IF 2 4区医学

Biomarkers Pub Date : 2025-06-21 DOI: 10.1080/1354750X.2025.2522888

Arpan Chattopadhyay, Harshita Tak, Hemanth Naick B

{"title":"Evaluating Cell-Free Circulatory Mitochondrial DNA as a Comprehensive Biomarker for Stress: Meta-Analysis of Psychological and Physiological Stress Responses.","authors":"Arpan Chattopadhyay, Harshita Tak, Hemanth Naick B","doi":"10.1080/1354750X.2025.2522888","DOIUrl":"https://doi.org/10.1080/1354750X.2025.2522888","url":null,"abstract":"Background: Mitochondria play a crucial role in cellular processes such as energy metabolism, reactive oxygen species (ROS) generation, and apoptosis. Mitochondrial dysfunction induced by stress has been implicated in various health conditions. Circulating cell-free mitochondrial DNA (CFC-MT-DNA) has emerged as a potential biomarker reflecting mitochondrial damage under stress.Methods: To evaluate the association between CFC-MT-DNA levels and human stress through a systematic review and meta-analysis of case-control studies. A comprehensive literature search was conducted across PubMed, Web of Science, and ScienceDirect databases up to September 2023. Eight eligible studies assessing CFC-MT-DNA levels in stressed versus control individuals were included. Data were analysed using RevMan 5.4 software.Results: The meta-analysis revealed significantly elevated CFC-MT-DNA levels in individuals experiencing stress (P = 0.03), particularly in psychological stress-related conditions such as bipolar disorder and major depressive disorder. However, no significant increase was observed in physiological stress conditions, including diabetes and sports training. High heterogeneity (I2 = 96%) was observed across studies.Conclusion: CFC-MT-DNA shows promise as a non-invasive biomarker for psychological stress. Further longitudinal and mechanistic studies are needed to clarify its role across different types of stress and its potential clinical utility.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosensor driven biomarker analysis: pioneering advancements in cancer diagnosis and therapeutic strategies. 生物传感器驱动的生物标志物分析：癌症诊断和治疗策略的开创性进展。

IF 2 4区医学

Biomarkers Pub Date : 2025-06-10 DOI: 10.1080/1354750X.2025.2515363

Gauri Nimhan, Mahavir Narwade, Kavita Gajbhiye

{"title":"Biosensor driven biomarker analysis: pioneering advancements in cancer diagnosis and therapeutic strategies.","authors":"Gauri Nimhan, Mahavir Narwade, Kavita Gajbhiye","doi":"10.1080/1354750X.2025.2515363","DOIUrl":"10.1080/1354750X.2025.2515363","url":null,"abstract":"Introduction: Early cancer detection significantly improves treatment outcomes; however, many cancers remain undiagnosed until advanced stages. This highlights the urgent need for rapid and precise diagnostic tools. Biosensors offer a transformative approach in cancer diagnostics by enabling early detection and continuous monitoring through the identification of molecular biomarkers.Methods: Biosensors function by converting biological elements-such as proteins, RNA, or genetic material-into measurable electrical signals. These devices are tailored to detect specific biomarkers, including proteins, peptides, gene mutations, or abnormal gene expression levels associated with various cancers.Results: Biosensors provide high sensitivity and specificity in identifying cancer cells. They enable real-time monitoring of tumour progression, angiogenesis, and treatment responses. These tools also facilitate accurate imaging of cancer cells and help evaluate the effectiveness of targeted therapies such as chemotherapy.Conclusion: The integration of biosensors into clinical practice could revolutionize cancer diagnostics by offering early, accurate, and minimally invasive detection methods. This review explores recent advances in biosensor development, the evolving landscape of cancer biomarkers, and the application of different biosensor technologies in cancer detection. Additionally, it addresses current limitations and challenges in clinical implementation, emphasizing the potential of biosensors to enhance patient outcomes through early intervention.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-20"},"PeriodicalIF":2.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of first-trimester blood biomarkers associated with preterm prelabor rupture of the fetal membranes. 与早产胎膜产前破裂相关的妊娠早期血液生物标志物的系统综述。

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1080/1354750X.2025.2475474

Mille Kirk, Josephine R Ekmann, Martin Overgaard, Charlotte K Ekelund, Hanne K Hegaard, Line Rode

{"title":"A systematic review of first-trimester blood biomarkers associated with preterm prelabor rupture of the fetal membranes.","authors":"Mille Kirk, Josephine R Ekmann, Martin Overgaard, Charlotte K Ekelund, Hanne K Hegaard, Line Rode","doi":"10.1080/1354750X.2025.2475474","DOIUrl":"10.1080/1354750X.2025.2475474","url":null,"abstract":"Background: Preterm prelabor rupture of the fetal membranes (PPROM) increases the risk of neonatal mortality and morbidity. The etiology behind the condition is multifactorial but believed to result from an overactivation of inflammatory pathways. This systematic review aimed to synthesize the literature behind first-trimester biomarkers associated with PPROM and compare it to literature within the same area for preterm birth.Methods: A search strategy was performed in PubMed, Embase, and CINAHL from 1993 to 2024 resulting in 14,889 articles screened by two independent authors and presented according to PRISMA guidelines. The biomarkers from the included articles were categorized into four medical headings: The immune system, metabolism and endocrinology, hematology, and reproduction.Results: Biomarkers associated with PPROM were primarily related to the immune system. C-reactive protein (CRP) and white blood cells (WBC) were often investigated for an association with PPROM but displayed divergent results of varying quality. Decreased concentrations of placental growth factor (PlGF) were associated with PPROM and spontaneous preterm birth, potentially highlighting a shared etiology, making soluble fms-like tyrosine kinase-1 (sFlt-1) interesting to investigate as well.Conclusion: Most biomarkers were examined in single studies, providing limited data to make significant conclusions about each biomarker. This review encourages further investigation of CRP, WBC, PlGF, and sFlt-1.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"271-283"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aqueous Pistacia lentiscus leaves extract protects against ethanol-induced gastroduodenal ulcers in rat. 黄连木叶提取物对乙醇性大鼠胃十二指肠溃疡的保护作用。

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-05-10 DOI: 10.1080/1354750X.2025.2501575

Yasmina Zahouani, Abdelhafidh Khazri, Samir Touaylia, Khemais Ben Rhouma, Hichem Sebai, Mohsen Sakly

{"title":"Aqueous Pistacia lentiscus leaves extract protects against ethanol-induced gastroduodenal ulcers in rat.","authors":"Yasmina Zahouani, Abdelhafidh Khazri, Samir Touaylia, Khemais Ben Rhouma, Hichem Sebai, Mohsen Sakly","doi":"10.1080/1354750X.2025.2501575","DOIUrl":"10.1080/1354750X.2025.2501575","url":null,"abstract":"Background and aim: The protective effects of aqueous extract of Pistacia lentiscus leaves (AELPL) against gastric and duodenal ulcers induced by alcohol oral gavage administration in Wistar rats were investigated in this study.Methods: The rats were divided into six groups control, ethanol single, ethanol + AEPL (25-50-100) and famotidine + ethanol.Results: HPLC-MS analysis allowed the identification of numerous phenolic compounds in P. lentiscus leaves such as flavonoids (isoquercetin and luteolin), flavonols (catechin, rutin and kaempferol), phenolic acids (ellagic and dicaffeoylquinic) and tannins. Ethanol administration induced significant gastric and duodenal ulcerative lesions, while AELPL pretreatment (25, 50 and 100 mg/kg) provided a dose-dependent mucosal protection comparable to famotidine, a widely used drug for the treatment of gastric ulcers. AELPL like famotidine also restored gastric pH and volume, counteracting ethanol-induced acidity. Biochemical analyses demonstrated that AELPL like famotidine mitigated oxidative stress by reducing lipid peroxidation, carbonylated proteins and hydrogen peroxide levels, whereas it restored non-protein thiols content in the stomach, duodenum and plasma in a dose-dependent manner. Additionally, AELPL restored antioxidant enzyme activities including catalase, superoxide dismutase, glutathione peroxidase and glutathione-S-transferase. AELPL also reduced ethanol-induced increase in free iron, ionized calcium and interleukin-6 levels, indicating its anti-inflammatory potential.Conclusion: These findings suggest that AELPL exhibits gastroduodenal protective effects against ethanol-induced damage, with efficacy comparable to famotidine. Protective mechanisms likely involve modulation of oxidative stress and inflammation, supporting AELPL's potential as a therapeutic agent for gastroduodenal injuries.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"256-270"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early warning system for player recovery? A series of case studies illustrating the application of individualised adaptive reference ranges in the longitudinal blood monitoring of English Premier League soccer players. 玩家恢复的早期预警系统？个性化自适应参考范围在英超球员纵向血液监测中的应用的一系列案例研究

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI: 10.1080/1354750X.2025.2473724

Diarmuid Daniels, Davood Roshan, Nathan A Lewis, John Newell, Georgie Bruinvels, Paul Catterson, Jamie Harley, Micheal Newell, Andrew Barr, Charles R Pedlar

{"title":"Early warning system for player recovery? A series of case studies illustrating the application of individualised adaptive reference ranges in the longitudinal blood monitoring of English Premier League soccer players.","authors":"Diarmuid Daniels, Davood Roshan, Nathan A Lewis, John Newell, Georgie Bruinvels, Paul Catterson, Jamie Harley, Micheal Newell, Andrew Barr, Charles R Pedlar","doi":"10.1080/1354750X.2025.2473724","DOIUrl":"10.1080/1354750X.2025.2473724","url":null,"abstract":"Blood biomarkers can provide objective insight into a player's physiological state of recovery. Individualised approaches to biomarker monitoring may be of higher potential value in assessing player health and recovery compared to population-based reference ranges. We aimed to explore the application of individualised adaptive reference ranges (IARR) in English Premier League (EPL) soccer players using a POC biomarker for C-Reactive Protein (CRP) as a marker of inflammation. Using historical data collected from players' CRP values during the 2019-2020 season, we evaluated the effectiveness of static and IARR in identifying abnormal values and reported sensitivity and specificity at a 5% significance level. Our analysis confirmed that monitoring with IARR is more effective in identifying true abnormalities compared to population-based static reference ranges, particularly when the intra-individual variability is considerably lower than inter-individual variability. The application of IARR for blood monitoring data could assist the practitioner in identifying periods where a player may require performance (e.g. workload management and recovery practices) or medical support from the multi-disciplinary team. However, IARR serve more as an early warning system than a diagnostic tool. Thus, significant care is needed to prevent misuse and misinterpretation when implementing this strategy in real-world settings.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"232-245"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of waterpipe smoking and its cessation on metabolic biomarkers and a novel biomarker omentin-1. 水烟吸烟及戒烟对代谢生物标志物及新的生物标志物网膜蛋白-1的影响

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI: 10.1080/1354750X.2025.2479664

Hiba A Yousif, Mohammed A Hami

{"title":"Effect of waterpipe smoking and its cessation on metabolic biomarkers and a novel biomarker omentin-1.","authors":"Hiba A Yousif, Mohammed A Hami","doi":"10.1080/1354750X.2025.2479664","DOIUrl":"10.1080/1354750X.2025.2479664","url":null,"abstract":"Background and objective: Waterpipe smoking (WPS) has increased globally and may lead to various metabolic disorders. However, its long-term effects and cessation impact on metabolic biomarkers and omentin-1 remain unclear. This study aims to evaluate the impact of WPS and its cessation on metabolic biomarkers and omentin-1 levels and explore their correlations.Materials and methods: 90 individuals were categorized into three groups (non-smokers, waterpipe smokers and cessation of waterpipe smokers). FBS and lipid profiles including TC, TG and HDL were measured using the Cobas 6000 c501 system, while FI was analyzed with the Cobas 6000 c601 system. Omentin-1 concentrations were determined using the enzyme-linked immunosorbent assay (ELISA) with a human omentin ELISA kit.Results: FI, HOMA-IR and lipid profiles were significantly elevated in WPS and cessation groups. Omentin-1 and DBP levels significantly decreased in both groups compared to non-smokers. Increased WPS duration leads to reduced BMI, WC and DBP, while cessation duration decreases FBS and SBP. A negative association was identified among omentin-1 with FBS and O2.Conclusion: WPS and its cessation adversely affect metabolic health, reducing omentin-1 levels and increasing the risk of metabolic disorders. Over time, cessation improves specific biochemical markers, highlighting the need for public health awareness.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"219-225"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum ferritin can serve as a biomarker for the prognosis and increased the prognostic predictive value of ISS/RISS in multiple myeloma patients. 血清铁蛋白可作为预后的生物标志物，提高了ISS/RISS对多发性骨髓瘤患者的预后预测价值。

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI: 10.1080/1354750X.2025.2485142

Mengmeng Dong, Jinna Zhang, Li Yang, Yi Li, Jingsong He, Zhen Cai

{"title":"Serum ferritin can serve as a biomarker for the prognosis and increased the prognostic predictive value of ISS/RISS in multiple myeloma patients.","authors":"Mengmeng Dong, Jinna Zhang, Li Yang, Yi Li, Jingsong He, Zhen Cai","doi":"10.1080/1354750X.2025.2485142","DOIUrl":"10.1080/1354750X.2025.2485142","url":null,"abstract":"Purpose: Multiple myeloma (MM) is a terminally differentiated plasma cell hematological malignancy. The revised international staging system (RISS) is commonly used in patients with de novo MM, but it has limitations in predicting prognosis. Better biomarkers need to added to the staging system.Results: This retrospective study included a total of 302 patients. Smooth curve fitting analysis showed that serum ferritin levels were associated with relapse and all-cause death. The K-M curve analysis indicated that MM patients with higher ferritin levels had shorter PFS (p < 0.0056) and OS (p = 0.0014). Multivariate Cox regression analysis also showed MM patients with high serum ferritin had poor PFS (p = 0.0012) and OS (p = 0.0258), with independent correlation. The prediction model of ROC analysis based on Cox regression validated ferritin had a predictive value for PFS and OS, and increased the predictive value of ISS and RISS for OS.Conclusion: We revealed that baseline serum ferritin levels were associated with prognosis in patients with MM, and patients with higher serum ferritin have poorer PFS and OS. Serum ferritin could increase the prediction value. The study provided a new evidence for searching for prognostic biomarkers in MM patients.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"246-255"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ischaemia-modified albumin test: new tricks for an old dog? 缺血修饰白蛋白试验：老狗的新把戏？

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-03-23 DOI: 10.1080/1354750X.2025.2481407

Alan H B Wu

引用次数: 0

Correction. 修正。

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1080/1354750X.2025.2486878

引用次数: 0

The role of maternal serum ischemia-modified albumin in the prediction of hyperemesis gravidarum: a prospective cohort study. 母体血清缺血修饰白蛋白在预测妊娠剧吐中的作用：一项前瞻性队列研究。

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-02-15 DOI: 10.1080/1354750X.2025.2465972

Pınar Yıldız, Murat Levent Dereli

{"title":"The role of maternal serum ischemia-modified albumin in the prediction of hyperemesis gravidarum: a prospective cohort study.","authors":"Pınar Yıldız, Murat Levent Dereli","doi":"10.1080/1354750X.2025.2465972","DOIUrl":"10.1080/1354750X.2025.2465972","url":null,"abstract":"Background: Ischemia and associated hypoxemia-induced oxidative stress play an important role in hyperemesis gravidarum (HG) pathogenesis.Objective: The aim was to investigate the role of ischemia-modified albumin (IMA) in predicting HG.Methods: A prospective cohort study was conducted with 138 participants with singleton pregnancies who had experienced HG in previous pregnancies. Blood samples were taken at or before 5 weeks, provided they had no symptoms of nausea and vomiting at that time. The samples were stored under appropriate conditions to be analyzed for IMA. All participants were then followed to determine whether they would develop HG.Results: HG occurred in 42 participants (HG group), while the remaining 96 participants did not develop HG (control group). Baseline characteristics showed no significant differences. IMA levels were significantly higher in the HG group (p < 0.001). IMA levels did not correlate with body mass index or maternal age. IMA with a cut-off of >74.74 ng/mL (95% sensitivity, 67% specificity) had a discriminatory power with an AUC value of 0.791 (95% CI: 0.714-0.856; p < 0.001) for predicting HG.Conclusion: Our results show an association between high IMA levels in early pregnancy and an increased risk of HG. IMA can be used as a predictive tool for HG.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"226-231"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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