluoroquinolones. 优化尿路感染结局：呋喃妥因与氟喹诺酮类药物。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223777
Shruti Vihang Brahmbhatt, Samarth Savaliya, Mahavirsingh Rajput, Archana Patel
{"title":"Optimizing urinary tract infection outcomes: nitrofurantoin versus fluoroquinolones.","authors":"Shruti Vihang Brahmbhatt, Samarth Savaliya, Mahavirsingh Rajput, Archana Patel","doi":"10.6026/973206300223777","DOIUrl":"10.6026/973206300223777","url":null,"abstract":"<p><p>The rising global prevalence of urinary tract infections and escalating antimicrobial resistance present a critical clinical challenge. Therefore, it is of interest to evaluate the clinical cure rates while minimizing adverse drug reactions (ADRs) and resistance, researchers studied 40 adult patients (80% female) divided into Group I (Nitrofurantoin) and Group II (Fluoroquinolones). Nitrofurantoin achieved a higher clinical cure rate (95%) with 4.75 times greater odds of success than fluoroquinolones (80%). The adverse reaction rate was significantly lower for nitrofurantoin (10% versus 26.7%), though both groups reported similar side effects. Thus, data shows the nitrofurantoin also maintained a lower failure rate (5% versus 15%), supporting its prioritization as a first-line empirical therapy.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3777-3780"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compliance towards post-exposure prophylaxis of rabies vaccination among animal bite patients at a tertiary care hospital in Khandwa, Madhya Pradesh: A retrospective study. 中央邦Khandwa一家三级医院动物咬伤患者对暴露后预防狂犬病疫苗接种的依从性：一项回顾性研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223437
Soumitra Sethia, Sachin Parmar, Admira Fernandes, Durga Ahujam, Priyaranjan Singh, Shreyash Dwivedi, Souryakant Varandani
{"title":"Compliance towards post-exposure prophylaxis of rabies vaccination among animal bite patients at a tertiary care hospital in Khandwa, Madhya Pradesh: A retrospective study.","authors":"Soumitra Sethia, Sachin Parmar, Admira Fernandes, Durga Ahujam, Priyaranjan Singh, Shreyash Dwivedi, Souryakant Varandani","doi":"10.6026/973206300223437","DOIUrl":"10.6026/973206300223437","url":null,"abstract":"<p><p>Rabies caused by lyssavirus is almost always deadly, with 59,000 deaths occurring in Asia and Africa due to poor access to PEP(Post- exposure prophylaxis). Hence, aretrospective study of 850 animal bite cases (April-September 2023) was conducted at a tertiary care hospital in Khandwa, Madhya Pradesh. Most patients were males (74.9%) and aged 21-30 years (23.9%), with Category II exposure being the most common (84%). Only 44.8% completed the four-dose intradermal ARV regime, with a high dropout rate of 55.2% especially after Dose 3. Thus, we show a major compliance gap, emphasizing the need for improved follow-up systems and targeted health education.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3437-3441"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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