{"title":"<i>in vitro</i> evaluation of mutagenic potential in common oral hygiene products.","authors":"Shweta Hegde, Prashanth Shetty, Mridula Nair, Arindam Dalal, Pankaj Bajaj, Sandhya James","doi":"10.6026/973206300211510","DOIUrl":null,"url":null,"abstract":"<p><p>The mutagenic potential of five commonly used oral hygiene products using the Ames test is of interest. Fluoridated and herbal toothpastes showed no mutagenicity. Alcohol-based and chlorhexidine mouthwashes demonstrated moderate mutagenic effects, especially with metabolic activation. Hydrogen peroxide mouth rinse exhibited the highest mutagenicity without S9 activation. Thus, the need for further <i>in vivo</i> investigation to validate safety profiles is relevant.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1510-1513"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449565/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/973206300211510","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The mutagenic potential of five commonly used oral hygiene products using the Ames test is of interest. Fluoridated and herbal toothpastes showed no mutagenicity. Alcohol-based and chlorhexidine mouthwashes demonstrated moderate mutagenic effects, especially with metabolic activation. Hydrogen peroxide mouth rinse exhibited the highest mutagenicity without S9 activation. Thus, the need for further in vivo investigation to validate safety profiles is relevant.
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