{"title":"唾液标志物白细胞介素-6在口腔鳞状细胞癌中的评价及其临床相关性。","authors":"Dipak Chaudhari, Shilpa Motghare, Vikas Pandey, Gunmeek Kaur, Sameer Gupta, Saptadisha Rakshit, Miral Mehta, Bhumika J Patel","doi":"10.6026/973206300211497","DOIUrl":null,"url":null,"abstract":"<p><p>Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy with high morbidity. Hence, this cross-sectional study evaluated salivary interleukin-6 (IL-6) levels in 30 OSCC patients versus 30 healthy controls. IL-6 levels were significantly higher in OSCC patients and increased progressively with advancing clinical stages. A strong positive correlation was found between IL-6 levels and disease stage (r = 0.82, p < 0.001). Salivary IL-6 shows promise as a non-invasive biomarker for OSCC detection and progression monitoring.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1497-1500"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449527/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evaluation of salivary biomarker interleukin-6 in oral squamous cell carcinoma and its clinical correlation.\",\"authors\":\"Dipak Chaudhari, Shilpa Motghare, Vikas Pandey, Gunmeek Kaur, Sameer Gupta, Saptadisha Rakshit, Miral Mehta, Bhumika J Patel\",\"doi\":\"10.6026/973206300211497\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy with high morbidity. Hence, this cross-sectional study evaluated salivary interleukin-6 (IL-6) levels in 30 OSCC patients versus 30 healthy controls. IL-6 levels were significantly higher in OSCC patients and increased progressively with advancing clinical stages. A strong positive correlation was found between IL-6 levels and disease stage (r = 0.82, p < 0.001). Salivary IL-6 shows promise as a non-invasive biomarker for OSCC detection and progression monitoring.</p>\",\"PeriodicalId\":8962,\"journal\":{\"name\":\"Bioinformation\",\"volume\":\"21 6\",\"pages\":\"1497-1500\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449527/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioinformation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.6026/973206300211497\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/973206300211497","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
口腔鳞状细胞癌（OSCC）是一种发病率很高的常见恶性肿瘤。因此，本横断面研究评估了30名OSCC患者和30名健康对照者的唾液白介素-6 （IL-6）水平。白细胞介素-6水平在OSCC患者中显著升高，并随着临床分期的进展而逐渐升高。IL-6水平与疾病分期呈正相关（r = 0.82, p < 0.001）。唾液IL-6有望成为OSCC检测和进展监测的非侵入性生物标志物。
Evaluation of salivary biomarker interleukin-6 in oral squamous cell carcinoma and its clinical correlation.
Oral Squamous Cell Carcinoma (OSCC) is a prevalent malignancy with high morbidity. Hence, this cross-sectional study evaluated salivary interleukin-6 (IL-6) levels in 30 OSCC patients versus 30 healthy controls. IL-6 levels were significantly higher in OSCC patients and increased progressively with advancing clinical stages. A strong positive correlation was found between IL-6 levels and disease stage (r = 0.82, p < 0.001). Salivary IL-6 shows promise as a non-invasive biomarker for OSCC detection and progression monitoring.
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