Biomarkers最新文献_第9页

Multidimensional metabolic profiling in carbon monoxide poisoning: acid-base disturbances correlate with neurological severity. 一氧化碳中毒的多维代谢谱分析：酸碱紊乱与神经系统严重程度相关。

IF 1.9 4区医学

Biomarkers Pub Date : 2025-07-01 Epub Date: 2025-09-04 DOI: 10.1080/1354750X.2025.2551303

Weiguang Wang, Huihua Huang, Xianwei Xiong, Changsheng Ye, Jin Huang, Yong Ai Ling

{"title":"Multidimensional metabolic profiling in carbon monoxide poisoning: acid-base disturbances correlate with neurological severity.","authors":"Weiguang Wang, Huihua Huang, Xianwei Xiong, Changsheng Ye, Jin Huang, Yong Ai Ling","doi":"10.1080/1354750X.2025.2551303","DOIUrl":"10.1080/1354750X.2025.2551303","url":null,"abstract":"Background: Acute carbon monoxide poisoning triggers complex metabolic derangements including acidosis and alkalosis, but their correlation with neurological injury severity remains insufficiently characterized clinically.Methods: Consecutive poisoning patients (age ≥14) admitted between January 2019 and February 2025 were classified by neurological impairment severity. Acid-base parameters were analysed using Kruskal-Wallis tests, Spearman's correlation, and principal component analysis with varimax rotation.Results: Among 940 patients (37.2% male), participants were categorized into three groups by neurological impairment severity: Mild (n = 597), moderate (n = 225), and severe (n = 118). Severe cases showed lower pH (7.39 vs. 7.41), reduced PaCO2 (34.5 vs. 38.2 mmHg), greater base excess deficit -3.3 vs. 0.4), and higher lactate (3.7 vs. 1.6 mmol/L) (all p < 0.001). Neurological severity positively correlated with lactate (rho = 0.338) and inversely with base excess (rho = -0.268). Principal component analysis identified two components: Factor Component 1 (FAC1) (metabolic compensation, 47-65% variance) and FAC2 (respiratory regulation, 26-41% variance), with FAC1 inversely correlating with severity (rho = -0.319, p < 0.001).Conclusions: Neurological impairment severity shows dose-dependent correlation with metabolic dysfunction (lactate accumulation, mixed metabolic acidosis-respiratory alkalosis). FAC1 (metabolic compensation) is a strong prognostic biomarker in acute carbon monoxide poisoning.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"363-370"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined plasma levels of A-type-natriuretic peptide and adrenomedullin are associated with appropriate anti-arrhythmia therapy in patients with an implantable cardioverter defibrillator but no prior device therapy. a型利钠肽和肾上腺髓质素联合血浆水平与植入心律转复除颤器但未接受器械治疗的患者适当的抗心律失常治疗相关

IF 1.9 4区医学

Biomarkers Pub Date : 2025-07-01 Epub Date: 2025-09-08 DOI: 10.1080/1354750X.2025.2553630

Farzin Beygui, Vincent Roule, Estelle Gandjbakhch, Pierre Ollitrault, Johanne Silvain, Paul Milliez, Nicolas Vignolles, Michel Zeitouni, Paul Guedeney, Laure Champ-Rigot, Katrien Blanchart, Gilles Montalescot

{"title":"Combined plasma levels of A-type-natriuretic peptide and adrenomedullin are associated with appropriate anti-arrhythmia therapy in patients with an implantable cardioverter defibrillator but no prior device therapy.","authors":"Farzin Beygui, Vincent Roule, Estelle Gandjbakhch, Pierre Ollitrault, Johanne Silvain, Paul Milliez, Nicolas Vignolles, Michel Zeitouni, Paul Guedeney, Laure Champ-Rigot, Katrien Blanchart, Gilles Montalescot","doi":"10.1080/1354750X.2025.2553630","DOIUrl":"10.1080/1354750X.2025.2553630","url":null,"abstract":"Background: Identifying patients benefiting from implantable cardioverter defibrillators (ICD) especially when replacing one that has never served may be challenging.Objectives: We assessed the association between plasma levels of mid-regional-pro-A-type-natriuretic peptide (ANP), Mid-regional-pro-adrenomedullin (ADM) and aldosterone and, appropriate Implantable Cardioverter Defibrillator (ICD)-therapy in patients with an ICD but no prior therapy.Methods: A cohort of 331 consecutive patients with an ICD but no prior ICD-therapy was prospectively included in 2 centers and followed-up for a median of 7.9 years. Plasma aldosterone, ANP and ADM levels were measured at inclusion. The primary outcome was the occurrence of appropriate ICD-therapy.Results: Appropriate ICD-therapy and death occurred in 106(32%) and 114(34%) patients respectively. Rates of ICD generator replacement were 62% regardless of ICD-therapy. The multivariable model showed significant relationships between ANP > median (adjusted HR 1.73[95% CI 1.04-2.86]) and ADM > median (HR 0.53 [95% CI 0.32-0.89]) but not aldosterone, and ICD-therapy. The Fine and Gray analysis accounting mortality as a competing risk showed similar results.Conclusions: The combination of ANP and ADM are independently associated with the risk of ICD-therapy in patients with an ICD that has never served, and may participate in stratifying patients who may benefit most from ICD generator replacement.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"371-379"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A diagnostic algorithm to evaluate elevated C-reactive protein levels in juvenile systemic lupus erythematosus. 评估少年系统性红斑狼疮患者c反应蛋白水平升高的诊断算法。

IF 1.9 4区医学

Biomarkers Pub Date : 2025-07-01 Epub Date: 2025-09-04 DOI: 10.1080/1354750X.2025.2556159

Ezgi Deniz Batu, Seher Sener, Sila Atamyildiz Ucar, Zeynep Balik, Gulsah Kavrul Kayaalp, Veysel Cam, Emil Aliyev, Yagmur Bayindir, Ozge Basaran, Nuray Aktay Ayaz, Betul Sozeri, Yelda Bilginer, Seza Ozen

{"title":"A diagnostic algorithm to evaluate elevated C-reactive protein levels in juvenile systemic lupus erythematosus.","authors":"Ezgi Deniz Batu, Seher Sener, Sila Atamyildiz Ucar, Zeynep Balik, Gulsah Kavrul Kayaalp, Veysel Cam, Emil Aliyev, Yagmur Bayindir, Ozge Basaran, Nuray Aktay Ayaz, Betul Sozeri, Yelda Bilginer, Seza Ozen","doi":"10.1080/1354750X.2025.2556159","DOIUrl":"10.1080/1354750X.2025.2556159","url":null,"abstract":"Objective: C-reactive protein (CRP) levels are generally not correlated with systemic lupus erythematosus (SLE) disease activity. We aimed to develop an algorithm to evaluate juvenile SLE (JSLE) patients with elevated CRP.Methods: JSLE patients diagnosed at <18 years were included. Each episode of CRP elevation was evaluated separately.Results: Of 190 JSLE patients (F/M:4/1), 88 (46.3%) never had an elevated CRP, while 102 (53.7%) had 174 episodes of CRP elevation. Causes were infection (n = 139), arthritis (n = 15), macrophage activation syndrome (MAS) (n = 9), MAS and infection (n = 3), serositis (n = 6), and vasculitis (n = 2). MAS was more common in the SLE disease activity index (SLEDAI)>4 group, while infections were more frequent in the SLEDAI ≤ 4 group. MAS episodes were more prevalent among patients with CRP >2x the upper limit of normal. We developed an algorithm to prioritize etiology in JSLE patients with elevated CRP. It led to the correct etiology in 164 of 165 episodes (99.4%) in the primary cohort. In an external JSLE cohort including 37 patients with 68 elevated CRP episodes, the algorithm led to the correct etiology in 67 (98.5%).Conclusion: Our algorithm could assist physicians evaluating elevated CRP episodes in JSLE patients. Validation in larger cohorts may improve its performance.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"380-385"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Integrated bioinformatics approach for the identification and validation of novel biomarkers in ACC progression and prognosis. 撤回声明：综合生物信息学方法用于鉴定和验证ACC进展和预后中的新型生物标志物。

IF 1.9 4区医学

Biomarkers Pub Date : 2025-07-01 Epub Date: 2025-09-29 DOI: 10.1080/1354750X.2025.2551424

引用次数: 0

Aluminium, lead and manganese mixture exacerbates oxidative stress, neuroinflammation and apoptosis via downregulation of Nrf-2/HO-1/BDNF signalling pathway in rats. 铝、铅、锰混合物通过下调Nrf-2/HO-1/BDNF信号通路加重大鼠氧化应激、神经炎症和细胞凋亡。

IF 1.9 4区医学

Biomarkers Pub Date : 2025-06-01 Epub Date: 2025-07-04 DOI: 10.1080/1354750X.2025.2522102

Baridoo Donatus Dooka, Chinna N Orish, Anthonet N Ezejiofor, Chidinma P Anyachor, Theresa C Umeji, Kpobari W Nkpaa, Cecilia N Obasi, Ana Cirovic, Aleksandar Cirovic, Orish E Orisakwe

{"title":"Aluminium, lead and manganese mixture exacerbates oxidative stress, neuroinflammation and apoptosis via downregulation of Nrf-2/HO-1/BDNF signalling pathway in rats.","authors":"Baridoo Donatus Dooka, Chinna N Orish, Anthonet N Ezejiofor, Chidinma P Anyachor, Theresa C Umeji, Kpobari W Nkpaa, Cecilia N Obasi, Ana Cirovic, Aleksandar Cirovic, Orish E Orisakwe","doi":"10.1080/1354750X.2025.2522102","DOIUrl":"10.1080/1354750X.2025.2522102","url":null,"abstract":"Heavy metals have been reported to induce neurotoxicity associated with neurodegenerative disorders. However, there is a dearth of information on Al, Pb and Mn mixture exposure on cerebral cortex functions. This study is aimed at evaluating the effects of Al, Pb and Mn mixture on the cerebral cortex functions. Rats were exposed to Pb 20 mg/kg, Al 35 mg/kg and Mn 0.564 mg/kg body weight singly or in combination for 90 d. Our results showed that Al, Pb and Mn singly or in combination exposure significantly (p ≤ 0.05) decreased antioxidant enzymes activities, glutathione level and increased oxidative stress and neuroinflammation biomarkers in the cerebral cortex of the exposed rats. Moreover, induction of inflammation maker, i.e. COX-2 was associated with increases in apoptotic induction. Furthermore, Al, Pb and Mn singling or in combination exposure significantly (p ≤ 0.05) increased Nrf-2 and decreased BDNF and HO-1 induction as well as increased amyloid precursor proteins and decreased occludin level. Taken together, our result indicates that Al, Pb and Mn mixture exacerbates oxidative stress, neuroinflammation, and apoptosis via downregulation of Nrf2/HO-1/BDNF signalling pathway.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"285-294"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosensor driven biomarker analysis: pioneering advancements in cancer diagnosis and therapeutic strategies. 生物传感器驱动的生物标志物分析：癌症诊断和治疗策略的开创性进展。

IF 1.9 4区医学

Biomarkers Pub Date : 2025-06-01 Epub Date: 2025-06-10 DOI: 10.1080/1354750X.2025.2515363

Gauri Nimhan, Mahavir Narwade, Kavita Gajbhiye

{"title":"Biosensor driven biomarker analysis: pioneering advancements in cancer diagnosis and therapeutic strategies.","authors":"Gauri Nimhan, Mahavir Narwade, Kavita Gajbhiye","doi":"10.1080/1354750X.2025.2515363","DOIUrl":"10.1080/1354750X.2025.2515363","url":null,"abstract":"Introduction: Early cancer detection significantly improves treatment outcomes; however, many cancers remain undiagnosed until advanced stages. This highlights the urgent need for rapid and precise diagnostic tools. Biosensors offer a transformative approach in cancer diagnostics by enabling early detection and continuous monitoring through the identification of molecular biomarkers.Methods: Biosensors function by converting biological elements-such as proteins, RNA, or genetic material-into measurable electrical signals. These devices are tailored to detect specific biomarkers, including proteins, peptides, gene mutations, or abnormal gene expression levels associated with various cancers.Results: Biosensors provide high sensitivity and specificity in identifying cancer cells. They enable real-time monitoring of tumour progression, angiogenesis, and treatment responses. These tools also facilitate accurate imaging of cancer cells and help evaluate the effectiveness of targeted therapies such as chemotherapy.Conclusion: The integration of biosensors into clinical practice could revolutionize cancer diagnostics by offering early, accurate, and minimally invasive detection methods. This review explores recent advances in biosensor development, the evolving landscape of cancer biomarkers, and the application of different biosensor technologies in cancer detection. Additionally, it addresses current limitations and challenges in clinical implementation, emphasizing the potential of biosensors to enhance patient outcomes through early intervention.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"332-351"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Markers of apoptosis and cardiac necrosis during the acute phase of catheter ablation using radiofrequency and pulsed-field energy. 使用射频和脉冲场能量进行导管消融急性期细胞凋亡和心肌坏死的标志物。

IF 1.9 4区医学

Biomarkers Pub Date : 2025-06-01 Epub Date: 2025-07-31 DOI: 10.1080/1354750X.2025.2536009

Sabri Hassouna, Marek Hozman, Barbora Bacova, Ivana Fiserova, Jana Vesela, Petr Waldauf, Dalibor Herman, Pavel Osmancik

{"title":"Markers of apoptosis and cardiac necrosis during the acute phase of catheter ablation using radiofrequency and pulsed-field energy.","authors":"Sabri Hassouna, Marek Hozman, Barbora Bacova, Ivana Fiserova, Jana Vesela, Petr Waldauf, Dalibor Herman, Pavel Osmancik","doi":"10.1080/1354750X.2025.2536009","DOIUrl":"10.1080/1354750X.2025.2536009","url":null,"abstract":"Introduction: The mechanism of cell death during pulsed-field ablation (PFA) appears distinct from thermal energy sources like radiofrequency ablation (RFA), with apoptosis often cited as the primary cause in PFA. This study aimed to clarify the mechanism by comparing markers of necrosis and apoptosis after PFA and RFA.Methods and results: Patients undergoing pulmonary vein isolation (PVI) for atrial fibrillation were randomized to receive either PFA (Farapulse, Boston Scientific) or RFA (CARTO Smart Touch, Biosense Webster). Myocardial necrosis was assessed via troponin I, and apoptosis via soluble cleaved caspase-3 and Fas ligand, measured pre- and one day post-ablation.Results: Sixty-five patients were enrolled (PFA: n = 33; RFA: n = 32), with comparable baseline characteristics. One day post-procedure, troponin I levels were significantly higher in the PFA group (median 10,102 ng/L; IQR 8,272-14,207) versus the RFA group (1,006 ng/L; IQR 603-1,433). No post-procedure increase in caspase-3 or Fas ligand was observed in the PFA group, and no differences in apoptotic markers were found between groups.Conclusion: In vivo, apoptosis does not appear to be the predominant mechanism of cardiomyocyte death following PFA for atrial fibrillation.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"327-331"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating cell-free circulatory mitochondrial DNA as a comprehensive biomarker for stress: meta-analysis of psychological and physiological stress responses. 评估无细胞循环线粒体DNA作为应激的综合生物标志物：心理和生理应激反应的荟萃分析。

IF 1.9 4区医学

Biomarkers Pub Date : 2025-06-01 Epub Date: 2025-07-15 DOI: 10.1080/1354750X.2025.2522888

Arpan Chattopadhyay, Harshita Tak, Hemanth Naick B

{"title":"Evaluating cell-free circulatory mitochondrial DNA as a comprehensive biomarker for stress: meta-analysis of psychological and physiological stress responses.","authors":"Arpan Chattopadhyay, Harshita Tak, Hemanth Naick B","doi":"10.1080/1354750X.2025.2522888","DOIUrl":"10.1080/1354750X.2025.2522888","url":null,"abstract":"Background: Mitochondria play a crucial role in cellular processes, such as energy metabolism, reactive oxygen species (ROS) generation and apoptosis. Mitochondrial dysfunction induced by stress has been implicated in various health conditions. Circulating cell-free mitochondrial DNA (CFC-MT-DNA) has emerged as a potential biomarker reflecting mitochondrial damage under stress.Methods: To evaluate the association between CFC-MT-DNA levels and human stress through a systematic review and meta-analysis of case-control studies. A comprehensive literature search was conducted across PubMed, Web of Science and ScienceDirect databases up to September 2023. Eight eligible studies assessing CFC-MT-DNA levels in stressed vs. control individuals were included. Data were analysed using RevMan version 5.4 software.Results: The meta-analysis revealed significantly elevated CFC-MT-DNA levels in individuals experiencing stress (p = 0.03), particularly in psychological stress-related conditions, such as bipolar disorder (BD) and major depressive disorder (MDD). However, no significant increase was observed in physiological stress conditions, including diabetes and sports training. High heterogeneity (I2 = 96%) was observed across studies.Conclusions: CFC-MT-DNA shows promise as a non-invasive biomarker for psychological stress. Further longitudinal and mechanistic studies are needed to clarify its role across different types of stress and its potential clinical utility.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"295-303"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CYP450 gene polymorphisms and the risk of taxane-induced neurotoxicity in breast cancer patients: a systematic review and meta-analysis. CYP450基因多态性与紫杉烷诱导乳腺癌患者神经毒性的风险：一项系统综述和荟萃分析。

IF 1.9 4区医学

Biomarkers Pub Date : 2025-06-01 Epub Date: 2025-07-24 DOI: 10.1080/1354750X.2025.2522892

Nayara Rozalem Moretti, Bárbara de Moura Moreira, Isabella Pimentel Braz, Isabella Caroline de Oliveira Barretto, Ana Laura Ayumi Zanoni Chiba, Angélica Augusta Grigoli Dominato, Francisco Cezar Aquino de Moraes

{"title":"CYP450 gene polymorphisms and the risk of taxane-induced neurotoxicity in breast cancer patients: a systematic review and meta-analysis.","authors":"Nayara Rozalem Moretti, Bárbara de Moura Moreira, Isabella Pimentel Braz, Isabella Caroline de Oliveira Barretto, Ana Laura Ayumi Zanoni Chiba, Angélica Augusta Grigoli Dominato, Francisco Cezar Aquino de Moraes","doi":"10.1080/1354750X.2025.2522892","DOIUrl":"10.1080/1354750X.2025.2522892","url":null,"abstract":"Background: Breast cancer (BC) is the most common cancer in women. Taxanes are widely used, but their neurotoxicity affects patients' quality of life. Genetic polymorphisms in CYP450 enzymes influence taxane metabolism, leading to variability in toxicity risk.Methods: A literature search was conducted to identify studies on the association between CYP450 polymorphisms and Taxane-Induced Peripheral Neuropathy (TIPN) in BC patients. Odds ratios (OR) and hazard ratios (HR) with 95% confidence intervals (CI) were estimated using a random-effects model in RStudio.Results: Nine studies with 3034 patients were included. Overall CYP polymorphisms showed a significant association with TIPN (OR: 1.2877, 95% CI: 1.0262-1.6157). CYP1B1 polymorphism had an inconsistent link to TIPN by OR of 1.1524 (95% CI: 0.7441-1.7849). CYP2C8 polymorphism demonstrated the strongest association (OR: 1.5532, 95% CI: 1.2013-2.0082; HR: 1.5236, 95% CI: 1.1317-2.0512). CYP3A4 showed no significant association (OR: 1.0988, 95% CI: 0.5022-2.4404).Conclusions: CYP2C8 polymorphisms were significantly linked to TIPN. While CYP1B1 showed inconsistent results, CYP3A4 had no significant association. These findings imply that CYP2C8 genetic variations may affect taxane metabolism and neurotoxicity risk, indicating that pharmacogenomic profiling could help personalize chemotherapy and reduce adverse effects.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"315-326"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the role of human neutrophil elastase, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio as predictive markers for severity of acute respiratory toxicity among patients admitted to Poison Control Center of Ain Shams University Hospitals. 人中性粒细胞弹性酶、中性粒细胞-淋巴细胞比率和血小板-淋巴细胞比率在艾因沙姆斯大学医院中毒控制中心入院患者急性呼吸道毒性严重程度预测指标中的作用评价

IF 1.9 4区医学

Biomarkers Pub Date : 2025-06-01 Epub Date: 2025-07-16 DOI: 10.1080/1354750X.2025.2529206

Alaa Mohammed, Mona Elkotb, Eglal Elawady, Sarah Eweda

{"title":"Evaluation of the role of human neutrophil elastase, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio as predictive markers for severity of acute respiratory toxicity among patients admitted to Poison Control Center of Ain Shams University Hospitals.","authors":"Alaa Mohammed, Mona Elkotb, Eglal Elawady, Sarah Eweda","doi":"10.1080/1354750X.2025.2529206","DOIUrl":"10.1080/1354750X.2025.2529206","url":null,"abstract":"Background: There are hundreds of xenobiotics that can damage the respiratory system, necessitating mechanical ventilation. Therefore, acute respiratory toxicity may represent a serious condition that can be complicated by acute respiratory distress syndrome (ARDS). This study aimed to evaluate the role of Human Neutrophil Elastase (HNE) as a predictor of acute respiratory toxicity outcome and to compare it with the neutrophil lymphocyte ratio (N/L ratio) and platelet lymphocyte ratio (P/L ratio).Methods: This prospective study was conducted on adult patients with acute respiratory toxicity admitted to Poison Control Center; Ain Shams University Hospitals from January 2022 to December 2022. Their HNE, N/L ratio, and P/L ratio levels were assessed twice: First upon admission and again 24 h later.Results: Fifty-five patients were enrolled in the study and were classified into ARDS group and non-ARDS group. HNE levels were significantly higher in ARDS patients at both time points with excellent predictive performance. Although the N/L and P/L ratios were significantly elevated in ARDS patients at 30 h, their diagnostic performance was inferior to HNE. Combining HNE with the N/L ratio offered minimal additional benefit over HNE alone.Conclusion: HNE Level can serve as predictor of ARDS in acutely intoxicated patients.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"304-314"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0