{"title":"口腔病原体对口腔细胞炎症介质表达的影响。","authors":"Pratik Sanjay Hodar, Mitesh Shah, Yihan Fu, Priti P Shah, Abhishek Haldia, Anagha Agrawal, Miral Mehta","doi":"10.6026/973206300211506","DOIUrl":null,"url":null,"abstract":"<p><p>Oral pathogens such as <i>P. gingivalis</i>, <i>F. nucleatum</i> and <i>A. actinomycetemcomitans</i> significantly elevate cytokine levels in oral epithelial cells. qRT - PCR analysis showed <i>P. gingivalis</i> induced a 4.2-fold increase in IL-1β, 3.8-fold in TNF-α, and 3.5-fold in IL-6 after 24 hours. The other pathogens also triggered a 2.4 to 3.6-fold cytokine rise (p < 0.05). This indicates their role in initiating oral inflammation through pro-inflammatory cytokine activation. Targeted microbial therapy may offer benefits in managing such conditions.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1506-1509"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449503/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of oral pathogens on inflammatory mediator expression in oral cells.\",\"authors\":\"Pratik Sanjay Hodar, Mitesh Shah, Yihan Fu, Priti P Shah, Abhishek Haldia, Anagha Agrawal, Miral Mehta\",\"doi\":\"10.6026/973206300211506\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Oral pathogens such as <i>P. gingivalis</i>, <i>F. nucleatum</i> and <i>A. actinomycetemcomitans</i> significantly elevate cytokine levels in oral epithelial cells. qRT - PCR analysis showed <i>P. gingivalis</i> induced a 4.2-fold increase in IL-1β, 3.8-fold in TNF-α, and 3.5-fold in IL-6 after 24 hours. The other pathogens also triggered a 2.4 to 3.6-fold cytokine rise (p < 0.05). This indicates their role in initiating oral inflammation through pro-inflammatory cytokine activation. Targeted microbial therapy may offer benefits in managing such conditions.</p>\",\"PeriodicalId\":8962,\"journal\":{\"name\":\"Bioinformation\",\"volume\":\"21 6\",\"pages\":\"1506-1509\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449503/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioinformation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.6026/973206300211506\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/973206300211506","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Impact of oral pathogens on inflammatory mediator expression in oral cells.
Oral pathogens such as P. gingivalis, F. nucleatum and A. actinomycetemcomitans significantly elevate cytokine levels in oral epithelial cells. qRT - PCR analysis showed P. gingivalis induced a 4.2-fold increase in IL-1β, 3.8-fold in TNF-α, and 3.5-fold in IL-6 after 24 hours. The other pathogens also triggered a 2.4 to 3.6-fold cytokine rise (p < 0.05). This indicates their role in initiating oral inflammation through pro-inflammatory cytokine activation. Targeted microbial therapy may offer benefits in managing such conditions.
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