{"title":"Impact of oral pathogens on inflammatory mediator expression in oral cells.","authors":"Pratik Sanjay Hodar, Mitesh Shah, Yihan Fu, Priti P Shah, Abhishek Haldia, Anagha Agrawal, Miral Mehta","doi":"10.6026/973206300211506","DOIUrl":null,"url":null,"abstract":"<p><p>Oral pathogens such as <i>P. gingivalis</i>, <i>F. nucleatum</i> and <i>A. actinomycetemcomitans</i> significantly elevate cytokine levels in oral epithelial cells. qRT - PCR analysis showed <i>P. gingivalis</i> induced a 4.2-fold increase in IL-1β, 3.8-fold in TNF-α, and 3.5-fold in IL-6 after 24 hours. The other pathogens also triggered a 2.4 to 3.6-fold cytokine rise (p < 0.05). This indicates their role in initiating oral inflammation through pro-inflammatory cytokine activation. Targeted microbial therapy may offer benefits in managing such conditions.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1506-1509"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449503/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/973206300211506","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Oral pathogens such as P. gingivalis, F. nucleatum and A. actinomycetemcomitans significantly elevate cytokine levels in oral epithelial cells. qRT - PCR analysis showed P. gingivalis induced a 4.2-fold increase in IL-1β, 3.8-fold in TNF-α, and 3.5-fold in IL-6 after 24 hours. The other pathogens also triggered a 2.4 to 3.6-fold cytokine rise (p < 0.05). This indicates their role in initiating oral inflammation through pro-inflammatory cytokine activation. Targeted microbial therapy may offer benefits in managing such conditions.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
