Biomarkers最新文献_第9页

Arginase is upregulated in healthy women infected by oncogenic HPV types. Arginase在感染致癌HPV类型的健康女性中上调。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2273226

Moufida Souid, Jaweher Bday, Sameh Souissi, Randa Ghedira, Sallouha Gabbouj, Salwa Shini-Hadhri, Dhekra Toumi, Haifa Bergaoui, Ines Zouari, Raja Faleh, Abdelfatteh Zakhama, Elham Hassen

{"title":"Arginase is upregulated in healthy women infected by oncogenic HPV types.","authors":"Moufida Souid, Jaweher Bday, Sameh Souissi, Randa Ghedira, Sallouha Gabbouj, Salwa Shini-Hadhri, Dhekra Toumi, Haifa Bergaoui, Ines Zouari, Raja Faleh, Abdelfatteh Zakhama, Elham Hassen","doi":"10.1080/1354750X.2023.2273226","DOIUrl":"10.1080/1354750X.2023.2273226","url":null,"abstract":"Introduction: The implication of arginase enzyme in Human Papillomavirus (HPV) infections has not been clearly elucidated. The present study investigates whether HPV infection is correlated with changes in plasmatic arginase activity and cervical ARG1 and ARG2 mRNA expression among infected women negative for intraepithelial lesions (NIL).Materiel and methods: The present study included 300 women. The plasmatic arginase activity was evaluated by a colorimetric assay. Cervical HPV was detected by real-time PCR. The circulating viral load and ARG1 and ARG2 mRNA expression quantification were performed by quantitative real-time PCR.Results: A significant increase in plasma arginase activity and ARG1 and ARG2 mRNA expression levels in cervical cells was observed among HPV-positive women compared to the HPV-negative group. The highest levels were significantly associated with oncogenic HPV, and increased arginase activity was associated with a high HPV circulating viral load. Moreover, the highest levels of arginase activity were observed in oncogenic HPV-positive inflammatory smears.Discussion: These data suggest that HPV could modulate arginase activity and expression, which may restrict arginine bioavailability and inhibit this amino acid's antiviral properties.Conclusion: Our findings revealed that arginase activity and isoform gene expression were upregulated in women with HPV infection, particularly the oncogenic HPV types.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"628-636"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite. 评估中性粒细胞与淋巴细胞比率（NLR）、血小板与淋巴细胞比值（PLR）和平均血小板体积（MPV）时间序列对血毒性毒蛇咬伤诊断和预后的预测作用。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2277668

Mariam M Abd El-Azim, Mona K Mousa, Ragaa M Abdelmaaboud, Nabil N Rezq, Sarah S Mohammed

{"title":"Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite.","authors":"Mariam M Abd El-Azim, Mona K Mousa, Ragaa M Abdelmaaboud, Nabil N Rezq, Sarah S Mohammed","doi":"10.1080/1354750X.2023.2277668","DOIUrl":"10.1080/1354750X.2023.2277668","url":null,"abstract":"Background: This study aimed to assess the predictive value of NLR, PLR, and MPV time series for diagnosis and prognosis of hemotoxic snakebite envenomation.Methods: This is a prospective study among snakebite patients admitted to the Poison Control Center of Ain Shams University Hospitals and Assiut University Hospitals from the beginning of July 2019 to the end of October 2021. Patients were classified according to their clinical severity into three groups: mild, moderate, and severe.Results: The maximum incidence of snakebite was found in males (95%) from rural areas (80%); at lower limbs (70%); at night (51%); and during the autumn season (43.3%). The admission NLR and PLR can predict hemotoxic snakebite envenomation with an AUC of 0.940 and 0.569. The combination of NLR with PLR can develop a more predominant prediction of snakebite envenomation with an area under the curve (AUC) of 0.979. Furthermore, higher admission NLR and PLR levels are associated with prolonged hospital stays.Conclusion: While NLR and PLR levels may be helpful in the diagnosis of snakebite, MPV plays no part in the prognosis of snakebite patients. Serial NLR, PLR initially, at 24 hours, and predischarge can be used to evaluate the early treatment response.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"652-662"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smoke exposure associated with higher urinary benzene biomarker muconic acid (MUCA) in Golestan Cohort Study participants. Golestan队列研究参与者中与较高尿苯生物标志物粘酸（MUCA）相关的烟雾暴露。

IF 2 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2276030

Deepak Bhandari, Yuyang Zhu, Can Zhang, Wanzhe Zhu, Apostolos Alexandridis, Arash Etemadi, Neal D Freedman, Cindy Chang, Christian C Abnet, Sanford M Dawsey, Maki Inoue-Choi, Hossein Poustchi, Akram Pourshams, Paolo Boffetta, Reza Malekzadeh, Benjamin Blount

{"title":"Smoke exposure associated with higher urinary benzene biomarker muconic acid (MUCA) in Golestan Cohort Study participants.","authors":"Deepak Bhandari, Yuyang Zhu, Can Zhang, Wanzhe Zhu, Apostolos Alexandridis, Arash Etemadi, Neal D Freedman, Cindy Chang, Christian C Abnet, Sanford M Dawsey, Maki Inoue-Choi, Hossein Poustchi, Akram Pourshams, Paolo Boffetta, Reza Malekzadeh, Benjamin Blount","doi":"10.1080/1354750X.2023.2276030","DOIUrl":"10.1080/1354750X.2023.2276030","url":null,"abstract":"Background. Benzene is a known human carcinogen. Human exposure to benzene can be assessed by measuring trans, trans-muconic acid (MUCA) in urine. Golestan Province in northeastern Iran has been reported to have high incidence of esophageal cancer linked to the use of tobacco products. This manuscript evaluates the urinary MUCA concentrations among the participants of the Golestan Cohort Study (GCS).Methods. We analyzed MUCA concentration in 177 GCS participants' urine samples and performed nonparametric pairwise multiple comparisons to determine statistically significant difference among six different product use groups. Mixed effects model was fitted on 22 participants who exclusively smoked cigarette and 51 participants who were classified as nonusers. The urinary MUCA data were collected at the baseline and approximately five years later, and intraclass correlation coefficient (ICC) was calculated from the model.Results. Compared with nonusers, tobacco smoking was associated with higher urinary MUCA concentrations. Based on the nonparametric test of pairwise multiple comparisons, MUCA concentrations among participants who smoked combusted tobacco products were statistically significantly higher compared to nonusers. Urinary MUCA collected five years apart from the same individuals showed moderate reliability (ICC = 0.41), which was expected given the relatively short half-life (∼6 h) of MUCA.Conclusion. Our study revealed that tobacco smoke was positively associated with increased levels of urinary MUCA concentration, indicating that it is a significant source of benzene exposure among GCS participants.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"637-642"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50160549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comet assay as a suitable biomarker for in vivo oral carcinogenesis: a systematic review. 彗星试验作为体内口腔癌发生的合适生物标志物：系统综述。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2024-01-22 DOI: 10.1080/1354750X.2023.2298182

Thiago Guedes Pinto, Daniel Vitor de Souza, Glenda Nicioli da Silva, Daisy Maria Favero Salvadori, Manoela Domingues Martins, Daniel Araki Ribeiro

{"title":"Comet assay as a suitable biomarker for in vivo oral carcinogenesis: a systematic review.","authors":"Thiago Guedes Pinto, Daniel Vitor de Souza, Glenda Nicioli da Silva, Daisy Maria Favero Salvadori, Manoela Domingues Martins, Daniel Araki Ribeiro","doi":"10.1080/1354750X.2023.2298182","DOIUrl":"10.1080/1354750X.2023.2298182","url":null,"abstract":"Background and objectives: In order to detect genetic damage, different methods have been developed, such as micronuclei and comet assay. The comet assay presents some advantages when compared to the other aforementioned methods, including wide versatility, as any eukaryotic cell can be evaluated at an individual cellular level. In this context, the aim of this systematic review was designed to help further elucidate the following question: is the comet assay a suitable biomarker of in vivo oral carcinogenesis?Material and methods: The present systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Full manuscripts from 18 studies were carefully selected in this setting.Results: A total of 15 studies demonstrated positive findings for genotoxicity in peripheral blood or oral cells in patients with pre-malignant lesions or oral cancer. In the quality assessment of studies, 1 was classified as Strong, 5 were considered as Moderate, and 12 were classified as Weak.Conclusion: In summary, the comet assay can be a useful biomarker for oral carcinogenesis. However, further studies with more strict parameters are suggested (with less uncontrolled confounders) in order to increase findings reliability for diagnosis of oral potentially malignant lesions.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"692-702"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of the ATPase alpha subunit of Trypanosoma cruzi as a potential biomarker for the diagnosis of Chagas disease. 鉴定克氏锥虫的 ATPase alpha 亚基作为诊断南美锥虫病的潜在生物标志物。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-09-10 DOI: 10.1080/1354750X.2023.2255756

M Morales-Velásquez, J P Barón-Vera, M I Pulgarín-Osorio, M M Sánchez-Jiménez, J D Ospina-Villa

{"title":"Identification of the ATPase alpha subunit of Trypanosoma cruzi as a potential biomarker for the diagnosis of Chagas disease.","authors":"M Morales-Velásquez, J P Barón-Vera, M I Pulgarín-Osorio, M M Sánchez-Jiménez, J D Ospina-Villa","doi":"10.1080/1354750X.2023.2255756","DOIUrl":"10.1080/1354750X.2023.2255756","url":null,"abstract":"Background: Chagas disease (CD) is considered by the World Health Organisation (WHO) a neglected disease endemic to the Americas, but it has spread throughout the world due to migrations. The disease is almost 100% curable if detected in time. Still, the lack of rapid diagnostic tests with sufficient sensitivity and specificity leads to a chronic phase with a mortality of about 50,000 people worldwide per year.Methods: Using the total proteins extracted from serum samples of patients confirmed with chronic phase CD; we performed the Bio-SELEX strategy. The best aptamers were selected using next-generation sequencing (NGS) based on their most abundant sequences (reads and rpm). Then, selected aptamers were used to isolate potential biomarkers directly from serum samples of patients with chronic phase CD using pull-down and mass spectrometry experiments.Results: CH1 aptamer was the aptamer selected after the NGS results analysis. The pull-down and mass spectrometry experiments identified the presence of the ATPase alpha subunit of T. cruzi circulating in serum samples of patients with chronic phase CD.Conclusions: We report the ATPase alpha subunit of T. cruzi as a potential biomarker for chronic phase CD and CH1 aptamer as a potential tool for diagnosing CD.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"599-607"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10251957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection and modification of biomarkers of inflammation determining successful rhythm control in patients with atrial fibrillation. 确定房颤患者心律控制成功的炎症生物标志物的检测和修饰。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2024-01-22 DOI: 10.1080/1354750X.2023.2284122

Tobias Schreiber, Jana Grune, Ulf Landmesser, Philipp Attanasio

{"title":"Detection and modification of biomarkers of inflammation determining successful rhythm control in patients with atrial fibrillation.","authors":"Tobias Schreiber, Jana Grune, Ulf Landmesser, Philipp Attanasio","doi":"10.1080/1354750X.2023.2284122","DOIUrl":"10.1080/1354750X.2023.2284122","url":null,"abstract":"Introduction: Multiple pathophysiological mechanisms are involved in the pathogenesis of atrial fibrillation (AF). Growing evidence suggests that both local and systemic inflammation plays a key role even in early stages and its progression towards persisting and permanent AF. Rhythm control therapy via pulmonary vein isolation or cardioversion is the cornerstone of AF therapy for most symptomatic patients, yet arrhythmia recurrence after treatment is still common, especially in patients with persistent AF.Material and methods: In this review, we summarize the current state of knowledge of biomarkers of inflammation with prognostic value in patients with atrial fibrillation as well as anti-inflammatory medication with potential benefits after rhythm control therapy.Results and discussion: Both onset of AF, progression and arrhythmia recurrence after rhythm control therapy can be caused by local and systemic inflammation. Various inflammatory biomarkers have been established to predict treatment success. Furthermore, additional anti-inflammatory therapy may significantly improve success rates.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"681-691"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MiR-150 and miR-155 expression predicts survival of cervical cancer patients: a translational approach to novel prognostic biomarkers. MiR-150和MiR-155的表达预测宫颈癌症患者的生存率：一种新的预后生物标志物的转化方法。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2269320

Joana M O Santos, Valéria Tavares, Rui M Gil da Costa, Rui Medeiros

{"title":"MiR-150 and miR-155 expression predicts survival of cervical cancer patients: a translational approach to novel prognostic biomarkers.","authors":"Joana M O Santos, Valéria Tavares, Rui M Gil da Costa, Rui Medeiros","doi":"10.1080/1354750X.2023.2269320","DOIUrl":"10.1080/1354750X.2023.2269320","url":null,"abstract":"Introduction: High-risk human papillomavirus (HPV) is the aetiological agent of cervical cancer, which remains the fourth leading cause of cancer death in women worldwide. K14-HPV16 transgenic mice are a model for HPV-induced cancers, which undergo multistep squamous carcinogenesis at the skin, that is histologically and molecularly similar to carcinogenesis of the human cervix. Previous screens of differentially regulated microRNAs (miRs) using K14-HPV16 mice showed a role for miR-21, miR-155, miR-150, miR-146a, miR-125b and miR-223 during carcinogenesis.Methods: We now aim to translate these observations into the clinical setting, using data provided by The Cancer Genome Atlas (TCGA) to explore whether those microRNAs can influence the survival of cervical cancer patients.Results: Results showed that low miR-150, miR-155 and miR-146a expression levels in primary tumours were associated with poor overall survival. However, only miR-150 and miR-155 were found to be independent predictors, increasing the risk of death. When patients were stratified by clinical stage, low miR-150, miR-155, miR-146a and miR-125b were associated with poor survival for clinical stages I and II. Only low miR-150 expression increased the death risk.Conclusion: We conclude that miR-150 and miR-155 may be potentially applied as prognostic biomarkers in cervical cancer patients. However, further investigation is required to determine their applicability.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"617-627"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of occupational exposure to pesticides with overweight in farmers in Southern Brazil. 巴西南部农民职业接触农药与超重的关系。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2268859

Calinca Skonieski, Karina Raquel Fagundes, Larissa da Silva, Hecson Jesser Segat, Anderson Joel Martino Andrade, Rodrigo Cordeiro Bolzan, Mario Hiroyuki Hirata, Glaucio Monteiro Ferreira, Dalila Moter Benvegnú

{"title":"Association of occupational exposure to pesticides with overweight in farmers in Southern Brazil.","authors":"Calinca Skonieski, Karina Raquel Fagundes, Larissa da Silva, Hecson Jesser Segat, Anderson Joel Martino Andrade, Rodrigo Cordeiro Bolzan, Mario Hiroyuki Hirata, Glaucio Monteiro Ferreira, Dalila Moter Benvegnú","doi":"10.1080/1354750X.2023.2268859","DOIUrl":"10.1080/1354750X.2023.2268859","url":null,"abstract":"Introduction: Exposure to pesticides may be related to overweight and associated comorbidities. The aim of this work was to evaluate occupational exposure to pesticides, overweight and associated comorbidities among farmers in Southern Brazil.Methods: This cross-sectional study included a random sample of 257 farmers, living in the municipality of Mafra and Planalto, southern Brazil. Data on pesticide use and overweight prevalence from farmers were collected using an in-person interview questionnaire, followed by blood collection and biochemical analyses.Results: Pesticide exposure was positively correlated with body mass index, waist circumference, waist-to-hip ratio, triglycerides and glucose levels, presence of hypertension and metabolic syndrome. Besides that, the fact of being exposed to pesticides represents a decrease of no protein thiol groups. Furthermore, the main pesticides used by farmers have hepatic toxicity.Conclusion: These findings suggest that exposure to pesticides may be associated with overweight and associated comorbidities. Further studies are required to validate our findings and elucidate the specific mechanisms by which these pollutants contribute to the development of overweight.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"608-616"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial subtype MB-G3 contains potential novel biomarkers and therapeutic targets associated with prognosis of medulloblastoma. 线粒体亚型MB-G3包含与髓母细胞瘤预后相关的潜在新生物标志物和治疗靶点。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2276670

Qiang Li, Yanfei Jia, Bo Tang, Hu Yang, Qiang Yang, Xiaodong Luo, Yawen Pan

{"title":"Mitochondrial subtype MB-G3 contains potential novel biomarkers and therapeutic targets associated with prognosis of medulloblastoma.","authors":"Qiang Li, Yanfei Jia, Bo Tang, Hu Yang, Qiang Yang, Xiaodong Luo, Yawen Pan","doi":"10.1080/1354750X.2023.2276670","DOIUrl":"10.1080/1354750X.2023.2276670","url":null,"abstract":"Background: Medulloblastoma is the most common malignant brain tumor in children. There are four groups, each with different causal mutations, affected pathways and prognosis. Here, we investigated the role of mitochondria in medulloblastoma and whether there are differences between the different groups.Methods: We compared the gene expression levels in the four different medulloblastoma groups (MB-WNT, MB-SHH, MB-G3 and MB-G4), with the focus on genes associated with mitochondria. We used several tools including Salmon, Tximeta, DESeq2, BiomaRt, STRING, Ggplot2, EnhancedVolcano, Venny 2.1 and Metscape.Results: A total of 668 genes were differentially expressed and the most abundant genes were associated with cell division pathway followed by modulation of chemical synaptic transmission. We also identified several genes (ABAT, SOX9, ALDH5A, FOXM1, ABL1, NHLH1, NEUROD1 and NEUROD2) known to play vital role in medulloblastoma. Comparative expression analysis revealed OXPHOS complex-associated proteins of mitochondria. The most significantly expressed genes in the MB-SHH and MB-G4 groups were AHCYL1 and SFXN5 while PAICS was significantly upregulated in MB-WNT group. Notably, MB-G3 contained the most downregulated genes from the OXPHOS complexes, except COX6B2 which was strongly upregulated.Conclusions: We show the importance of mitochondria and compare their role in the four different medulloblastoma groups.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"643-651"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54227471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationships between Charlson comorbidity index associated biomarkers and outcomes among participants in the Malmö diet and cancer study. 马尔默饮食与癌症研究参与者的夏尔森综合症指数相关生物标志物与结果之间的关系。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2024-01-22 DOI: 10.1080/1354750X.2023.2298651

Torgny Wessman, Toralph Ruge, Axel Carl Carlsson, Per Wändell, Ardavan Khoshnood, Olle Melander

{"title":"Relationships between Charlson comorbidity index associated biomarkers and outcomes among participants in the Malmö diet and cancer study.","authors":"Torgny Wessman, Toralph Ruge, Axel Carl Carlsson, Per Wändell, Ardavan Khoshnood, Olle Melander","doi":"10.1080/1354750X.2023.2298651","DOIUrl":"10.1080/1354750X.2023.2298651","url":null,"abstract":"Introduction: The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population.Methods: Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC). Individuals with CCI diagnoses and other major comorbidities were excluded. Another score of 11 biomarkers associated with comorbidity burden from a previous study of acute dyspnea was also created (BSADYS). The scores were prospectively evaluated for prediction of mortality, and some chronic diseases, using Cox Proportional Hazards Model.Results: Fully adjusted models showed that BSMDC was significantly associated per 1 SD increment of the score with incident COPD, 55%, and congestive heart failure, 32%; and with mortality, 33% cardiovascular, 91% respiratory, 30% cancer, and 45% with all-cause mortality. The BSADYS showed no association with these outcomes, after simultaneous inclusion of both biomarker scores to all the clinical covariates.Conclusion: BSMDC shows strong prediction of morbidity and mortality in individuals free from comorbidities at baseline, and the results suggest that healthy individuals with high level of BSMDC would benefit from intense preventive actions.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"722-730"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0