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Antimicrobial efficacy of disinfecting solutions against S. mutans on toothbrushes for school children in Uttar Pradesh, India. 消毒溶液对印度北方邦学龄儿童牙刷上的变形链球菌的抗菌效果。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223619
Shivani Singh, Abhijeet Alok, Kamil Shahnawaz, Surender Kumar, Shantala Ramdas Naik, Kumar Piyush
{"title":"Antimicrobial efficacy of disinfecting solutions against <i>S. mutans</i> on toothbrushes for school children in Uttar Pradesh, India.","authors":"Shivani Singh, Abhijeet Alok, Kamil Shahnawaz, Surender Kumar, Shantala Ramdas Naik, Kumar Piyush","doi":"10.6026/973206300223619","DOIUrl":"10.6026/973206300223619","url":null,"abstract":"<p><p>Toothbrush bristles harbor pathogenic microorganisms like Streptococcus mutans, posing a continuous risk for reinfection and dental caries in children. Therefore, it is of interest to evaluate the ability of 5% neem, 5% green tea, 5% turmeric, 0.2% chlorhexidine (CHX) and tap water to disinfect Streptococcus mutans-contaminated toothbrushes after 12 hours of soaking. A randomized double-blind crossover study of 40 students (12-15 years) was conducted. All disinfectants significantly reduced bacterial counts compared to baseline, with the greatest reduction observed with 0.2% chlorhexidine, followed by 5% green tea. Thus, data shows that all disinfectants were effective, 0.2% chlorhexidine was the most effective and 5% green tea was a strong herbal alternative.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3619-3623"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulpal response following SDF application for deep carious lesions:An in vivo study. SDF应用于深部龋齿病变后的牙髓反应：一项体内研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223491
Shelly Singh, Sugandha Sharma, Shraddha Shetti, Ashtha Arya, Gaurav Mishra, Sudha Patil
{"title":"Pulpal response following SDF application for deep carious lesions:An <i>in vivo</i> study.","authors":"Shelly Singh, Sugandha Sharma, Shraddha Shetti, Ashtha Arya, Gaurav Mishra, Sudha Patil","doi":"10.6026/973206300223491","DOIUrl":"10.6026/973206300223491","url":null,"abstract":"<p><p>Deep carious lesions often threaten pulpal vitality and limited evidence exists regarding the pulpal response to 38% silver diamine fluoride (SDF) in primary and permanent molars. Therefore, it is of interest to evaluate the pulpal response to 38% SDF in deep carious lesions of primary and permanent molars. Hence, a total of 70 molars (35 primary, 35 permanent) were treated with SDF following selective caries removal and monitored clinically and radiographically for 12 months. Most teeth maintained pulpal vitality, with overall success rates of 80% in primary molars and 85.7% in permanent molars. Failures were mainly associated with spontaneous pain or radiographic periapical changes during follow-up. Thus, we show that SDF is a minimally invasive and biologically compatible option for managing deep caries while preserving pulp vitality in both dentitions.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3491-3495"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C - reactive protein to albumin ratio as predictor of severity and outcome in acute pancreatitis. C -反应蛋白与白蛋白比值作为急性胰腺炎严重程度和预后的预测因子。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223521
Umesh Pratap Singh, Manzar Hussain Usmani, Mukund Pandey, Pooja Patel
{"title":"C - reactive protein to albumin ratio as predictor of severity and outcome in acute pancreatitis.","authors":"Umesh Pratap Singh, Manzar Hussain Usmani, Mukund Pandey, Pooja Patel","doi":"10.6026/973206300223521","DOIUrl":"10.6026/973206300223521","url":null,"abstract":"<p><p>Early and accurate prediction of severity in acute pancreatitis remains a major clinical challenge, particularly in resource-limited settings. Hence, this cross-sectional study evaluated 100 patients to assess the prognostic value of the CRP/Albumin ratio (CAR) in comparison with BISAP and other parameters. Disease severity was mild in 40%, moderate in 30% and severe in 30%, with ICU admission in 23% and overall mortality of 5%, increasing with severity. Non-survivors had significantly higher age (62.6 ± 7.09 vs 40.41 ± 13.66 years), urea (78.72 ± 66.08 vs 24.09 ± 13.99 mg/dL), creatinine (2.69 ± 1.68 vs 0.84 ± 0.43 mg/dL), CRP (182.61 ± 141.55 vs 75.98 ± 82.76 mg/L), CAR (107.18 ± 106.30 vs 28.09 ± 38.10) and BISAP scores (4.6 ± 0.55 vs 0.85 ± 0.99), along with lower albumin levels (2.11 ± 0.87 vs 3.20 ± 0.98 g/dL). Thus, BISAP showed the highest predictive accuracy (AUC = 1.000), followed by creatinine (0.985), age (0.952) and CAR (0.930).</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3521-3526"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet indices as prognostic markers of vascular complications in type-2 diabetes mellitus. 血小板指数作为2型糖尿病血管并发症的预后指标。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223486
Anita Omhare, Kanhaiya Lal Mishra, Medha Misra, Preeti Verma, Sandeep Kumar, Prashant Kumar
{"title":"Platelet indices as prognostic markers of vascular complications in type-2 diabetes mellitus.","authors":"Anita Omhare, Kanhaiya Lal Mishra, Medha Misra, Preeti Verma, Sandeep Kumar, Prashant Kumar","doi":"10.6026/973206300223486","DOIUrl":"10.6026/973206300223486","url":null,"abstract":"<p><p>With its rising incidence and substantial risk of microvascular and macrovascular consequences, diabetes mellitus (DM) is a serious health concern of global magnitude. Therefore, it is of interest to determine the distribution of platelet indices in type 2 diabetes mellitus (T2DM) patients with and without vascular complications and assess their potential as predictive biomarkers. The cross-sectional study was undertaken over 18 months, which included 107 diagnosed T2DM patients and 69 age and gender-matched healthy controls. Platelet count and MPV were significantly altered in diabetics, especially among those with complications, whereas PDW showed no significant difference and logistic regression displayed a significant correlation of abnormal platelet count (Adjusted OR: 2.95, 95% CI: 1.23-7.06; p=0.015) and MPV (Adjusted OR: 0.31, 95% CI: 0.10-0.92; p=0.036) with vascular complications. Platelet count and MPV are promising, economical biomarkers for the early prediction of vascular complications in T2DM patients and their frequent monitoring may lead to early disease detection, timely anagement and better clinical outcomes.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3486-3490"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of osseointegration in photo-functionalized versus PRF-coated implants: A split-mouth clinical study. 光功能化与prf涂层种植体骨整合的比较评价：一项裂口临床研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223686
Devupalli Sudha Madhuri, Papala Sesha Reddy, Reddy Chaithanya, Shaik Mohammed Abbas, T Naga Sruthi, Sashideepth Reddy
{"title":"Comparative evaluation of osseointegration in photo-functionalized versus PRF-coated implants: A split-mouth clinical study.","authors":"Devupalli Sudha Madhuri, Papala Sesha Reddy, Reddy Chaithanya, Shaik Mohammed Abbas, T Naga Sruthi, Sashideepth Reddy","doi":"10.6026/973206300223686","DOIUrl":"10.6026/973206300223686","url":null,"abstract":"<p><p>Early implant failure and marginal bone loss remain important clinical challenges in implant dentistry and various surface modification techniques have been proposed to enhance osseointegration. Therefore, it is of interest to compare the osseointegration and marginal bone loss of photofunctionalized and PRF-coated implants in completely edentulous mandibular arches. Twelve patients received a total of twenty-four implants, with each patient receiving one UV-activated implant and one PRF-coated implant. Implant stability was evaluated using resonance frequency analysis and marginal bone loss was assessed radiographically over a period of three months. Both groups showed steady improvement in osseointegration, with PRF-coated implants demonstrating slightly higher mean ISQ values, although the difference was not statistically significant. Marginal bone loss was minimal and comparable in both groups, indicating that both techniques performed similarly in terms of early implant stability and bone preservation.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3686-3691"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-epitope design against emerging nipah virus towards peptide vaccine development. 针对新发尼帕病毒的多表位设计与肽疫苗的开发。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223786
Motukuri Naveen Kumar, Dokka Muni Kumar, Bharathi B V N V, Vamseedhar Annam, Aarthi Pradhan, Shaik Rajiya Sulthana, Yashasvi Singam
{"title":"Multi-epitope design against emerging nipah virus towards peptide vaccine development.","authors":"Motukuri Naveen Kumar, Dokka Muni Kumar, Bharathi B V N V, Vamseedhar Annam, Aarthi Pradhan, Shaik Rajiya Sulthana, Yashasvi Singam","doi":"10.6026/973206300223786","DOIUrl":"10.6026/973206300223786","url":null,"abstract":"<p><p>The lack of an approved vaccine against Nipah virus (NiV), a highly fatal zoonotic pathogen causing severe neurological and respiratory disease, remains a major global health challenge. Therefore, it is of interest to design a multi-epitope vaccine targeting the NiV phosphoprotein (UniProt ID: Q9IK91). Conserved B-cell, cytotoxic T-lymphocyte (CTL) and helper T-lymphocyte (HTL) epitopes were identified and selected based on antigenicity, immunogenicity and safety. The resulting vaccine construct was evaluated through structural modeling, TLR4 docking, codon optimization and immune simulation analyses. Thus, data shows the favorable stability, strong receptor interaction, efficient expression potential and the ability to elicit robust humoral and cellular immune responses.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3786-3798"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular docking analysis of FAS II from Neisseria meningitides with marine phytochemicals. 脑膜炎奈瑟菌FASⅱ与海洋植物化学物质的分子对接分析。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223752
Priyanka Kumari, Diksha Ranga, Pooja Yadav, Vandana Saini, Ajit Kumar
{"title":"Molecular docking analysis of FAS II from <i>Neisseria meningitides</i> with marine phytochemicals.","authors":"Priyanka Kumari, Diksha Ranga, Pooja Yadav, Vandana Saini, Ajit Kumar","doi":"10.6026/973206300223752","DOIUrl":"10.6026/973206300223752","url":null,"abstract":"<p><p><i>Neisseria meningitidis</i> remains a serious global health threat due to rapid progression, high mortality and rising antibiotic resistance. FabF, a key enzyme in the bacterial fatty acid synthesis (FAS II) pathway, is a promising target for new antimicrobials. A 3D model of FabF was constructed and validated and 2,583 marine natural compounds were screened for drug-likeness and ADMET properties. Molecular docking of 241 selected compounds identified three candidates with stronger binding affinity than minocycline. Compounds CMNPD5392, CMNPD14910 and CMNPD14926 showed promising interactions, indicating potential as FabF-targeted therapeutics.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3752-3757"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of fluoride release from type II GIC, ketac molar and ketac universal: An in vitro study. II型GIC、kettac磨牙和kettac universal对氟的体外释放比较分析。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223390
Sushmita Shivanna, Prakash H, Juan M, Murali Sivakumar, Megavarnan Ravi
{"title":"Comparative analysis of fluoride release from type II GIC, ketac molar and ketac universal: An <i>in vitro</i> study.","authors":"Sushmita Shivanna, Prakash H, Juan M, Murali Sivakumar, Megavarnan Ravi","doi":"10.6026/973206300223390","DOIUrl":"10.6026/973206300223390","url":null,"abstract":"<p><p>Limited evidence exists regarding the comparative fluoride release of different glass ionomer restorative materials used in clinical dentistry. Therefore, it is of interest to evaluate and compare the fluoride release of Type II GIC, Ketac Molar, and Ketac Universal at different time intervals. Fluoride ion release from these materials was assessed over 1, 7, and 28 days using a UV-visible spectrophotometer. Significant differences in fluoride release were observed among the materials (p < 0.001). Ketac Universal showed the highest fluoride release at all evaluated intervals. Fluoride release from Ketac Molar and Ketac Universal increased over time, whereas Type II GIC remained relatively unchanged. The superior fluoride release of Ketac Universal suggests its potential clinical advantage for long-term caries prevention in patients at high risk of dental caries.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3390-3394"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical presentation and epidemiological patterns of breast lesions: Experience from a tertiary care hospital. 乳腺病变的临床表现和流行病学模式：来自三级护理医院的经验。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223465
Chakresh Jain, Sarita Shah, Sarita Singh
{"title":"Clinical presentation and epidemiological patterns of breast lesions: Experience from a tertiary care hospital.","authors":"Chakresh Jain, Sarita Shah, Sarita Singh","doi":"10.6026/973206300223465","DOIUrl":"10.6026/973206300223465","url":null,"abstract":"<p><p>Breast lesions constitute a wide spectrum of conditions ranging from benign disorders to malignancies, with varying clinical presentations influenced by demographic and epidemiological factors. Therefore, it is of interest to evaluate the clinical presentation and epidemiological patterns of breast lesions in patients attending a tertiary care hospital. Hence, a prospective observational study was conducted on patients presenting with breast complaints, including detailed clinical evaluation, radiological assessment and histopathological confirmation. The majority of patients presented with breast lumps, with benign lesions being more common in younger age groups and malignant lesions predominating in older patients, showing significant associations with age and symptom duration. Thus, understanding these patterns aids in early diagnosis for appropriate management and improved patient outcomes, especially in resource- limited healthcare settings.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3465-3468"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of immediate implant placement on buccal bone stability in fresh extraction sockets: A prospective study. 即刻种植对新鲜拔牙槽位颊骨稳定性的影响：一项前瞻性研究。
IF 1.9
Bioinformation Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.6026/973206300223702
Fiza Khanam, Vansh Jaiswal, Keshav Tukaram Handge, Ashok Kumar Singh, Vyankatesh Sahu, Anand Rajapur
{"title":"Effect of immediate implant placement on buccal bone stability in fresh extraction sockets: A prospective study.","authors":"Fiza Khanam, Vansh Jaiswal, Keshav Tukaram Handge, Ashok Kumar Singh, Vyankatesh Sahu, Anand Rajapur","doi":"10.6026/973206300223702","DOIUrl":"10.6026/973206300223702","url":null,"abstract":"<p><p>Immediate implant placement in fresh extraction sockets has been advocated to preserve buccal bone architecture and shorten overall treatment time. Therefore, it is of interest to evaluate changes in buccal bone thickness and height in 30 patients receiving immediate implants using CBCT measurements at baseline, immediately after placement and at a 6-month follow-up. Hence, a statistically significant but clinically limited reduction in buccal bone dimensions, with all implants remaining stable and no failures observed during the study period. Thus, data shows the immediate implant placement shows favorable buccal bone stability when adequate primary stability and appropriate case selection were ensured.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"22 6","pages":"3702-3706"},"PeriodicalIF":1.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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