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Comparative analysis of EGFR expression in tobacco-related and HPV-associated oral cancer. EGFR在烟草相关和hpv相关口腔癌中的表达比较分析。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223310
Lavanya R M, Megha Modi, Devashree Shukla, Nandini C, Tamoghna Biswas, Arvind Jain
{"title":"Comparative analysis of EGFR expression in tobacco-related and HPV-associated oral cancer.","authors":"Lavanya R M, Megha Modi, Devashree Shukla, Nandini C, Tamoghna Biswas, Arvind Jain","doi":"10.6026/973206300223310","DOIUrl":"10.6026/973206300223310","url":null,"abstract":"<p><p>Differences in epidermal growth factor receptor (EGFR) expression between tobacco-related and human papillomavirus (HPV)-associated oral squamous cell carcinoma (OSCC) remain insufficiently defined. Therefore, it is of interest to compare EGFR expression in 90 histopathologically confirmed OSCC cases, including tobacco-related OSCC and HPV-associated OSCC. Immunohistochemistry (IHC) was used to assess EGFR expression, while p16 immunostaining served as a surrogate marker for HPV status. Tobacco-related OSCC demonstrated higher EGFR expression than HPV-associated OSCC, indicating differences in tumor biology and therapeutic response. Thus, we show etiological variation in EGFR expression in OSCC, supporting development of targeted and personalized treatment strategies.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3310-3313"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of microleakage and internal voids in class II restorations using open sandwich technique: An in vitro study. 开放式夹层技术对II类修复体微渗漏和内部空隙的比较评价：一项体外研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223254
Kirti Rathee, Reena Rani, Parthivi Singh, Heena Gandhi, Lakshika Sharma, Sagar Hiwale
{"title":"Comparative evaluation of microleakage and internal voids in class II restorations using open sandwich technique: An <i>in vitro</i> study.","authors":"Kirti Rathee, Reena Rani, Parthivi Singh, Heena Gandhi, Lakshika Sharma, Sagar Hiwale","doi":"10.6026/973206300223254","DOIUrl":"10.6026/973206300223254","url":null,"abstract":"<p><p>The achievement of a durable and hermetic seal at the tooth restoration interface remains a significant challenge in restorative dentistry, particularly with Class II composite restorations. Therefore, it is of interest to compare microleakage and internal voids in Class II restorations using different intermediate materials in the open sandwich technique. The materials evaluated included ACTIVA Bioactive, Resin-modified Glass Ionomer Cement (RMGIC), Smart Dentin Replacement (SDR) and a control group with nanohybrid composite. Data showed that ACTIVA Bioactive showed the least microleakage and void formation, followed by RMGIC and SDR. Thus, we show the superior performance of bioactive materials in improving marginal sealing and reducing void formation in composite restorations.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3254-3258"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational insights for target prioritization and pesticide effects on intrauterine growth restriction (IUGR). 目标优先排序和农药对宫内生长限制（IUGR）影响的计算见解。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223501
Adarsh Kumar Shukla, Anuj Kumar Tyagi, Sandeep Kumar
{"title":"Computational insights for target prioritization and pesticide effects on intrauterine growth restriction (IUGR).","authors":"Adarsh Kumar Shukla, Anuj Kumar Tyagi, Sandeep Kumar","doi":"10.6026/973206300223501","DOIUrl":"10.6026/973206300223501","url":null,"abstract":"<p><p>Intrauterine growth restriction (IUGR) is a leading cause of maternal and neonatal morbidity and mortality, particularly in low- and middle-income countries. Placental transcriptomics data were analysed to mapped dysregulated pathways via STRING-based PPI networks, identifying hubs and validating pesticide targets by molecular simulations. Rank-based prioritization identified IL7R, LCK and ZAP70 as top hub proteins driving placental dysfunction with cypermethrin exhibiting the lowest binding affinities across them (docking scores: -7.7, -8.7, -9.3 kcal/mol, respectively). Molecular dynamics simulations confirmed the stability of these docked complexes, while toxicity profiling indicated genotoxic potential for permethrin and high aquatic toxicity for deltamethrin. Thus, we show the critical molecular mediators linking pyrethroid exposure to IUGR, suggesting further experimental validation to support maternal health risk assessment.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3501-3509"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic efficacy of pulse oximetry versus Ankle-Brachial index for peripheral vascular disease in type 2 diabetes. 脉搏血氧测定与踝肱指数对2型糖尿病外周血管病变的诊断价值。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223496
Mohammad Kamran Iqbal, Jayballabh Kumar, Ritu Adhana, Vinod Kumar Singh
{"title":"Diagnostic efficacy of pulse oximetry versus Ankle-Brachial index for peripheral vascular disease in type 2 diabetes.","authors":"Mohammad Kamran Iqbal, Jayballabh Kumar, Ritu Adhana, Vinod Kumar Singh","doi":"10.6026/973206300223496","DOIUrl":"10.6026/973206300223496","url":null,"abstract":"<p><p>The Peripheral Vascular Disease (PVD) is a debilitating macrovascular complication associated with Type 2 Diabetes Mellitus (T2DM) with significant mortality. This remains undiagnosed in the asymptomatic cases due to diabetic neuropathy. Therefore, it is of interest to evaluate the diagnostic accuracy of the pulse oximetry against the gold-standard Ankle-Brachial Index (ABI). Data shows a high prevalence of PVD with ABI, whereas the pulse oximetry validated moderate sensitivity but low specificity, limiting its utility as a standalone diagnostic tool. While ABI remains the superior standard for definitive diagnosis, pulse oximetry offers a viable, cost-effective preliminary screening option for high-risk populations in resource-constrained healthcare centers.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3496-3500"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DFDBA with or without allogenic human dental pulp derived mesenchymal stem cells in treatment of mandibular class II furcation defects. DFDBA加或不加同种异体人牙髓间充质干细胞治疗下颌骨II类功能缺损。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223357
Kousain Sehar, Abhima Kumar, Sabiha Parwaiz, Shrey Shaileshbhai Patel, Mohd Irfan, Kamalnathgandhi M
{"title":"DFDBA with or without allogenic human dental pulp derived mesenchymal stem cells in treatment of mandibular class II furcation defects.","authors":"Kousain Sehar, Abhima Kumar, Sabiha Parwaiz, Shrey Shaileshbhai Patel, Mohd Irfan, Kamalnathgandhi M","doi":"10.6026/973206300223357","DOIUrl":"10.6026/973206300223357","url":null,"abstract":"<p><p>It is a challenging task to regenerate the periodontium at the furcation defect. Tissue engineering techniques using stem cells have gained importance in medical field in recent years. Various methods are tried to treat furcation defects. Therefore, it is of interest to assess DFDBA with or without allogenic human dental pulp derived mesenchymal stem cells in treatment of mandibular class II furcation defects. Hence, 28 systemically healthy individuals with at least one mandibular class II furcation defect were divided into 2 groups. Group A (n=14) patients were treated with DFDBA alone and Group B (n= 14) were treated with combination of DFBDA and allogenic dental pulp derived mesenchymal stem cells. Clinical parameters i.e., vertical relative attachment level (V-RAL), vertical probing depth (VPD), horizontal probing depth (HPD) and gingival recession (GR) were recorded at baseline and 6-months post-operatively. DPSCs with DFDBA did not show any statistical significance in both clinical and hard tissue outcome parameters.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3357-3361"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soft tissue considerations in modern restorative dental practice. 现代牙科修复实践中对软组织的考虑。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223652
Fatima Sarwar, Osiris Toledo Calixto, Nisha Dholakiya, Ramin Torkizadeh, Anuja Chandra, Gandharvi Kakarla
{"title":"Soft tissue considerations in modern restorative dental practice.","authors":"Fatima Sarwar, Osiris Toledo Calixto, Nisha Dholakiya, Ramin Torkizadeh, Anuja Chandra, Gandharvi Kakarla","doi":"10.6026/973206300223652","DOIUrl":"10.6026/973206300223652","url":null,"abstract":"<p><p>In dentistry, the success of a restoration depends not only on the choice of material or technique but also on the preservation of periodontal physiology and health. A healthy periodontium forms the essential foundation for long-term restorative success, making an interdisciplinary approach indispensable. Respecting biologic width is critical to prevent inflammation and attachment loss, while non- surgical methods such as provisional contouring can effectively guide soft tissue healing. Surgical strategies, including crown lengthening, are employed to correct deficiencies and establish harmony between esthetics and function. In complex restorative situations, gingival margin elevation requires precise planning to balance tissue stability and restorative demands. Patient-related factors, such as gingival biotype and healing capacity, further influence tissue behavior and outcomes. Ultimately, careful management of both soft and hard tissues ensures predictable and durable prosthodontic results.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3652-3657"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amniotic membrane for oral surgical defect coverage: A clinical study. 羊膜用于口腔外科缺损覆盖的临床研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223527
Meenakshi Kothari, Satishkumar G Patil, Ashwin Shah, Udupikrishna Joshi, Chaitanya Kothari
{"title":"Amniotic membrane for oral surgical defect coverage: A clinical study.","authors":"Meenakshi Kothari, Satishkumar G Patil, Ashwin Shah, Udupikrishna Joshi, Chaitanya Kothari","doi":"10.6026/973206300223527","DOIUrl":"10.6026/973206300223527","url":null,"abstract":"<p><p>Reconstruction of oral soft-tissue defects remains limited by donor-site morbidity and inconsistent healing with currently available grafts. In this prospective interventional study, we assessed human amniotic membrane (HAM) as a biologically active scaffold in 15 patients (6 cleft alveolus, 2 oral submucous fibrosis, 7 vestibuloplasty; ages 8-65 years). HAM integrated without complications in all cases, with no necrosis, infection, or immunologic rejection; median pain (VAS) fell from 2 on day 1 to 0 by day 7 (p < 0.00001) and swelling resolved by day 7 (p < 0.00001). Epithelialization reached \"good\" by 1 month (p < 0.00001); mucosal suppleness remained preserved through 6 months and in OSMF cases interincisal opening improved to 35-50 mm. Thus, data shows the HAM as a safe, donor-site-sparing, clinically translatable biomaterial that accelerates healing and improves function in oral soft-tissue reconstruction.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3527-3533"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual screening of human pancreatic lipase inhibitors using an integrated transfer learning and molecular dynamics simulation. 人胰脂肪酶抑制剂的虚拟筛选使用集成迁移学习和分子动力学模拟。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223002
C Tamilselvan, B S Lakshmi
{"title":"Virtual screening of human pancreatic lipase inhibitors using an integrated transfer learning and molecular dynamics simulation.","authors":"C Tamilselvan, B S Lakshmi","doi":"10.6026/973206300223002","DOIUrl":"10.6026/973206300223002","url":null,"abstract":"<p><p>Human pancreatic lipase (hPL), a major enzyme involved in dietary lipid digestion is a crucial therapeutic target for the management of obesity. Therefore, it is of interest to identify hPL inhibitors using an integrated transfer learning and molecular dynamics simulation. Transfer learning predicted 17,309 active candidates based on the pIC<sub>50</sub>, from which prenylated flavanonol was identified as the top-ranked compound with a binding affinity of 9.85 kcal/mol in comparison to reference inhibitor orlistat using Glide XP docking. Moreover, 200ns molecular dynamics simulations confirmed the stability of the protein-ligand complex through sustained interactions with key catalytic residues, including Ser152 and Asp79. Thus, data shows that prenylated flavanonol as a promising natural inhibitor of hPL.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3002-3009"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytomorphological spectrum of thyroid lesions using the Bethesda system: A retrospective study. 使用Bethesda系统的甲状腺病变细胞形态学谱：回顾性研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223453
Akanksha Awasthi, Shruti Semwal, Sakshi Chaurasia
{"title":"Cytomorphological spectrum of thyroid lesions using the Bethesda system: A retrospective study.","authors":"Akanksha Awasthi, Shruti Semwal, Sakshi Chaurasia","doi":"10.6026/973206300223453","DOIUrl":"10.6026/973206300223453","url":null,"abstract":"<p><p>Fine Needle Aspiration Cytology (FNAC) is a reliable, minimally invasive technique for evaluating thyroid lesions and the Bethesda System standardizes cytological reporting and clinical decision-making. This retrospective study analyzed 105 patients with palpable thyroid swellings over 1.5 years, classifying lesions according to the Bethesda System (Categories I-VI). The majority of patients were females (86%) with peak incidence in the 31-40 years age group. Most cases were benign (Category II), accounting for 88.5%, while 11.5% were categorized as follicular neoplasm or suspicious for malignancy, indicating higher malignancy risk. Thus, data shows the effectiveness of FNAC combined with the Bethesda system in ensuring accurate diagnosis, risk stratification and appropriate management of thyroid lesions.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3453-3456"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of thyroid dysfunction in psychiatric inpatients: A cross sectional prevalence study. 精神科住院患者甲状腺功能障碍的患病率：一项横断面患病率研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223259
Rajeev Ranjan Raj, Surbhi Chaudhary, Firoz Sheikh, Mimansha Patel, Vikram Karande, Yugantar N Wakde, Anukriti Kumari
{"title":"Prevalence of thyroid dysfunction in psychiatric inpatients: A cross sectional prevalence study.","authors":"Rajeev Ranjan Raj, Surbhi Chaudhary, Firoz Sheikh, Mimansha Patel, Vikram Karande, Yugantar N Wakde, Anukriti Kumari","doi":"10.6026/973206300223259","DOIUrl":"10.6026/973206300223259","url":null,"abstract":"<p><p>Thyroid dysfunction, despite its established connection to various psychiatric disorders, is underexplored in psychiatric inpatients, particularly in relation to mood disorders like depression and anxiety. A cross-sectional analysis was performed on 124 patients at a medical college, with first-episode psychiatric disorders. Thyroid function tests (TSH, T3, T4) revealed high rates of thyroid dysfunction, particularly in non-affective and affective psychoses, with common abnormalities including low TSH and high T4. Socio-demographic factors such as age, sex and family income influenced thyroid health. Thus, we show the prevalence of thyroid dysfunction in psychiatric patients and emphasizing the need for routine thyroid function testing in psychiatric assessments to improve the management of mental illnesses.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3259-3263"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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