IF 2.2 4区医学

Biomarkers Pub Date : 2026-10-14 DOI: 10.1080/1354750X.2026.2744746

María Jesús Fernández Aceñero, Wenceslao Vásquez Jiménez, Emma Sola Vendrell, Olga Mateo Sierra, Coca-Mihaela Vieru

{"title":"FRMD6 expression can predict relapse of colorectal carcinoma after cytoreductive surgery with HIPEC.","authors":"María Jesús Fernández Aceñero, Wenceslao Vásquez Jiménez, Emma Sola Vendrell, Olga Mateo Sierra, Coca-Mihaela Vieru","doi":"10.1080/1354750X.2026.2744746","DOIUrl":"10.1080/1354750X.2026.2744746","url":null,"abstract":"Background: 4.1-ezrin-radixin-moesin (FERM) domain containing protein 6 (FRMD6), a component of Hippo/YAP pathway, behaves as a tumor suppressor gene and is aprotein used for colorectal carcinomas (CRC) molecular classification. As its potential prognostic role has not been widely analyzed, this study aims to determine it in the management of CRC with peritoneal involvement.Methods: Clinicopathological data from 37 patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for CRC with peritoneal involvement after preoperative chemotherapy, were collected and immunohistochemistry for FRMD6 in preoperative samples was performed.Results: After neoadjuvant chemotherapy, 5 patients achieved pathologic complete response. After CRS/HIPEC, disease progressed in 66.7% of the patients and at the time of the study 48.6% had died of disease. FRMD6 expression was positive in 45.9% of cases. Statistical analysis revealed a significant association between FRMD6 expression and prognosis both in terms of disease free survival and overall survival and a tendency to significance for the association with pathological response to therapy.Conclusions: Our results align with the few previous studies findings, which have shown a better prognosis for patients overexpressing FRMD6, but for the first time in the world literature we have analyzed this marker in patients undergoing HIPEC.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-7"},"PeriodicalIF":2.2,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Claudin 18.2: From a Tight Junction Protein to a Breakthrough Target in Solid Tumor Immunotherapy. Claudin 18.2：从紧密连接蛋白到实体瘤免疫治疗的突破性靶点。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-10-13 DOI: 10.1080/1354750X.2026.2749578

Mohammad Bahrami, Masoud Hassanzadeh Makoui, Amir Bayat Bodaghi, Mansour Rajabi Vahid

{"title":"Claudin 18.2: From a Tight Junction Protein to a Breakthrough Target in Solid Tumor Immunotherapy.","authors":"Mohammad Bahrami, Masoud Hassanzadeh Makoui, Amir Bayat Bodaghi, Mansour Rajabi Vahid","doi":"10.1080/1354750X.2026.2749578","DOIUrl":"https://doi.org/10.1080/1354750X.2026.2749578","url":null,"abstract":"Claudin 18.2 (CLDN18.2), a tight junction protein largely confined to normal gastric mucosa, is overexpressed and mislocalized on the surface of gastric, gastroesophageal, pancreatic, and other gastrointestinal cancers. This pattern has made CLDN18.2 a leading target in solid tumor immunotherapy. This review traces its path from a structural junctional component to a clinically relevant antigen and assesses the therapeutic platforms built around it. We discuss monoclonal antibodies, especially zolbetuximab, whose phase III SPOTLIGHT and GLOW trials improved survival in CLDN18.2-positive, HER2-negative gastric and gastroesophageal junction adenocarcinoma and led to regulatory approval. We then evaluate antibody-drug conjugates, bispecific T-cell engagers, and CAR T-cell therapies, comparing their mechanisms, efficacy, toxicity, and resistance. We also examine the rationale for combining CLDN18.2-directed agents with immune checkpoint inhibitors, although clinical evidence for synergy remains indirect. Major challenges include antigen loss and heterogeneity, autophagy-mediated ADC resistance, on-target gastrointestinal toxicity, cytokine release syndrome, and unstandardized expression thresholds. Because optimal cutoffs differ by modality, patient selection should follow the intended therapeutic class rather than a universal biomarker score. Overall, CLDN18.2-directed therapy is a maturing precision oncology strategy; its impact will depend on randomized data, better biomarkers, and rational combinations.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-38"},"PeriodicalIF":2.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-sensitivity cardiac troponin T is associated with acute kidney injury in emergency department patients. 高敏感性心肌肌钙蛋白T与急诊科患者急性肾损伤相关

IF 2.2 4区医学

Biomarkers Pub Date : 2026-10-08 DOI: 10.1080/1354750X.2026.2742157

Megan Woelkers, Sutton Fox, Davis C Murray, Saiharinath Nerella, Elizabeth Tabornal, Nicholas Bevins, Robert Fitzgerald, Lori B Daniels

{"title":"High-sensitivity cardiac troponin T is associated with acute kidney injury in emergency department patients.","authors":"Megan Woelkers, Sutton Fox, Davis C Murray, Saiharinath Nerella, Elizabeth Tabornal, Nicholas Bevins, Robert Fitzgerald, Lori B Daniels","doi":"10.1080/1354750X.2026.2742157","DOIUrl":"10.1080/1354750X.2026.2742157","url":null,"abstract":"Introduction: Chronic high-sensitivity cardiac troponin T (hs-cTnT) elevations are common in chronic kidney disease, but whether hs-cTnT predicts subsequent acute kidney injury (AKI) is unclear.Methods: We examined the association between maximum hs-cTnT and subsequent AKI in 23,292 Emergency Department encounters. AKI was defined as serum creatinine (sCr) increase ≥0.3 mg/dL within 48 hours or ≥1.5x the presenting value; secondary endpoints were time to AKI and peak sCr.Results: AKI occurred in 8.9% of encounters. Maximum hs-cTnT was independently associated with AKI (adjusted OR 1.58 [95% CI 1.53-1.63] per 1-unit increase in ln[hs-cTnT]), with similar associations among encounters with and without reduced kidney function at presentation. The median interval from maximum hs-cTnT to AKI was 43 hours (IQR, 21-97). A data-derived hs-cTnT cutoff of 148 ng/L yielded an AUC of 0.82, 80% sensitivity, 70% specificity, and 97% negative predictive value for AKI. Among encounters with AKI, maximum ln(hs-cTnT) was modestly associated with ln(sCr) at AKI in univariable analysis (R2=0.10) and with subsequent maximum ln(sCr) after multivariable adjustment (incremental R2=0.04; both P < 0.0001).Conclusion: Maximum hs-cTnT identified patients at increased risk for subsequent AKI, including those with normal renal function at presentation, and may help identify patients warranting closer kidney-function monitoring.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons learned from predicting hospital admission criteria comparing two COVID-19 waves: An Emergency Department's perspective. 从预测住院标准比较两次COVID-19浪潮的经验教训：急诊科的角度。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-09-16 DOI: 10.1080/1354750X.2026.2725728

Miriam Mayer, Anna Slagman, Samipa Pudasaini, Kira Louisa Boldt, Mareen Pigorsch, Jennifer Hitzek, Martin Möckel

{"title":"Lessons learned from predicting hospital admission criteria comparing two COVID-19 waves: An Emergency Department's perspective.","authors":"Miriam Mayer, Anna Slagman, Samipa Pudasaini, Kira Louisa Boldt, Mareen Pigorsch, Jennifer Hitzek, Martin Möckel","doi":"10.1080/1354750X.2026.2725728","DOIUrl":"https://doi.org/10.1080/1354750X.2026.2725728","url":null,"abstract":"Introduction Emergency Departments (ED) play a central role in providing healthcare during crises such as pandemics. Evaluation of admission criteria under the circumstances of wave-dynamics is the bottleneck question for both clinical practice and planning on a structural level.Methods This study compares patient characteristics, clinical biomarkers and outcomes during wave 1 (W1) and wave 2 (W2) of the COVID-19 pandemic at two tertiary care EDs in Berlin. We validated parameters predicting hospital admission by a CART-analysis of W1 in W2 and compared the findings to a CART-model derived from W2 by a decision curve analysis.Results A total of 1,204 patients with suspected COVID-19 presented in W1 and 1,440 in W2; 106 in W1 and 722 in W2 tested positive. Patients in W2 were older (>65 years, W1: 22.2%; W2: 34.6%) and multimorbid. Mortality of positive tested (W1: 1.9%; W2:8.6%) rose in W2. The admission-predicting parameters O2 saturation <95%, dyspnea, and cardiovascular comorbidities of W1 were applicable with a sensitivity of 98.5% (CI-95%: 96.3% - 99.4%) and specificity of 68.4% (61.0%-74.9%) in W2.Conclusions Our results show transferability of admission-criteria despite changing pandemic conditions and serve as lessons learned to support future pandemic preparedness and capacity planning.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-32"},"PeriodicalIF":2.2,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-dependent changes in YKL-40 and inflammatory markers in experimental acute mesenteric ischaemia. 实验性急性肠系膜缺血中YKL-40和炎症标志物的时间依赖性变化。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-09-10 DOI: 10.1080/1354750X.2026.2723432

Muhammed Ali Akbulut, Mehmet Aykut Yıldırım, Rahim Kocabaş, Fahriye Kılınç, Abdullah Gürhan Duyan

{"title":"Time-dependent changes in YKL-40 and inflammatory markers in experimental acute mesenteric ischaemia.","authors":"Muhammed Ali Akbulut, Mehmet Aykut Yıldırım, Rahim Kocabaş, Fahriye Kılınç, Abdullah Gürhan Duyan","doi":"10.1080/1354750X.2026.2723432","DOIUrl":"10.1080/1354750X.2026.2723432","url":null,"abstract":"Background: Early diagnosis of acute mesenteric ischaemia (AMI) remains challenging due to the lack of reliable biomarkers. This study aimed to investigate the time-dependent changes in chitinase-3-like protein 1 (YKL-40) and selected inflammatory markers in an experimental AMI model.Methods: A randomized controlled experimental study was conducted on 48 Wistar-albino rats. Mesenteric ischaemia was induced by ligation of the superior mesenteric artery. Blood and tissue samples were collected at 1, 3 and 6 h. Serum YKL-40, interleukin-6 (IL-6), interleukin-10 (IL-10) and lactate levels were measured, and histopathological damage was assessed.Results: IL-6 levels increased significantly as early as 1 h (p = 0.010) and showed a progressive rise over time (p < 0.001), with a strong positive correlation with histopathological damage (r = 0.805). Lactate levels increased significantly at later time points. YKL-40 levels did not differ in the early phase but were significantly elevated at 6 h (p < 0.001). IL-10 levels decreased significantly in advanced ischaemia (p = 0.005).Conclusion: IL-6 showed an early increase and a strong association with histopathological damage, whereas YKL-40 appeared to be associated with later-stage inflammation rather than early ischaemic injury. These findings highlight the importance of time-dependent biomarker interpretation and support further evaluation of combined biomarker strategies in AMI.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of colchicine on C-reactive protein level following hospitalization for myocardial infarction: a meta-analysis of randomized, placebo-controlled trials. 秋水仙碱对心肌梗死住院后c反应蛋白水平的影响：随机、安慰剂对照试验的荟萃分析

IF 2.2 4区医学

Biomarkers Pub Date : 2026-09-07 DOI: 10.1080/1354750X.2026.2726961

Srikiran Dasari, Thomas Fretz, John Sakaleros, Eduardo Aviles, Rishith Mishra, Celestine Willie, David Santistevan, Mohammad Thawabi

{"title":"Effect of colchicine on C-reactive protein level following hospitalization for myocardial infarction: a meta-analysis of randomized, placebo-controlled trials.","authors":"Srikiran Dasari, Thomas Fretz, John Sakaleros, Eduardo Aviles, Rishith Mishra, Celestine Willie, David Santistevan, Mohammad Thawabi","doi":"10.1080/1354750X.2026.2726961","DOIUrl":"10.1080/1354750X.2026.2726961","url":null,"abstract":"Background: C-reactive protein (CRP) is a biomarker of vascular inflammation with prognostic value for future cardiovascular events. This meta-analysis investigates the effect of colchicine, a cheap and widely available anti-inflammatory medication, on CRP levels in the months following myocardial infarction (MI).Methods: PubMed, EMBASE, and Cochrane were queried from inception to April 2026 to identify randomized controlled trials comparing colchicine to placebo for at least 1 month following MI. The primary outcome was mean CRP level at follow-up. Effect estimates were pooled with random-effects models and reported as mean differences for continuous variables using 95% confidence intervals.Results: Four studies met inclusion criteria comprising 3384 patients (mean age 60.7 years; 78.3% male), including 1669 patients randomized to the colchicine arm, and 1715 to placebo. Median follow-up period was 3 months (range: 1-6 months). Colchicine following MI resulted in a statistically significant decrease in mean CRP level (mg/L) at follow-up versus placebo (MD: -0.69; [-1.21, -0.17], p = 0.009). Heterogeneity of effect size estimates was high (I2 = 97%).Conclusion: Daily colchicine following MI decreases CRP at a median follow-up period of 3 months compared to placebo. The correlation between CRP reduction with colchicine and adverse cardiovascular event reduction warrants additional study.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the Geriatric Nutritional Risk Index and the risk of readmission in older inpatients: a systematic review and meta-analysis. 老年营养风险指数与老年住院患者再入院风险之间的关系：系统回顾和荟萃分析。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-09-03 DOI: 10.1080/1354750X.2026.2725723

Jing Wang, Guifang Liao, Qiwu Jin

{"title":"Association between the Geriatric Nutritional Risk Index and the risk of readmission in older inpatients: a systematic review and meta-analysis.","authors":"Jing Wang, Guifang Liao, Qiwu Jin","doi":"10.1080/1354750X.2026.2725723","DOIUrl":"10.1080/1354750X.2026.2725723","url":null,"abstract":"Background: The Geriatric Nutritional Risk Index (GNRI) is associated with readmission risk in older inpatients, but evidence is from single-centre studies.Aim: To quantify the association between GNRI and readmission risk, total hospital stay and intensive care unit (ICU) stay in older hospitalized patients.Methods: Searched Cochrane Library, Web of Science, PubMed and Embase until 23 October 2024 for case-control or cohort studies on GNRI and readmission in patients aged ≥60. Study quality was assessed using the Newcastle-Ottawa Scale. Analyses were performed in Stata 15.0 using random- or fixed-effects models based on heterogeneity (I2≥50%, p < 0.05). Effect sizes were reported as relative risk (RR) or standardized mean difference (SMD) with 95% confidence intervals (CI). Subgroup and sensitivity analyses were conducted.Results: Thirty-six studies were included. Twelve studies (n = 234,116) confirmed lower readmission risk in the high-GNRI group (RR = 0.60, 95%CI: 0.53-0.68; I2 = 70.8%). Twenty-six studies (n = 30,461) showed shorter total hospital and ICU stays.Conclusions: Lower GNRI is significantly associated with higher readmission risk and longer total hospital and ICU stays in older inpatients, supporting its role as a biomarker for adverse outcomes.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined metabolic-inflammatory biomarkers for predicting complicated acute appendicitis: a comparative analysis. 联合代谢-炎症生物标志物预测复杂急性阑尾炎：比较分析。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-09-02 DOI: 10.1080/1354750X.2026.2725727

Nur Kezban Akman, Hikmet Pehlevan Özel, Derviş Duru, Yusuf Yilmaz, Sedat Kıran, Tezcan Akın, Sadettin Er, Özgür Akgül, Mesut Tez

{"title":"Combined metabolic-inflammatory biomarkers for predicting complicated acute appendicitis: a comparative analysis.","authors":"Nur Kezban Akman, Hikmet Pehlevan Özel, Derviş Duru, Yusuf Yilmaz, Sedat Kıran, Tezcan Akın, Sadettin Er, Özgür Akgül, Mesut Tez","doi":"10.1080/1354750X.2026.2725727","DOIUrl":"10.1080/1354750X.2026.2725727","url":null,"abstract":"Introduction: Early identification of complicated acute appendicitis remains clinically important for guiding timely surgical management. Composite indices integrating metabolic and inflammatory parameters have recently been proposed as potential predictors of disease severity. This study aimed to compare the diagnostic performance of metabolic-inflammatory composite indices with conventional hematological markers in predicting complicated acute appendicitis.Methods: This retrospective cohort study included adult patients who underwent appendectomy between January 2022 and January 2025. Complicated appendicitis was defined by intraoperative findings of perforation, gangrene, periappendiceal abscess, or generalized peritonitis. Various inflammatory and metabolic indices were calculated from routine laboratory parameters. Diagnostic performance was evaluated using ROC analysis and logistic regression models.Results: A total of 1,871 patients were included, of whom 210 (11.2%) had complicated appendicitis. The C-reactive protein-to-albumin ratio (CAR) showed the highest diagnostic performance (AUC = 0.734). In multivariable analysis, both CAR and the inflammatory metabolic index (IMI) remained independent predictors. The final model incorporating age, sex, CAR, and IMI demonstrated the best discriminative performance (AUC = 0.795).Conclusion: Metabolic-inflammatory composite biomarkers, particularly CAR, may provide valuable adjunctive information for early prediction of complicated acute appendicitis.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of respiratory rate-oxygenation index (ROX), HACOR score and the C-reactive protein for prediction of mechanical ventilation and mortality in acutely intoxicated patients. 评估呼吸速率-氧合指数（ROX）、HACOR评分和c反应蛋白对急性中毒患者机械通气和死亡率的预测价值。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-09-01 Epub Date: 2026-07-27 DOI: 10.1080/1354750X.2026.2706480

Aya Saber Sayed, Eglal Hassan Elawady, Sarah Ahmed Elmorsy

{"title":"Assessment of respiratory rate-oxygenation index (ROX), HACOR score and the C-reactive protein for prediction of mechanical ventilation and mortality in acutely intoxicated patients.","authors":"Aya Saber Sayed, Eglal Hassan Elawady, Sarah Ahmed Elmorsy","doi":"10.1080/1354750X.2026.2706480","DOIUrl":"10.1080/1354750X.2026.2706480","url":null,"abstract":"Background: Acute respiratory toxicity is a common presenting emergency in acutely poisoned patients. Unpredictable respiratory deterioration can occur regardless of the on-admission patients' stable state, leading to increased morbidity and mortality. This study aimed to evaluate the respiratory rate-oxygenation (ROX) index, heart rate, acidosis, consciousness, oxygenation and respiratory rate (HACOR) score and C-reactive protein (CRP) as predictors of mechanical ventilation (MV) in poisoned patients.Methods: This prospective study was conducted on poisoned patients with acute respiratory failure presented to the Poison Control Center-Ain Shams University Hospitals (PCC-ASUHs). Upon admission, all patients had their ROX index, HACOR score and CRP level measured at the time of admission and at 24 hours.Results: Seventy-two patients were enrolled in the study, where forty-one cases were mechanically ventilated. The initial ROX index was significantly lower in the mechanically ventilated group with a cut-off ≤ 18.85 at AUC (0.74). The 24-hour ROX index, HACOR score and CRP level were predictors of mechanical ventilation need at AUC (0.97, 0.94, 0.85, respectively).Conclusion: It was concluded from this study that the initial and 24-hour ROX index, 24-hour HACOR and CRP level can be predictors of MV in poisoned patients.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"474-484"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinopenia as an independent predictor of complicated acute appendicitis: usefulness in adults, not in children. 红细胞减少作为复杂急性阑尾炎的独立预测因子：对成人有用，对儿童无效。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-09-01 Epub Date: 2026-08-26 DOI: 10.1080/1354750X.2026.2714026

Angie Bedolla-Pulido, Jaime Morales-Romero, Felipe de Jesús Bustos-Rodríguez, Martín Robles-Figueroa, Martín Bedolla-Barajas

{"title":"Eosinopenia as an independent predictor of complicated acute appendicitis: usefulness in adults, not in children.","authors":"Angie Bedolla-Pulido, Jaime Morales-Romero, Felipe de Jesús Bustos-Rodríguez, Martín Robles-Figueroa, Martín Bedolla-Barajas","doi":"10.1080/1354750X.2026.2714026","DOIUrl":"10.1080/1354750X.2026.2714026","url":null,"abstract":"Background: The role of eosinophils in acute appendicitis (AA) is not well known. The aim of this study is to analyze whether peripheral blood eosinophil concentration can be useful in predicting episodes of complicated AA in both paediatric and adult populations.Methods: A retrospective cohort study was conducted in patients with a clinical diagnosis of AA confirmed by histopathological findings. Receiver operating characteristic (ROC) curve analysis and multivariate models were performed.Results: A total of 531 cases were included (43.7% children). Complicated AA was present in 31.5% of children and 34.4% of adults. Symptom duration among children was ≥36 hours (aOR 2.24, p = 0.006) and a neutrophil-to-lymphocyte ratio (NLR) ≥4.7 (aOR 3.63, p = 0.006) increased the likelihood of complicated AA. In adults, eosinophil concentration <40 cells/µL (aOR 1.88, p = 0.033), being male (aOR 2.53, p < 0.001), and having an NLR ≥4.7 (aOR 2.98, p = 0.006) were independent factors associated with complicated AA.Conclusions: Peripheral blood eosinophils appear to serve as a valuable biomarker for identifying cases of complicated AA among the adult population but not among children. Prospective studies will help elucidate this phenomenon.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"428-434"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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