{"title":"维生素D缺乏及其与多发性硬化症复发关系的前瞻性队列研究。","authors":"Lokesh Kumar Gurram, Rohan Hassan Chandrashekara, Ashok Nimmakanty Ramadas, Sushmitha Rameshbabu, Harinishri Thambi, Sarita Sunil Chammanam, Karrar Shaaban Imran","doi":"10.6026/973206300211639","DOIUrl":null,"url":null,"abstract":"<p><p>Vitamin D deficiency has been related to the pathogenesis and clinical course of multiple sclerosis (MS), especially with relapse frequency. Hence, a prospective cohort study explored the relationship between serum vitamin D level and MS relapses in 120 patients in a two-year follow-up. Baseline and follow-up serum 25-hydroxyvitamin D were measured and relapse events registered and examined. The result indicated a strong negative correlation between the frequency of relapse and vitamin D (p < 0.01), such that patients with low levels of vitamin (<20 ng/mL) had higher frequencies of relapse.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1639-1642"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449534/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prospective cohort study on vitamin D deficiency and its association with multiple sclerosis relapses.\",\"authors\":\"Lokesh Kumar Gurram, Rohan Hassan Chandrashekara, Ashok Nimmakanty Ramadas, Sushmitha Rameshbabu, Harinishri Thambi, Sarita Sunil Chammanam, Karrar Shaaban Imran\",\"doi\":\"10.6026/973206300211639\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Vitamin D deficiency has been related to the pathogenesis and clinical course of multiple sclerosis (MS), especially with relapse frequency. Hence, a prospective cohort study explored the relationship between serum vitamin D level and MS relapses in 120 patients in a two-year follow-up. Baseline and follow-up serum 25-hydroxyvitamin D were measured and relapse events registered and examined. The result indicated a strong negative correlation between the frequency of relapse and vitamin D (p < 0.01), such that patients with low levels of vitamin (<20 ng/mL) had higher frequencies of relapse.</p>\",\"PeriodicalId\":8962,\"journal\":{\"name\":\"Bioinformation\",\"volume\":\"21 6\",\"pages\":\"1639-1642\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449534/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioinformation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.6026/973206300211639\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/973206300211639","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Prospective cohort study on vitamin D deficiency and its association with multiple sclerosis relapses.
Vitamin D deficiency has been related to the pathogenesis and clinical course of multiple sclerosis (MS), especially with relapse frequency. Hence, a prospective cohort study explored the relationship between serum vitamin D level and MS relapses in 120 patients in a two-year follow-up. Baseline and follow-up serum 25-hydroxyvitamin D were measured and relapse events registered and examined. The result indicated a strong negative correlation between the frequency of relapse and vitamin D (p < 0.01), such that patients with low levels of vitamin (<20 ng/mL) had higher frequencies of relapse.
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