Biomarkers最新文献_第10页

Identification of the ATPase alpha subunit of Trypanosoma cruzi as a potential biomarker for the diagnosis of Chagas disease. 鉴定克氏锥虫的 ATPase alpha 亚基作为诊断南美锥虫病的潜在生物标志物。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-09-10 DOI: 10.1080/1354750X.2023.2255756

M Morales-Velásquez, J P Barón-Vera, M I Pulgarín-Osorio, M M Sánchez-Jiménez, J D Ospina-Villa

{"title":"Identification of the ATPase alpha subunit of Trypanosoma cruzi as a potential biomarker for the diagnosis of Chagas disease.","authors":"M Morales-Velásquez, J P Barón-Vera, M I Pulgarín-Osorio, M M Sánchez-Jiménez, J D Ospina-Villa","doi":"10.1080/1354750X.2023.2255756","DOIUrl":"10.1080/1354750X.2023.2255756","url":null,"abstract":"Background: Chagas disease (CD) is considered by the World Health Organisation (WHO) a neglected disease endemic to the Americas, but it has spread throughout the world due to migrations. The disease is almost 100% curable if detected in time. Still, the lack of rapid diagnostic tests with sufficient sensitivity and specificity leads to a chronic phase with a mortality of about 50,000 people worldwide per year.Methods: Using the total proteins extracted from serum samples of patients confirmed with chronic phase CD; we performed the Bio-SELEX strategy. The best aptamers were selected using next-generation sequencing (NGS) based on their most abundant sequences (reads and rpm). Then, selected aptamers were used to isolate potential biomarkers directly from serum samples of patients with chronic phase CD using pull-down and mass spectrometry experiments.Results: CH1 aptamer was the aptamer selected after the NGS results analysis. The pull-down and mass spectrometry experiments identified the presence of the ATPase alpha subunit of T. cruzi circulating in serum samples of patients with chronic phase CD.Conclusions: We report the ATPase alpha subunit of T. cruzi as a potential biomarker for chronic phase CD and CH1 aptamer as a potential tool for diagnosing CD.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"599-607"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10251957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection and modification of biomarkers of inflammation determining successful rhythm control in patients with atrial fibrillation. 确定房颤患者心律控制成功的炎症生物标志物的检测和修饰。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2024-01-22 DOI: 10.1080/1354750X.2023.2284122

Tobias Schreiber, Jana Grune, Ulf Landmesser, Philipp Attanasio

{"title":"Detection and modification of biomarkers of inflammation determining successful rhythm control in patients with atrial fibrillation.","authors":"Tobias Schreiber, Jana Grune, Ulf Landmesser, Philipp Attanasio","doi":"10.1080/1354750X.2023.2284122","DOIUrl":"10.1080/1354750X.2023.2284122","url":null,"abstract":"Introduction: Multiple pathophysiological mechanisms are involved in the pathogenesis of atrial fibrillation (AF). Growing evidence suggests that both local and systemic inflammation plays a key role even in early stages and its progression towards persisting and permanent AF. Rhythm control therapy via pulmonary vein isolation or cardioversion is the cornerstone of AF therapy for most symptomatic patients, yet arrhythmia recurrence after treatment is still common, especially in patients with persistent AF.Material and methods: In this review, we summarize the current state of knowledge of biomarkers of inflammation with prognostic value in patients with atrial fibrillation as well as anti-inflammatory medication with potential benefits after rhythm control therapy.Results and discussion: Both onset of AF, progression and arrhythmia recurrence after rhythm control therapy can be caused by local and systemic inflammation. Various inflammatory biomarkers have been established to predict treatment success. Furthermore, additional anti-inflammatory therapy may significantly improve success rates.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"681-691"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MiR-150 and miR-155 expression predicts survival of cervical cancer patients: a translational approach to novel prognostic biomarkers. MiR-150和MiR-155的表达预测宫颈癌症患者的生存率：一种新的预后生物标志物的转化方法。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2269320

Joana M O Santos, Valéria Tavares, Rui M Gil da Costa, Rui Medeiros

{"title":"MiR-150 and miR-155 expression predicts survival of cervical cancer patients: a translational approach to novel prognostic biomarkers.","authors":"Joana M O Santos, Valéria Tavares, Rui M Gil da Costa, Rui Medeiros","doi":"10.1080/1354750X.2023.2269320","DOIUrl":"10.1080/1354750X.2023.2269320","url":null,"abstract":"Introduction: High-risk human papillomavirus (HPV) is the aetiological agent of cervical cancer, which remains the fourth leading cause of cancer death in women worldwide. K14-HPV16 transgenic mice are a model for HPV-induced cancers, which undergo multistep squamous carcinogenesis at the skin, that is histologically and molecularly similar to carcinogenesis of the human cervix. Previous screens of differentially regulated microRNAs (miRs) using K14-HPV16 mice showed a role for miR-21, miR-155, miR-150, miR-146a, miR-125b and miR-223 during carcinogenesis.Methods: We now aim to translate these observations into the clinical setting, using data provided by The Cancer Genome Atlas (TCGA) to explore whether those microRNAs can influence the survival of cervical cancer patients.Results: Results showed that low miR-150, miR-155 and miR-146a expression levels in primary tumours were associated with poor overall survival. However, only miR-150 and miR-155 were found to be independent predictors, increasing the risk of death. When patients were stratified by clinical stage, low miR-150, miR-155, miR-146a and miR-125b were associated with poor survival for clinical stages I and II. Only low miR-150 expression increased the death risk.Conclusion: We conclude that miR-150 and miR-155 may be potentially applied as prognostic biomarkers in cervical cancer patients. However, further investigation is required to determine their applicability.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"617-627"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of occupational exposure to pesticides with overweight in farmers in Southern Brazil. 巴西南部农民职业接触农药与超重的关系。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2268859

Calinca Skonieski, Karina Raquel Fagundes, Larissa da Silva, Hecson Jesser Segat, Anderson Joel Martino Andrade, Rodrigo Cordeiro Bolzan, Mario Hiroyuki Hirata, Glaucio Monteiro Ferreira, Dalila Moter Benvegnú

{"title":"Association of occupational exposure to pesticides with overweight in farmers in Southern Brazil.","authors":"Calinca Skonieski, Karina Raquel Fagundes, Larissa da Silva, Hecson Jesser Segat, Anderson Joel Martino Andrade, Rodrigo Cordeiro Bolzan, Mario Hiroyuki Hirata, Glaucio Monteiro Ferreira, Dalila Moter Benvegnú","doi":"10.1080/1354750X.2023.2268859","DOIUrl":"10.1080/1354750X.2023.2268859","url":null,"abstract":"Introduction: Exposure to pesticides may be related to overweight and associated comorbidities. The aim of this work was to evaluate occupational exposure to pesticides, overweight and associated comorbidities among farmers in Southern Brazil.Methods: This cross-sectional study included a random sample of 257 farmers, living in the municipality of Mafra and Planalto, southern Brazil. Data on pesticide use and overweight prevalence from farmers were collected using an in-person interview questionnaire, followed by blood collection and biochemical analyses.Results: Pesticide exposure was positively correlated with body mass index, waist circumference, waist-to-hip ratio, triglycerides and glucose levels, presence of hypertension and metabolic syndrome. Besides that, the fact of being exposed to pesticides represents a decrease of no protein thiol groups. Furthermore, the main pesticides used by farmers have hepatic toxicity.Conclusion: These findings suggest that exposure to pesticides may be associated with overweight and associated comorbidities. Further studies are required to validate our findings and elucidate the specific mechanisms by which these pollutants contribute to the development of overweight.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"608-616"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial subtype MB-G3 contains potential novel biomarkers and therapeutic targets associated with prognosis of medulloblastoma. 线粒体亚型MB-G3包含与髓母细胞瘤预后相关的潜在新生物标志物和治疗靶点。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2276670

Qiang Li, Yanfei Jia, Bo Tang, Hu Yang, Qiang Yang, Xiaodong Luo, Yawen Pan

{"title":"Mitochondrial subtype MB-G3 contains potential novel biomarkers and therapeutic targets associated with prognosis of medulloblastoma.","authors":"Qiang Li, Yanfei Jia, Bo Tang, Hu Yang, Qiang Yang, Xiaodong Luo, Yawen Pan","doi":"10.1080/1354750X.2023.2276670","DOIUrl":"10.1080/1354750X.2023.2276670","url":null,"abstract":"Background: Medulloblastoma is the most common malignant brain tumor in children. There are four groups, each with different causal mutations, affected pathways and prognosis. Here, we investigated the role of mitochondria in medulloblastoma and whether there are differences between the different groups.Methods: We compared the gene expression levels in the four different medulloblastoma groups (MB-WNT, MB-SHH, MB-G3 and MB-G4), with the focus on genes associated with mitochondria. We used several tools including Salmon, Tximeta, DESeq2, BiomaRt, STRING, Ggplot2, EnhancedVolcano, Venny 2.1 and Metscape.Results: A total of 668 genes were differentially expressed and the most abundant genes were associated with cell division pathway followed by modulation of chemical synaptic transmission. We also identified several genes (ABAT, SOX9, ALDH5A, FOXM1, ABL1, NHLH1, NEUROD1 and NEUROD2) known to play vital role in medulloblastoma. Comparative expression analysis revealed OXPHOS complex-associated proteins of mitochondria. The most significantly expressed genes in the MB-SHH and MB-G4 groups were AHCYL1 and SFXN5 while PAICS was significantly upregulated in MB-WNT group. Notably, MB-G3 contained the most downregulated genes from the OXPHOS complexes, except COX6B2 which was strongly upregulated.Conclusions: We show the importance of mitochondria and compare their role in the four different medulloblastoma groups.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"643-651"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54227471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationships between Charlson comorbidity index associated biomarkers and outcomes among participants in the Malmö diet and cancer study. 马尔默饮食与癌症研究参与者的夏尔森综合症指数相关生物标志物与结果之间的关系。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2024-01-22 DOI: 10.1080/1354750X.2023.2298651

Torgny Wessman, Toralph Ruge, Axel Carl Carlsson, Per Wändell, Ardavan Khoshnood, Olle Melander

{"title":"Relationships between Charlson comorbidity index associated biomarkers and outcomes among participants in the Malmö diet and cancer study.","authors":"Torgny Wessman, Toralph Ruge, Axel Carl Carlsson, Per Wändell, Ardavan Khoshnood, Olle Melander","doi":"10.1080/1354750X.2023.2298651","DOIUrl":"10.1080/1354750X.2023.2298651","url":null,"abstract":"Introduction: The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population.Methods: Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC). Individuals with CCI diagnoses and other major comorbidities were excluded. Another score of 11 biomarkers associated with comorbidity burden from a previous study of acute dyspnea was also created (BSADYS). The scores were prospectively evaluated for prediction of mortality, and some chronic diseases, using Cox Proportional Hazards Model.Results: Fully adjusted models showed that BSMDC was significantly associated per 1 SD increment of the score with incident COPD, 55%, and congestive heart failure, 32%; and with mortality, 33% cardiovascular, 91% respiratory, 30% cancer, and 45% with all-cause mortality. The BSADYS showed no association with these outcomes, after simultaneous inclusion of both biomarker scores to all the clinical covariates.Conclusion: BSMDC shows strong prediction of morbidity and mortality in individuals free from comorbidities at baseline, and the results suggest that healthy individuals with high level of BSMDC would benefit from intense preventive actions.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"722-730"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphisms in ERCC1, ERCC4 and ERCC5 genes as biomarkers of susceptibility for pesticide-induced DNA damage in North-West Indian agricultural workers. ERCC1、ERCC4和ERCC5基因多态性作为西北印度农业工人农药诱导DNA损伤易感性的生物标志物

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2284109

Karashdeep Kaur, Rupinder Kaur

{"title":"Polymorphisms in ERCC1, ERCC4 and ERCC5 genes as biomarkers of susceptibility for pesticide-induced DNA damage in North-West Indian agricultural workers.","authors":"Karashdeep Kaur, Rupinder Kaur","doi":"10.1080/1354750X.2023.2284109","DOIUrl":"10.1080/1354750X.2023.2284109","url":null,"abstract":"Background: Occupational pesticides exposure has raised health concerns due to genotoxicity and accumulation of DNA damage. Polymorphisms in genes encoding enzymes involved in nucleotide excision repair (NER) may affect the individual's susceptibility to pesticide toxicity.Methods: This study evaluates the association of excision repair cross complementation group 1 (ERCC1) (8092 C > A, 3'UTR, rs3212986) and ERCC1 (19007 C > T, Asn118Asn, rs11615), ERCC4 (1244 G > A, Arg415Gln, rs1800067) and ERCC5 (3507 G > C, Asp1104His, rs17655) polymorphisms with pesticide-induced DNA damage in North-West Indian agricultural workers. The study population comprised 225 agricultural workers exposed to pesticides and 225 non-exposed controls.Results: Our study demonstrate that exposed workers carrying variant ERCC1 8092AA genotype showed higher total comet DNA migration (p = 0.015) as well as increased frequency of cells showing DNA migration (p = 0.027). Exposed agricultural workers with variant ERCC4 1244AA (415Gln/Gln) and ERCC5 3507CC (1104His/His) genotypes exhibited elevation in total comet DNA migration (p < 0.01). However, genotypes of ERCC1 19007 C > T (Asn118Asn) showed no association with total comet DNA migration (p = 0.963), frequency of cells showing DNA migration (p = 0.423) as well as mean tail length (p = 0.432).Conclusion: ERCC1, ERCC4 and ERCC5 polymorphisms influence DNA damage and can be used as biomarkers of susceptibility for pesticide-induced DNA damage in North-West Indian agricultural workers.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"672-679"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The combination of preoperative fibrinogen-to-albumin ratio and postoperative TNM stage (FAR-TNM) predicts the survival in gastric cancer patients after gastrectomy. 术前纤维蛋白原与白蛋白比值与术后TNM分期(FAR-TNM)联合预测胃癌患者胃切除术后的生存。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2024-01-22 DOI: 10.1080/1354750X.2023.2281870

Xunlei Zhang, Xinyue Qiu, Haibing Yin, Wenjing Zhao, Li Song, Xingsong Zhang, Lei Yang, Min Tao

{"title":"The combination of preoperative fibrinogen-to-albumin ratio and postoperative TNM stage (FAR-TNM) predicts the survival in gastric cancer patients after gastrectomy.","authors":"Xunlei Zhang, Xinyue Qiu, Haibing Yin, Wenjing Zhao, Li Song, Xingsong Zhang, Lei Yang, Min Tao","doi":"10.1080/1354750X.2023.2281870","DOIUrl":"10.1080/1354750X.2023.2281870","url":null,"abstract":"Objective: There are many factors that affect the survival of patients with gastric cancer, such as TNM stage, the patient's nutritional status, inflammation, and so on. In this study, the prognostic significance of preoperative fibrinogen-to-albumin ratio (FAR) and postoperative TNM staging in patients with gastric cancer was retrospectively studied.Methods: A total of 265 patients (surgery dates from January 2007 to December 2013) were included in this retrospective study. All the patients were confirmed by pathology after operation. Categorical variables were compared using the χ2 test. Kaplan-Meier and log-rank tests were used for survival analysis. Cox proportional hazard models were used to assess prognostic factors. Nomogram was applied to predict the prognosis of overall survival (OS).Results: The higher the FAR value, the more lymph node metastasis, the later the TNM stage, and the shorter the survival time. We established a new scoring system, the FAR-TNM score, which combined FAR and TNM stage. The FAR-TNM score was significantly related to tumor location, tumor size, Bormann types, differentiation, operative type, vascular invasion, nerve invasion, depth of invasion, lymphatic metastasis, and advanced TNM stage. Multivariate Cox regression analysis demonstrated that tumor location, TNM stage, adjuvant chemotherapy, and FAR-TNM score were independent prognostic elements for OS in patients with GC.Conclusions: The FAR-TNM score was a valuable independent prognostic indicator for GC patients after surgery, which can help clinicians to assist the treatment and long-term management of patients with gastric cancer.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"714-721"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138497745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer. 单核髓过氧化物酶是早期卵巢癌的特异性生物标志物。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2284106

Ghassan M Saed, Asad Nawaz, Ayesha A Alvero, Amy K Harper, Robert T Morris

{"title":"Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer.","authors":"Ghassan M Saed, Asad Nawaz, Ayesha A Alvero, Amy K Harper, Robert T Morris","doi":"10.1080/1354750X.2023.2284106","DOIUrl":"10.1080/1354750X.2023.2284106","url":null,"abstract":"Background: Ovarian cancer cells are known to express myeloperoxidase (MPO), an oxidant-producing enzyme with a 150 kDa homodimer, consisting of two identical monomers connected by a disulfide bond. Here, we aim to validate monomeric MPO (mMPO) as a biomarker for the early detection of ovarian cancer.Methods: Human ovarian cancer cells, sera from patients at various stages, sera from non-cancer inflammatory gynecological diseases, and healthy volunteers were used. Monomeric and dimeric MPO were measured by ELISA. Receiver operating curves were used to compare the predictive powers of serum dimeric and monomeric MPO to discriminate between samples.Results: The expression of MPO was unique to ovarian cancer cells. Specifically, mMPO was found to be the only form of MPO in all ovarian cancer cell lines. Intriguingly, mMPO was detected in the sera from all patients with ovarian cancer at various stages, but not from healthy individuals. Serum mMPO discriminated between early-stage ovarian cancer, healthy controls, and benign inflammatory gynecologic disorders. In addition, mMPO discriminated between the early and late stages of the disease.Conclusion: This work highlights mMPO as a potential biomarker for early detection of ovarian cancer, which is critically needed.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"663-671"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138046142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of grape seed extract and exercise training on tissues toxicities in doxorubicin-treated healthy rat. 葡萄籽提取物和运动训练对阿霉素治疗的健康大鼠组织毒性的保护作用。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1080/1354750X.2023.2246698

Feiza Belhadjali, Slim Ghrir, Féryel Ksia, Ferid Limam, Ezzedine Aouani, Meherzia Mokni

{"title":"Protective effect of grape seed extract and exercise training on tissues toxicities in doxorubicin-treated healthy rat.","authors":"Feiza Belhadjali, Slim Ghrir, Féryel Ksia, Ferid Limam, Ezzedine Aouani, Meherzia Mokni","doi":"10.1080/1354750X.2023.2246698","DOIUrl":"10.1080/1354750X.2023.2246698","url":null,"abstract":"Objective: The aim of the present study was to investigate the effects of Grape seed extract (GSE) and exercise training on Doxorubicin (Doxo)-induced cardio, hepato and myo toxicities in healthy rats.Methods: Thirty male Wistar rats were randomly divided into five groups and daily treated by intraperitoneal route during two months either with ethanol 10% (Control); Doxo (1.5 mg/kg); Doxo + exercise (1.5 mg/kg + swimming exercise for 30 min twice a week); Doxo + GSE (1.5 mg/kg + GSE 2.5 g/kg); Doxo + GSE + exercise (1.5 mg/kg + GSE 2.5 g/kg + swimming exercise for 30 min twice a week). At the end of the treatment, tissues were collected and processed for the determination of oxidative stress (OS), intracellular mediators, energy fuelling biomarkers, carbohydrate metabolism parameters and muscle histopathology.Results: Doxo provoked OS characterised by an increased lipoperoxidation (LPO) and protein carbonylation and decreased antioxidant enzyme activities. Doxo also affected intracellular mediators, disturbed carbohydrate metabolism and energy fuelling in skeletal muscle as assessed by down-regulated Electron Transport Chain (ETC) complex activities leading in fine to altered skeletal muscle structure and function.Conclusion: Almost all Doxo-induced disturbances were partially corrected with GSE and exercise on their own and more efficiently with the combined treatment (GSE + exercise).","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"544-554"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10059834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0