{"title":"<i>In vitro</i> assessment of cytokine release from gingival fibroblasts exposed to periodontal pathogens.","authors":"Kaushal Pati Tripathi, Rohit Mishra, Varsha Choubey, Ajay Kumar, Arohi Aglawe, Anshul Gulati","doi":"10.6026/973206300211501","DOIUrl":null,"url":null,"abstract":"<p><p>Cytokine responses of gingival fibroblasts from healthy and inflamed tissues upon exposure to <i>P. gingivalis</i> <i>lipopolysaccharide</i> (LPS) are of interest. Samples were obtained from 20 individuals undergoing periodontal procedures. Inflamed fibroblasts showed elevated secretion of IL-6, MCP-1, IL-8, and GRO. <i>P. gingivalis</i> LPS induced a stronger cytokine response than controls. Thus, inflamed fibroblasts can mount a secondary inflammatory response to periodontal pathogens.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"21 6","pages":"1501-1505"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449547/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/973206300211501","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Cytokine responses of gingival fibroblasts from healthy and inflamed tissues upon exposure to P. gingivalislipopolysaccharide (LPS) are of interest. Samples were obtained from 20 individuals undergoing periodontal procedures. Inflamed fibroblasts showed elevated secretion of IL-6, MCP-1, IL-8, and GRO. P. gingivalis LPS induced a stronger cytokine response than controls. Thus, inflamed fibroblasts can mount a secondary inflammatory response to periodontal pathogens.
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