氧化性DNA损伤可能通过激活端粒酶和延长端粒长度来促进子宫内膜异位症的发展：一项荟萃分析。

IF 1.9 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biomarkers Pub Date : 2025-09-16 DOI:10.1080/1354750X.2025.2557452

Huanli He, Xiaohui Yang, Kai Wang, Qingjian Ye

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引用次数: 0

摘要

目的：通过荟萃分析，探讨DNA氧化损伤生物标志物[8-羟基-2′-脱氧鸟苷（8-OHdG）水平、端粒长度（TL）、人端粒酶逆转录酶（hTERT）、端粒酶活性（TA）及人8-氧鸟嘌呤糖基化酶1 （hOGG1）或x射线修复交叉互补组4 （XRCC4）多态性]与子宫内膜异位症（EMT）的关系。方法：检索至2024年8月的5个数据库。使用Stata 15.0估计合并优势比（OR）或标准化平均差（SMD）， 95%置信区间（ci）。结果：纳入42项研究。总体荟萃分析显示，与对照组相比，EMT女性的8-OHdG （SMD = 1.84; 95%CI = 1.29 - 2.39）、TA （SMD = 3.03; 95%CI = 2.07 - 4.00）和hTERT （SMD = 2.55; 95%CI = 1.55 - 3.55）显著升高。携带hOGG1 rs1052133的GG基因型（vs GC + CC: OR = 1.34; 95%CI = 1.00 ~ 1.78）、XRCC4 rs6869366的TT基因型（vs TG + GG: OR = 2.67; 95%CI = 1.63 ~ 4.38）和T等位基因（vs G: OR = 3.49; 95%CI = 2.27 ~ 5.35）的女性发生EMT的风险较高。亚组和修整填充分析表明，较长的TL是EMT的危险因素。结论：8-OHdG、TA、hTERT、TL、rs1052133和rs6869366是EMT潜在的预测生物标志物和治疗靶点。

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Oxidative DNA damage may promote the development of endometriosis by activating telomerase and extending telomere length: a meta-analysis.

Objective: To investigate the associations between oxidative DNA damage biomarkers (levels of 8-hydroxy-2'-deoxyguanosine [8-OHdG], telomere length [TL], human telomerase reverse transcriptase [hTERT], telomerase activity [TA] and polymorphisms of human 8-oxoguanine glycosylase 1 [hOGG1] or X-ray repair cross-complementing group 4 [XRCC4]) and endometriosis (EMT) by a meta-analysis.

Methods: Five databases were searched until August 2024. Stata version 15.0 was used to estimate pooled odds ratio (OR) or standardized mean difference (SMD) with 95% confidence intervals (CIs).

Results: Forty-two studies were included. Overall meta-analysis revealed significantly elevated 8-OHdG (SMD = 1.84; 95%CI = 1.29-2.39), TA (SMD = 3.03; 95%CI = 2.07-4.00) and hTERT (SMD = 2.55; 95%CI = 1.55-3.55) in EMT women compared to controls. Women carrying GG genotype (vs. GC+CC: OR = 1.34; 95%CI = 1.00-1.78) of hOGG1 rs1052133, TT genotype (vs. TG+GG: OR = 2.67; 95%CI = 1.63-4.38) and T allele (vs. G: OR = 3.49; 95%CI = 2.27-5.35) of XRCC4 rs6869366 had a higher risk of developing EMT. Subgroup and trim-and-fill analyses indicated longer TL was a risk factor for EMT.

Conclusions: 8-OHdG, TA, hTERT, TL, rs1052133 and rs6869366 represent potential prediction biomarkers and treatment targets for EMT.

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来源期刊

Biomarkers 医学-毒理学

CiteScore

5.00

自引率

3.80%

发文量

140

审稿时长

3 months

期刊介绍： The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.