Biomarkers最新文献_第9页

The combination of preoperative fibrinogen-to-albumin ratio and postoperative TNM stage (FAR-TNM) predicts the survival in gastric cancer patients after gastrectomy. 术前纤维蛋白原与白蛋白比值与术后TNM分期(FAR-TNM)联合预测胃癌患者胃切除术后的生存。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2024-01-22 DOI: 10.1080/1354750X.2023.2281870

Xunlei Zhang, Xinyue Qiu, Haibing Yin, Wenjing Zhao, Li Song, Xingsong Zhang, Lei Yang, Min Tao

{"title":"The combination of preoperative fibrinogen-to-albumin ratio and postoperative TNM stage (FAR-TNM) predicts the survival in gastric cancer patients after gastrectomy.","authors":"Xunlei Zhang, Xinyue Qiu, Haibing Yin, Wenjing Zhao, Li Song, Xingsong Zhang, Lei Yang, Min Tao","doi":"10.1080/1354750X.2023.2281870","DOIUrl":"10.1080/1354750X.2023.2281870","url":null,"abstract":"Objective: There are many factors that affect the survival of patients with gastric cancer, such as TNM stage, the patient's nutritional status, inflammation, and so on. In this study, the prognostic significance of preoperative fibrinogen-to-albumin ratio (FAR) and postoperative TNM staging in patients with gastric cancer was retrospectively studied.Methods: A total of 265 patients (surgery dates from January 2007 to December 2013) were included in this retrospective study. All the patients were confirmed by pathology after operation. Categorical variables were compared using the χ2 test. Kaplan-Meier and log-rank tests were used for survival analysis. Cox proportional hazard models were used to assess prognostic factors. Nomogram was applied to predict the prognosis of overall survival (OS).Results: The higher the FAR value, the more lymph node metastasis, the later the TNM stage, and the shorter the survival time. We established a new scoring system, the FAR-TNM score, which combined FAR and TNM stage. The FAR-TNM score was significantly related to tumor location, tumor size, Bormann types, differentiation, operative type, vascular invasion, nerve invasion, depth of invasion, lymphatic metastasis, and advanced TNM stage. Multivariate Cox regression analysis demonstrated that tumor location, TNM stage, adjuvant chemotherapy, and FAR-TNM score were independent prognostic elements for OS in patients with GC.Conclusions: The FAR-TNM score was a valuable independent prognostic indicator for GC patients after surgery, which can help clinicians to assist the treatment and long-term management of patients with gastric cancer.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"714-721"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138497745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer. 单核髓过氧化物酶是早期卵巢癌的特异性生物标志物。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-12-01 Epub Date: 2023-12-11 DOI: 10.1080/1354750X.2023.2284106

Ghassan M Saed, Asad Nawaz, Ayesha A Alvero, Amy K Harper, Robert T Morris

{"title":"Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer.","authors":"Ghassan M Saed, Asad Nawaz, Ayesha A Alvero, Amy K Harper, Robert T Morris","doi":"10.1080/1354750X.2023.2284106","DOIUrl":"10.1080/1354750X.2023.2284106","url":null,"abstract":"Background: Ovarian cancer cells are known to express myeloperoxidase (MPO), an oxidant-producing enzyme with a 150 kDa homodimer, consisting of two identical monomers connected by a disulfide bond. Here, we aim to validate monomeric MPO (mMPO) as a biomarker for the early detection of ovarian cancer.Methods: Human ovarian cancer cells, sera from patients at various stages, sera from non-cancer inflammatory gynecological diseases, and healthy volunteers were used. Monomeric and dimeric MPO were measured by ELISA. Receiver operating curves were used to compare the predictive powers of serum dimeric and monomeric MPO to discriminate between samples.Results: The expression of MPO was unique to ovarian cancer cells. Specifically, mMPO was found to be the only form of MPO in all ovarian cancer cell lines. Intriguingly, mMPO was detected in the sera from all patients with ovarian cancer at various stages, but not from healthy individuals. Serum mMPO discriminated between early-stage ovarian cancer, healthy controls, and benign inflammatory gynecologic disorders. In addition, mMPO discriminated between the early and late stages of the disease.Conclusion: This work highlights mMPO as a potential biomarker for early detection of ovarian cancer, which is critically needed.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"663-671"},"PeriodicalIF":2.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138046142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of grape seed extract and exercise training on tissues toxicities in doxorubicin-treated healthy rat. 葡萄籽提取物和运动训练对阿霉素治疗的健康大鼠组织毒性的保护作用。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1080/1354750X.2023.2246698

Feiza Belhadjali, Slim Ghrir, Féryel Ksia, Ferid Limam, Ezzedine Aouani, Meherzia Mokni

{"title":"Protective effect of grape seed extract and exercise training on tissues toxicities in doxorubicin-treated healthy rat.","authors":"Feiza Belhadjali, Slim Ghrir, Féryel Ksia, Ferid Limam, Ezzedine Aouani, Meherzia Mokni","doi":"10.1080/1354750X.2023.2246698","DOIUrl":"10.1080/1354750X.2023.2246698","url":null,"abstract":"Objective: The aim of the present study was to investigate the effects of Grape seed extract (GSE) and exercise training on Doxorubicin (Doxo)-induced cardio, hepato and myo toxicities in healthy rats.Methods: Thirty male Wistar rats were randomly divided into five groups and daily treated by intraperitoneal route during two months either with ethanol 10% (Control); Doxo (1.5 mg/kg); Doxo + exercise (1.5 mg/kg + swimming exercise for 30 min twice a week); Doxo + GSE (1.5 mg/kg + GSE 2.5 g/kg); Doxo + GSE + exercise (1.5 mg/kg + GSE 2.5 g/kg + swimming exercise for 30 min twice a week). At the end of the treatment, tissues were collected and processed for the determination of oxidative stress (OS), intracellular mediators, energy fuelling biomarkers, carbohydrate metabolism parameters and muscle histopathology.Results: Doxo provoked OS characterised by an increased lipoperoxidation (LPO) and protein carbonylation and decreased antioxidant enzyme activities. Doxo also affected intracellular mediators, disturbed carbohydrate metabolism and energy fuelling in skeletal muscle as assessed by down-regulated Electron Transport Chain (ETC) complex activities leading in fine to altered skeletal muscle structure and function.Conclusion: Almost all Doxo-induced disturbances were partially corrected with GSE and exercise on their own and more efficiently with the combined treatment (GSE + exercise).","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"544-554"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10059834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis of the prognostic value of soluble programmed death ligand-1 (sPD-L1) in cancers. 可溶性程序性死亡配体-1（sPD-L1）对癌症预后价值的荟萃分析。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-07-02 DOI: 10.1080/1354750X.2023.2198168

Jinfan Sun, Shuenqin Hu, Xiuying Li

{"title":"Meta-analysis of the prognostic value of soluble programmed death ligand-1 (sPD-L1) in cancers.","authors":"Jinfan Sun, Shuenqin Hu, Xiuying Li","doi":"10.1080/1354750X.2023.2198168","DOIUrl":"10.1080/1354750X.2023.2198168","url":null,"abstract":"Background: The soluble programmed death ligand-1 (sPD-L1) and its prognostic role in cancers have been investigated in numerous studies. However, due to the inconsistency on some findings, this meta-analysis was performed to assess the prognostic value of sPD-L1 in patients with cancer.Methods: We searched the PubMed, Web of Science, MEDLINE, Wiley Online Library and ScienceDirect, and screened the studies for eligibility. Recurrence-free survival (RFS), progression-free survival (PFS) and disease-free survival (DFS) were for short term survival. The overall survival (OS) was for long term survival.Results: Forty studies with 4441 patients were included in this meta-analysis. Elevated sPD-L1 was associated with short OS [HR = 2.44 (2.03-2.94), p = 0.000]. Moreover, a high sPD-L1 was predictive of worse DFS/RFS/PFS [HR = 2.52 (1.83-3.44), p = 0.000]. In addition, high sPD-L1 was consistently correlated with poor OS in irrespective of study type, univariate and multivariate analysis, ethnicity, cut-off value of sPD-L1, sample and treatment. In the subgroup analysis, high sPD-L1 was correlated with poor OS in gastrointestinal cancer, lung cancer, hepatic cancer, oesophageal cancer and clear cell renal cell carcinoma.Conclusions: The present meta-analysis showed that a high level of sPD-L1 was associated with worse prognosis in some types of cancer.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"477-485"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9730800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomal miRNAs and breast cancer: a complex theranostics interlink with clinical significance. 外体miRNA与癌症：一种复杂的与临床意义相关的治疗方法。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-06-29 DOI: 10.1080/1354750X.2023.2229537

Sayantanee Mukherjee, Rajib Dhar, Swathi Jonnalagadda, Sukhamoy Gorai, Sagnik Nag, Rishav Kar, Nobendu Mukerjee, Dattatreya Mukherjee, Rishabh Vatsa, Devi Arikketh, Anand Krishnan, Rohit Gundamaraju, Saurabh Kumar Jha, Athanasios Alexiou, Marios Papadakis

{"title":"Exosomal miRNAs and breast cancer: a complex theranostics interlink with clinical significance.","authors":"Sayantanee Mukherjee, Rajib Dhar, Swathi Jonnalagadda, Sukhamoy Gorai, Sagnik Nag, Rishav Kar, Nobendu Mukerjee, Dattatreya Mukherjee, Rishabh Vatsa, Devi Arikketh, Anand Krishnan, Rohit Gundamaraju, Saurabh Kumar Jha, Athanasios Alexiou, Marios Papadakis","doi":"10.1080/1354750X.2023.2229537","DOIUrl":"10.1080/1354750X.2023.2229537","url":null,"abstract":"Breast cancer (BC) remains the most challenging global health crisis of the current decade, impacting a large population of females annually. In the field of cancer research, the discovery of extracellular vesicles (EVs), specifically exosomes (a subpopulation of EVs), has marked a significant milestone. In general, exosomes are released from all active cells but tumour cell-derived exosomes (TDXs) have a great impact (TDXs miRNAs, proteins, lipid molecules) on cancer development and progression. TDXs regulate multiple events in breast cancer such as tumour microenvironment remodelling, immune cell suppression, angiogenesis, metastasis (EMT-epithelial mesenchymal transition, organ-specific metastasis), and therapeutic resistance. In BC, early detection is the most challenging event, exosome-based BC screening solved the problem. Exosome-based BC treatment is a sign of the transforming era of liquid biopsy, it is also a promising therapeutic tool for breast cancer. Exosome research goes to closer precision oncology via a single exosome profiling approach. Our hope is that this review will serve as motivation for researchers to explore the field of exosomes and develop an efficient, and affordable theranostics approach for breast cancer.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"502-518"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9751651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Conjunctival microbiome changes in soft contact lens users and contact lens discomfort patients. 软性隐形眼镜使用者和隐形眼镜不适患者的结膜微生物组变化。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-07-11 DOI: 10.1080/1354750X.2023.2229532

Kang Xiao, Hang Song, Zhengyu Chen, Qin Long

{"title":"Conjunctival microbiome changes in soft contact lens users and contact lens discomfort patients.","authors":"Kang Xiao, Hang Song, Zhengyu Chen, Qin Long","doi":"10.1080/1354750X.2023.2229532","DOIUrl":"10.1080/1354750X.2023.2229532","url":null,"abstract":"Introduction: Contact lens discomfort (CLD) acts as a challenging problem, and the associated conjunctival microbiome changes were unclear.Material and methods: Conjunctival sac swab samples were collected from 12 eyes of nonwearers (NW), 12 eyes of asymptomatic contact lens (ACL) wearers, and 11 eyes of CLD. The V3-V4 region of the 16S rRNA gene sequencing was used to investigate differences among three groups.Results: No differences in alpha diversity were observed among the three groups. The beta diversity showed a distinct microbiome composition between ACL and CLD group (P = 0.018) with principal coordinate analysis. The relative abundance of Firmicutes was significantly higher in CLD (48.18%) than in ACL (13.21%) group (P = 0.018). The abundance of Bacillus in patients with ACL (0.05%) or with CLD (0.02%) were significantly lower than that in the NW (1.27%) group (P = 0.024, 0.028, respectively). Moreover, the abundance of Firmicutes was positively correlated with the OSDI scores in CLD patients (r = 0.817, P < 0. 01, Spearman).Discussions: Patients with CLD have various degrees of bacterial microbiota imbalance in the conjunctival sac, compared with NW and ACL groups.Conclusion: Firmicutes may serve as a potential biomarker for the CLD patients.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"531-537"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9769553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance. 探索人蛋白作为癌症早期检测生物标志物的潜力：血清水平和诊断性能的研究。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-08-13 DOI: 10.1080/1354750X.2023.2246700

Munevver Gizem Hekim, Sibel Ozcan, Mesut Yur, Nilgun Yildirim, Mete Ozcan

{"title":"Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance.","authors":"Munevver Gizem Hekim, Sibel Ozcan, Mesut Yur, Nilgun Yildirim, Mete Ozcan","doi":"10.1080/1354750X.2023.2246700","DOIUrl":"10.1080/1354750X.2023.2246700","url":null,"abstract":"Introduction: Breast cancer is a leading cause of cancer death in women worldwide, and early detection is crucial for effective treatment. Mitochondrial dysfunction has been linked to cancer development and progression. Humanin, a mitochondrial-derived peptide, has been shown to have cytoprotective effects and may be involved in breast cancer development. In this study, we aimed to investigate the potential of humanin as a biomarker for breast cancer.Methods: We recruited 45 female patients diagnosed with primary invasive ductal breast cancer and 45 healthy volunteers. Serum humanin levels were measured using ELISA, and other cancer markers were measured using an Advia Centaur Immunology Analyser.Results: Our results showed that serum humanin levels were significantly higher in breast cancer patients than in healthy controls (p = 0.008). ROC curve analysis indicated that humanin could effectively discriminate between patients and healthy individuals, with a sensitivity of 62.5% and a specificity of 77.5%.Conclusion: This suggests that humanin may be a potential new biomarker for breast cancer screening and early detection. Further research is needed to fully understand the relationship between humanin and breast cancer and to develop new diagnostic and therapeutic strategies.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"555-561"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9986277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Mullerian hormone and cardiometabolic status: a systematic review. 抗苗勒管激素与心脏代谢状况：系统综述。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-06-12 DOI: 10.1080/1354750X.2023.2223365

Aida Fallahzadeh, Fahimeh Ramezeni Tehrani, Malihe Rezaee, Fatemeh Mahboobifard, Mina Amiri

{"title":"Anti-Mullerian hormone and cardiometabolic status: a systematic review.","authors":"Aida Fallahzadeh, Fahimeh Ramezeni Tehrani, Malihe Rezaee, Fatemeh Mahboobifard, Mina Amiri","doi":"10.1080/1354750X.2023.2223365","DOIUrl":"10.1080/1354750X.2023.2223365","url":null,"abstract":"Background: To summarise the relationship between Anti-mullerian hormone (AMH) levels and cardiometabolic status in different populations.Methods: PubMed, Scopus, and Embase were searched for retrieving observational studies published up to February 2022 investigating the relationship between AMH level and cardiometabolic status.Results: Of 3,643 studies retrieved from databases, a total of 37 observational studies were included in this review. The majority of the included studies revealed an inverse association between AMH and lipid profiles, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and a positive correlation with high-density lipoprotein (HDL). While some studies have revealed a significant inverse association between AMH and glycemic parameters, including fasting plasma glucose (FPG), fasting insulin, and HOMA-IR, others found no such relationships. There is also an inconsistency among studies regarding the association of AMH with adiposity indices and blood pressure. Evidence indicates a significant association between AMH and some vascular markers, such as intima-media thickness and coronary artery calcification. Of 3 studies evaluating the relationship between AMH and cardiovascular events, two studies showed an inverse relationship between AMH levels and cardiovascular (CVD), whereas another study showed no significant association.Conclusions: The results of this systematic review suggest that serum AMH levels can be associated with CVD risk. This may provide new insight into the use of AMH concentrations as a predictive marker for assessing the risk of cardiovascular disease, although more well-design longitudinal studies are still necessary for this area. Future studies on this topic will hopefully provide an opportunity to run a meta-analysis; it will increase the persuasiveness of this interpretation.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"486-501"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9994080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive biomarkers for colorectal cancer: a state-of-the-art systematic review. 结直肠癌癌症的预测生物标志物：一项最先进的系统综述。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-09-12 DOI: 10.1080/1354750X.2023.2247185

Moeez Maqbool, Aden Khan, Areej Shahzad, Zouina Sarfraz, Azza Sarfraz, Hinna Aftab, Ali Jaan

{"title":"Predictive biomarkers for colorectal cancer: a state-of-the-art systematic review.","authors":"Moeez Maqbool, Aden Khan, Areej Shahzad, Zouina Sarfraz, Azza Sarfraz, Hinna Aftab, Ali Jaan","doi":"10.1080/1354750X.2023.2247185","DOIUrl":"10.1080/1354750X.2023.2247185","url":null,"abstract":"Introduction: Colorectal cancer (CRC) poses a substantial health burden, with early detection paramount for improved prognosis. This study aims to evaluate potential CRC biomarkers and detection techniques.Materials and methods: This systematic review, reported in adherence to PRISMA Statement 2020 guidelines, collates the latest research on potential biomarkers and detection/prognosis methods for CRC, spanning the last decade.Results: Out of the 38 included studies, diverse biomarkers and detection methods emerged, with DNA methylation markers like SFRP2 and SDC2, microRNAs including miR-1290, miR-506, and miR-4316, and serum and plasma markers such as NTS levels and U2 snRNA fragments standing out. Methylated cfDNA and m5C methylation alteration in immune cells of the blood, along with circular RNA, showed promise as diagnostic markers. Meanwhile, techniques involving extracellular vesicles and lateral flow immunoassays exhibited potential for swift and effective CRC screening.Discussion: Our state-of-the-art review identifies potential biomarkers, including SFRP2, SDC2, miR-1290, miR-506, miR-4316, and U2 snRNA fragments, with significant potential in enhancing CRC detection. However, comprehensive validation studies and a rigorous evaluation of clinical utility and cost-effectiveness remain necessary before integration into routine clinical practice.Conclusion: The findings emphasize the need for continued research into biomarkers and detection methods to improve patient outcomes.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"562-598"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10206947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association between polymorphisms in connexin 40 gene (Cx40) and risk of atrial fibrillation: a meta-analysis based on 3,452 subjects. 连接蛋白40基因（Cx40）多态性与心房颤动风险的相关性：一项基于3452名受试者的荟萃分析。

IF 2.6 4区医学

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-07-13 DOI: 10.1080/1354750X.2023.2227361

Zheng Lian, Zheng Ma, Zhi-Li Zhang, Pei-Lin Liu, Guo-Yong Zhang, Cai-Xia Guo

{"title":"Association between polymorphisms in connexin 40 gene (Cx40) and risk of atrial fibrillation: a meta-analysis based on 3,452 subjects.","authors":"Zheng Lian, Zheng Ma, Zhi-Li Zhang, Pei-Lin Liu, Guo-Yong Zhang, Cai-Xia Guo","doi":"10.1080/1354750X.2023.2227361","DOIUrl":"10.1080/1354750X.2023.2227361","url":null,"abstract":"Introduction: Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with heart failure and stroke, leading sometimes to death. But the pathogenesis of AF remains unclear. Numerous studies have investigated whether the connexin 40 (Cx40) polymorphisms influences the risk of AF, but the results are controversial.Methods: We searched English and Chinese databases and calculated the odds ratio (OR) and 95% confidence interval (CI) to examine the existence of genetic associations between the Cx40 polymorphisms and the risk of AF. All relevant studies were screened and meta-analyzed using Review Manager 5.0.Results: A total of 12 studies, including 10 studies for -44 polymorphism (rs35594137) and 4 studies for -26 polymorphism (rs10465885), were identified for the meta-analysis. For -44 polymorphism, the results showed a significantly increased risk of AF in the five genetic models in the overall analysis. Furthermore, in subgroup analysis, increased AF risks were also observed in Asian and non-Asian populations. For -26 polymorphism, the overall OR revealed an increased risk of AF in dominant model. In subgroup analysis, increased AF risk was only found in recessive genetic model of the Asian population.Conclusions: The Cx40 polymorphisms were positively associated with AF in both populations, especially on -44 polymorphism.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"519-530"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9775439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0