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Investigating the diagnostic potential of IL-1β, IL-10, and IL-36γ in gingival crevicular fluid in patients with different periodontal conditions. 研究不同牙周病患者牙龈蠕动液中 IL-1β、IL-10 和 IL-36γ 的诊断潜力
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-05-01 Epub Date: 2024-03-11 DOI: 10.1080/1354750X.2024.2318256
Mihtikar Gürsel, Tuba Bayat, Niyazi Dündar, Ayşegül Yabacı Tak, Burcu Karaduman
{"title":"Investigating the diagnostic potential of IL-1β, IL-10, and IL-36γ in gingival crevicular fluid in patients with different periodontal conditions.","authors":"Mihtikar Gürsel, Tuba Bayat, Niyazi Dündar, Ayşegül Yabacı Tak, Burcu Karaduman","doi":"10.1080/1354750X.2024.2318256","DOIUrl":"10.1080/1354750X.2024.2318256","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to analyze cytokine levels, including interleukin (IL)-1β, IL-10, and IL-36γ, to investigate the link between pro- and anti-inflammatory responses in periodontal conditions and assess their potential as diagnostic biomarkers for distinguishing between different types of periodontal conditions.</p><p><strong>Methods: </strong>80 systemically healthy non-smokers (25 periodontally healthy, 25 with gingivitis, 30 with periodontitis) were included. Clinical periodontal parameters were recorded, and gingival crevicular fluid (GCF) samples were obtained. Receiver operating characteristic (ROC) curve analysis was applied to determine the diagnostic value of cytokines.</p><p><strong>Results: </strong>IL-36γ had the highest sensitivity for diagnosing periodontitis, although its specificity for identifying those without periodontitis was relatively low. The combination of IL-1β and IL-36γ was the most effective in differentiating periodontitis from periodontal health. IL-10 was found to be an acceptable discriminator for distinguishing gingivitis from healthy conditions. However, its sensitivity and specificity for identifying gingivitis were lower. The combination of the three cytokines showed the highest ability to distinguish between periodontitis and gingivitis.</p><p><strong>Conclusion: </strong>The levels of IL-1β, IL-10, and IL-36γ in GCF may provide insights into periodontal health and disease status. Further studies are needed to validate these results and explore the potential of these cytokines in periodontal disease management.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"118-126"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BCAT1, IKZF1 and SEPT9: methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas BCAT1、IKZF1 和 SEPT9：用于检测泛胃肠道腺癌的甲基化 DNA 生物标记物
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-04-22 DOI: 10.1080/1354750x.2024.2340663
Geraldine Laven-Law, Ganessan Kichenadasse, Graeme P. Young, Erin L. Symonds, Jean M. Winter
{"title":"BCAT1, IKZF1 and SEPT9: methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas","authors":"Geraldine Laven-Law, Ganessan Kichenadasse, Graeme P. Young, Erin L. Symonds, Jean M. Winter","doi":"10.1080/1354750x.2024.2340663","DOIUrl":"https://doi.org/10.1080/1354750x.2024.2340663","url":null,"abstract":"Methylated circulating tumour DNA (ctDNA) blood tests for BCAT1/IKZF1 (COLVERA) and SEPT9 (Epi proColon) are used to detect colorectal cancer (CRC). However, there are no ctDNA assays approved for ...","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":"79 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140635306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prognostic risk model based on lactate metabolism and transport-related lncRNAs for gastric adenocarcinoma 基于乳酸代谢和转运相关 lncRNA 的胃腺癌预后风险模型
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-04-17 DOI: 10.1080/1354750x.2024.2341411
Zhenyuan Qian, Fang Wu, Guoqing Feng, Wenfa Lin, Xufan Cai, Jianzhang Wu, Kun Ke, Zaiyuan Ye, Guoxi Xu
{"title":"A prognostic risk model based on lactate metabolism and transport-related lncRNAs for gastric adenocarcinoma","authors":"Zhenyuan Qian, Fang Wu, Guoqing Feng, Wenfa Lin, Xufan Cai, Jianzhang Wu, Kun Ke, Zaiyuan Ye, Guoxi Xu","doi":"10.1080/1354750x.2024.2341411","DOIUrl":"https://doi.org/10.1080/1354750x.2024.2341411","url":null,"abstract":"Increased lactate levels and metastasis in tumours are strongly associated with dismal outcomes. But prognostic value of lactate metabolism and transport-related lncRNAs in gastric adenocarcinoma (...","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":"6 5 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140628588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarker-guided drug development provides value for patients, payers and drug developers: lessons learned from 25 years in the biomarker industry 生物标志物指导下的药物开发为患者、支付方和药物开发商带来价值：生物标志物行业 25 年的经验教训
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-04-12 DOI: 10.1080/1354750x.2024.2342016
Alexander L. Reese-Petersen, Helene W. Breisnes, Daniel Gabor, Sarah R. Rønnow, Bruna Manoel, Mayuur Bajaj, Claus S. von Arenstorff, Elijah Aighobahi, Rune Vestermark, Morten A. Karsdal
{"title":"Biomarker-guided drug development provides value for patients, payers and drug developers: lessons learned from 25 years in the biomarker industry","authors":"Alexander L. Reese-Petersen, Helene W. Breisnes, Daniel Gabor, Sarah R. Rønnow, Bruna Manoel, Mayuur Bajaj, Claus S. von Arenstorff, Elijah Aighobahi, Rune Vestermark, Morten A. Karsdal","doi":"10.1080/1354750x.2024.2342016","DOIUrl":"https://doi.org/10.1080/1354750x.2024.2342016","url":null,"abstract":"IntroductionThere is an urgent, persistent, need for better biomarkers in clinical drug development. More informative biomarkers can increase the likelihood of drug advancement or approval, and imp...","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":"39 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of Matrix Metalloproteinase-2 and Galectin-3 as predictive biomarkers for all-cause mortality in patients undergoing transfemoral transcatheter aortic valve implantation 基质金属蛋白酶-2和Galectin-3作为经口经导管主动脉瓣植入术患者全因死亡率预测生物标志物的作用
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-04-08 DOI: 10.1080/1354750x.2024.2341409
Kerstin Piayda, Julian Tim Heilemann, Stanislav Keranov, Luisa Schulz, Mani Arsalan, Christoph Liebetrau, Won-Keun Kim, Felix J. Hofmann, Pascal Bauer, Sandra Voss, Christian Troidl, Samuel T. Sossalla, Christian W. Hamm, Holger M. Nef, Oliver Dörr
{"title":"The role of Matrix Metalloproteinase-2 and Galectin-3 as predictive biomarkers for all-cause mortality in patients undergoing transfemoral transcatheter aortic valve implantation","authors":"Kerstin Piayda, Julian Tim Heilemann, Stanislav Keranov, Luisa Schulz, Mani Arsalan, Christoph Liebetrau, Won-Keun Kim, Felix J. Hofmann, Pascal Bauer, Sandra Voss, Christian Troidl, Samuel T. Sossalla, Christian W. Hamm, Holger M. Nef, Oliver Dörr","doi":"10.1080/1354750x.2024.2341409","DOIUrl":"https://doi.org/10.1080/1354750x.2024.2341409","url":null,"abstract":"Background: Currently available risk scores fail to accurately predict morbidity and mortality in patients with severe symptomatic aortic stenosis who undergo transcatheter aortic valve implantatio...","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":"66 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association Between Inflammatory Biomarkers and Low Back Disorder: A Systematic Review and Meta-analysis 炎症生物标志物与腰背痛之间的关系：系统回顾与元分析
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-04-05 DOI: 10.1080/1354750x.2024.2339285
Stone Sima, Xiaolong Chen, Ashish D. Diwan
{"title":"The Association Between Inflammatory Biomarkers and Low Back Disorder: A Systematic Review and Meta-analysis","authors":"Stone Sima, Xiaolong Chen, Ashish D. Diwan","doi":"10.1080/1354750x.2024.2339285","DOIUrl":"https://doi.org/10.1080/1354750x.2024.2339285","url":null,"abstract":"Introduction: Low back disorder (LBD) is a major cause of disability worldwide. Inflammation results in proliferation of cytokines or consequent degradation products (collectively known as Inflamma...","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":"212 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer ESPL1的上调与子宫内膜癌的不良预后有关
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-04-03 DOI: 10.1080/1354750x.2024.2339288
Yuzhong Yang, Ying Sheng, Jinhua Zheng, Aiyu Ma, Shaohua Chen, Jing Lin, Xiaozhen Yang, Yuanna Liang, Yan Zhang, Xiang Zheng
{"title":"Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer","authors":"Yuzhong Yang, Ying Sheng, Jinhua Zheng, Aiyu Ma, Shaohua Chen, Jing Lin, Xiaozhen Yang, Yuanna Liang, Yan Zhang, Xiang Zheng","doi":"10.1080/1354750x.2024.2339288","DOIUrl":"https://doi.org/10.1080/1354750x.2024.2339288","url":null,"abstract":"Background: Extra spindle pole bodies-like 1 (ESPL1) is known to play a crucial role in the segregation of sister chromatids during mitosis. Overexpression of ESPL1 is considered to have oncogenic ...","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":"50 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exocyclic DNA adducts and oxidative stress parameters: useful tools for biomonitoring exposure to aldehydes in smokers 外环 DNA 加合物和氧化应激参数：对吸烟者接触醛类物质情况进行生物监测的有用工具
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-03-20 DOI: 10.1080/1354750x.2024.2333361
Héléna Alamil, Marie-Lise Colsoul, Natacha Heutte, Marie Van Der Schueren, Laurence Galanti, Mathilde Lechevrel
{"title":"Exocyclic DNA adducts and oxidative stress parameters: useful tools for biomonitoring exposure to aldehydes in smokers","authors":"Héléna Alamil, Marie-Lise Colsoul, Natacha Heutte, Marie Van Der Schueren, Laurence Galanti, Mathilde Lechevrel","doi":"10.1080/1354750x.2024.2333361","DOIUrl":"https://doi.org/10.1080/1354750x.2024.2333361","url":null,"abstract":"Exocyclic DNA adducts have been shown to be potential biomarkers of cancer risk related to oxidative stress and exposure to aldehydes in smokers. In fact, aldehydes potentially arise from tobacco c...","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpreting quantitative RNA expression prognostic and predictive results generated from synchronous rather than solitary breast cancers 解读同步乳腺癌而非单发乳腺癌的定量 RNA 表达预后和预测结果
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-03-04 DOI: 10.1080/1354750x.2024.2324871
Steven Sorscher, Priya Gor
{"title":"Interpreting quantitative RNA expression prognostic and predictive results generated from synchronous rather than solitary breast cancers","authors":"Steven Sorscher, Priya Gor","doi":"10.1080/1354750x.2024.2324871","DOIUrl":"https://doi.org/10.1080/1354750x.2024.2324871","url":null,"abstract":"Published in Biomarkers (Just accepted, 2024)","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":"255 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140036619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of exosomal tetraspanin profile in sepsis patients as a promising diagnostic biomarker. 脓毒症患者外泌体Tetraspanin谱作为一种有前途的诊断生物标记物的研究
IF 2.6 4区 医学
Biomarkers Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI: 10.1080/1354750X.2024.2319296
Roushka Bhagwan Valjee, Irene Mackraj, Roshila Moodley, Usri H Ibrahim
{"title":"Investigation of exosomal tetraspanin profile in sepsis patients as a promising diagnostic biomarker.","authors":"Roushka Bhagwan Valjee, Irene Mackraj, Roshila Moodley, Usri H Ibrahim","doi":"10.1080/1354750X.2024.2319296","DOIUrl":"10.1080/1354750X.2024.2319296","url":null,"abstract":"<p><strong>Introduction: </strong>Sepsis, a leading cause of mortality globally, has a complex and multifaceted pathophysiology which still requires elucidation. Therefore, this study aimed to analyze and quantify the number of exosomes in sepsis patients from a South African cohort using the ExoView (NanoView Biosciences, Boston, MA) platform.</p><p><strong>Methods: </strong>Blood samples were collected from black South African patients attending the local Intensive Care Unit (ICU) hospital. Exosomes were isolated and characterize via TEM and CD63 ELISA kits. ExoView was used to determine particle count, particle size distribution and colocalization of different tetraspanin markers.</p><p><strong>Results: </strong>Exosomal levels in sepsis patients were significantly higher compared to the control group (<i>p</i> < 0.05). Sepsis exosomes showed a homogenous size distribution ranging from 55 to 70 nm. Tetraspanin colocalization analysis revealed that sepsis exosomes have significantly higher CD63/CD9, CD63/CD81 and CD63/CD9/CD81 colocalization percentages than the control group.</p><p><strong>Conclusion: </strong>This unique tetraspanin colocalization pattern of sepsis exosomes could serve as a potential sepsis biomarker. Further investigations are required to identify sepsis exosomal cargo signatures for further understanding of sepsis pathophysiology in order to develop effective diagnostics and treatments.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"78-89"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139728853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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