BioinformationPub Date : 2025-06-30eCollection Date: 2025-01-01DOI: 10.6026/973206300211324
Prathibha Elavala, Chaitra M C, Prabhavathi K, Suresh T N
{"title":"Correlation between red blood cell distribution width-to-albumin ratio and diabetic retinopathy.","authors":"Prathibha Elavala, Chaitra M C, Prabhavathi K, Suresh T N","doi":"10.6026/973206300211324","DOIUrl":"10.6026/973206300211324","url":null,"abstract":"<p><p>Diabetic retinopathy is always asymptomatic before entering the later stage. Therefore, it is of interest to determine the red cell distribution width to albumin ratio (RAR) and correlate RAR with Diabetic Retinopathy through cross-sectional study among 384 patients. On applying Z test, there was a statistically significant difference found between RAR and Presence of diabetic retinopathy. These findings suggest that RAR could serve as a useful biomarker for early detection and risk stratification of DR.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1324-1327"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prospective cohort study on vitamin D deficiency and its association with multiple sclerosis relapses.","authors":"Lokesh Kumar Gurram, Rohan Hassan Chandrashekara, Ashok Nimmakanty Ramadas, Sushmitha Rameshbabu, Harinishri Thambi, Sarita Sunil Chammanam, Karrar Shaaban Imran","doi":"10.6026/973206300211639","DOIUrl":"10.6026/973206300211639","url":null,"abstract":"<p><p>Vitamin D deficiency has been related to the pathogenesis and clinical course of multiple sclerosis (MS), especially with relapse frequency. Hence, a prospective cohort study explored the relationship between serum vitamin D level and MS relapses in 120 patients in a two-year follow-up. Baseline and follow-up serum 25-hydroxyvitamin D were measured and relapse events registered and examined. The result indicated a strong negative correlation between the frequency of relapse and vitamin D (p < 0.01), such that patients with low levels of vitamin (<20 ng/mL) had higher frequencies of relapse.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1639-1642"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2025-06-30eCollection Date: 2025-01-01DOI: 10.6026/973206300211475
Padmaja N, Deborah Purushottam M, Srilalitha V
{"title":"Prevalence of multi-drug resistant, extensively drug resistant, pan drug resistant bacteria from intensive care units of a tertiary care teaching hospital, Amalapuram, India.","authors":"Padmaja N, Deborah Purushottam M, Srilalitha V","doi":"10.6026/973206300211475","DOIUrl":"10.6026/973206300211475","url":null,"abstract":"<p><p>The prevalence of MDR, XDR and PDR gram-negative bacteria, drug resistance and sensitivity patterns in the intensive care unit of the tertiary care hospital Amalapuram from June 2023 to July 2024 is of interest. The study included all patients who were admitted to the intensive care unit and various clinical samples like blood, urine, respiratory samples, body fluids and pus received in the lab were inoculated on different media like Mac-Conkey agar and blood agar according to Standard Microbiological methods. Bacterial identification was done based on colony morphology, Gram stain and various biochemical reactions after obtaining pure growth. Gram-negative bacteria were identified using a series of biochemical tests, like oxidase, catalase, indole production, methyl red, V-P, citrate, urease and triple sugar iron agar tests. Antibiotic susceptibility testing was performed using the Kirby-Bauer disk diffusion method according to CLSI guidelines. We found a high frequency of antibiotic resistance in ICU isolates, primarily caused by <i>gram-negative bacilli</i> like <i>Klebsiella</i> and <i>E. coli</i>.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1475-1480"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction of type 2 diabetes mellitus risk using Indian diabetes risk score among individuals of 30 years and above in an Indian population.","authors":"Jagdeep Singh, Himani Marmat, Ikraz Patel, Siddhant Gupta","doi":"10.6026/973206300211481","DOIUrl":"10.6026/973206300211481","url":null,"abstract":"<p><p>Indian Diabetes Risk Score (IDRS) was assessed among 2,847 adults aged 30 and above living in urban and rural areas in India. Data showed that 41.3% of participants were at high risk (IDRS ≥60) and these individuals often had obesity, a family history of the disease and a sedentary way of life. IDRS was found to be trustworthy, affordable and easy on patients. It is valuable for discovering diabetes at the earliest stage. Thus, this approach can be used in diabetes prevention programs across India.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1481-1485"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Telerehabilitation in India: From awareness to acceptance.","authors":"Saurabh Agnihotri, Naveen Kumar Singh, Nalina Gupta","doi":"10.6026/973206300211689","DOIUrl":"10.6026/973206300211689","url":null,"abstract":"<p><p>Telerehabilitation is gaining prominence in improving healthcare access, especially in underserved regions. Therefore, it is of interest to evaluate the knowledge, attitudes and practices (KAP) of the general population in Western Uttar Pradesh, India. A cross-sectional survey of 455 individuals was conducted using a validated, Hindi-translated questionnaire. While only 40.7% were previously aware of telerehabilitation, 81.8% showed willingness to use it, particularly among younger, male and better-educated participants. Thus, the need for targeted awareness and digital inclusion strategies to enable equitable access to telerehabilitation across populations is reported.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1689-1692"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postgraduate students' perception of current and future pre-clinical prosthodontics curriculum: A web-based survey.","authors":"Kritika Kar, Arti Shyam, Harsh Chansoria, Alka Gupta, Subhash Sonkesriya, Shivani Gupta","doi":"10.6026/973206300211421","DOIUrl":"10.6026/973206300211421","url":null,"abstract":"<p><p>The perceptions of postgraduate Prosthodontic students regarding their preclinical curriculum in India are of interest. A web-based survey of 200 second - and third-year students highlighted a demand for a more contemporary and technologically integrated curriculum. Students found the current exercises to be either adequate or excessive, with casting procedures in fixed prosthodontics being the most challenging. The majority supported the inclusion of modern technologies, such as CAD/CAM systems and 3D scanners. The findings suggest that curriculum reform should focus on enhancing technological integration to better prepare students for clinical practice.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1421-1428"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of oral pathogens on inflammatory mediator expression in oral cells.","authors":"Pratik Sanjay Hodar, Mitesh Shah, Yihan Fu, Priti P Shah, Abhishek Haldia, Anagha Agrawal, Miral Mehta","doi":"10.6026/973206300211506","DOIUrl":"10.6026/973206300211506","url":null,"abstract":"<p><p>Oral pathogens such as <i>P. gingivalis</i>, <i>F. nucleatum</i> and <i>A. actinomycetemcomitans</i> significantly elevate cytokine levels in oral epithelial cells. qRT - PCR analysis showed <i>P. gingivalis</i> induced a 4.2-fold increase in IL-1β, 3.8-fold in TNF-α, and 3.5-fold in IL-6 after 24 hours. The other pathogens also triggered a 2.4 to 3.6-fold cytokine rise (p < 0.05). This indicates their role in initiating oral inflammation through pro-inflammatory cytokine activation. Targeted microbial therapy may offer benefits in managing such conditions.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1506-1509"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BioinformationPub Date : 2025-06-30eCollection Date: 2025-01-01DOI: 10.6026/973206300211755
Gurav Priyankaben Rajeshbhai, Mahalakshmi B, Siva Subramanian N
{"title":"Impact of integrative energy healing on anxiety among individuals with cancer.","authors":"Gurav Priyankaben Rajeshbhai, Mahalakshmi B, Siva Subramanian N","doi":"10.6026/973206300211755","DOIUrl":"10.6026/973206300211755","url":null,"abstract":"<p><p>Cancer diagnosis during adolescence can be overwhelming, often leading to heightened anxiety levels due to physical discomfort, treatment stress and psychological burden. Reiki therapy, an energy-based healing technique, has gained attention as a complementary approach to alleviate anxiety. Therefore, it is of interest to assess the impact of Reiki therapy on anxiety levels among adolescents (aged 13-17) with cancer in selected hospitals in Gujarat. A quasi-experimental pre-test and post-test control group design was used with 92 participants (46 in the intervention group and 46 in the control group). The intervention group received six daily sessions of Reiki therapy (21 minutes each), while the control group received standard care. Anxiety was assessed using the Hamilton Anxiety Rating Scale. Results showed a significant reduction in anxiety scores post-intervention in the Reiki group (Mean difference = 8.58, p < 0.001), whereas the control group did not show statistically significant improvement (p = 0.055). Thus, the effectiveness of Reiki therapy in reducing anxiety among adolescents with cancer is reported advocate its integration into holistic pediatric oncology care.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1755-1759"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analytical study on systemic lupus erythematosus and its association with cutaneous manifestations.","authors":"Nutheti Pavani, Himanshu Dua, Mohammed Zakiullah Shareef, Megha Joy, Trisha Hammigi, Sobiya Farook, Kosmita Karki","doi":"10.6026/973206300211627","DOIUrl":"10.6026/973206300211627","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune illness with cutaneous involvement being the most frequent of its clinical presentations. Therefore, it is of interest to determine the prevalence and patterns of cutaneous manifestations among SLE patients and their relationship with disease activity. Data comparison of 120 SLE patients was done based on demographic profile, nature of the cutaneous lesions and association with disease activity indices like the SLE disease activity index (SLEDAI). It was found that 75% of the patients presented with cutaneous involvement, of which malar rash was the most frequent manifestation, followed by discoid lesions and photosensitivity. Higher SLEDAI scores were significantly associated with more severe cutaneous symptoms (p < 0.01). The findings underscore the importance of early recognition and treatment of skin lesions for optimal disease outcome in SLE patients.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1627-1630"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A retrospective evaluation of bone graft success, implant survival rate and marginal bone loss.","authors":"Laxman Singh Kaira, Virag Srivastava, Sauvik Mazumdar, Ishita Mudgal, Karandeep Singh, Ashish Prajapati, Megha Patel","doi":"10.6026/973206300211534","DOIUrl":"10.6026/973206300211534","url":null,"abstract":"<p><p>Bone grafting serves to restore the alveolar bone defect, providing adequate alveolar bone essential for long-term implant survival. Therefore, it is of interest to evaluate bone graft success, implant survival rate and marginal bone loss. Hence, data from 85 patients showed 112 implants performed in grafted sites achieved a 95.5% survival rate and the bone grafting success reached 92.8%. Auto-genous grafts displayed higher functionality than allografts and xenografts did. At 12 months the mean marginal bone loss measured 1.12± 0.28 mm according to graft classification and implant placement site (p<0.05). Bone grafting shows its effectiveness for improving implant stability and achieving enduring success within patients who need large bone grafts.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1534-1538"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}