Snigdha M K, Krishnavajhala Padma Theja, Kondeti Ganga Bhavani, Chennakesavulu Dara, Pranavi Paloju, Shiva Kumar Nimma
{"title":"Clinical spectrum of tuberculosis among HIV infected patients in India: Correlation with immunological status using CD4 counts.","authors":"Snigdha M K, Krishnavajhala Padma Theja, Kondeti Ganga Bhavani, Chennakesavulu Dara, Pranavi Paloju, Shiva Kumar Nimma","doi":"10.6026/973206300211602","DOIUrl":null,"url":null,"abstract":"<p><p>Tuberculosis (TB) remains a common and serious opportunistic infection among HIV-infected individuals, with clinical presentation closely tied to immune status. In this prospective study of 100 HIV-positive patients with TB, pulmonary TB predominated in those with CD4 counts >200, while extra pulmonary and disseminated TB were strongly associated with CD4 counts <200. Symptoms such as cough and fever were prevalent and radiographic findings varied with immune suppression levels. CD4 counts served as a critical marker in determining the clinical spectrum and severity of TB. These findings underscore the importance of CD4-based assessment in guiding timely diagnosis and targeted management of TB in HIV patients.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1602-1605"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449502/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/973206300211602","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Tuberculosis (TB) remains a common and serious opportunistic infection among HIV-infected individuals, with clinical presentation closely tied to immune status. In this prospective study of 100 HIV-positive patients with TB, pulmonary TB predominated in those with CD4 counts >200, while extra pulmonary and disseminated TB were strongly associated with CD4 counts <200. Symptoms such as cough and fever were prevalent and radiographic findings varied with immune suppression levels. CD4 counts served as a critical marker in determining the clinical spectrum and severity of TB. These findings underscore the importance of CD4-based assessment in guiding timely diagnosis and targeted management of TB in HIV patients.
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