IF 2.6 4区医学

Biomarkers Pub Date : 2024-09-13 DOI: 10.1080/1354750x.2024.2402419

Heng Zhang,Xuan Tang,Junfang Zhang,Dapeng Jiang,Dandan Gong,Yu Fan

{"title":"Serum prealbumin level as a biomarker of survival outcomes in patients with gastric cancer: a meta-analysis.","authors":"Heng Zhang,Xuan Tang,Junfang Zhang,Dapeng Jiang,Dandan Gong,Yu Fan","doi":"10.1080/1354750x.2024.2402419","DOIUrl":"https://doi.org/10.1080/1354750x.2024.2402419","url":null,"abstract":"BACKGROUNDPrevious studies have reported inconsistent results on the association between serum prealbumin level and survival outcomes in patients with gastric cancer. This meta-analysis aimed to determine the serum prealbumin level as a biomarker of survival outcomes in gastric cancer patients.METHODSTwo independent reviewers conducted a thorough search of PubMed, Embase, and Web of Science databases until April 17, 2024. Studies reporting the association between serum prealbumin level and survival outcomes and presented the multivariable-adjusted relative risks for gastric cancer patients were included. The pooled HR and 95% CI were used to assess the strength of the association.RESULTSTwelve studies, with a total of 9,351 patients were included in the meta-analysis. The combined data showed that low serum prealbumin level was associated with shorter overall survival (HR 1.65; 95% CI 1.42-1.91) and disease-free survival (HR 1.39; 95% CI 1.14-1.70). Subgroup analysis showed that low serum prealbumin level significantly predicted poorer overall survival, regardless of patients' age, sample sizes, cutoff value for prealbumin level, and follow-up time.CONCLUSIONSLow serum prealbumin level is an independent prognostic biomarker for shorter survival outcomes in patients with gastric cancer. Assessing serum prealbumin levels could potentially improve risk stratification for this disease.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the role of N-terminal pro-B-type natriuretic peptide as a predictive biomarker of mortality in acute aluminum phosphide poisoning. 评估 N 端前 B 型钠尿肽作为急性磷化铝中毒死亡率预测生物标志物的作用。

IF 2 4区医学

Biomarkers Pub Date : 2024-09-13 DOI: 10.1080/1354750X.2024.2400910

Emad Ahmed Elsayed, Sarah Atef Eweda, Sarah Ahmad El-Morsy

{"title":"Assessment of the role of N-terminal pro-B-type natriuretic peptide as a predictive biomarker of mortality in acute aluminum phosphide poisoning.","authors":"Emad Ahmed Elsayed, Sarah Atef Eweda, Sarah Ahmad El-Morsy","doi":"10.1080/1354750X.2024.2400910","DOIUrl":"10.1080/1354750X.2024.2400910","url":null,"abstract":"Background: In Egypt, aluminum phosphide (ALP) is a known lethal poison due to its cardiotoxicity. This study aimed to evaluate the predictive ability of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for mortality in ALP-poisoned patients.Methods: This prospective study was conducted on patients with ALP poisoning admitted to the Poison Control Center Ain Shams University Hospitals between July and December 2022. Upon admission, all patients were followed up and had their levels of NT-proBNP, troponin I (cTnI), and creatine kinase myocardial band (CK-MB) analyzed.Results: Thirty patients were enrolled in the study and were divided into survivors and non-survivors. The initial NT-proBNP levels were significantly higher among non-survivors in contrast to the initial cTnI and CK-MB levels. The study identified that the best cutoff point of NT-proBNP for predicting mortality was ≥72 pg/ml, with AUC (0.869).Conclusion: It can be concluded that NT-proBNP can serve as an early predictor of mortality in ALP poisoning.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Diagnostic Value of Serum Trefoil Factor 3 and Pepsinogen combination in Chronic Atrophic Gastritis: A Retrospective Study Based on a Gastric Cancer Screening Cohort in the Community Population. 血清三叶因子 3 和胃蛋白酶原组合对慢性萎缩性胃炎的诊断价值：基于社区人群胃癌筛查队列的回顾性研究

IF 2 4区医学

Biomarkers Pub Date : 2024-09-05 DOI: 10.1080/1354750X.2024.2400927

Jiamin Zhao, Wenying Tian, Xiaoxue Zhang, Shengrong Dong, Yao Shen, Xiaojuan Gao, Mei Yang, Jiale Lv, Feifan Hu, Jinglve Han, Qiang Zhan, Fangmei An

{"title":"The Diagnostic Value of Serum Trefoil Factor 3 and Pepsinogen combination in Chronic Atrophic Gastritis: A Retrospective Study Based on a Gastric Cancer Screening Cohort in the Community Population.","authors":"Jiamin Zhao, Wenying Tian, Xiaoxue Zhang, Shengrong Dong, Yao Shen, Xiaojuan Gao, Mei Yang, Jiale Lv, Feifan Hu, Jinglve Han, Qiang Zhan, Fangmei An","doi":"10.1080/1354750X.2024.2400927","DOIUrl":"https://doi.org/10.1080/1354750X.2024.2400927","url":null,"abstract":"Background and Aims：Chronic atrophic gastritis (CAG) is an important precursor of gastric cancer(GC), and there is currently a lack of reliable non-invasive diagnostic markers. This study aims to find a biomarker for non-invasive screening of CAG in the community. Methods: A total of 540 individuals were enrolled (test set = 385, validation set = 155). ROC curve analysis was used to evaluate the diagnostic significance of Trefoil Factor 3(TFF3) alone or in combination with pepsinogen (PG) for CAG in test and validation set. Furthermore, the diagnostic value of TFF3 and PG in different H. pylori infection states was studied. Results：When compared with the chronic superficial gastritis (CSG), the expression level of TFF3 in the CAG was higher (27ng/ml VS 19.61, P < 0.001). ROC curve analysis found that the sensitivity, specificity, and area under the curve (AUC) of CAG diagnosis using serum TFF3 alone at the optimal cut-off value of 26.55ng/ml were 0.529, 0.87, and 0.739, respectively. When TFF3 was combined with The Ratio of PGI to PGII (PGR), the AUC and specificity reached to 0.755 and 0.825 respectively. TFF3 individual or combined with PGR had good predictive value especially in the H. Pylori negative patients. Conclusion: TFF3 combined with PGR can effectively predict CAG especially in the patients with H. pylori negative.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High circulating microRNA-197 levels are associated with an increased risk of incident stroke among elderly survivors of the Great East Japan Earthquake. 高循环 microRNA-197 水平与东日本大地震老年幸存者发生中风的风险增加有关。

IF 2 4区医学

Biomarkers Pub Date : 2024-08-29 DOI: 10.1080/1354750X.2024.2394109

Yoshiki Tsuboi, Hiroya Yamada, Ryosuke Fujii, Mirai Yamazaki, Eiji Munetsuna, Yoshitaka Ando, Koji Ohashi, Hiroaki Ishikawa, Hiroshi Okumiyama, Masaya Nakae, Haruki Shimoda, Kiyomi Sakata, Koji Suzuki

{"title":"High circulating microRNA-197 levels are associated with an increased risk of incident stroke among elderly survivors of the Great East Japan Earthquake.","authors":"Yoshiki Tsuboi, Hiroya Yamada, Ryosuke Fujii, Mirai Yamazaki, Eiji Munetsuna, Yoshitaka Ando, Koji Ohashi, Hiroaki Ishikawa, Hiroshi Okumiyama, Masaya Nakae, Haruki Shimoda, Kiyomi Sakata, Koji Suzuki","doi":"10.1080/1354750X.2024.2394109","DOIUrl":"https://doi.org/10.1080/1354750X.2024.2394109","url":null,"abstract":"Background: Incidence of ischemic stroke increased after natural disasters. Therefore, it is important to establish a means of identifying high-risk populations for incident stroke. We performed a prospective cohort study to examine whether these three cardiovascular disease-related miRNAs (miR-126, miR-197, and miR-223) are associated with incident stroke among elderly survivors of the Great East Japan Earthquake.Method: This cohort study was conducted using the data of 1192 survivors of the Great East Japan Earthquake over 60-years old who underwent a health check-up in December 2011. We followed up participants to record stroke cases until the end of 2016. We measured serum miRNAs by quantitative real-time polymerase chain reaction. HRs for incident stroke were estimated by Cox proportional hazard regression analyses.Result: The serum miR-197 level was significantly associated with the incident stroke; the HR per one standard deviation change in the miR-197 level was 1.65 (95% confidence interval: 1.19 - 2.30). In contrast, the levels of miR-126 and miR-223 were not associated with the incident stroke.Conclusion: We found that a higher miR-197 level is associated with an increased risk of incident stroke; thus, miR-197 is expected to be useful as a predictive biomarker.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical value of prokineticin 2 in the diagnosis of neonatal necrotizing enterocolitis. 促红细胞生成素 2 在诊断新生儿坏死性小肠结肠炎中的临床价值。

IF 2 4区医学

Biomarkers Pub Date : 2024-08-23 DOI: 10.1080/1354750X.2024.2393342

Qiuli Zeng, Li Zeng, Xiaoyan Yu, Xi Yuan, Wenjing Ma, Zhixin Song, Dapeng Chen

{"title":"Clinical value of prokineticin 2 in the diagnosis of neonatal necrotizing enterocolitis.","authors":"Qiuli Zeng, Li Zeng, Xiaoyan Yu, Xi Yuan, Wenjing Ma, Zhixin Song, Dapeng Chen","doi":"10.1080/1354750X.2024.2393342","DOIUrl":"10.1080/1354750X.2024.2393342","url":null,"abstract":"Background: Necrotizing enterocolitis (NEC) is an inflammatory and necrotizing intestinal emergency that occurs in preterm infants and low birth weight newborns; however, no specific serum biomarkers for the diagnosis of NEC has been identified so far.Methods: Serum samples were collected from healthy neonatal controls and patients with NEC newly admitted to the Children's Hospital of Chongqing Medical University. ELISA was used to measure serum PK2 levels, and ROC curve analysis was sued to evaluate the diagnostic efficacy of PK2 and other clinical biomarkers.Results: Serum PK2 levels in the NEC group (n = 53) were significantly lower than those in the control group (n = 18), but increased to near-normal levels after the postoperative recovery period. The NLR value of NEC group was higher than that of control group (P < 0.05). There was no significant difference in WBC and PLT count between NEC group and control group (P > 0.05). Serum CRP and PCT levels in NEC group were significantly higher than those in control group (P < 0.001 for CRP and P < 0.05 for PCT, respectively). After surgery, serum CRP, NLR and PCT levels were lower than before surgery, while serum PK2 levels were higher than before surgery (P < 0.05). The areas under the ROC curve (AUC) of PK2, PCT and CRP for the diagnosis of NEC were 0.837, 0.662 and 0.552, respectively. The AUC of PK2 combined with PCT, PK2 combined with CRP, and PK2 combined with PCT and CRP were 0.908, 0.854 and 0.981, respectively. PK2 exhibited the highest diagnostic efficacy for NEC.Conclusion: PK2 has higher diagnostic efficacy than PCT and CRP in the diagnosis of NEC; the combination of PK2 and PCT or CRP can significantly improve its diagnostic efficiency, especially when the three are combined at the same time.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of biomarkers of chlorine exposure from biological samples: a review of analysis techniques. 从生物样本中确定氯暴露的生物标志物：分析技术综述。

IF 2 4区医学

Biomarkers Pub Date : 2024-08-21 DOI: 10.1080/1354750X.2024.2390563

Sharmin Sultana, Brian A Logue

{"title":"Determination of biomarkers of chlorine exposure from biological samples: a review of analysis techniques.","authors":"Sharmin Sultana, Brian A Logue","doi":"10.1080/1354750X.2024.2390563","DOIUrl":"10.1080/1354750X.2024.2390563","url":null,"abstract":"Introduction: Chlorine gas can be toxic when inhaled or absorbed at high concentrations through the skin. It can cause pulmonary edema, pulmonary inflammation, respiratory failure, and potentially death. Monitoring chlorine exposure helps in determining treatment regimens and may inform safeguards, such as personal protective equipment and ventilation systems. Therefore, verification of chlorine exposure is crucial to protecting human health. This has led to identification of multiple biomarkers of Cl2 exposure with associated innovations in methods of analysis to monitor these markers.Materials and methods: In this review of the last 30 years of literature, biomarkers and associated methods of detection for the determination of chlorine exposure from biological samples are detailed and critically evaluated.Results and discussion: From the 36 included studies, the most useful biomarkers for Cl2 exposure include tyrosine adducts, chlorohydrin, chloro-fatty-acids, chloro-fatty-aldehydes, and chloro-fatty-alcohols. The most common sample preparation methods for these markers are hydrolysis and extraction and the most common analysis techniques are chromatographic separation with mass spectrometric detection.Conclusion: The findings of this review emphasize the need for continued research into biomarkers and stronger evaluation of proposed analytical methods, including validation, to allow more appropriate comparison, which will ultimately improve patient outcomes.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary anatalline and nicotelline cut-points to distinguish between exclusive and dual use of tobacco products. 区分烟草制品专用和双重用途的尿液锐毒碱和烟碱切点。

IF 2 4区医学

Biomarkers Pub Date : 2024-08-19 DOI: 10.1080/1354750X.2024.2389047

Kathryn C Edwards, Gideon St Helen, Peyton Jacob, Jenny E Ozga, Cassandra A Stanton

{"title":"Urinary anatalline and nicotelline cut-points to distinguish between exclusive and dual use of tobacco products.","authors":"Kathryn C Edwards, Gideon St Helen, Peyton Jacob, Jenny E Ozga, Cassandra A Stanton","doi":"10.1080/1354750X.2024.2389047","DOIUrl":"10.1080/1354750X.2024.2389047","url":null,"abstract":"Objective: This study measured anatalline and nicotelline, two minor tobacco alkaloids, to discriminate between exclusive smokeless tobacco (SLT) use, exclusive electronic nicotine delivery systems (ENDS) use, exclusive cigarette use, dual SLT and cigarette use, and dual ENDS and cigarette use.Methods: N = 664 urine samples from participants in the Population Assessment of Tobacco and Health Study were analyzed for anatalline and nicotelline. Geometric means and 95% confidence intervals were calculated for biomarker levels and their ratios. Non-parametric Receiver Operating Characteristic analyses were used to determine optimal cut-points of natural log-transformed biomarker ratios for distinguishing between tobacco use groups.Results: The anatalline/nicotelline ratio distinguished exclusive cigarette from exclusive SLT use (threshold = 18.1, sensitivity = 89.3%, specificity = 86.4%, AUC = 0.90), and exclusive SLT from exclusive ENDS use (threshold = 12.8, sensitivity = 96.4%, specificity = 76.3%, AUC = 0.90) very well, but had reduced sensitivity and specificity when distinguishing exclusive cigarette from exclusive ENDS or any dual use with cigarettes.Conclusions: This research fills a gap in understanding the public health consequences of SLT and ENDS use by providing objective measures that can signal use of these products alone or in combination with cigarettes.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the methylations of RUNX3 in peripheral blood and lung cancer: a case-control study. 外周血中 RUNX3 甲基化与肺癌的关系：一项病例对照研究。

IF 2 4区医学

Biomarkers Pub Date : 2024-07-23 DOI: 10.1080/1354750X.2024.2373714

Jun Wang, Jue Wang, Jie Zhang, Haixia Gong, Jinchang Li, Yakang Song, Yuyang Huang, Boyue Ma, Wanjian Gu, Rongxi Yang

{"title":"Association between the methylations of RUNX3 in peripheral blood and lung cancer: a case-control study.","authors":"Jun Wang, Jue Wang, Jie Zhang, Haixia Gong, Jinchang Li, Yakang Song, Yuyang Huang, Boyue Ma, Wanjian Gu, Rongxi Yang","doi":"10.1080/1354750X.2024.2373714","DOIUrl":"10.1080/1354750X.2024.2373714","url":null,"abstract":"Background: RUNX3 is hypermethylated in multiple cancers. TIMP2 also functions as a regulator of tumors. However, there are only very few reports on the association of methylation of RUNX3 and TIMP2 with lung cancer (LC) in peripheral blood.Methods: 426 LC patients and 428 age- and sex-matched healthy controls were recruited. DNA methylation in blood was semi-quantitively assessed by mass spectrometry. For the association analysis, binary logistic regression analysis adjusted covariant was applied, and ORs were presented as per +10% methylation.Results: Hypermethylation of CpG_1, CpG_5 and CpG_8 in RUNX3 was significantly associated with LC (ORs = 1.45, 1.35 and 1.35, respectively, adjusted p < 0.05), and even stage I LC. The association between the three RUNX3 CpG sites and LC was enhanced by increased age (> 55 years, ORs ranged from 1.43 to 1.75, adjusted p < 0.05), male gender (ORs ranged from 1.47 to 1.59, adjusted p < 0.05) and tumor stage (stage II&III&IV, ORs ranged from 1.86 to 3.03, adjusted p < 0.05).Conclusions: This study suggests a significant association between blood-based RUNX3 hypermethylation and LC, especially in elder people, in males and in LC patients with advanced stage.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts for the 18th Annual Biomarkers and Personalized Medicine in Cardiovascular Disease Symposium 第18届心血管疾病生物标记物与个性化医疗年度研讨会摘要

IF 2.6 4区医学

Biomarkers Pub Date : 2024-07-10 DOI: 10.1080/1354750x.2024.2376798

引用次数: 0

CCDC12 gene methylation in peripheral blood as a potential biomarker for breast cancer detection. 外周血中的 CCDC12 基因甲基化是检测乳腺癌的潜在生物标志物。

IF 2 4区医学

Biomarkers Pub Date : 2024-07-01 Epub Date: 2024-06-07 DOI: 10.1080/1354750X.2024.2358302

Jingjing Liu, Yunhui Qu, Yutong Zhao, Feifei Liang, Longtao Ji, Zhi Wang, Jinyu Li, Zishan Zang, Haixia Huang, Jie Zhang, Wanjian Gu, Liping Dai, Rongxi Yang

{"title":"CCDC12 gene methylation in peripheral blood as a potential biomarker for breast cancer detection.","authors":"Jingjing Liu, Yunhui Qu, Yutong Zhao, Feifei Liang, Longtao Ji, Zhi Wang, Jinyu Li, Zishan Zang, Haixia Huang, Jie Zhang, Wanjian Gu, Liping Dai, Rongxi Yang","doi":"10.1080/1354750X.2024.2358302","DOIUrl":"10.1080/1354750X.2024.2358302","url":null,"abstract":"Background: Aberrant DNA methylation has been identified as biomarkers for breast cancer detection. Coiled-coil domain containing 12 gene (CCDC12) implicated in tumorigenesis. This study aims to investigate the potential of blood-based CCDC12 methylation for breast cancer detection.Methods: DNA methylation level of CpG sites (Cytosine-phosphate Guanine dinucleotides) in CCDC12 gene was measured by mass spectrometry in 255 breast cancer patients, 155 patients with benign breast nodules and 302 healthy controls. The association between CCDC12 methylation and breast cancer risk was evaluated by logistic regression and receiver operating characteristic curve analysis.Results: A total of eleven CpG sites were analyzed. The CCDC12 methylation levels were higher in breast cancer patients. Compared to the lowest tertile of methylation level in CpG_6,7, CpG_10 and CpG_11, the highest quartile was associated with 82, 91 and 95% increased breast cancer risk, respectively. The CCDC12 methylation levels were associated with estrogen receptor (ER) and human epidermal growth factor 2 (HER2) status. In ER-negative and HER2-positive (ER-/HER2+) breast cancer subtype, the combination of four sites CpG_2, CpG_5, CpG_6,7 and CpG_11 methylation levels could distinguish ER-/HER2+ breast cancer from the controls (AUC = 0.727).Conclusion: The hypermethylation levels of CCDC12 in peripheral blood could be used for breast cancer detection.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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