Biomarkers最新文献_第9页

Phœnix dactylifera, L. seed oil alleviates Bleomycin-induced pulmonary fibrosis and oxidative stress in Wistar rats. Phœnix dactylifera, L. 种子油能减轻博莱霉素诱导的 Wistar 大鼠肺纤维化和氧化应激。

IF 2.6 4区医学

Biomarkers Pub Date : 2024-03-01 Epub Date: 2024-02-05 DOI: 10.1080/1354750X.2024.2311178

Sana Bahri, Raed Abdennabi, Asma Chaker, Afef Nahdi, Amine Elgheryeni, Mona Mlika, Saloua Jameleddine

{"title":"Phœnix dactylifera, L. seed oil alleviates Bleomycin-induced pulmonary fibrosis and oxidative stress in Wistar rats.","authors":"Sana Bahri, Raed Abdennabi, Asma Chaker, Afef Nahdi, Amine Elgheryeni, Mona Mlika, Saloua Jameleddine","doi":"10.1080/1354750X.2024.2311178","DOIUrl":"10.1080/1354750X.2024.2311178","url":null,"abstract":"Objective: Idiopathic pulmonary fibrosis (IPF) is the most serious form of interstitial lung disease. We aimed to investigate the effect of Phœnix dactylifera, L. seed oil (DSO) on a murine model of IPF induced by bleomycin (BLM).Methods: Male Wistar rats were treated with a single intra-tracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of DSO (75, 150 and 300 mg/kg) for 4 weeks.Results: Our phytochemical results showed that DSO has an important antioxidant activity with a high content of polyphenols and flavonoids. High-Performance Liquid Chromatography (HPLC) and Gas chromatography/mass spectrometry (GC-MS) analysis revealed a high amount of oleic and lauric acids and a large quantity of vitamins. Histological examination showed a significant reduction in fibrosis score and collagen bands in the group of rats treated with 75 mg/kg of DSO compared to the BLM group. DSO (75 mg/kg) reversed also the increase in catalase and malondialdehyde (MDA) levels while higher doses (150 and 300 mg/kg) are ineffective against the deleterious effects of BLM. We revealed also that DSO has no renal or hepatic cytotoxic effects.Conclusion: DSO can play antioxidant and antifibrotic effects on rat models of pulmonary fibrosis at the lowest dose administered.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"45-54"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of ASXL1 mutations and ASXL1 CircRNAs in cancer. ASXL1 基因突变和 ASXL1CircRNAs 在癌症中的作用

IF 2.6 4区医学

Biomarkers Pub Date : 2024-02-01 Epub Date: 2024-02-12 DOI: 10.1080/1354750X.2024.2304187

Narges Jafarbeik-Iravani, Sara Kolahdozan, Rezvan Esmaeili

{"title":"The role of ASXL1 mutations and ASXL1 CircRNAs in cancer.","authors":"Narges Jafarbeik-Iravani, Sara Kolahdozan, Rezvan Esmaeili","doi":"10.1080/1354750X.2024.2304187","DOIUrl":"10.1080/1354750X.2024.2304187","url":null,"abstract":"Background: Mutations in the Additional Sex Combs Like 1 (ASXL1) gene were first reported in myelodysplastic syndromes. Recent studies have clarified the relationship between ASXL1 mutations and the development of cancers.Objective: This study aims to review the roles of ASXL1 and ASXL1 CircRNAs, such as epigenetic regulation, chromatin modification, and transcription factor function in malignancies.Method: This study is a review of articles related to the role of ASXL1 and ASXL1 CircRNAs in malignancies, retrieved from PubMed and Scopus.Results: ASXL1 plays a role in malignancies and is also related to poor overall survival and cancer metastasis. ASXL1 encodes conserved and abundant Circular RNAs (circRNAs) that act as post-transcriptional regulators, regulating tumorigenesis and progression in cancer. ASXL1 circRNA was identified in the top 10% of differentially expressed circRNAs in clinically relevant tissues. Additionally, the role of ASXL1 gene circRNAs in cancer development is reviewed in this study.Conclusion: ASXL1 and ASXL1circRNA have dual functions in combination with different proteins, being involved in both transcriptional activation and repression in a context-dependent manner. Moreover, studies indicate these genes play an important role in epithelial-mesenchymal transition (EMT) and metastasis. Ongoing research is aimed at determining this gene family's function in biological events.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-6"},"PeriodicalIF":2.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the potential of proteomic-based biomarkers in women's reproductive diseases: empowering precision medicine in gynecology. 解密基于蛋白质组的妇女生殖疾病生物标志物的潜力：为妇科精准医疗赋能。

IF 2.6 4区医学

Biomarkers Pub Date : 2024-02-01 DOI: 10.1080/1354750X.2024.2308827

Ishwerpreet Kaur Jawanda, Thomson Soni, Seema Kumari, Vijay Prabha

{"title":"Deciphering the potential of proteomic-based biomarkers in women's reproductive diseases: empowering precision medicine in gynecology.","authors":"Ishwerpreet Kaur Jawanda, Thomson Soni, Seema Kumari, Vijay Prabha","doi":"10.1080/1354750X.2024.2308827","DOIUrl":"10.1080/1354750X.2024.2308827","url":null,"abstract":"Context: Gynecological disorders represent a complex set of malignancies that result from a diverse array of molecular changes affecting the lives of over a million women worldwide. Ovarian, Endometrial, and Cervical cancers, Endometriosis, PCOS are the most prevalent ones that pose a grave threat to women's health. Proteomics has emerged as an invaluable tool for developing novel biomarkers, screening methods, and targeted therapeutic agents for gynecological disorders. Some of these biomarkers have been approved by the FDA, but regrettably, they have a constrained diagnostic accuracy in early-stage diagnosis as all of these biomarkers lack sensitivity and specificity. Lately, high-throughput proteomics technologies have made significant strides, allowing for identification of potential biomarkers with improved sensitivity and specificity. However, limited successes have been shown with translation of these discoveries into clinical practice.Objective: This review aims to provide a comprehensive overview of the current and potential protein biomarkers for gynecological cancers, endometriosis and PCOS, discusses recent advances and challenges, and highlights future directions for the field.Conclusion: We propose that proteomics holds great promise as a powerful tool to revolutionize the fight against female reproductive diseases and can ultimately improve personalized patient outcomes in women's biomedicine.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"7-17"},"PeriodicalIF":2.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing angiogenesis factors as prognostic biomarkers in breast cancer patients and their association with clinicopathological factors. 评估作为乳腺癌患者预后生物标志物的血管生成因子及其与临床病理因素的关系

IF 2.6 4区医学

Biomarkers Pub Date : 2024-02-01 Epub Date: 2024-02-05 DOI: 10.1080/1354750X.2024.2309541

Tannaz Abbasi-Dokht, Farhad Malek, Nahid Nafissi, Maryam Mohammadlou, Maryam Sheikh, Sedigheh Akbari, Mohammad Hossein Zargaran, Rasoul Baharlou

{"title":"Assessing angiogenesis factors as prognostic biomarkers in breast cancer patients and their association with clinicopathological factors.","authors":"Tannaz Abbasi-Dokht, Farhad Malek, Nahid Nafissi, Maryam Mohammadlou, Maryam Sheikh, Sedigheh Akbari, Mohammad Hossein Zargaran, Rasoul Baharlou","doi":"10.1080/1354750X.2024.2309541","DOIUrl":"10.1080/1354750X.2024.2309541","url":null,"abstract":"Introduction: Angiogenesis is fundamental for tumor growth and metastasis across many solid malignancies. Considerable interest has focused on the molecular regulation of tumor angiogenesis as a means to predict disease outcomes and guide therapeutic decisions.Methods: In the present study, we investigated the prognostic value of transforming growth factor beta (TGF-β), epidermal growth factor (EGF), fibroblast growth factor (FGF), delta-like ligand 4 (DLL4), and vascular endothelial growth factor (VEGF) in the serum of 120 women diagnosed with breast cancer using ELISA as well as examined their associations with clinical parameters and the outcome of the disease.Results: Our results demonstrated that the serum concentration of TGF-β and EGF were remarkably higher in patients with higher tumor size, end stages of the disease, and positive lymph node involvement compared to patients with lower tumor size, early stages of the disease, and negative lymph node involvement. In addition, we found a significant correlation between the serum concentration of VEGF and the level of EGF, FGF, and DLL4 in patients with breast cancer. Furthermore, both univariate and multivariate analyses showed that TGF-β and EGF can be used as end-stage predictors.Discussion/conclusion: Based on our findings, increasing the level of angiogenesis factors is significantly associated with higher tumor size and late stages of the disease in patients with breast cancer. Moreover, measuring the level of angiogenesis factors could lead to better prediction of disease outcomes and choosing the best treatments for patients.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"36-43"},"PeriodicalIF":2.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility. 胃癌患者中的核糖体组装蛋白 1-like 1 (NAP1L1)：具有诊断和预后作用的潜在生物标志物

IF 2.6 4区医学

Biomarkers Pub Date : 2024-02-01 Epub Date: 2024-02-05 DOI: 10.1080/1354750X.2024.2309540

Gungor Gul, Mehmet Akif Aydin, Sermin Algul, Remzi Kiziltan, Ozgur Kemik

{"title":"Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility.","authors":"Gungor Gul, Mehmet Akif Aydin, Sermin Algul, Remzi Kiziltan, Ozgur Kemik","doi":"10.1080/1354750X.2024.2309540","DOIUrl":"10.1080/1354750X.2024.2309540","url":null,"abstract":"Background: The nucleosome assembly protein 1-like 1 (NAP1L1) is suggested to have an oncogenic role in several tumors based on its overexpression. However, its diagnostic and prognostic role in gastric cancer remains unclarified. This study aimed to evaluate the diagnostic and prognostic utility of NAP1L1 in gastric cancer patients.Methods: A total of 85 patients [mean (SD) age: 60.9 (1.6) years, 49.4% were males] with newly-diagnosed gastric cancer and 40 healthy individuals [mean (SD) age: 60.7 (1.7) years, 52.5% were males] were included. Data on patient demographics (age, gender), TNM stages and tumor size, and the serum NAP1L1 levels were recorded.Results: Serum NAP1L1 levels were significantly higher in gastric cancer patients than in control subjects [12 (9.5-13.8) vs. 1.8 (1.5-2.4) ng/mL, p < 0.001]. Also, certain tumor characteristics such as tumor size of >4 vs. <4 cm (p < 0.001), M1 vs. M0 stage (p < 0.001), N2 vs. N0 and N1 stage (p < 0.001), and T4 vs. lower T stage (p < 0.001) were associated with significantly higher serum NAP1L1 levels in gastric cancer patients.Conclusions: Our findings revealed for the first time that serum levels for NAP1L1 were overexpressed in the gastric cancer, as also correlated with the disease progression. NAP1L1 seems to be a potential biomarker for gastric cancer, providing clinically important information on early diagnosis and risk stratification.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"30-35"},"PeriodicalIF":2.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139519922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross talk on the role of contemporary biomarkers in depression. 关于当代生物标志物在抑郁症中的作用的交叉讨论。

IF 2.6 4区医学

Biomarkers Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/1354750X.2024.2308834

Aditi Vyas, Gaurav Doshi

{"title":"A cross talk on the role of contemporary biomarkers in depression.","authors":"Aditi Vyas, Gaurav Doshi","doi":"10.1080/1354750X.2024.2308834","DOIUrl":"10.1080/1354750X.2024.2308834","url":null,"abstract":"Introduction: Biomarkers can be used to identify determinants of response to various treatments of mental disorders. Evidence to date demonstrates that markers of inflammatory, neurotransmitter, neurotrophic, neuroendocrine, and metabolic function can predict the psychological and physical consequences of depression in individuals, allowing for the development of new therapeutic targets with fewer side effects. Extensive research has included hundreds of potential biomarkers of depression, but their roles in depression, abnormal patients, and how bioinformatics can be used to improve diagnosis, treatment, and prognosis have not been determined or defined. To determine which biomarkers can and cannot be used to predict treatment response, classify patients for specific treatments, and develop targets for new interventions, proprietary strategies, and current research projects need to be tailored.Material and Methods: This review article focuses on - biomarker systems that would help in the further development and expansion of newer targets - which holds great promise for reducing the burden of depression.Results and Discussion: Further, this review point to the inflammatory response, metabolic marker, and microribonucleic acids, long non-coding RNAs, HPA axis which are - related to depression and can serve as future targets.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"18-29"},"PeriodicalIF":2.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139541610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A future blood test for acute traumatic spinal cord injury 急性创伤性脊髓损伤的未来血液检测方法

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-21 DOI: 10.1080/1354750x.2023.2298650

Tej D. Azad, Kathleen R. Ran, Jiaqi Liu, Vikas N. Vattipally, Harmon Khela, Enzo Leite, Joshua D. Materi, A. Daniel Davidar, Chetan Bettegowda, Nicholas Theodore

引用次数: 0

Arginase is upregulated in healthy women infected by oncogenic HPV types. Arginase在感染致癌HPV类型的健康女性中上调。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2273226

Moufida Souid, Jaweher Bday, Sameh Souissi, Randa Ghedira, Sallouha Gabbouj, Salwa Shini-Hadhri, Dhekra Toumi, Haifa Bergaoui, Ines Zouari, Raja Faleh, Abdelfatteh Zakhama, Elham Hassen

{"title":"Arginase is upregulated in healthy women infected by oncogenic HPV types.","authors":"Moufida Souid, Jaweher Bday, Sameh Souissi, Randa Ghedira, Sallouha Gabbouj, Salwa Shini-Hadhri, Dhekra Toumi, Haifa Bergaoui, Ines Zouari, Raja Faleh, Abdelfatteh Zakhama, Elham Hassen","doi":"10.1080/1354750X.2023.2273226","DOIUrl":"10.1080/1354750X.2023.2273226","url":null,"abstract":"Introduction: The implication of arginase enzyme in Human Papillomavirus (HPV) infections has not been clearly elucidated. The present study investigates whether HPV infection is correlated with changes in plasmatic arginase activity and cervical ARG1 and ARG2 mRNA expression among infected women negative for intraepithelial lesions (NIL).Materiel and methods: The present study included 300 women. The plasmatic arginase activity was evaluated by a colorimetric assay. Cervical HPV was detected by real-time PCR. The circulating viral load and ARG1 and ARG2 mRNA expression quantification were performed by quantitative real-time PCR.Results: A significant increase in plasma arginase activity and ARG1 and ARG2 mRNA expression levels in cervical cells was observed among HPV-positive women compared to the HPV-negative group. The highest levels were significantly associated with oncogenic HPV, and increased arginase activity was associated with a high HPV circulating viral load. Moreover, the highest levels of arginase activity were observed in oncogenic HPV-positive inflammatory smears.Discussion: These data suggest that HPV could modulate arginase activity and expression, which may restrict arginine bioavailability and inhibit this amino acid's antiviral properties.Conclusion: Our findings revealed that arginase activity and isoform gene expression were upregulated in women with HPV infection, particularly the oncogenic HPV types.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"628-636"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite. 评估中性粒细胞与淋巴细胞比率（NLR）、血小板与淋巴细胞比值（PLR）和平均血小板体积（MPV）时间序列对血毒性毒蛇咬伤诊断和预后的预测作用。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2277668

Mariam M Abd El-Azim, Mona K Mousa, Ragaa M Abdelmaaboud, Nabil N Rezq, Sarah S Mohammed

{"title":"Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite.","authors":"Mariam M Abd El-Azim, Mona K Mousa, Ragaa M Abdelmaaboud, Nabil N Rezq, Sarah S Mohammed","doi":"10.1080/1354750X.2023.2277668","DOIUrl":"10.1080/1354750X.2023.2277668","url":null,"abstract":"Background: This study aimed to assess the predictive value of NLR, PLR, and MPV time series for diagnosis and prognosis of hemotoxic snakebite envenomation.Methods: This is a prospective study among snakebite patients admitted to the Poison Control Center of Ain Shams University Hospitals and Assiut University Hospitals from the beginning of July 2019 to the end of October 2021. Patients were classified according to their clinical severity into three groups: mild, moderate, and severe.Results: The maximum incidence of snakebite was found in males (95%) from rural areas (80%); at lower limbs (70%); at night (51%); and during the autumn season (43.3%). The admission NLR and PLR can predict hemotoxic snakebite envenomation with an AUC of 0.940 and 0.569. The combination of NLR with PLR can develop a more predominant prediction of snakebite envenomation with an area under the curve (AUC) of 0.979. Furthermore, higher admission NLR and PLR levels are associated with prolonged hospital stays.Conclusion: While NLR and PLR levels may be helpful in the diagnosis of snakebite, MPV plays no part in the prognosis of snakebite patients. Serial NLR, PLR initially, at 24 hours, and predischarge can be used to evaluate the early treatment response.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"652-662"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smoke exposure associated with higher urinary benzene biomarker muconic acid (MUCA) in Golestan Cohort Study participants. Golestan队列研究参与者中与较高尿苯生物标志物粘酸（MUCA）相关的烟雾暴露。

IF 2 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2276030

Deepak Bhandari, Yuyang Zhu, Can Zhang, Wanzhe Zhu, Apostolos Alexandridis, Arash Etemadi, Neal D Freedman, Cindy Chang, Christian C Abnet, Sanford M Dawsey, Maki Inoue-Choi, Hossein Poustchi, Akram Pourshams, Paolo Boffetta, Reza Malekzadeh, Benjamin Blount

{"title":"Smoke exposure associated with higher urinary benzene biomarker muconic acid (MUCA) in Golestan Cohort Study participants.","authors":"Deepak Bhandari, Yuyang Zhu, Can Zhang, Wanzhe Zhu, Apostolos Alexandridis, Arash Etemadi, Neal D Freedman, Cindy Chang, Christian C Abnet, Sanford M Dawsey, Maki Inoue-Choi, Hossein Poustchi, Akram Pourshams, Paolo Boffetta, Reza Malekzadeh, Benjamin Blount","doi":"10.1080/1354750X.2023.2276030","DOIUrl":"10.1080/1354750X.2023.2276030","url":null,"abstract":"Background. Benzene is a known human carcinogen. Human exposure to benzene can be assessed by measuring trans, trans-muconic acid (MUCA) in urine. Golestan Province in northeastern Iran has been reported to have high incidence of esophageal cancer linked to the use of tobacco products. This manuscript evaluates the urinary MUCA concentrations among the participants of the Golestan Cohort Study (GCS).Methods. We analyzed MUCA concentration in 177 GCS participants' urine samples and performed nonparametric pairwise multiple comparisons to determine statistically significant difference among six different product use groups. Mixed effects model was fitted on 22 participants who exclusively smoked cigarette and 51 participants who were classified as nonusers. The urinary MUCA data were collected at the baseline and approximately five years later, and intraclass correlation coefficient (ICC) was calculated from the model.Results. Compared with nonusers, tobacco smoking was associated with higher urinary MUCA concentrations. Based on the nonparametric test of pairwise multiple comparisons, MUCA concentrations among participants who smoked combusted tobacco products were statistically significantly higher compared to nonusers. Urinary MUCA collected five years apart from the same individuals showed moderate reliability (ICC = 0.41), which was expected given the relatively short half-life (∼6 h) of MUCA.Conclusion. Our study revealed that tobacco smoke was positively associated with increased levels of urinary MUCA concentration, indicating that it is a significant source of benzene exposure among GCS participants.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"637-642"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50160549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0