Bioinformation最新文献_第8页

Detection of corneal pathology among Indians using WBC count as inflammatory marker. 用白细胞计数作为炎症标志物检测印度人的角膜病变。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200478

Susmitha Joshy, M C Chaitra

引用次数: 0

Evaluation of alveolar bone width alterations around dental implants. 评估种植牙周围牙槽骨宽度的变化。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200579

K Sai Priyanka, Pushkar Gupta, Lipika Gopal, A Karan Kumar, Anas Abdul A Karan, Banashree Baishya, Nazargi Mohabob

{"title":"Evaluation of alveolar bone width alterations around dental implants.","authors":"K Sai Priyanka, Pushkar Gupta, Lipika Gopal, A Karan Kumar, Anas Abdul A Karan, Banashree Baishya, Nazargi Mohabob","doi":"10.6026/973206300200579","DOIUrl":"10.6026/973206300200579","url":null,"abstract":"Teeth that are lost can be replaced with dental implants. A sufficient width of bone surrounding the implant is beneficial to its success. Therefore, it is of interest to examine alterations in width of alveolar bone surrounding dental implants at natural and rebuilt bone locations [alveolar ridge preservation (ARP) /Guided Bone Regeneration (GBR)] using CTBT. A CBCT examination of the implant recipient site was performed on sixty patients (both male and female), who had undergone dental implants. All conventional surgical procedures were followed for inserting dental implants. All participants had their horizontal alveolar bone widths around implants assessed at 3 positions: subcrestal width 1 mm (CW1 (crestal level-CW1), subcrestal width 4 mm (CW4), and subcrestal width 7 mm (CW7). There were 32 male patients and 28 female patients out of 60 totals. The mean bone width was 7.02 mm at CW1 prior to surgery and 6.91 mm afterward; it was 8.52 mm at CW4 and 8.13 mm afterward; and it was 10.21 mm at CW7 prior to surgery and 10.08 mm afterward. There was a substantial difference (P<0.05). At CW1, the bone width was 0.38 mm at local bone and -0.02 mm at ARP/GBR; at CW4, the bone width was 0.46 mm at local bone and 0.23 mm at ARP/GBR; and at CW7, the bone width was 0.22 mm at local bone and 0.02 mm at ARP/GBR. There was no discernible difference (P>0.05). Resorption of the alveolar bone width was only noticeable at the middle third of the sites. Long-term alterations in the alveolar bone width surrounding dental implants at local and rebuilt bone sites can be observed using CBCT images.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 5","pages":"579-582"},"PeriodicalIF":1.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of life and level of burden for caregivers of Indian children with post-operative congenital anorectal malformations. 印度先天性肛门直肠畸形术后患儿护理人员的生活质量和负担水平。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200566

Nitu Godara, Geetarani Nayak, Bikasha Bihary Tripathy

引用次数: 0

Impact of reflection writing on the learning ability of Indian medical students. 反思写作对印度医科学生学习能力的影响。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200587

Rekha Jiwane, Vivekanand Gajbhiye, Sandip Hulke, Ruchi Singh, Ragini Shrivastava, Varun Malhotra

{"title":"Impact of reflection writing on the learning ability of Indian medical students.","authors":"Rekha Jiwane, Vivekanand Gajbhiye, Sandip Hulke, Ruchi Singh, Ragini Shrivastava, Varun Malhotra","doi":"10.6026/973206300200587","DOIUrl":"10.6026/973206300200587","url":null,"abstract":"Reflective writing develops meta-cognition among students. Therefore, it is of interest to compare effectiveness of post lecture reflective writing to didactic lecture between individual and group reflective writing. Hence, we included 124 first-year students from AIIMS Bhopal, India and divided them in two groups of 62 students. Both groups took a pre-test using a reflection questionnaire. Students were taught reflective writing. Both groups attended physiology lectures on two different topics. First lecture on body fluids where Group A wrote reflections individually and Group B did so in sub-groups (B1 to B6). After another lecture on Pathophysiology of oedema, Group A wrote reflections in groups and Group B wrote individually (A1 to A6). Both groups took a test in the form of MCQ about reflective writing on lectures. After intervention both groups took a post-test using a reflection questionnaire. Mean and standard deviation of Pre-test is 3.86 ± 0.86 and Post-test is 7.58 ± 1.01, respectively. The Mean and standard deviation of reflection who wrote individually is 38.05 ± 4.41 and in group is 27.45 ± 3.93, respectively with p-value < 0.05. Evaluation of students who wrote reflection in groups after second lecture the mean and standard deviation of reflection who wrote individually is 38.22 ± 4.64 and in group is 27.03 ± 2.87 respectively with p-value < 0.05. The performance of students who wrote reflection in groups is not satisfactory as compared to students who wrote their reflection individually.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 5","pages":"587-591"},"PeriodicalIF":1.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening type 2 Diabetes mellitus among Indians using inflammatory biomarkers. 利用炎症生物标志物筛查印度人中的 2 型糖尿病。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200515

Mohammad Arif, Shreya Nigoskar, Manish Kumar Verma, Ameerul Hasan Amir

{"title":"Screening type 2 Diabetes mellitus among Indians using inflammatory biomarkers.","authors":"Mohammad Arif, Shreya Nigoskar, Manish Kumar Verma, Ameerul Hasan Amir","doi":"10.6026/973206300200515","DOIUrl":"10.6026/973206300200515","url":null,"abstract":"Diabetes is a metabolic disorder associated with chronic inflammation; pre-diabetes phase promotes to inflammatory mechanism then finally progress to diabetes and its associated complications. Therefore, it is of interest to investigate the changes in inflammatory biomarkers Evidence that inflammatory markers play a role in the development as well as severity of Type 2 diabetes mellitus (T2DM). This study has been designed to decipher the involvement of Tumor Necrosis Factor (TNFα), Interleukin-6 (IL-6), Nesfatin-1 and Blood sugar in the etiopathogenesis of T2DM. This retrospective observational study analyzed patient records from our hospital, focusing on those with diabetes or pre-diabetes. Glycosylated hemoglobin, inflammatory biomarkers, Fasting Blood Glucose, and Post-Prandial Blood Glucose were assessed. SPSS 28 facilitated statistical analysis; utilizing Bivariate Correlation assessed the relationship between inflammatory biomarkers and diabetes status (glycosylated hemoglobin). In the pre-diabetic vs. diabetic groups, significant differences exist in IL-6 (p=0.0344), TNF-α (p=0.041), Nesfatin-1 (p=0.0485), fasting blood glucose (p=0.036), and 2h post-prandial blood glucose (p=0.048). IL6 (AUC=0.729, p<0.001), TNF (AUC=0.761, p<0.001), and Nesfatin1 (AUC=0.892, p<0.001) show moderate discriminative power. PP (AUC=0.992, p<0.001) and hbA1c (AUC=0.993, p<0.001) exhibit excellent discriminatory ability. Correlations: IL6 with TNF (r=0.672, p<0.001) and Nesfatin1 (r=0.542, p<0.001); TNF with Nesfatin1 (r=0.591, p<0.001), hbA1c (r=0.683, p<0.001), and PP (r=0.367, p<0.001); Nesfatin1 with PP (r=0.594, p<0.001) and hbA1c (r=0.800, p<0.001). Age has a negative correlation with hbA1c (r=-0.119, p=0.086). Thus, data shows a significant association between inflammatory markers, blood glucose levels, and the progression from pre-diabetes to diabetes.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 5","pages":"515-519"},"PeriodicalIF":1.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and antioxidant effect of mucilage in leaves from Cocculus hirsutus. Cocculus hirsutus 叶子粘液的特性和抗氧化作用。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200439

Devasahayam Leema Rose Mary, Antonysamy Lawrance, Arokiadoss Edwina Sherley Felicita, Pushpam Marie Arockianathan

{"title":"Characterization and antioxidant effect of mucilage in leaves from Cocculus hirsutus.","authors":"Devasahayam Leema Rose Mary, Antonysamy Lawrance, Arokiadoss Edwina Sherley Felicita, Pushpam Marie Arockianathan","doi":"10.6026/973206300200439","DOIUrl":"10.6026/973206300200439","url":null,"abstract":"Natural polysaccharides are attractive biodegradable polymers. Among the natural plant-based polysaccharides, mucilage is an interest for numerous biomedical applications. Hence, mucilage was isolated from the leaves of Cocculus hirsutus (Family; Menispermaceae) and tested for its phytochemicals, physio-chemical characteristics using standard procedure such as solubility, pH, swelling index etc., and structural characterization studies using FTIR, GC-MS and SEM followed by antioxidant and in vitro cytotoxic assays. The phytochemical results showed the presence of carbohydrates, amino acids, flavonoids, alkaloids, tannins, terpenes, saponin, glycosides and steroids. The yield percentage of mucilage was 26% and showed swelling index of 6.8-7.4. The FTIR spectra of mucilage showed characteristics strong peaks of major functional groups. The SEM image showed the porous and rough surface morphological characters of mucilage. The obtained mucilage showed antioxidant potential by DPPH, FRAP and Total reducing power assay and also exhibited non-cytotoxic character against fibroblast cell lines. Thus, the isolated mucilage showed promising characteristics which can be exploited for various biological applications from food to drug release studies.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 5","pages":"439-448"},"PeriodicalIF":1.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the anti-cancer potential of Pexidartinib (PLX3397), a Fms-like tyrosine kinase 3 inhibitor, using next-generation knowledge discovery methods. 利用新一代知识发现方法解码Fms样酪氨酸激酶3抑制剂Pexidartinib（PLX3397）的抗癌潜力。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200460

Roaa Mahdi Alreemi

{"title":"Decoding the anti-cancer potential of Pexidartinib (PLX3397), a Fms-like tyrosine kinase 3 inhibitor, using next-generation knowledge discovery methods.","authors":"Roaa Mahdi Alreemi","doi":"10.6026/973206300200460","DOIUrl":"10.6026/973206300200460","url":null,"abstract":"Acute Myeloid Leukemia (AML) is a complex hematologic malignancy characterized by the rapid proliferation of abnormal myeloid precursor cells. The FMS-like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase, plays a pivotal role in regulating cell survival, proliferation, and differentiation within the hematopoietic system. Mutations in FLT3, particularly internal tandem duplications (ITDs) and point mutations within the tyrosine kinase domain (TKD), are prevalent in AML and are associated with poor prognosis and increased risk of relapse. The development of targeted therapies has revolutionized the landscape of cancer treatment by focusing on the inhibition of kinase signalling. Small-molecule inhibitors designed to selectively target receptor tyrosine kinases, such as PLX3397, have shown promising results in preclinical studies and early phase clinical trials. PLX3397 exerts its inhibitory effects by targeting CSF1R and KIT, leading to the disruption of receptor tyrosine kinase signalling cascades, suppression of leukemic cell growth, and induction of apoptosis. This study emphasizes the significance of FLT3 as a receptor tyrosine kinase as a therapeutic target for PLX3397. After evaluating the usefulness of PLX3397 as an enzyme inhibitor using ADMET prediction, PLX3397 was prepared for molecular docking in the FLT3 crystal structure (PDB: 4XUF). A molecular dynamics simulation was performed on PLX3397 to evaluate its binding affinity and protein stability in a simulated physiological environment. In conclusion, targeting FLT3 as a receptor tyrosine kinase with PLX3397 represents a promising therapeutic strategy for improving outcomes in patients with FLT3-mutated AML. Further clinical investigations are warranted to validate the efficacy and safety of PLX3397 and to optimize treatment strategies for AML patients based on the FLT3 mutational status.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 5","pages":"460-472"},"PeriodicalIF":1.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and treatment for hypomineralization of incisor and molar among school going Indian children. 印度学龄儿童门牙和臼齿矿化不足的发生率和治疗方法。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200575

Sajid Khan, Shweta Sharma, Arunendra Singh Chauhan, Aiyana Parthi, Saima Ali, Mohd Amjad Tahseen

引用次数: 0

BRCAFem: A database for breast cancer research. BRCAFem：乳腺癌研究数据库。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200473

Ghazala Sultan, Swaleha Zubair

引用次数: 0

Cytotoxic, antioxidant, antibacterial activity of phytochemicals from Phragmanthera austroarabica. 葭藻中植物化学物质的细胞毒性、抗氧化和抗菌活性。

IF 1.9

Bioinformation Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.6026/973206300200487

Moodi S A Alsubeie, Nasir A Ibrahim, Ahmed A Alghamdi, Nosiba S Basher, B S Al-Ammari, Awadallah B Dafaallah, Vajid Nettoor Veettil

{"title":"Cytotoxic, antioxidant, antibacterial activity of phytochemicals from Phragmanthera austroarabica.","authors":"Moodi S A Alsubeie, Nasir A Ibrahim, Ahmed A Alghamdi, Nosiba S Basher, B S Al-Ammari, Awadallah B Dafaallah, Vajid Nettoor Veettil","doi":"10.6026/973206300200487","DOIUrl":"10.6026/973206300200487","url":null,"abstract":"The cytotoxic, antioxidant, anticancer, and antibacterial properties of ethanolic extracts from Phragmanthera austroarabica is of interest. Plants of P. austroarabica were gathered from the southern Saudi Arabian region of Albaha. P. austroarabica extract was assessed using DPPH (2, 2-diphenyl-1-picrylhydrazyl). The German Collection of Microorganisms and Cell Cultures (DSMZ) cancer cell lines used in this investigation. The cytotoxic activity of P. austroarabica extract was explored against MCF-7 breast and A549 lung cancer cell lines, along with doxorubicin as a positive control. In both treated cells, P. austroarabica showed a remarkable activity via suppressing the cell's survival. In terms of IC50 (concentration equivalent to a survival rate of 50%), MCF-7 breast cancer cells were more sensitive to P. austroarabica extract.) DPPH colorimetric assay was employed to assess the antioxidant properties of P. austroarabica extract, the antioxidant activity was increased along with increment of extract concentrations. The leaves aqueous extract of P. austroarabica inhibited the growth of S. aureus by 6.3±0.12 mm and 24±0.43 mm and 15±0.56 mm respectively for seed, leaf and stem at concentrations 50 µl. However, the same concentrations inhibited the growth of E. coli by 25±0.75, 0.00 mm and 24±0.18 mm, following the same order. Different superscript letters indicate means that are significantly different at level (p<0.05). Minimal inhibitory concentrations (MIC) of P. austroarabica ethanolic extracts against the tested microorganisms were 1.5, 1.6 and 1.5, respectively for seed, leaf and stem against Staph. Aureus and were 1.2, 0.00 and 1.2, respectively for seed, leaf and stem against E. coli.","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"20 5","pages":"487-494"},"PeriodicalIF":1.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0