Perk和ATF6信号通路在慢性淋巴细胞白血病患者未折叠蛋白反应中的作用

IF 1.9 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biomarkers Pub Date : 2025-08-29 DOI:10.1080/1354750X.2025.2553628

Nergiz Erkut, Merve Kestane, Selim Demir, Ahmet Mentese, Ozlen Balta, Mehmet Sonmez

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引用次数: 0

摘要

PERK、ATF6和IRE1α信号通路是未折叠蛋白反应（UPR）信号通路。在这项研究中，我们评估了PERK和ATF6信号通路（UPR信号通路）在慢性淋巴细胞白血病（CLL）患者中的作用。方法：采用ELISA法检测CLL患者及对照组外周血血浆eIF2AK3、GRP78、ATF6、CHOP、HIF-1α、caspase 3等标志物。结果：本研究中，CLL患者的eIF2AK3、GRP78、ATF6和CHOP水平高于对照组（p =）。讨论：本研究中，与PERK和ATF6信号通路相关的标志物在CLL患者中较高。

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Involvement of Perk and ATF6 Signal Pathways in Indicating Unfolded Protein Response in Patients with Chronic Lymphocytic Leukaemia.

Introduction: PERK, ATF6, and IRE1α signalling pathways are unfolded protein response (UPR) signalling pathways. In this study, we evaluated the effect of PERK and ATF6 signalling pathways, which are UPR signalling pathways, in chronic lymphocytic leukaemia (CLL) patients.

Methods: ELISA was performed on peripheral blood plasma samples from CLL patients and the control group for the markers eIF2AK3, GRP78, ATF6, CHOP, HIF-1α and caspase 3.

Results: In this study, the levels of eIF2AK3, GRP78, ATF6 and CHOP were higher in the CLL group than in the control group (p = <0.001, p = <0.001, p = <0.001, p = <0.001, respectively). While no difference was observed between the CLL group and the control group in terms of HIF-1α level, caspase 3 level was higher in the CLL group (p = <0.001). There was a positive relationship between the level of HIF-1α and the levels of ATF6 and CHOP (r = 0.648, p = <0.001; r = 0.727, p = <0.001, respectively). Also, a positive correlation was observed between caspase 3 level and ATF6 level (r = 0.301, p = 0.030).

Discussion: In this study, markers associated with PERK and ATF6 signalling pathways were higher in CLL patients.

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来源期刊

Biomarkers 医学-毒理学

CiteScore

5.00

自引率

3.80%

发文量

140

审稿时长

3 months

期刊介绍： The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.