IF 1.9 4区医学

Biomarkers Pub Date : 2026-05-04 DOI: 10.1080/1354750X.2026.2664868

Toni Febriyanto, Yosua Yerico Hutajulu, Noka Yogahutama, Wynne Wijaya, Ahmad Zulfan Hendri

{"title":"Circulating KIM-1 as a prognostic biomarker and predictor of systemic treatment response in renal cell carcinoma: a systematic review and meta-analysis.","authors":"Toni Febriyanto, Yosua Yerico Hutajulu, Noka Yogahutama, Wynne Wijaya, Ahmad Zulfan Hendri","doi":"10.1080/1354750X.2026.2664868","DOIUrl":"https://doi.org/10.1080/1354750X.2026.2664868","url":null,"abstract":"Background: Renal cell carcinoma (RCC) exhibits heterogeneity and variable responses to systemic therapy. Kidney injury molecule-1 (KIM-1) has emerged as a biomarker in RCC, but its prognostic and treatment-response value has not been quantified. This review and meta-analysis evaluated whether baseline KIM-1 predicts survival in RCC and whether post-treatment changes in KIM-1 reflect systemic therapy response.Methods: A search of PubMed, Embase and the Cochrane Library was conducted through November 2025. Eligible studies measured serum or plasma KIM-1 in RCC and reported survival or treatment-response outcomes. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled.Results: Eight studies including 3002 patients met inclusion criteria. High baseline KIM-1 was associated with worse survival (HR 1.44, 95% CI 1.27-1.62) and disease-free survival (HR 1.72, 95% CI 1.45-2.04), with no heterogeneity (I2 = 0%). Declines in KIM-1 after systemic therapy were associated with improved progression-free survival (HR 0.55, 95% CI 0.32-0.94; I2 = 71.5%) and improved disease-free survival (HR 0.66, 95% CI 0.50-0.87).Conclusions: Elevated baseline circulating KIM-1 indicates higher RCC recurrence and mortality risk, while post-treatment declines may reflect therapeutic response. Preliminary evidence suggests KIM-1 prognostic and predictive value for RCC biomarker, though further validation is required due to lower certainty.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-11"},"PeriodicalIF":1.9,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in concentrations of tobacco specific nitrosamines in saliva in the general population of Barcelona before and after implementation of tobacco control legislation. 烟草控制立法实施前后巴塞罗那普通人群唾液中烟草特异性亚硝胺浓度的变化。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-04-26 DOI: 10.1080/1354750X.2026.2657869

Hipólito Pérez-Martín, Cristina Lidón-Moyano, Adrián González-Marrón, Juan Carlos Martín-Sánchez, Marcela Fu, Montse Ballbè, Raúl Pérez-Ortuño, Jose A Pascual, Esteve Fernández, Jose M Martínez-Sánchez

{"title":"Changes in concentrations of tobacco specific nitrosamines in saliva in the general population of Barcelona before and after implementation of tobacco control legislation.","authors":"Hipólito Pérez-Martín, Cristina Lidón-Moyano, Adrián González-Marrón, Juan Carlos Martín-Sánchez, Marcela Fu, Montse Ballbè, Raúl Pérez-Ortuño, Jose A Pascual, Esteve Fernández, Jose M Martínez-Sánchez","doi":"10.1080/1354750X.2026.2657869","DOIUrl":"10.1080/1354750X.2026.2657869","url":null,"abstract":"Context: This study evaluated changes in salivary tobacco-specific nitrosamines (TSNAs) in smokers and non-smokers before and after Spain's smoke-free legislation.Methods: We conducted a longitudinal study of 272 adults in Barcelona, surveyed in 2004-2005 and 2013-2014, spanning the 2006 legislation and its 2011 extension. Saliva samples were analyzed for NNN, NNK, and NNAL, and geometric means with 95% confidence intervals were calculated. Data were stratified by sociodemographics, smoking status, smoking behavior, and anthropometrics. Linear mixed-effects models assessed adjusted percentage changes in TSNA concentrations.Results: At baseline, overall TSNA concentrations were 1.5 [1.2-1.8] pg/mL for NNN, 1.4 [1.3-1.5] pg/mL for NNK, and 0.5 [0.5-0.6] pg/mL for NNAL. Among baseline smokers who quit, TSNAs decreased by -90.5% (NNN), -48.7% (NNK), and -86.2% (NNAL). Continuing smokers showed a 149.8% increase in NNN, while non-smokers showed no significant change.Conclusions: Concentrations of salivary TSNAs declined in those who quit smoking but increased for continuing smokers. Monitoring TSNAs in saliva is useful for assessing legislative impact.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating SEPHS2 expression and glutathione peroxidase as biomarkers in recurrent pregnancy loss: a new insight. 评估SEPHS2表达和谷胱甘肽过氧化物酶作为复发性妊娠丢失的生物标志物：新的见解。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-04-22 DOI: 10.1080/1354750X.2026.2659525

Mai M Shaker, Eman Reda Galal, Taghreed A Shalabi, Nesma M Elaraby, Fatma Elzahraa Sobhy Ammar, Fatma Alzahraa Mohamed Hassan

{"title":"Evaluating SEPHS2 expression and glutathione peroxidase as biomarkers in recurrent pregnancy loss: a new insight.","authors":"Mai M Shaker, Eman Reda Galal, Taghreed A Shalabi, Nesma M Elaraby, Fatma Elzahraa Sobhy Ammar, Fatma Alzahraa Mohamed Hassan","doi":"10.1080/1354750X.2026.2659525","DOIUrl":"10.1080/1354750X.2026.2659525","url":null,"abstract":"Background: Selenophosphate synthetase 2 (SEPHS2) activates selenophosphate, a donor for selenocysteine required for glutathione peroxidase (GPX) production. GPX protects placental tissue. Dysregulation of SEPHS2 and reduced GPX activity may contribute to oxidative stress-mediated placental dysfunction in recurrent pregnancy loss (RPL).Aim: To evaluate SEPHS2 gene expression and plasma GPX levels as prognostic biomarkers in women with idiopathic RPL and their association with oxidative imbalance.Methods: A total of 100 women with idiopathic RPL and 100 healthy women without history of RPL were included. SEPHS2 gene expression was quantified using quantitative reverse transcription polymerase chain reaction (qRT-PCR), and plasma GPX levels were measured using enzyme-linked immunosorbent assay (ELISA).Results: SEPHS2 expression was significantly elevated in the RPL group compared with controls (mean fold change: 14 ± 11.4 vs. 5 ± 8), while plasma GPx levels were markedly reduced in women with RPL (5.57 ± 0.40 vs. 9.53 ± 3.28; P < 0.001, 95% CI: 3.32-4.62). These findings indicate an association between increased SEPHS2 expression, reduced antioxidant activity, and recurrent pregnancy loss.Conclusion: Elevated SEPHS2 expression suggests disrupted selenoprotein-mediated antioxidant defense in RPL. SEPHS2 and GPX may serve as prognostic biomarkers.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic significance of the combination of serum CCL20 and Oncostatin M for early-stage endometrial cancer. 血清CCL20与癌抑素M联合检测对早期子宫内膜癌的诊断意义。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-04-16 DOI: 10.1080/1354750X.2026.2628040

Yuhua Wei, Xiaojuan Lv, Huan Tang, Yeliang Sun, Li Chen, Liping Han, Xiaohong Zhu

{"title":"Diagnostic significance of the combination of serum CCL20 and Oncostatin M for early-stage endometrial cancer.","authors":"Yuhua Wei, Xiaojuan Lv, Huan Tang, Yeliang Sun, Li Chen, Liping Han, Xiaohong Zhu","doi":"10.1080/1354750X.2026.2628040","DOIUrl":"10.1080/1354750X.2026.2628040","url":null,"abstract":"Aim: Our study aimed to preliminarily investigate the role of combined detection of serum CCL20 and Oncostatin M in the diagnosis of early-stage endometrial cancer (EC).Methods: A retrospective study was conducted on 109 patients with early-stage EC. Serum CCL20 and Oncostatin M levels were determined, and their correlations with sex hormone indicators (TTE and DHEAS) in EC patients were analyzed. Influencing factors for EC and the early diagnostic value of each indicator were analyzed.Results: Serum CCL20 and Oncostatin M were high in EC patients and positively correlated with TTE and DHEAS. Elevated CCL20 and Oncostatin M were independent risk factors for EC. The diagnostic efficacy of serum CCL20 + Oncostatin M in combination was better than that of serum CCL20, Oncostatin M, CA125, and HE4 alone. The diagnostic test combining serum CCL20 and Oncostatin M in endometrioid carcinoma demonstrated an AUC of 0.855, with a sensitivity of 68.00% and a specificity of 92.86%, comparable to that in the whole early-stage endometrial carcinoma group (AUC = 0.867).Conclusion: Combined detection of serum CCL20 and Oncostatin M may offer a promising adjunctive approach for the diagnosis of early-stage EC, with their levels correlated to sex hormones and clinicopathological characteristics.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146130961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Mrm2 as a Key Regulator in Mitochondrial Dysfunction During Radiation-Induced Intestinal Injury. Mrm2在辐射诱导的肠道损伤中作为线粒体功能障碍关键调节因子的鉴定。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-04-03 DOI: 10.1080/1354750X.2026.2653892

Zhongwei Zhang, Jun Liu, Wei Xue, Haoran Zhang, Mimi Wang, Qing-Jie Liu

引用次数: 0

The effects of apigenin on immune responses and inflammatory biomarkers in sepsis: a comprehensive systematic review. 芹菜素对败血症免疫反应和炎症生物标志物的影响：一项全面的系统综述。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-04-02 DOI: 10.1080/1354750X.2026.2641063

Ghaleb Oriquat, Waleed K Abdulsahib, Sanan Thaer Abdal-Wahab, H Malathi, Biswaranjan Mohanty, J Bethanney Janney, Vimal Arora, Aashna Sinha, Zafar Aminov

{"title":"The effects of apigenin on immune responses and inflammatory biomarkers in sepsis: a comprehensive systematic review.","authors":"Ghaleb Oriquat, Waleed K Abdulsahib, Sanan Thaer Abdal-Wahab, H Malathi, Biswaranjan Mohanty, J Bethanney Janney, Vimal Arora, Aashna Sinha, Zafar Aminov","doi":"10.1080/1354750X.2026.2641063","DOIUrl":"10.1080/1354750X.2026.2641063","url":null,"abstract":"Background: Apigenin, a flavonoid predominantly found in citrus fruits, particularly grapefruit, has attracted significant attention in ethnopharmacology for its diverse therapeutic properties.Method: This systematic review focuses on the potential therapeutic impact of Apigenin on sepsis complications. Google Scholar, Scopus, Web of Science, PubMed and Embase databases were searched for relevant keywords up to August 2025.Results: A total of 421 articles were screened in the databases. Finally, only 30 studies remain. Evidence from in vivo and in vitro studies indicates that Apigenin modulates key signalling pathways, such as Rho-associated coiled-coil containing protein kinase (ROCK)/Ras homolog family member A (RhoA)/Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB), Peroxisome Proliferator-activated receptor gamma (PPARγ)/microRNA-21 (miR-21) and Kelch-like eCH-associated protein 1 (KEAP1)/Nuclear factor erythroid 2-related factor 2 (Nrf2), to alleviate sepsis-induced damage in organs such as the lungs, intestines, heart and kidneys. Additionally, Apigenin promotes macrophage polarization towards the M2 macrophage phenotype (M2) phenotype and reduces proinflammatory cytokines (Interleukin-6 (IL-6), Tumour necrosis factor alpha (TNF-α), Interleukin-1 beta (IL-1β).Conclusion: Despite its promising effects, further clinical trials are needed to confirm its efficacy and safety in septic patients.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-13"},"PeriodicalIF":1.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short- and long-term metabolic exposure data as predicators of coronary microvascular dysfunction in a positron emission tomography myocardial perfusion imaging (PET-MPI) cohort with near concurrent angiography. 短期和长期代谢暴露数据作为冠脉微血管功能障碍的预测因子在正电子发射断层扫描心肌灌注成像（PET-MPI）队列与近并发血管造影。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-03-23 DOI: 10.1080/1354750X.2026.2639408

Joseph Van Galen, Sarah J Ratcliffe, Jamieson Bourque

{"title":"Short- and long-term metabolic exposure data as predicators of coronary microvascular dysfunction in a positron emission tomography myocardial perfusion imaging (PET-MPI) cohort with near concurrent angiography.","authors":"Joseph Van Galen, Sarah J Ratcliffe, Jamieson Bourque","doi":"10.1080/1354750X.2026.2639408","DOIUrl":"10.1080/1354750X.2026.2639408","url":null,"abstract":"Background: Coronary microvascular disease (CMD) is defined by impaired myocardial stress flow reactivity and is associated with worse cardiovascular outcomes. Studying CMD is complicated by the overlap of its risk factors and patient-important cardiovascular sequelae with those of epicardial atherosclerotic disease. Published studies have not yet used longitudinal data to investigate the time dependencies of dynamic processes like obesity in their effects on microvascular health.Methods and results: In a mixed-sex cohort of 85 patients for whom epicardial obstruction was angiographically excluded, a multivariate model was developed to measure strengths of association between repeated-measurement metabolic data and microvascular stress flow reactivity as assessed by position emission tomography myocardial perfusion imaging (PET-MPI). Body mass index (BMI) and the diagnosis of insulin-dependent diabetes mellitus (DM) were associated with CMD on clinically meaningful scales when analysing all metabolic data collected in the year prior to stress PET-MPI (β [95% CI]: -0.019 [-0.033, -0.0051], p = 0.0072; -0.33 [-0.65, -0.0026], p = 0.048). Parallel modelling using single-time-point metabolomics data generated comparable results, suggesting that simplified assessments may be used as valid surrogates for repeated-measurement data in this setting.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and validation of AFAP1L1 as an immune-related prognostic biomarker in clear cell renal cell carcinoma. AFAP1L1在透明细胞肾细胞癌中作为免疫相关预后生物标志物的鉴定和验证

IF 1.9 4区医学

Biomarkers Pub Date : 2026-03-23 DOI: 10.1080/1354750X.2026.2630072

Qiaoping Yan, Binbin Zhang, Yunhan Yu, Yuewen Si, Yuan Zhang, Zijian Ye, Qingming Zhang, Wenling Wu, Xuegang Luo, Biao Xie

{"title":"Identification and validation of AFAP1L1 as an immune-related prognostic biomarker in clear cell renal cell carcinoma.","authors":"Qiaoping Yan, Binbin Zhang, Yunhan Yu, Yuewen Si, Yuan Zhang, Zijian Ye, Qingming Zhang, Wenling Wu, Xuegang Luo, Biao Xie","doi":"10.1080/1354750X.2026.2630072","DOIUrl":"10.1080/1354750X.2026.2630072","url":null,"abstract":"Background: Clear cell renal cell carcinoma (ccRCC) accounts for over 75% of all renal cancer and contributes significantly to cancer-associated mortality. This study aims to identify a new ccRCC biomarker.Methods: Univariate and multivariate Cox regression models were performed for prognostic analysis. Differentially expressed genes (DEGs) were identified based on high and low expression AFAP1L1 groups. Functional enrichment analysis was conducted on the DEGs. Immunoassays were conducted on immune checkpoints, immune cells, and other components. Single-cell expression of AFAP1L1, along with associated pseudo-temporal trajectory analyses, was evaluated. The Connectivity Map was employed to identify potentially small-molecules. AFAP1L1 mRNA expression was measured via quantitative real-time PCR (qRT-PCR) experiment.Results: AFAP1L1 was significantly upregulated in training cohort and qRT-PCR, and lower expression level was correlated with shorter overall survival, which was also confirmed in E-MTAB-1980 and CPTAC validation cohorts. The upregulated DEGs were primarily involved in signaling pathways, nephron development, and transporter activity. AFAP1L1 was positively related with neutrophils and macrophages. AFAP1L1 exhibited a relatively higher expression level in endothelial cells at the single-cell level. Five potential therapeutic agents targeting ccRCC were identified.Conclusions: AFAP1L1 may impact the ccRCC development and progression, acting as an immune-related prognostic marker for ccRCC.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-16"},"PeriodicalIF":1.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative approaches in lung cancer diagnosis: bridging molecular biomarkers and AI driven imaging. 肺癌诊断的综合方法：连接分子生物标志物和人工智能驱动成像。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-03-19 DOI: 10.1080/1354750X.2026.2644329

Purabi Saha, Azra Yasmin, Ritesh Jha, Aarti Passi, Manpreet Kaur, Shammy Jindal, Vikramdeep Monga, Kamya Goyal

{"title":"Integrative approaches in lung cancer diagnosis: bridging molecular biomarkers and AI driven imaging.","authors":"Purabi Saha, Azra Yasmin, Ritesh Jha, Aarti Passi, Manpreet Kaur, Shammy Jindal, Vikramdeep Monga, Kamya Goyal","doi":"10.1080/1354750X.2026.2644329","DOIUrl":"10.1080/1354750X.2026.2644329","url":null,"abstract":"Background: Early and accurate detection of lung cancer remains a major clinical challenge. Conventional diagnostics, including X-ray, tissue biopsy etc., have limited sensitivity for identifying tumors early. Recent advances in molecular biology and computational technologies have significantly transformed lung cancer diagnostics.Methods: This review examines recent developments in biomarker-driven and technology-assisted diagnostic strategies for lung cancer. It highlights clinical relevance of molecular biomarkers, including EGFR, ALK etc., and evaluates emerging approaches like next-generation sequencing (NGS), ctDNA analysis, AI-based analytical tools.Results: Integration of molecular biomarkers into routine diagnostics has improved tumor subtyping and enabled more targeted therapeutic selection. Non-invasive approaches like liquid biopsy facilitate real-time tumor characterization and disease monitoring. In parallel, NGS and multi-omics technologies like genomics, transcriptomics provide comprehensive insights into tumor biology and tumor microenvironment. Advances in radiomics and AI-driven image analysis, particularly machine learning and deep learning applied to low-dose CT imaging, enhancing early detection and risk stratification. AI-powered detection systems and predictive models further support clinical decision-making.Conclusions: The convergence of biomarker research, multi-omics technologies, and AI-driven analytics is reshaping lung cancer diagnostics toward more precise and personalized approaches. However, challenges related to data standardization, interpretability, clinical validation, and ethical considerations must be addressed to enable widespread clinical implementation.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-31"},"PeriodicalIF":1.9,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LSP1 is a prognostic biomarker associated with apoptosis in acute myeloid leukemia. LSP1是急性髓系白血病中与细胞凋亡相关的预后生物标志物。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-03-17 DOI: 10.1080/1354750X.2025.2578006

Chenxing Zhang, Xiaomei Liang, Bangxue Jiang, Yige Hu, Wenhao Zhong, Yunxin Zeng, Minyi Zhao, Dongjun Lin

{"title":"LSP1 is a prognostic biomarker associated with apoptosis in acute myeloid leukemia.","authors":"Chenxing Zhang, Xiaomei Liang, Bangxue Jiang, Yige Hu, Wenhao Zhong, Yunxin Zeng, Minyi Zhao, Dongjun Lin","doi":"10.1080/1354750X.2025.2578006","DOIUrl":"10.1080/1354750X.2025.2578006","url":null,"abstract":"Background: The leukocyte-specific protein 1 (LSP1) has been implicated in cancer progression, and this paper aims to reveal the prognostic value and pathogenic role of LSP1 in acute myeloid leukemia (AML).Methods: The TCGA and GTEx datasets were performed to assess the expression and prognostic significance of LSP1 in AML. RT-qPCR was utilized to detect LSP1 expression in AML patients. The impact of LSP1 knockdown on AML was assessed using CCK-8, 7-AAD/Annexin-V assays, and xenograft mouse models. Gene Set Enrichment Analysis (GSEA), RT-qPCR, and functional experiments were employed to explore and verify the potential mechanism of LSP1 in AML.Results: Our findings revealed that a high expression level of LSP1 indicated poor prognosis for AML. Meanwhile, the knockdown of LSP1 could inhibit AML in vitro and in vivo. Next, we observed that the NF-κB signaling pathway, associated with anti-apoptotic effects, was significantly upregulated in the high LSP1 expression group, and knocking down LSP1 could inhibit it. In addition, we also found that the NF-κB pathway-related anti-AML effect of bortezomib partially relied on LSP1.Conclusions: This study revealed that LSP1 plays a crucial role in the progression of AML, indicating its potential as a prognostic biomarker and therapeutic target.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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