IF 2 4区医学

Biomarkers Pub Date : 2025-07-11 DOI: 10.1080/1354750X.2025.2522891

Sarah Saxena, Luca Marino, Barbara Hammer, Federico Bilotta, Joana Berger-Estilita

{"title":"Peripheral Cytokine Modulation by Anesthetic Agents: A Systematic Review of Neuroprotective and Anti-Inflammatory Effects in Randomised Clinical Trials.","authors":"Sarah Saxena, Luca Marino, Barbara Hammer, Federico Bilotta, Joana Berger-Estilita","doi":"10.1080/1354750X.2025.2522891","DOIUrl":"https://doi.org/10.1080/1354750X.2025.2522891","url":null,"abstract":"Introduction: Perioperative neurocognitive disorders remain a complex and under-diagnosed complication of surgery, linked to increased mortality and reliance on unemployment or disability benefits. Trauma-induced inflammatory responses are a major mechanism behind perioperative neurocognitive disorders. Understanding the impact of pharmacological interventions on modulating inflammatory and neuronal damage markers is crucial for improving perioperative care and patient outcomes.The objective is to evaluate the effects of neuroprotective pharmacological agents: dexmedetomidine, lidocaine, propofol, and magnesium, on peripheral inflammatory and neuronal damage markers in surgical patients.Material and methods: Studies were retrieved from Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases, covering articles published until January 2024.Results: Nine RCTs involving 870 patients were included. Dexmedetomidine significantly reduced S100β and NSE levels. IL-6 and TNF-α levels were significantly reduced post-surgery in dexmedetomidine-treated patients, highlighting its anti-inflammatory effects.Discussion: Lidocaine effectively reduced S100β and NSE. Propofol and magnesium also demonstrated neuroprotective properties. However, significant heterogeneity in dosing and timing among studies limits the generalizability of these findings.Conclusion: Dexmedetomidine, lidocaine, propofol, and magnesium show promise in reducing biomarkers associated with brain injury and inflammation during surgery, offering potential benefits for perioperative neuroprotection.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-18"},"PeriodicalIF":2.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the role of Human Neutrophil Elastase, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio as Predictive Markers For severity of acute respiratory toxicity Among Patients Admitted to Poison Control Center of Ain Shams University Hospitals. 人中性粒细胞弹性酶、中性粒细胞-淋巴细胞比率和血小板-淋巴细胞比率在艾因沙姆斯大学医院中毒控制中心入院患者急性呼吸道毒性严重程度预测指标中的作用评价

IF 2 4区医学

Biomarkers Pub Date : 2025-07-09 DOI: 10.1080/1354750X.2025.2529206

Alaa Mohammed, Mona Elkotb, Eglal Elawady, Sarah Eweda

{"title":"Evaluation of the role of Human Neutrophil Elastase, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio as Predictive Markers For severity of acute respiratory toxicity Among Patients Admitted to Poison Control Center of Ain Shams University Hospitals.","authors":"Alaa Mohammed, Mona Elkotb, Eglal Elawady, Sarah Eweda","doi":"10.1080/1354750X.2025.2529206","DOIUrl":"https://doi.org/10.1080/1354750X.2025.2529206","url":null,"abstract":"Background: There are hundreds of xenobiotics that can damage the respiratory system, necessitating mechanical ventilation. Therefore, acute respiratory toxicity may represent a serious condition that can be complicated by acute respiratory distress syndrome (ARDS). This study aimed to evaluate the role of Human Neutrophil Elastase (HNE) as a predictor of acute respiratory toxicity outcome and to compare it with the neutrophil lymphocyte ratio (N/L ratio) and platelet lymphocyte ratio (P/L ratio).Methods: This prospective study was conducted on adult patients with acute respiratory toxicity admitted to Poison Control Center; Ain shams university hospitals from January 2022 till December 2022. Their HNE, N/L ratio, and P/L ratio levels were assessed twice: first upon admission and again 24 hours later.Results: Fifty-five patients were enrolled in the study and were classified into ARDS group and non-ARDS group. HNE levels were significantly higher in ARDS patients at both time points with excellent predictive performance. Although the N/L and P/L ratios were significantly elevated in ARDS patients at 30 hours, their diagnostic performance was inferior to HNE. Combining HNE with the N/L ratio offered minimal additional benefit over HNE alone.Conclusion: HNE Level can serve as predictor of ARDS in acutely intoxicated patients.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-17"},"PeriodicalIF":2.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CYP450 Gene Polymorphisms and the Risk of Taxane-Induced Neurotoxicity in Breast Cancer Patients: A Systematic Review and Meta-Analysis. CYP450基因多态性与紫杉烷诱导乳腺癌患者神经毒性的风险：一项系统综述和荟萃分析。

IF 2 4区医学

Biomarkers Pub Date : 2025-06-25 DOI: 10.1080/1354750X.2025.2522892

Nayara Moretti Rozalem, Bárbara de Moura Moreira, Isabella Pimentel Braz, Isabella Caroline de Oliveira Barretto, Ana Laura Ayumi Zanoni Chiba, Angélica Augusta Grigoli Dominato, Francisco Cezar Aquino de Moraes

{"title":"CYP450 Gene Polymorphisms and the Risk of Taxane-Induced Neurotoxicity in Breast Cancer Patients: A Systematic Review and Meta-Analysis.","authors":"Nayara Moretti Rozalem, Bárbara de Moura Moreira, Isabella Pimentel Braz, Isabella Caroline de Oliveira Barretto, Ana Laura Ayumi Zanoni Chiba, Angélica Augusta Grigoli Dominato, Francisco Cezar Aquino de Moraes","doi":"10.1080/1354750X.2025.2522892","DOIUrl":"https://doi.org/10.1080/1354750X.2025.2522892","url":null,"abstract":"Background: Breast cancer (BC) is the most common cancer in women. Taxanes are widely used, but their neurotoxicity affects patients' quality of life. Genetic polymorphisms in CYP450 enzymes influence taxane metabolism, leading to variability in toxicity risk.Methods: A literature search was conducted to identify studies on the association between CYP450 polymorphisms and Taxane-Induced Peripheral Neuropathy (TIPN) in BC patients. Odds ratios (OR) and hazard ratios (HR) with 95% confidence intervals (CI) were estimated using a random-effects model in RStudio.Results: Nine studies with 3034 patients were included. Overall CYP polymorphisms showed a significant association with TIPN (OR: 1.2877, 95% CI: 1.0262-1.6157). CYP1B1 polymorphism had an inconsistent link to TIPN by OR of 1.1524 (95% CI: 0.7441-1.7849). CYP2C8 polymorphism demonstrated the strongest association (OR: 1.5532, 95% CI: 1.2013-2.0082; HR: 1.5236, 95% CI: 1.1317-2.0512). CYP3A4 showed no significant association (OR: 1.0988, 95% CI: 0.5022-2.4404).Conclusions: CYP2C8 polymorphisms were significantly linked to TIPN. While CYP1B1 showed inconsistent results, CYP3A4 had no significant association. These findings imply that CYP2C8 genetic variations may affect taxane metabolism and neurotoxicity risk, indicating that pharmacogenomic profiling could help personalize chemotherapy and reduce adverse effects.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-17"},"PeriodicalIF":2.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aluminum, lead and manganese mixture exacerbates oxidative stress, neuroinflammation, and apoptosis via downregulation of Nrf-2/HO-1/BDNF signaling pathway in rats. 铝、铅、锰混合物通过下调Nrf-2/HO-1/BDNF信号通路加重大鼠氧化应激、神经炎症和细胞凋亡。

IF 2 4区医学

Biomarkers Pub Date : 2025-06-24 DOI: 10.1080/1354750X.2025.2522102

Baridoo Donatus Dooka, Chinna N Orish, Anthonet N Ezejiofor, Chidinma P Anyachor, Theresa C Umeji, Kpobari W Nkpaa, Cecilia N Obasi, Ana Cirovic, Aleksandar Cirovic, Orish E Orisakwe

{"title":"Aluminum, lead and manganese mixture exacerbates oxidative stress, neuroinflammation, and apoptosis via downregulation of Nrf-2/HO-1/BDNF signaling pathway in rats.","authors":"Baridoo Donatus Dooka, Chinna N Orish, Anthonet N Ezejiofor, Chidinma P Anyachor, Theresa C Umeji, Kpobari W Nkpaa, Cecilia N Obasi, Ana Cirovic, Aleksandar Cirovic, Orish E Orisakwe","doi":"10.1080/1354750X.2025.2522102","DOIUrl":"https://doi.org/10.1080/1354750X.2025.2522102","url":null,"abstract":"Heavy metals have been reported to induce neurotoxicity associated with neurodegenerative disorders. However, there is a dearth of information on Al, Pb, and Mn mixture exposure on cerebral cortex functions. This study is aimed at evaluating the effects of Al, Pb, and Mn mixture on the cerebral cortex functions. Rats were exposed to Pb 20 mg/kg, Al 35mg/kg and Mn 0.564mg/kg body weight singly or in combination for 90 days. Our results showed that Al, Pb and Mn singly or in combination exposure significantly (p ≤ 0.05) decreased antioxidant enzymes activities, glutathione level and increased oxidative stress and neuroinflammation biomarkers in the cerebral cortex of the exposed rats. Moreover, induction of inflammation maker i.e., COX-2 was associated with increases in apoptotic induction. Furthermore, Al, Pb and Mn singling or in combination exposure significantly (p ≤ 0.05) increased Nrf-2 and decreased BDNF and HO-1 induction as well as increased amyloid precursor proteins and decreased occludin level. Taken together, our result indicates that Al, Pb, and Mn mixture exacerbates oxidative stress, neuroinflammation, and apoptosis via downregulation of Nrf2/HO-1/BDNF signaling pathway.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-16"},"PeriodicalIF":2.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Cell-Free Circulatory Mitochondrial DNA as a Comprehensive Biomarker for Stress: Meta-Analysis of Psychological and Physiological Stress Responses. 评估无细胞循环线粒体DNA作为应激的综合生物标志物：心理和生理应激反应的荟萃分析。

IF 2 4区医学

Biomarkers Pub Date : 2025-06-21 DOI: 10.1080/1354750X.2025.2522888

Arpan Chattopadhyay, Harshita Tak, Hemanth Naick B

{"title":"Evaluating Cell-Free Circulatory Mitochondrial DNA as a Comprehensive Biomarker for Stress: Meta-Analysis of Psychological and Physiological Stress Responses.","authors":"Arpan Chattopadhyay, Harshita Tak, Hemanth Naick B","doi":"10.1080/1354750X.2025.2522888","DOIUrl":"10.1080/1354750X.2025.2522888","url":null,"abstract":"Background: Mitochondria play a crucial role in cellular processes such as energy metabolism, reactive oxygen species (ROS) generation, and apoptosis. Mitochondrial dysfunction induced by stress has been implicated in various health conditions. Circulating cell-free mitochondrial DNA (CFC-MT-DNA) has emerged as a potential biomarker reflecting mitochondrial damage under stress.Methods: To evaluate the association between CFC-MT-DNA levels and human stress through a systematic review and meta-analysis of case-control studies. A comprehensive literature search was conducted across PubMed, Web of Science, and ScienceDirect databases up to September 2023. Eight eligible studies assessing CFC-MT-DNA levels in stressed versus control individuals were included. Data were analysed using RevMan 5.4 software.Results: The meta-analysis revealed significantly elevated CFC-MT-DNA levels in individuals experiencing stress (P = 0.03), particularly in psychological stress-related conditions such as bipolar disorder and major depressive disorder. However, no significant increase was observed in physiological stress conditions, including diabetes and sports training. High heterogeneity (I2 = 96%) was observed across studies.Conclusion: CFC-MT-DNA shows promise as a non-invasive biomarker for psychological stress. Further longitudinal and mechanistic studies are needed to clarify its role across different types of stress and its potential clinical utility.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosensor driven biomarker analysis: pioneering advancements in cancer diagnosis and therapeutic strategies. 生物传感器驱动的生物标志物分析：癌症诊断和治疗策略的开创性进展。

IF 2 4区医学

Biomarkers Pub Date : 2025-06-10 DOI: 10.1080/1354750X.2025.2515363

Gauri Nimhan, Mahavir Narwade, Kavita Gajbhiye

{"title":"Biosensor driven biomarker analysis: pioneering advancements in cancer diagnosis and therapeutic strategies.","authors":"Gauri Nimhan, Mahavir Narwade, Kavita Gajbhiye","doi":"10.1080/1354750X.2025.2515363","DOIUrl":"10.1080/1354750X.2025.2515363","url":null,"abstract":"Introduction: Early cancer detection significantly improves treatment outcomes; however, many cancers remain undiagnosed until advanced stages. This highlights the urgent need for rapid and precise diagnostic tools. Biosensors offer a transformative approach in cancer diagnostics by enabling early detection and continuous monitoring through the identification of molecular biomarkers.Methods: Biosensors function by converting biological elements-such as proteins, RNA, or genetic material-into measurable electrical signals. These devices are tailored to detect specific biomarkers, including proteins, peptides, gene mutations, or abnormal gene expression levels associated with various cancers.Results: Biosensors provide high sensitivity and specificity in identifying cancer cells. They enable real-time monitoring of tumour progression, angiogenesis, and treatment responses. These tools also facilitate accurate imaging of cancer cells and help evaluate the effectiveness of targeted therapies such as chemotherapy.Conclusion: The integration of biosensors into clinical practice could revolutionize cancer diagnostics by offering early, accurate, and minimally invasive detection methods. This review explores recent advances in biosensor development, the evolving landscape of cancer biomarkers, and the application of different biosensor technologies in cancer detection. Additionally, it addresses current limitations and challenges in clinical implementation, emphasizing the potential of biosensors to enhance patient outcomes through early intervention.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-20"},"PeriodicalIF":2.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aqueous Pistacia lentiscus leaves extract protects against ethanol-induced gastroduodenal ulcers in rat. 黄连木叶提取物对乙醇性大鼠胃十二指肠溃疡的保护作用。

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-05-10 DOI: 10.1080/1354750X.2025.2501575

Yasmina Zahouani, Abdelhafidh Khazri, Samir Touaylia, Khemais Ben Rhouma, Hichem Sebai, Mohsen Sakly

{"title":"Aqueous Pistacia lentiscus leaves extract protects against ethanol-induced gastroduodenal ulcers in rat.","authors":"Yasmina Zahouani, Abdelhafidh Khazri, Samir Touaylia, Khemais Ben Rhouma, Hichem Sebai, Mohsen Sakly","doi":"10.1080/1354750X.2025.2501575","DOIUrl":"10.1080/1354750X.2025.2501575","url":null,"abstract":"Background and aim: The protective effects of aqueous extract of Pistacia lentiscus leaves (AELPL) against gastric and duodenal ulcers induced by alcohol oral gavage administration in Wistar rats were investigated in this study.Methods: The rats were divided into six groups control, ethanol single, ethanol + AEPL (25-50-100) and famotidine + ethanol.Results: HPLC-MS analysis allowed the identification of numerous phenolic compounds in P. lentiscus leaves such as flavonoids (isoquercetin and luteolin), flavonols (catechin, rutin and kaempferol), phenolic acids (ellagic and dicaffeoylquinic) and tannins. Ethanol administration induced significant gastric and duodenal ulcerative lesions, while AELPL pretreatment (25, 50 and 100 mg/kg) provided a dose-dependent mucosal protection comparable to famotidine, a widely used drug for the treatment of gastric ulcers. AELPL like famotidine also restored gastric pH and volume, counteracting ethanol-induced acidity. Biochemical analyses demonstrated that AELPL like famotidine mitigated oxidative stress by reducing lipid peroxidation, carbonylated proteins and hydrogen peroxide levels, whereas it restored non-protein thiols content in the stomach, duodenum and plasma in a dose-dependent manner. Additionally, AELPL restored antioxidant enzyme activities including catalase, superoxide dismutase, glutathione peroxidase and glutathione-S-transferase. AELPL also reduced ethanol-induced increase in free iron, ionized calcium and interleukin-6 levels, indicating its anti-inflammatory potential.Conclusion: These findings suggest that AELPL exhibits gastroduodenal protective effects against ethanol-induced damage, with efficacy comparable to famotidine. Protective mechanisms likely involve modulation of oxidative stress and inflammation, supporting AELPL's potential as a therapeutic agent for gastroduodenal injuries.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"256-270"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of first-trimester blood biomarkers associated with preterm prelabor rupture of the fetal membranes. 与早产胎膜产前破裂相关的妊娠早期血液生物标志物的系统综述。

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1080/1354750X.2025.2475474

Mille Kirk, Josephine R Ekmann, Martin Overgaard, Charlotte K Ekelund, Hanne K Hegaard, Line Rode

{"title":"A systematic review of first-trimester blood biomarkers associated with preterm prelabor rupture of the fetal membranes.","authors":"Mille Kirk, Josephine R Ekmann, Martin Overgaard, Charlotte K Ekelund, Hanne K Hegaard, Line Rode","doi":"10.1080/1354750X.2025.2475474","DOIUrl":"10.1080/1354750X.2025.2475474","url":null,"abstract":"Background: Preterm prelabor rupture of the fetal membranes (PPROM) increases the risk of neonatal mortality and morbidity. The etiology behind the condition is multifactorial but believed to result from an overactivation of inflammatory pathways. This systematic review aimed to synthesize the literature behind first-trimester biomarkers associated with PPROM and compare it to literature within the same area for preterm birth.Methods: A search strategy was performed in PubMed, Embase, and CINAHL from 1993 to 2024 resulting in 14,889 articles screened by two independent authors and presented according to PRISMA guidelines. The biomarkers from the included articles were categorized into four medical headings: The immune system, metabolism and endocrinology, hematology, and reproduction.Results: Biomarkers associated with PPROM were primarily related to the immune system. C-reactive protein (CRP) and white blood cells (WBC) were often investigated for an association with PPROM but displayed divergent results of varying quality. Decreased concentrations of placental growth factor (PlGF) were associated with PPROM and spontaneous preterm birth, potentially highlighting a shared etiology, making soluble fms-like tyrosine kinase-1 (sFlt-1) interesting to investigate as well.Conclusion: Most biomarkers were examined in single studies, providing limited data to make significant conclusions about each biomarker. This review encourages further investigation of CRP, WBC, PlGF, and sFlt-1.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"271-283"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early warning system for player recovery? A series of case studies illustrating the application of individualised adaptive reference ranges in the longitudinal blood monitoring of English Premier League soccer players. 玩家恢复的早期预警系统？个性化自适应参考范围在英超球员纵向血液监测中的应用的一系列案例研究

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI: 10.1080/1354750X.2025.2473724

Diarmuid Daniels, Davood Roshan, Nathan A Lewis, John Newell, Georgie Bruinvels, Paul Catterson, Jamie Harley, Micheal Newell, Andrew Barr, Charles R Pedlar

{"title":"Early warning system for player recovery? A series of case studies illustrating the application of individualised adaptive reference ranges in the longitudinal blood monitoring of English Premier League soccer players.","authors":"Diarmuid Daniels, Davood Roshan, Nathan A Lewis, John Newell, Georgie Bruinvels, Paul Catterson, Jamie Harley, Micheal Newell, Andrew Barr, Charles R Pedlar","doi":"10.1080/1354750X.2025.2473724","DOIUrl":"10.1080/1354750X.2025.2473724","url":null,"abstract":"Blood biomarkers can provide objective insight into a player's physiological state of recovery. Individualised approaches to biomarker monitoring may be of higher potential value in assessing player health and recovery compared to population-based reference ranges. We aimed to explore the application of individualised adaptive reference ranges (IARR) in English Premier League (EPL) soccer players using a POC biomarker for C-Reactive Protein (CRP) as a marker of inflammation. Using historical data collected from players' CRP values during the 2019-2020 season, we evaluated the effectiveness of static and IARR in identifying abnormal values and reported sensitivity and specificity at a 5% significance level. Our analysis confirmed that monitoring with IARR is more effective in identifying true abnormalities compared to population-based static reference ranges, particularly when the intra-individual variability is considerably lower than inter-individual variability. The application of IARR for blood monitoring data could assist the practitioner in identifying periods where a player may require performance (e.g. workload management and recovery practices) or medical support from the multi-disciplinary team. However, IARR serve more as an early warning system than a diagnostic tool. Thus, significant care is needed to prevent misuse and misinterpretation when implementing this strategy in real-world settings.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"232-245"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of waterpipe smoking and its cessation on metabolic biomarkers and a novel biomarker omentin-1. 水烟吸烟及戒烟对代谢生物标志物及新的生物标志物网膜蛋白-1的影响

IF 2 4区医学

Biomarkers Pub Date : 2025-05-01 Epub Date: 2025-03-19 DOI: 10.1080/1354750X.2025.2479664

Hiba A Yousif, Mohammed A Hami

{"title":"Effect of waterpipe smoking and its cessation on metabolic biomarkers and a novel biomarker omentin-1.","authors":"Hiba A Yousif, Mohammed A Hami","doi":"10.1080/1354750X.2025.2479664","DOIUrl":"10.1080/1354750X.2025.2479664","url":null,"abstract":"Background and objective: Waterpipe smoking (WPS) has increased globally and may lead to various metabolic disorders. However, its long-term effects and cessation impact on metabolic biomarkers and omentin-1 remain unclear. This study aims to evaluate the impact of WPS and its cessation on metabolic biomarkers and omentin-1 levels and explore their correlations.Materials and methods: 90 individuals were categorized into three groups (non-smokers, waterpipe smokers and cessation of waterpipe smokers). FBS and lipid profiles including TC, TG and HDL were measured using the Cobas 6000 c501 system, while FI was analyzed with the Cobas 6000 c601 system. Omentin-1 concentrations were determined using the enzyme-linked immunosorbent assay (ELISA) with a human omentin ELISA kit.Results: FI, HOMA-IR and lipid profiles were significantly elevated in WPS and cessation groups. Omentin-1 and DBP levels significantly decreased in both groups compared to non-smokers. Increased WPS duration leads to reduced BMI, WC and DBP, while cessation duration decreases FBS and SBP. A negative association was identified among omentin-1 with FBS and O2.Conclusion: WPS and its cessation adversely affect metabolic health, reducing omentin-1 levels and increasing the risk of metabolic disorders. Over time, cessation improves specific biochemical markers, highlighting the need for public health awareness.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"219-225"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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